Kemikari 17-OH-progesterone. 17-OH-progesterone: mwero ropa

The chikuru chinangwa hormone kutenderera vakadzi panguva kuenda kumwedzi - ovulation. Panguva iyi, zviri pasi kudzorwa hypothalamus. Panyaya iyi, kuti zvinhu yaidzorwa zvigadzirwa kuti secreted mune Anterior pituitary shwanu: FSH uye LH.

nezvekugadzirwa ovulation

Mugore pre-ovulatory chokutambudzika kumwedzi kutenderera ovarian follicle kaviri transformations akawanda. Kuchinja aya kuitika pasi pokudzora FSH. Mushure follicle zvasvika mumwe saizi, uyewo dzichipfekeka basa LH ovulatory yepamusoro aumbwa. Izvi zvichaita nokuparura "kuibvisa" ovum (wokutanga meiotic kupesana). Shure kwaizvozvo danho discontinuity rikaitika follicle maumbirwo, uye kunze kuburikidza iyo zai. The penguva pakati yepamusoro uye ovulation chokutambudzika hurongwa maawa 36-48. Panguva postovulatory kutotanga misha kunoitika yemanyorero zai kuti dumbu yacho fallopian chubhu. Kana wekusangana rechitatu-rechina zuva embryo chinopinda kupinda uterine mhango. Pane kwayo muchibereko. Kana pakusangana kumboitika, ipapo zai masikati unofira fallopian chubhu.

Zvinhu munyaya nechouviri munhukadzi dzokubereka basa

Ari kwemakemikari anobudiswa mumasero vari aumba kubva pakugadzira vanoshingaira yeimwe. Ndivo vakadanwa mahormone. Zviri ngaavongwe kwavari nomukombiyuta hypothalamic-pituitary-ovarian maitiro uye kuona pane simba basa nhengo dzokubereka nadzo. Mumwe remubatanidzwa anoita mamwe mabasa. Mumwe zvinhu muzvirongwa pezvakaitwa munyika dzokubereka nadzo, 17-OH-progesterone. Follicular danho inoyerera kuwedzera zvayo yevasungwa. remubatanidzwa Izvi synthesized mune diki zvakawanda zviri ovary. Kuwedzera zviri pafuma ndiwo yepamusoro padanho ph. Zvadaro, muna pakati kutenderera, wevasungwa ipfupi kwenguva pfupi. Progesterone ari follicular chokutambudzika DZEMUNHU DZINODZORA endometrial kuwanda dzinovhurika ne inonzi estrogen. The zvichiguma remubatanidzwa iri pasi shanduko. The chikuru chinokonzera kumwedzi ndicho kamwe kumbomira okuwana kubudikidza corpus luteum mbeu progesterone kutenderera kupera. Izvi hazvizivi kuwedzera luteal danho endometrial stroma vakaumba decidual kuita. Zvakafanana kuchinja kuitika kumavambo pamuviri. Progesterone rinopa mutemo kwemasero vari cervix, kunoderedza contractility mhango. Mukomboni zvakare kuchititadzisa kumwedzi.

Kemikari 17-OH-progesterone. tsananguro

Ndiro aizotangira steroids. Dzaro adrenal cortisol aumba pasi pokudzora makemikari akadai 11-b 21-hydroxylase kana hydroxylase. 17-OH-progesterone vakadzi vanogona synthesize androstenedione. Ichi acho ndiwo aizotangira kuti testosterone uye estradiol. Zvinonzi akaumba muna ovaries uye adrenal mumasero. Ropa progesterone-17-OH aripo akasununguka uye akasungwa pamwe keriya mapuroteni sezvo transcortin uye sealbumin. Pasina wekusangana fuma wevasungwa kunodzikira. Kana muchibereko zai iri ovaries, iyo corpus luteum mbeu kuramba kubereka nayo.

