"Asparkam": analogues, mirayiridzo kushandiswa

Medicaments yokudzora metabolic pezvakaitwa ari muviri, ndivo yoga boka zvinodhaka inowanzoshandiswa kurapa marudzi ose zvirwere. Uye regai mutsara uyu sezvisipo kujeka chakunoreva, Ichokwadi. chirwere Chero, chero pathological muitiro kuti kunoitika mumuviri wedu, achiperekedzwa kutyorwa metabolic pezvakaitwa panguva cellular chechetere. Uye kuti nokururamiswa metabolic zvirwere vakawanda kunotungamirira apore. Mumwe mishonga inoshandiswa nokururamiswa akati zvirwere mumuviri ndiye "Asparkam". Zvinonzi nezvaro pathologies zhinji. Ngatitarisei "Asparkam" analogues zvinodhaka kuti anoshandiswa nhasi.

Pharmacological characterization kuti "Asparkama"

Sezvambotaurwa, kugadzirira "Asparkam" anoreva boka mishonga kukanganisa metabolic pezvakaitwa muviri. The mashandiro kuita zvinodhaka inobva pfungwa dzinotevera.

Kuzivikanwa chokwadi zvakakodzera kuti tirambe kuramba ari intracellular Ionic Zvinoumba svikiro. Pfungwa iri rwakabhadharwa kuna dzinotsanagura muchitokisi muviri kuti potassium uye magnesium ions. Nokuda kwaniso ainzi asparginatov (chikamu zvinodhaka) kuita intracellular Ion chokufambisa kupiwa "Asparkama" chinowedzera kuwedzera wevasungwa dzavo uye uvandudze foni muviri.

Nokuti chikuru muviri mutete vanoteerera kuti kusaenzana kwezvinhu ions (kunyanya potassium ions), mwoyo, "Asparkam" rinoratidza cardioprotective mugumisiro kusava chinhu Ion kusaenzana mune cardiomyocytes. Izviwo vanoratidza vasanyanye excitability uye conduction pezvakaitwa, izvo zvinoratidzwa antiarrhythmic mugumisiro chezvinodhaka.

Kuburikidza simba pamusoro zviri "Asparkam" magnesium ions kunokanganisa cellular yavaibvisa-potassium pombi, kuderedza wevasungwa pakati yavaibvisa vnutriklutochnuyu uye kurongedza kuita repolarization muchitokisi membrane. The kuwedzera muna Kamudzira mukana kunotungamirira pakuti shomanana calcium ions vari cytoplasm iri pokuita dzinotsanagura iri electromechanical coupling actin uye myosin cardiomyocytes.

Asparginat Uyezve, chikamu chinodhaka, vatsigiri activation pakati metabolic urongwa, anowedzera haangogoni amino iine acid usage, asiwo kwetunhu amino shuga uye lipids, munyaya mutemo intracellular muviri. Izvi runogonesa simba muviri ari ischemic myocardial nyama uye nzvimbo. "Panangin" - analogue "Asparkama" - nokuda dzakafanana zviri potassium uye magnesium asparginata rinoratidza chete pharmacodynamic migumisiro. Izvi zvinobatsira substantially hwakapararira "Pananginum" zvakafanana mune emwoyo tsika.

The pharmacokinetic zvechadenga

Sam "Asparkam" analogues zvinodhaka riri nokukurumidza uye akapotsa zvachose kupinda systemic riparadzirwe. Excretion zvinodhaka kunoitika zvikurukuru achishandisa neitsvo. Pashure chete dose kunonyanyisa zvinodhaka wevasungwa muropa murukova zvasvika mumaawa 1-2. "Asparkam" kubva muropa Falls sezvo ions kuti potassium, magnesium uye asparginatov masero uye anotanga kuita metabolic dzavo kwendangariro.

zvairatidza

Hwendefa chimiro "Asparkam" Pfungwa yokuti aida (uye zvinobudirira kushandiswa) nokuti kurapwa kwezvirwere chokuita cardiac insufficiency. Saka, zvichiratidza kuti rwendo kungava postinfarction mamiriro ezvinhu pashure cardioversions kana aine arrhythmia uye myocardial conduction. "Asparkam" unoshanda pakurapa mwoyo kukundikana nokushandiswa kwezvinhu cardiac glycosides, uyewo mamiriro ovhadhozi kana chepfu saluretikami (diuretic zvinodhaka kuti kunze kuwedzera diuresis dzekugonesa kukurudzira kusukwa ions kubva muviri).

