"Aminofillin": mirayiridzo yekushandiswa, yakafanana

Ndinofanira kushandisa Aminophylline sei? Mirayiridzo yekushandiswa, zvakafanana uye zviito zvechigadziri ichi zvichakurukurwa zvakare.

Kuumbwa nemafomu

Chii chinonzi "Aminophylline" mishonga ine? Mirayiridzo yekushandisa inotaura kuti chinhu chinoshingaira chemujaira iyi chinhu chimwechete - aminophylline.

Mishonga inoenderera mberi kutengeswa nenzira yegadziriro yekutengesa mukati, pamwe chete nemapiritsi, kirimu kana mafuta.

Pharmacological features

Chii chinogadzirisa saAminophylline? Mirayiridzo yekushandiswa (mumagetsi aya ichi zvinogona kutengwa pane imwe yemishonga) inoshuma kuti iyo vasodilating, spasmolytic, diuretic uye bronchodilating mishonga.

Icho chinoshanda chechirapa iyi ndiyo ethylenediamine munyu we theophylline. Iyo ine bronchodilator uye bronchodilator inoitika, iyo inokonzerwa nekukanganiswa kwayo zvakananga pamusana unotapira mutsvuku yemidziyo yemapapu uye nzira yekufema. Izvi zvinokonzerwa nokusarudzwa kusarudzwa kwebasa re phosphodiesterase, izvo zvinoita kuti kuwedzere muzvinyorwa zve intracellular zvemuCAMP.

Zvimwe zvemurapa

Chii chinoshamisa pamusoro pe "Aminophylline"? Dzidziso yekushandisa inotaura kuti inokwanisa kuderedza hyperreactivity yenzira yekufema. Nzira yechiito ichi haisati yazivikanwa, asi nyanzvi dzinopikisa kuti kushandiswa kwechirwere ichi kunokonzera kuwedzera kwenhamba uye basa reT-suppressors muropa.

Kuwedzera kusununguka kwehupenyu, kusimbisa kushandiswa kwechidimbu, uyewo kusimudzira basa remasikirwo emhepo ekuputira, izvi zvinoreva kushandura nzvimbo yekufema, zvichiita kuti inzwisise, uye inovandudza vhudziro rekuvhenekera, izvo zvinozoguma zvichiita kuti kuderera kwechiitiko uye kuoma kwezvikamu zvepnea.

Ndeipi zvimwe zvinodhaka "Aminophylline" inoshanda? Mirayiridzo yekushandiswa (mafuta nemafuta anogadzirisa zvakafanana mumuviri) inoshuma kuti mumiriri ari kutarisa anoronga basa rekupumha, rinovandudza kuvhara ropa kweO2 uye kunodzikisa kukanda kwekodhi dioxide. Mukuwedzera, iyi mishonga inokwanisa kukurudzira kuputika kwemapapu ne hypokalemia.

Izvo zvinofanira kuonekwa zvakare kuti "Aminophylline", murayiridzo wezvinorondedzerwa pasi apa, inobatsira basa remwoyo, inowedzera huwandu uye simba remoyo, inowedzera kukosha kwemuviri wemumuviri mu O ₂ uye inonyanya kuwedzera ropa remwoyo.

Kushandiswa kwechirwere ichi kunobatsira kuderedza inzwi remidziyo yeuropi, itsvo uye ganda. Nyanzvi dzinopikisa kuti mujeri uri pasi pekufungidzira ane chirwere chinotarisa uye chinoputika veno-expansive chiito, kunoderedza kusagadzikana kwemidziyo yemapapu, kunoderedza kushungurudzika mumapurmonary kupararira uye kunoita kuti ropa riyerere muitsvo. Uyezve, ichi chinodhaka chinowedzera bhaariary, chinoderedza kubatana kweplatelets uye kusunungurwa kwevanopindirana kwehutachiona hwehutachiona, kunogadzirisa masvingo emasero evanhu, kuronga microcirculation, kunoderedza ngozi yeprombosi uye kunowedzera kusimba kwemasero matsvuku eropa.

Muchirairo chikuru, mishonga iri mubvunzo inoratidzira epileptogenic properties.

Kinetics

Ndezvipi zvinokonzera maitiro zvinoratidza "Aminophylline"? Mirayiridzo yekushandiswa (pakurasikirwa kwechirwere ichi chinoshandiswa kakawanda) inotaura kuti mushure mokupinda mumuviri wemunhu izvo zvinoshandiswa zvechirwere ichi zvinoshandiswa nekusunungurwa kunotevera kweusbound theophylline, iyo inosungira mapuroteni emu plasma ne40%.

Mushandi ari pasi pekufungidzira anokwanisa kupinda nepakadzikidzwa kwepakati uye zvakare kuwedzerwa pamwe chete nemukaka waamai.

Iko kushanduka kweTheophylline kunoitika muchiropa nekubatanidzwa kwe enzyme cytochrome P450.

Muchimiro chayo chepakutanga, mishonga yacho yakanyanyisa pa 10% nemuyo. Iyo hafu-hupenyu hwemugadziro wevasina kusvuta, pamwe chete nevarwere vane chirwere chechirwere chinonzi bronchial asthma, inenge maawa gumi nemaviri, vana vana maawa 1-5, kwevana vacheche - kusvika mumazuva maviri, uye nekusvuta 4 maawa.

Kana uchisarudzwa?

Zviratidzo zvekushandiswa kwechirwere ichi zvinoenderana nemhando yekusunungurwa kwayo.