ubindikiti

17-OH-progesterone kwakawedzera mangwanani. Minimum zvirimo yakaratidza usiku. Masikati, ayo mwero zvinosiyana. Uye remubatanidzwa wevasungwa kunosiyana-siyana panguva kuenda kumwedzi. A chinokosha yakawedzera sandara vaichengeta zuva pamberi LH yepamusoro. Izvi kunoteverwa chehupenyu kunonyanyisa pfungwa (mid-kutenderera). Panguva pamuviri, fuma tigutsikane ari yekudyidzana ichiwedzerwa. 17-OH-progesterone, mwero zviri zvakatemwa maererano nemakore vana zviri zvishoma. kuwanda Large anowanikwa chete rakaorera nguva uye pakarepo pashure pokuberekwa. Muchiitiko chino, mu vakurumidze vacheche zvirimo achiri yakakura. Muvhiki yokutanga kubatana chechetere mapopoma. Yakati kunoramba kuwedzera pakuyaruka. Panguva iyi, progesterone-17-OH kuyaruka zvishoma nezvishoma chinosvika zvakafanana wevasungwa sezvo nedzevakuru.

Ko sei uchifanira kuva bvunzo ropa?

17-OH-progesterone chinhu zvenguva chigadzirwa. Zvisinei, kudzidza chinhu danho rinokosha nechirwere pamusoro pathologies siyana. By uchapupu nokudzidza zvinosanganisira kushaya mbereko, hirsutism, kutenderera zvirwere. Apo adrenal hyperplasia isiri yekenza sezvo kurapa varwere raitongwa steroid yokutsiva mishonga. Kuongorora kwayo kushanda kuongorora anopiwawo. 17-OH-progesterone akadzidza mu vacheche. Its wevasungwa kudzidza vaifungira 21-hydroxylase kukanganisika. Kushayikwa enzayemu ichi akaona vachiberekwa adrenal hyperplasia isiri yekenza mhando.

Kugadzirira rabhoritari yokuedzwa

Kana chiremba asina chimwe nguva, ropa rinopa pamusoro rechitatu reshanu yatinofema. Kudzidza chaiitirwa usina chawadya mangwanani. It haabvumirwi kushandiswa kofi kana tii. Kubvumirwa kunwa mvura pachena. Sezvo rokupedzisira kudya pamberi ropa mari inofanira kuva maawa masere kana kupfuura. Nyanzvi funga izvozvo kukodzera kemikari kudzidza rechipiri danho iri 20-23 zuva. Kana ya ichitanga mazuva 42, ropa mharidzo rinoitwa pazuva 35 zuva fung. Pazuva yechi23 zuva rokutanga kutotanga ichiri mberi. Padanho progesterone ipfupi, asi haina kunoratidza kukundikana luteal kutotanga kana anovulation. Hazvina zvazvinoreva kuti azodzidza kufungisisa panguva yepamuviri uye kutora chero zvinodhaka. Muchiitiko chino, yakakwirira 17-OH-progesterone - vasingambooni chakaipa nazvo. kugutsikana rwakadaro havana hanya haina kuzvireva.

kududzira zvabuda

Sezvataurwa pamusoro apa, sevamwe pamwero kemikari progesterone, 17-OH kunobva zera. Kukosha uye kurara kuti nyaya. Wevasungwa iri akatsunga Ng / Rine mamiririta. Zvakanyanya Kunaka Panguva Yepamuviri kugutsikana vana kusvikira mwedzi - 0-16,63; 1-2- mwedzi. - 1,8-9,7; 3 months. - 0,07-1,7. Nokuti varwere pasi rimwe gore - 0-1,65; kusvika 3 years - 0-0,99; kubva 3 kusvika 10 - 0,07-1,69. Bvumidzwa pamwero nevarume - 0.5-2.1. Nokuti vakadzi follicular chokutambudzika - 0,41-2,72; ovulatory - 0,33-2,8; luteal - 0,33-2,8. In wokutanga trimester pamuviri progesterone-17-OH anofanira kuvapo ari wevasungwa pamusoro 1,17-5,62; Chechipiri - 1,17-6,7; ari wechitatu - 1,24-11. In postmenopausal Zvakanyanya Kunaka Panguva Yepamuviri zviri 0,13-0,51.

