Cholinesterase FIs: kushandiswa pharmacological

Zvinozivikanwa kuti tsinga ane synapses zhinji. Ivo zvinodiwa nokupfuuridzirwa nomunhu. Izvi zvinosanganisira marudzi vanoverengeka nevamiririri. Pakati pavo, - .., Acetylcholine, norepinephrine, neGebha, kweserotonin, etc. nevamiririri (zvinotakura) anodiwa kuti kuchinjwa anonongedzera pakati Tutsinga tunofambisa mashoko utwu. Uyezve, nokuda kwavari voitakura excitation kana chinovhiringidza musculature. In pathologies siyana tsinga neurotransmitters basa anogona chibharo. Izvi zvinoitika nokuda atrophic uye chinopedza pezvakaitwa muuropi. Muzviitiko izvi, kushandisa zvinodhaka zvinodiwa amplifying kana attenuating nokupfuuridzirwa chiratidzo. By rimwe pharmacological boka yakafanana vari cholinesterase FIs. Ivo zvinoshandiswa myasthenia, neuritis, chinonzi amyotrophic lateral sclerosis, chirwere cheAlzheimer, vairwara pathologies.

Mugumisiro cholinesterase FIs

Cholinesterase FIs - a mishonga kuti zvinowanzoshandiswa neurology uye wepfungwa. Vari rakakamurwa mapoka akawanda, mumwe nomumwe riri kushanda mune imwe nyaya. Kuitwa zvinodhaka izvi vanoita maererano ichivharira cholinesterase. enzayemu ichi inowanikwa zvose vanhu utano uye avo vanotambura nezvirwere zvakasiyana siyana. Zvakakodzera kuputsa neurotransmitter - acetylcholine. Somugumisiro kwayo chiito wokutepfenyurisa akafumuka kuti choline uye acetic acid. In pathologies siyana uropi cortex atrophy kunoitika zvishoma nezvishoma. Somugumisiro, mimwe zvivako anogona richaparara zvachose, kusanganisira cholinergic hurongwa. Kunze uropi atrophy, ichi zvinotungamirira chinopedza dzinotsanagura autoimmune, zvinotapukira, nemavhairasi zvisikwa. Nokuda kuparadzwa hunoita nhengo nhatu nuclei pane raidudzwa kushayikwa neurotransmitter - acetylcholine. Kwenguva refu sezvinobvira yaiva haazivani nefuma, zvinokosha kuita pamusoro enzayemu kuti anouparadza. Nokuti chinangwa ichi, kuti cholinesterase FIs anoshandiswa. Nemhaka kwavari, neurotransmitter basa kungapfuurira kwemakore akawanda.

Cholinesterase FIs: zvinodhaka kupatsanura

Kune mhando wandei anticholinesterase zvinodhaka. Ivo dzinoiswa maererano pharmacological migumisiro pamusoro enzayemu. Vamwe vavo vari ichivharira cholinesterase kusingarapiki, vamwe - kwenguva pfupi. Govera 3 Mapoka medicaments. Pakati pavo:

1. Reversible blockers. Izvi cholinesterase FIs chiito postsynaptic zvichikurukura. Pamusana navo, enzayemu iri chakambovhiringidzwa. boka iri zvinosanganisira acridines uye piperidine.
2. Psevdoneobratimye cholinesterase blockers. mashandiro avo vaite pachiimbwa onionovoy chikamu enzayemu Morekuru. Mukuwedzera, vanokwanisa kusunga kusvika acetylcholine receptors. ehupfumi ava boka carbamates.
3. Kusingarapiki FIs ose cholinesterase. boka iri zvinodhaka rinozivikanwa organo-phosphates nzira. Mumiriri weimwe medicament "Metrifonate".

Boka acridines zvinosanganisira "keriya ndege" zvinodhaka uye "Velnakrin". Representatives carbamates - mishonga "rivastigmine", "Epistatigmin".

Zvairatidza kuti kushandiswa cholinesterase FIs

Cholinesterase FIs anoshandiswa kurapa tsandanyama zvirwere nechepakati mavambo, atrophy uye chinopedza pfungwa zvirwere. Uyezve, dzimwe mishonga zvinowanikwa muchimiro samadonhwe. Ivo anoshandiswa pana yakakwirira intraocular kumanikidzwa - yemaziso. Zvinodhaka kuti tunodzivisa cholinesterase reversible, akaratidza kuti chokuita nokurapa kurasika pfungwa, Pick nechirwere uye yeAlzheimer. Zvatinofarira ndiko kupa boka piperidine, sezvo vari kusarudza uye vane zvishoma nemishonga. Mumakore achangopfuura, nyika zviratidzo kuti kushandisa zvinodhaka yakawedzera. Izvi imhaka uwane kudzidza zvivako zvavo. For nezvirwere izvo ushandiswe anticholinesterase zvinodhaka zvinosanganisira myasthenia gravis, intestinal atony, chirwere chinonzi muscular dystrophy, chinonzi amyotrophic lateral sclerosis, kuoma Mbabvu chinopedza mavambo. Kusingarapiki FIs anoshandiswa kana nomuchetura.

Contraindications pakushandisa cholinesterase zvinodhaka

Mishonga iri boka iri harina kushandiswa convulsive zvinetso, hyperkinesis chero etiology. Vanewo contraindicated mu varwere zvikuru mwoyo nokukundikana, asima, thyrotoxicosis. Hazvina kunaka kutora anticholinesterases pamwe concomitant gastric urikanwi, enteritis. Mishonga mukasazivisa vakadzi pamuviri uye lactating.

Cholinesterase FIs: pakusarudza zvinodhaka nokuda cheAlzheimer

CheAlzheimer - ndiko atrophic CNS, umo kukanganwa, unhu chirwere uye dementia. Masayendisiti munyika yose vari kuedza kuwana mushonga chirwere ichi. At nepakati kwokuomerwa hosha ndiwo mushonga kusarudza "donepezil". Rinoreva reversible cholinesterase inhibitor, ane haangotongi nomugumisiro. A mushonga rakashandiswa nechinangwa pathogenetic mishonga. Haasi kukwanisa kurapa murwere zvakakwana, asi DZEMUNHU DZINODZORA kukura cheAlzheimer zviratidzo.