Mahwendefa "fenigidin": mirayiridzo kushandiswa, zvechokwadi

Chii chinorehwa mushonga "fenigidin"? Mirayiridzo kushandiswa vanachiremba mudziyo, contraindications ayo, nemishonga uye analogs zvinotsanangurwa zvizere munyaya ino. Uyezve, uchadzidza kana kupiwa mushonga (zvairatidza), ndedzipi chipimo chemushonga zvinofanira kutorwa, zvavanotaura nezvazvo, varwere uye vanachiremba.

Murwiyo uye chimiro zvinodhaka yokusunungurwa

Drug "fenigidin" inogona kuwanikwa Pharmacies mu piritsi fomu. Vane Coated uye ane basa chirungiso akadai nifedipine. In kutengeswa vanachiremba mumiririri zvikurukurwe nenzira atorwa bhokisi, apo rinogona kunge pellets 40, kana 50.

Tinewo amutsvaka medicament inogona kutengeswa sezvo mhinduro intravenous kana intracoronary yaitonga. chinodhaka ichi rine chete rinoita wemafuta sezvo tablet.

Pharmacological zvechadenga zvinodhaka

Chii chinodhaka "fenigidin"? Mirayiridzo kushandiswa kwezvinodhaka inoti kuti iri kusarudza karusiyamu mugero blocker kirasi 2, uye dihydropyridine nomukaka.

The mashandiro chiito zvinodhaka ichi ndechokuti DZEMUNHU DZINODZORA karusiyamu kudirana mune masero vascular kumeso tsandanyama uye cardiomyocytes. Mishonga anokwanisa anewo hypotensive uye antianginal nemigumisiro. Rinotaurawo anowedzera kuti peripheral uye coronary arteries, lowers mataurire midziyo, kunoderedza BP, systemic vascular nemishonga, myocardial contractility, kwokudiwa kwemoyo tsandanyama reokisijeni uye kunoderedza afterload pamwoyo. Mukuwedzera, mushonga yekudyidzana kunonatsiridza ropa riyerere coronary.

Mahwendefa "fenigidin" zvishoma kana kwete Anti-arrhythmic basa. Uyezve, havaiti inoodza mwoyo myocardial conduction.

Pharmacokinetics zvinodhaka

Where wefodya zvinodhaka "fenigidin"? Instructions ari kushanda rinoti kuti pashure kuitwa mapiritsi avo vanoshingaira fuma nokukurumidza wefodya kubva zvomudumbu turakiti. The mushonga rinoita mune chiropa. Izvi zvinoitika apo "vanopfuura wokutanga", zvichiguma nokuumbwa basa metabolites.

medicament mapuroteni tichisunga iri vanenge 92-98%. The hafu-upenyu rinovapo anenge 2 h.

Kunosiya zvinodhaka fuma sezvo metabolites mu unmodified chimiro (mu zvisaririra mari) kunyanya neitsvo. Uyewo, kuti mushonga uri goho kuburikidza ura (20%).

Zvairatidza kuti kushandisa mishonga

Kana zvarakasiya vanachiremba varayire varwere vavo mushonga se "fenigidin"? Kushandiswa kwezvinodhaka ichi inoratidzwa zvinotevera pathological ezvinhu:

• kuitira kudzivirira sitiroko, kusanganisira vasospastic angina;
• nokuti zvakazorodza angina;
• mune chirwere cheBP nematambudziko;
• chirwere cheBP;
• chirwere Raynaud vake.

Contraindications pakushandisa mishonga

Mune zvimwe zviitiko, hapana nyaya hakufaniri raitongwa murwere zvinodhaka "fenigidin"? Mirayiridzo kushandiswa mahwendefa pasi kufunga anoti vari contraindicated anotevera zvarakasiya:

• mu cardiogenic kugwinha;
• arterial hypotension (systolic BP kana ane ukoshi asingasviki 90 mm HG ..);
• kwazvo kutsemuka stenosis;
• panguva dhirika;
• kwazvo mwoyo kutadza;
• kana murwere ane rakawedzera aikanganiswa yezviri maatomu akafanana zvakadai nifedipine.

Nzira chikumbiro uye chipimo chemushonga zvinodhaka

The mushonga "fenigidin" nhamo iri ushandiswe chete varwere nomumwe. Nokuti zvokuudzwa Kutarisirwa kutanga chipimo chemushonga 10 MG runa pazuva.

Kana kutsvakwa, bhuku mishonga iri kuwedzera zvishoma nezvishoma. Panyaya iyi, kuti chipimo chemushonga yaizova 20 MG mana kanomwe pazuva.