adrenal hyperplasia isiri yekenza

Zviri vachiberekwa autoimmune zvokurwara. Kazhinji anovandudza somugumisiro kushayiwa makemikari munyaya kwetunhu steroids. Kushaya yeimwe vangava madhigirii siyana zvakaoma. In kuchangotanga mu vachiberekwa hyperplasia isiri yekenza hwapedyo virilization (paumbwe rume unhu vakadzi). In Muzviitiko zvakaipisisa, imwe enzayemu kushaikwa chinokurwadzai zvakakomba yokutyora ari kwetunhu steroids, munyu kurasikirwa, izvo zvinogona upenyu pangozi. Rushoma kushayiwa of enzayemu kwakawanwa vakuru, uyewo chinogona kuva vachiberekwa zvakasikwa. Muchiitiko chino, pakutanga kutyorwa kuitika mune Isimba rakadini rinogona kubudiswa chimiro, uye haana nguva dzose dzakaonekwa muuduku. Vasingadzoreki kwetunhu makemikari anogona kuva nezvishoma hunhu. Nokupesvedzera rwakashata pathological zvinhu kunowedzera ndingangokuvara chadzo uye morphological kuchinja adrenal omumuviri, zvakafanana kuratidzwa vachiberekwa syndrome. Somugumisiro kwakakanganiswa pabonde kugadzira kuyaruka. In yakawanda progesterone, 17-OH chinotarisa kwayakaita pamusoro kwetunhu androgens. yeimwe izvi achiparadzira achiri mucheche uye vanotsamwisa vasikana kutaura zvepabonde zvechadenga munhurume mhando. Naizvozvo, kudzidza kwayo mumisasa zvakakosha kuona kubudirira kurapwa akapiwa.

Kushayiwa pakati enzayemu 21-hydroxylase nengozi zvikuru

Kushaikwa remubatanidzwa Exhibits akaderedza aldosterone inotungamirwa. Izvi kemikari adrenal anopa mitemo nemvura munyu mwero, sokunonoka mumuviri yomunyu. In vacheche, pane "dambudziko varasikirwa." Nokuti zvakadaro ichazivikanwa noku kuunganidza Urume akawanda. Panguva iyoyowo muviri vanoshingaira kutora mashoko anodiwa munyu. Somugumisiro, mashoko potassium tigutsikane anotanga kukura, uye yavaibvisa - kuderera. Mienzaniso enzayemu insufficiency inozivikanwa vakadzima kunotoda mufananidzo. Nokufungirana kuti kushaikwa kuonekwa mune pakanyorwa kutyorwa pakuyaruka uye kukura mune pakuyaruka, panguva mukuru zera - ne mwana uye vasingadzoreki panguva kuenda kumwedzi, vasikana - pamwe hirsutism.

mhedziso

Basa zvepabonde mahormone mumwe kuziva zvikonzero havasi chete nokushanda kwenhengo dzokubereka nadzo vakadzi. Zvingaitwa yeimwe, avo kutsiga uye vakakwana basa, kubatanidzwa pezvakaitwa siyana, uyewo kuvapo imwe Zvakanyanya Kunaka Panguva Yepamuviri mumisasa ane nezvainoita zvinonyatsorehwa kukura kwomuviri uye utano zvavo. The vanachiremba vanonyevera kuti chero yakatsauka kubva huripo zvaanoda mushonga havasi nguva dzose chiratidzo zvokurwara. Nezvenyaya iyi, mumwe nomumwe zvakafamba haatarisiri kurapwa. Zvisinei, vanachiremba vanokurudzira kuti nguva dzose kupa ropa kuti murabhoritari pachisara zvakaitika bvunzo. Vamwe zvirwere vane Isimba rakadini rinogona kubudiswa chimiro uye kukurumidza chirwere kunotungamirira zvakakomba. Zvikuru kukosha ndiwo mamiriro vakadzi hormone. Not kuzivikanwa pauduku zvirwere nezera mberi, kukonzera disruptions ari kushanda okubereka uye nedzimwe enyika mumuviri. Mune zvimwe zviitiko, kushaya mbereko - mumwe matambudziko zvikuru nokukurumidza nhasi - ndiwo mugumisiro vachangobva nechirwere. Varwere kugamuchira yokutsiva kurapa, vanofanira kugara kunoonekwa nachiremba uye miedzo ropa. Migumisiro kubvumira kwete chete rokuongorora kuchirapa efficacy zvinodhaka, asi kuchinja zvavanofunga kushanda zano.