Imidazoliletanamid pentandiovoy asidhi: pharmacological chiito, chikumbiro, analogues

Kana chiremba wenyu akaonekwa ari "nemavhairasi chirwere", zvinoreva kuti unofanira kurapa zvakanaka. A kumbonyanya guru boka redu vagari vemo vanodavira kuti nemishonga - yakanakisisa mushonga zvirwere zvose. Sezvineiwo, ndiko zvisizvo kukuvadza yakawanda kupfuura chaiko chirwere. Mishonga ndivo chete kushingaira pamusoro zvinokonzerwa noutachiona, asi ivo havana simba pamusoro wanda.

Sei mushonga mabasa?

Pane chaizvo vakawanda zvinodhaka antiviral basa. Chimwe chezvinhu zvakafanana zvinhu zvine pfuma iyi - nayo imidazoliletanamid pentandiovoy acid.

Hazvina basa pamusoro utachiona mhando yokuSpain A uye B, adenovirus, parainfluenza uye anobatsira vane kufema syncytial utachiwana hweHIV.

Ichi kushingaira remubatanidzwa ane yakasiyana mashandiro kuita. It kuchititadzisa dzokubereka kwacho nemavhairasi tsanga chehupenyu rwakazara uye retards yokutama vachangotanga zvinotapukira mumiririri kubva cytoplasmic kwezvakatipoteredza Mwoyo wesero masero.

Uyewo imidazoliletanamid pentandiovoy asidhi ari kushingaira mumabasa masoja yevanhu ezvinhu kungotaurwa modulating maturo. The fuma anowedzera ropa interferon tigutsikane kuti ufanane vasiri ndozvakajairwa. uyewo kunomutsa nedanho α-, γ-interferonproduktsii leukocytes, zvichiguma runoenzanirana mamiriro mabasa aya.

Investigations yezviri fuma kwakaratidza kuti imidazoliletanamid pentandiovoy asidhi inosimudzira chizvarwa cytotoxic lymphocytes chiito. Uyezve, anowedzera uwandu NK-T-nevasori kuti vane risingaenzaniswi kukwanisa kuparadza masero kushandurwa pamwe nemavhairasi, uyewo chiito zvakananga utachiona.

The anobatsirwei pamberi zvinodhaka akanga Anti-anogumbura ehupfumi. Vari inopiwa kudzvanyirira kugadzirwa cytokines Profile, uyewo kuderera basa enzayemu myeloperoxidase.

kuchirapa kushanda

Imidazoliletanamid pentandiovoy acid, wongororo zvacho zvakanaka, rakatevera inoratidza kuchirapa mugumisiro pakurapa SARS uye bembo:

• It kunoderedza ya febrile kwacho.
• Zvinoderedza zviratidzo kudhaka (dzungu, kurwadziwa, utera).
• Kunoderedza catarrhal kuratidzwa.
• Waanodzikisira matambudziko chirwere ichi.
• Zvinoderedza nguva chirwere.

Zvinodhaka imidazoliletanamidom pentandiovoy asidhi

Chemishonga anogona kuwanikwa zvinotevera Formulations ane imidazoliletanamid pentandiovoy asidhi:

• "Vitaglutam" Nezvakakuyiwa.
• "Ingavirin" dziri capsules.
• "Dicarbamine" mapiritsi.

Contraindications

Kungofanana zvinodhaka imidazoliletanamid pentandiovoy asidhi - mushonga zvinofanira kutarisirwa kuti kupinda chiremba. Izvi mishonga chigadzirwa ane contraindications, kusanganisira:

• Panguva pamuviri uye lactation.
• Vana kusvika nemakore 18.
• Hypersensitivity zvinodhaka zvinoriumba.

Side migumisiro kubva kurapwa chine zvinorondedzerwa rinoita fuma kungaratidzwa nenzira sema kuita.

Izvi inopiwa kuti munhu ane mumwe aikanganiswa imidazoliletanamidu pentandiovoy asidhi kana ebetsero zvinhu, izvo zviri chikamu zvinodhaka.

chengetedzo

Vamwe vanhu vanoedza kudzivisa kushandiswa kwezvinodhaka ichi, muchitenda kuti imidazoliletanamid pentandiovoy asidhi - chiri mushonga. maonero Izvi kururama, sezvo iri rinoita fuma rinoratidza antiviral basa chete. Akadana Unhu kumira naye zvose nemishonga kuti vari yokusafa inorwisa utachiona zvinodhaka profile. The mushonga hakuna immunotoxic, carcinogenic, mutagenic kana allergenic chiito pasina muchishungurudza ari zvomudumbu turakiti havasi wakaderedzwa dzokubereka nerevane asina embryotoxic kana teratogenic kushanda.

Kunoonekwa nokuva nani yakakwirira basa zvinodhaka kuti akaumbwa imidazoliletanamid pentandiovoy asidhi analogs izvo vanobviswa nomuromo. Ivo vari kukurumidza kunakidzwa nemudumbu uye zvakaenzana akaparadzirwa mapazi uye munyama. Nechekare pashure hafu yeawa pashure ingestion pamusoro somushonga chirungiso runosvika kunonyanyisa wevasungwa muropa uye akabata maawa 37. Ya kurapwa raiva 5 mazuva. Kutarisirwa imwe neimwe zvinodhaka ane kusvetuka yawo tigutsikane muropa, izvo zvinoderedza zvishoma nezvishoma masikati. The mushonga mumuviri womunhu haana rinoita goho kuchinja nokuda neitsvo ura.

mamiriro mutambo

Zvinokosha kuona chipimo chemushonga zvaiitwa zvinodhaka. Imidazoliletanamid pentandiovoy asidhi analogs vanoonekwa ne anenge chete dzinoenda kuti kushandiswa, apere nomuromo kamwe zuva imwe mari 90 MG pamusoro mazuva 5-7, pasinei kudya.