Mune mamwe mamiriro ezvinhu zvekuchipatara (semuenzaniso, musiyano wezvinyorwa angina, kana zvakakomba neBP) kwenguva pfupi nguva anobvumirwa kuwedzera zvinodhaka dose 30 MG mana kanomwe pazuva.

Kusunga vane chirwere cheBP dambudziko, uyewo angina, mushonga inogona kushandiswa non-nomuromo uye sublingually. In ichi zvakafamba chinotarisirwa mune imwe mari 10-20 MG (Kashoma 30 MG).

Kusunungurwa kubva vane chirwere cheBP dambudziko uye angina vanoshingaira medicament dzimwe nguva achiita nomutsinga (5 MG pamusoro 4-8 maawa).

Intracoronary bolus zvinodhaka mhinduro raitongwa 100-200 MG. kurapwa kwakadaro Kazhinji kuitwa kuti kubviswa chakasimba coronary tsinga kurwadza kwacho. Vascular stenoses kwokutanga chipimo chemushonga inofanira kuva 50-100 micrograms.

Kufadza daily dose vaiona isu medicament pamusoro ingestion 120 MG. For intravenous Kutarisirwa, vhoriyamu yacho haafaniri kupfuudza 30 MG.

Side Migumisiro zvinodhaka

Intravenous mhinduro uye mahwendefa "fenigidin" kungaita kuti kumbonyanya vazhinji nemishonga. Imhandoi funga zvakanaka zvino:

• Kumwoyo: asystole, Flushing ganda, tachycardia, ventricular, manzwiro nokupisa, kuwedzera angina kurwiswa, tachycardia, peripheral edema, hypotension, bradycardia.
• Peripheral uye nechepakati tsinga: tsandanyama marwadzo, kutemwa nomusoro, chiedza kutarisana nenyonganiso, paresthesia, hope kunetswa uye tremor.
• Kugaya: manyoka, kuda kurutsa, kuwedzera chiropa, hyperplasia isiri yekenza kuti chingamu. Kana kushandisa zvinodhaka nokuda yakarebesa, uye pamatunhu mishonga, pangava dyspepsia, intrahepatic cholestasis uye chakakwirira chiropa transaminases.
• hemopoiesis hurongwa: chaizvo kashoma kuchengetwa thrombocytopenia uye leukopenia.
• Kwemakemikari anobudiswa System: gynecomastia kashoma kuchengetwa.
• Urinary maitiro: kuwedzera zuva weti goho. Kana iwe utore mushonga kwenguva refu uye pamatunhu mishonga, pangava kutyora neitsvo.
• Chisimbwa: ganda nekumhanyirira.
• Local siyana: kana iwe baya jekiseni mushonga nomutsinga, zvinokwanisika kuti ichipfuta panguva jekiseni nzvimbo.

Mumwe havafaniri kukanganwa kuti mumwe miniti pashure intracoronary kutarisira murwere anogona kuonekwa kunaka inotropic migumisiro nifedipine uye vawedzere kwemwoyo uye kufamba kweropa. Zviratidzo izvi inonyangarika zvishoma nezvishoma pashure anenge 8-15 maminitsi.

mushonga kudyidzana nevamwe mishonga

Tingaregererwa, pamwe chete nemamwe zvinodhaka kutora mushonga "fenigidin Health"? Instructions akanyudzwa kavha, kuyambira kuti utano hwevanhu anogona yekudyidzana kuderera kana tiri kufunga kushandisa mushonga zvakanaka. Panyaya iyi, pamberi mabiko tinoratidza kuti bvunza chiremba wako.

Apo mumwe-nguva kushanda diuretics, antihypertensive vamiririri uye phenothiazine nomukaka anogona huchawedzerwa antihypertensive mugumisiro nifedipine.

Tiine mawa kushandiswa anticholinergic zvinodhaka kungakanganiswa kutarisirwa uye ndangariro pavarwere pre-mudyandigere uye pamudyandigere zera.

Kana panguva iyoyowo achitora mushonga pamwe Beta-blockers, ipapo munhu anogona kuva zvakakomba arterial hypotension, uye mune zvimwe zviitiko - uye mwoyo nokukundikana.

Pamwe mawa Kushandiswa nitrates kunowedzera antianginal migumisiro nifedipine.

Disposable kugamuchirwa karusiyamu zvinoderedza kuti kunyatsoshanda yezviri maatomu akafanana. Izvi vawadzane anopikisana kusakarongeka nokuda vawedzere wevasungwa calcium ions mune dzinonzi extracellular mvura.