The injectable chimiro "Asparkama" rave zvinobudirira kushandiswa kunzwisisa kurapa echirwere mwoyo kukundikana, kusanganisira post-myocardial infarction, kusagadzikana mutinhimira uye conduction ari kurapa yaisanganisa.

Contraindications kuti mushonga

Nokuti kuti "Asparkam" rine yakawanda magnesium uye potassium ions, zvinonzi contraindicated panguva chakasimba uye chisingaperi renal kukundikana, uyewo yakawedzera aikanganiswa mumwe kana kupfuura zvinoumba chezvinodhaka.

In cardiogenic kuvhunduka (kana systolic BP anodonhedza pazasi 90 mm HG. V.) Ko varumbidzwa kushandisa "Asparkam" analogs. Mirayiridzo yokushandisa kunoratidza kuti mushonga iri contraindicated muna Addison nehosha uye dzichipfekeka adrenal insufficiency, vanenge zvomurwere vysokostepennoy atrioventricular nechigumbuso uye yakakwirira zviri potassium uye magnesium ions muropa plasma.

Dosing uye Administration

Kana tichishandisa pahwendefa chimiro "Asparkam" mushonga tora mumwe kana vaviri mahwendefa pashure zvokudya katatu pazuva. Duration of marapirwo iri pakutsvaga kupinda chiremba kwakavakirwa kunotoda mukurwara uye rabhoritari Data uye richishanda nzira.

The injectable chimiro iri basa chete intravenous yaitonga. Zviri chimwe chinu ikaparara muna 50 kana 100 ml chena isotonic shuga mhinduro, dzakabatwa nomutsinga zvishoma nezvishoma. Akadzokorora Kutarisirwa zvinogona kudzokororwa Achangopedza pane maawa 4-6 pashure yapfuura rwendo "Asparkam" gadziriro. Analogs zvinodhaka (semuenzaniso, "Panangin") vanotumirwa zvakafanana. "Panangin" se "Asparkam", ane raidudzwa simba pamusoro muviri kuti myocardiocytes. Naizvozvo, analogue ichi "Asparkama" muna Russian iri zvinowanzoshandiswa cardiology muzvipatara.

nemishonga

Kana kugamuchira hwendefa chimiro may panowanikwa zvinetso zviri nemudumbu, ayo kunoratidzwa marwadzo uye nokupisa epigastric, kuda kurutsa, kurutsa. Chirwere Kutarisirwa kungaita nemaronda yacho mucosa.

Sezvo mushonga ine koshesa simba kumwoyo, pamusoro wayo chikamu kungaita arrhythmias, conduction nenyonganiso, atrioventricular chidhina, BP.

Tsinga inodaro panowanikwa paresthesia, tingling, twitching.

Nokuda mukuru zviri magnesium ions vavo kupinda munzvimbo nechepakati tsinga anogona kufema kuora mwoyo ushande. kazhinji uyewo ndipo pakatanga pamusoro kutekenyedzwa nokupisa "Asparkam" chinodhaka. Analogs zvinodhaka zvakafanana zviratidzo nenjodzi uye kakawanda panowanikwa yavo. Tichifunga izvi, iva nechokwadi kuti kukumbira murwere isati kubvuma zvinodhaka.

Mirayiridzo Special kushandiswa "Asparkam" chinodhaka

Analogs vana vari zvinowanzoshandiswa varwere chiremba, kunyange zvazvo pane pari kukwana mashoko pamusoro kushandiswa "Asparkama" vana. Pasinei neizvi, mushonga yave kushandiswa zvinobudirira nokuti pakurapa zvemwoyo mu Pediatrics.

Kana mabatiro kwenguva refu "Asparkama" akataura nokungwarira richiona nezvezvabuda electrolytes muropa plasma, kuongorora electrocardiographic parameters. Uyewo nokungwarira hwakanyanya mushonga inoshandiswa varwere yakakwirira potassium mumatunhu ari plasma.

"Asparkam": dzomuzana

Pakati ano mishonga pamusika Generic "Asparkam" chinodhaka ndiko kupa "Panangin". With yakakwirira kunyatsoshanda, vanoshingaira analoginen "Asparkama" iri zvinowanzoshandiswa Russia sezvo ane akafanana marongerwo uye ukuwo zvairatidza zvakafanana. Uye cardiology tsika muenzaniso. Saka, "Panangin" - zvineringanidzo "Asparkama" pamwe chete nziyo.

Pakati pezvimwe zvinodhaka ane ndozvinoitawo zvinofanira kucherechedzwa, "Inosine" "Riboxinum" "Meksaritm" "Propanorm" "Ritmokard".