The peculiarity kurapwa iyi mishonga mumiririri ndechokuti mukuru kunyatsoshanda kunokwanisika kana kupiwa pashure Detective zviratidzo chirwere yokutanga mukati memazuva maviri okutanga.

"Vitaglutam" - panobva boka antiviral vamiririri

Nhoroondo zvinodhaka anodzokera kuna 70s remakore rapfuura. Rakanga yakataurwa akakurumbira Russian chiremba pulmonologist Alexander Chuchalin. The medicament unotora sechinhu chikuru vanoshingaira chirungiso imidazoliletanamid pentandiovoy acid. "Vitaglutam" wakatangwa pasi kutengeswa zita "Dicarbamine" kusvikira 2008. Chinangwa chake chaiva chokuti, kuti kukurudzira hematopoiesis kwacho varwere vanenge inini kurapa kurapwa kenza.

Muna 2009, vanhu akatarisana inotyisa utachiona hweHIV - yenguruve dzihwa, kana A / H1N1. Panguva ino, "Vitaglutama 'kukura kunge akakodzera chaizvo. Aleksandr Chuchalin, uyo panguva iyoyo chiremba mukuru Russian Federation, akasarudza kuedza kwake zvisikwa pamusoro penguruve furuwenza utachiona uye unozadzisa vakabudirira zvabuda. Akati kuti zvipfuwo chigadzirwa, iyo yakavakirwa imidazoliletanamid pentandiovoy acid, "Vitaglutam" anoratidza kukuru efficacy pazvirwere inotyisa kupfuura American mishonga chigadzirwa "Tamiflu". Ari kushingaira revatema kupinda nemavhairasi genome, uye akariuraya.

New Life "Vitaglutam" zvinodhaka "Ingavirin"

Chuchalin zvinganaka Gennady Onishchenko, mukuru utsanana chiremba mukuru Russian Federation, kushandisa michina yake sezvo kunobatsira vari kurapwa renguruve besa. Somugumisiro kurapwa miedzo zvinodhaka yave ichiitwa, pazviri akasimbisa kushanda kwayo panyaya dzakasiyana-siyana kutapukirwa noutachiona. The mushonga wakapiwa zita idzva "Ingavirin" uye rakanyoreswa zviri mazita boka zvinodhaka antiviral uye immunostimulatory.

Kamwe chigadzirwa ichi chinhu mishonga kambani "Valenta" akapfuurira sale, yakanga pamutemo ndakarumbidzwa Bazi Health sezvo kurapa nokuda renguruve dzihwa uye akatanga kurova zvinyorwa kukurumbira pakati yevagari. Saka, tinogona kutaura pamusoro kufanana "Dicarbamine" - imidazoliletanamid pentandiovoy asidhi - "Vitaglutam", kuti chokwadi, mumwe chete mushonga.

Zvinokosha kucherechedza kuti "Ingavirin" akapfuurira Sale 2008 akaita pasina miedzo zvizere zvekuchipatara. With rubatsiro Onishchenko muna 2009 wakakurumidza miedzo zvekuchipatara dziri mumarabhoritari mbeva dzakatangwa. Uyewo chiitiko ichi, wakapindwa varwere vanenge 100 muchirongwa. Zvichienderana migumisiro yokudzidza chikwata kwakatungamirira Chuchalin akagumisa kuti "Ingavirin" mukati maawa 48 kubva pakutanga chirwere yokutanga yakaratidza nekaupenyu yakakwirira kunyatsoshanda chirwere utachiona. chiito Its zvinoratidzwa rutapudzo pamusoro febrile kumwedzi, kudzikira toxicity mu murabhoritari mhuka uye varwere uye kuderedza catarrhal kuratidzwa.

Naizvozvo, hapana chikonzero chokufunga pamusoro imidazoliletanamid pentandiovoy asidhi kuti chokunyepera - kushanda kwaro nekusimba akaora.

"Dicarbamine" nhasi

Pari, zvose zvinodhaka matatu pahwaro imidazoliletanamida pentandiovoy asidhi kutengeswa dziripo uye vari papi sezvo dzomuzana kune mumwe.

"Dicarbamine" rakarumbidzwa kushandiswa varwere pamberi nyanyisa anomera. Kuwedzera huru vanoshingaira chirungiso, rine mukaka shuga, talc, mbatatisi starch, magnesium stearate, colloidal mhinduro kubva nesilicon yakasviba uye stearic acid.

"Dicarbamine" rine zvinotevera kuchirapa Migumisiro:

• Kumhanyisa kuti neutrophil Kusiyanisa uye dzichipfekeka kuibvisa.
• Gematoprotektsiya pamwe myelosuppressive mishonga.
• Kuderedza kakawanda panowanikwa uye dhigirii chepfu neutropenia, leukopenia vakaomerwa.

gadziriro iyi inokurudzirwa kushandisa pakati yamabwe mishonga.

Kugona kwaro kwatova pachena mushure memazuva 21-28 chourongwa zuva nezuva pamahwendefa.

A chete dose mishonga - 100 MG (1 piritsi) - akatorwa 5 mazuva asati atanga mishonga uye akaramba yose kurapwa. "Dicarbamine" ane pfuma kusimudzira uye achawedzera kuitwa anticancer cytotoxic zvinodhaka, kuti kuderedza chepfu migumisiro cyclophosphamide uye Platinum kunobva zvinodhaka, uye kuguma kwomuzvarirwo dzinotsanagura hematopoiesis.