Dzinozivikanwa zviitiko tsandanyama simba, uye mukuru kuneta apo kutora mushonga pamwe magnesium munyu.

Kana kushandisa "fenigidin" pamwe digoxin, zvinogona kunetesa kubviswa yokupedzisira kubva pamuviri, iyo zvino yava nechikonzero zvibereko zvayo wevasungwa muropa.

A imwe-nguva dose kurapwa pamwe diltiazem runogonesa kuti antihypertensive mugumisiro.

Tiine mawa kushandiswa theophylline chinowanzoitika kuchinja mune wevasungwa neyokupedzisira muropa plasma.

Rifampicin fuma inokwanisa kufurira chiropa enzayemu basa uye mhanyisa muviri kuti nifedipine, iyo pakupedzisira inotungamirira chinokosha kuderera simba raro.

Kana kushandiswa kwezvinodhaka panguva imwe chete phenytoin, phenobarbital uye carbamazepine, mikana vari kuderedza wevasungwa yezviri fuma iri plasma.

Pane zvakawanda mishumo kuwedzera nifedipine yeplasma kuwanda uye kuwedzera zvayo AUC panguva chete kushanda pamwe itraconazole uye fluconazole.

Kana iwe utore mushonga pamwe fluoxetine, zvingangoita kusimbisa divi kukanganiswa nifedipine pamusoro womunhu.

Mune zvisingawanzoitiki pacho concomitant kushandiswa mishonga pamwe quinidine kunogona kuderedza wevasungwa neyokupedzisira muropa uye kubvisa mushonga - yekudyidzana kuwedzera izvozvo, izvo, chokwadi, kubatsira prolongation of QT penguva pamusoro kwemwoyo unonzi, electrocardiograph.

Zvakadai vanoshingaira zvinhu sezvo ranitidine uye cimetidine, dzimwe nguva kuwedzera wevasungwa kuti nifedipine muropa, kuwedzera rayo antihypertensive kushanda.

Medicines ane doro kungawedzera zvinokonzerwa nifedipine, kukonzera dzungu nezvimwe nenjodzi.

Medicine "fenigidin" panguva yepamuviri uye lactation

Kunyatsoteerera aidzora uye zvakakwana kuchengeteka zvidzidzo yezviri maatomu akafanana zvakadai nifedipine panguva pamuviri asina. Saka, shandisa mushonga uyu panguva gestation haisi inokurudzirwa.

Nokuda kuti nifedipine ukasunungurwa pamwe mukaka waamai, unofanira kudzivisa kushandiswa kwayo panguva kuyamwisa mwana kana kuita kuti kurega lactation.

In experimental ongororo yakaratidza embryotoxic, foetotoxic uye teratogenic migumisiro nifedipine pamusoro muviri womukadzi.

Analogs medicament

The mushonga inogona kutsiviwa "fenigidin"? Analogues venyika chokushandisa ichi anowanika Pharmacies zvose. Pakati pavo pane zvinotevera mishonga: "Adalat", Sponif "," Vero Nifedipine, "" Sanfidipin "," Zanifed "," Osmo-Adalat "," Kaltsigard kutadzisa "," Nifecard "," Kordafen "," Nifelat " "Kordafleks", "Nifedipine", "cordipin", "Nifedikor", "Corinfar", "Nifedikap", "Nikardiya", "Nifedeks", "Nifadyev", "Nifegeksal", "Nifebene" uye vamwe.

Ipa mari izvi vanofanira chiremba chete.

Medicine "fenigidin": wongororo vanachiremba uye varwere

Nyanzvi dzinoti kubudirira zvinodhaka "fenigidin". Rakakurumidza Unotsigira angina, uyewo anobatsira vane chirwere cheBP nematambudziko, Raynaud chirwere, uye BP. Zvisinei, pamusoro chikamu varwere, kune vakawanda mashoko asina kunaka pamusoro gadziriro iyi. Maererano navo, rinoita zvakawanda nemishonga. Inonyanyoshandiswa kwakaratidzwa vari tsandanyama pari uye dzungu. Zvisinei, vanachiremba vanoti wanda zvakadai zvinogoneka chete kana zvisiri pokushandisa zvinodhaka. Panyaya iyi, inofanira kushandiswa chete pasi pokudzora nyanzvi, kunyanya kana murwere ane chakasimba myocardial infarction, kwazvo kutyorwa chepfungwa kuparadzirwa, chirwere cheshuga, kusagadzikana chiropa uye itsvo, uyewo akaipa neBP uye hypovolemia.