Parenteral administration inokurudzirwa apo:

• Kutapuka kweIschemic yekupararira kwepfungwa;
• Chirwere chechirwere ;
• Kukundikana kwevasiyeri ventricular, iyo yaiva yakaoma nehutano hwepumusoro uye bronchospasm;
• Apnea of the newborns;
• Kurwara uye kushaya mwoyo kusakundikana;
• Edema yemavambo emafungiro.

Mune zviitiko zvipi unoshandisa "Aminophylline" (mapiritsi) mumuromo? Mirayiridzo yekushandiswa inoratidza kuti mishonga iyi inoratidzika zvakanaka mu pulmonary heart, bronchial obstructive syndrome ye etiology yakasiyana (somuenzaniso, emphysema, bronchial asthma, COPD, obstructive bronchitis), usiku hwemazuva ano, kuwedzera kwemhepo mumhepo inopararira, kushaya mwoyo mukati mekusingaperi .

Contraindications

Iwe haufaniri kushandisa rinani chirwere "Aminophylline"? Mirayiridzo yekushandisa inozivisa kuti inopesana ne:

• Kuwedzera kwehutachiona hwehutachiona kana hypotension, tachyarrhythmia, maviri emagumisi ekuonda, kusanganisira muchikamu chekuwedzera;
• Hyperacidity gastritis, kuora mwoyo kwakanyanya kwechirwere kana chepenzi, chirwere chinopisa, kuora mwoyo, kushaya ropa mukati me retina yeziso;
• Kushandiswa panguva imwechete ne ephedrine muvana vasati vava nemakore matatu, hypersensitivity kuna aminophylline kana theophylline.

Kugadzirira "Aminofillin": mirayiridzo yekushandiswa

Kubva ku cellulite (kuongororwa kwevarwere kuchakurukurwa pasi apa) chigadzirwa ichi chinobatsira chaizvo, zvisinei ichi hachisi chinangwa chikuru chechirwere chiri mubvunzo.

Ndinofanira kuishandisa sei? Chirongwa chekutora iyi mishonga ndeyega. Mishonga inokurudzirwa nechiremba ane ruzivo zvichienderana nekliniki yemufananidzo, zera remurwere, zviratidzo uye kuvapo kweicicine inodhaka.

Iyo mishonga iri munzira yegadziriro inogona kuendeswa mukati memaoko kana intravenously, uye muchimiro chemafuta - anoshandiswa pamvura yakaoma uye nerazdrazhennuyu.

Nzira yekushandisa sei kuderedza kurasikirwa?

Zvinokwanisika kushandisa Aminophylline mishonga kuderedza uremu here? Mirayiridzo yekushandiswa (kubva ku cellulite, ichi chinodhaka chinowanzoshandiswa nenzira yemafuta) haina humwe ruzivo pamusoro pegwaro iri. Zvisinei, nyanzvi dzinopikisa kuti chinhu chinoshanda chechirwere ichi chinobatsira kuderedza uremu hwemuviri, pamwe nekubvisa chikamu che "orange peel". Izvi zvinoitika sei? Ichokwadi ndechokuti aminophylline inokwanisa kuwedzera kupararira kweropa mumasukisi, uyewo kugadzirisa mvura yavo inoshandiswa. Izvi zvinowanika muzvikanda zvizhinji kubva ku cellulite (somuenzaniso, Turboslim, Draine Minceur, Reflexe Minceur, Phyto-Complexe, Shape-up nevamwe).

Zvirongwa zvezoro nemaminophylline zvinotarisana nehuwandu hwazvo hwakagadzirwa uye mugadziri.

Zvikanganiso

Ndeipi migumisiro yechirwere inogona kuitika kana uchishandisa mushonga uyu mubvunzo? Maererano nemirairo, inokwanisa kukonzera:

• Kurara kuvhiringidzika, kuzvidya mwoyo, chizivo, kunetseka uye kudengenyeka;
• Gastroesophageal reflux, kurutsira, chirwere, chirwere, kushungurudza mwoyo, anorexia uye kuwedzera kwehuputi chekuonda;
• Mwoyo rwiyo rwakavhiringidzika, kurwadziwa mumoyo, kukura kwe angina pectoris, kupera kwemaviri, cardialgia uye tachycardia;
• Hematuria, albuminuria;
• Itching, fever nekukurumidza;
• Hypoglycemia;
• Hyperemia, unyoro uye denseness munzvimbo yejojo;
• Tachypnea, albuminuria, kurwadziwa kwepfupa, hematuria, kupisa kunopisa, hypoglycemia, kuwedzera kutuka, uye kuwedzerwa diuresis zuva nezuva.

Kuwirirana nekuwedzeresa

Kusvikira ikozvino, pakange pasina marangariro ekudarika kwemujeri uyu. Kana izvi zvikaitika, zvadaro rega kutora mishonga uye utange zviratidzo zvinoshandiswa.

Apo mishonga inotorwa nenzira yakafanana ne sympathomimetics, chiito chavo chemasikirwo chinoshandiswa pamwe chete. Kana zviri zve beta-blockers uye lithium agents, zvinokonzerwa zvinopesana.

Kurapa kwe "Aminophylline" kunonyatsoderedzwa kana inoshandiswa panguva imwe chete ne "Phenobarbital", "Rifampicin", "Isoniazid", "Carbamazepine", "Sulfinpirazone", "Phenytoin" (kusanganisira vanosvuta).

Mhedziso yemishonga iri mubvunzo inogona kuwedzerwa nekubatanidza-co-administration ne quinolones, lincomycin, macrolides, cimetidine, allopurinol, isoprenaline, beta adrenoblockers, fluvoxamine, mishonga inoberekwa mumuromo, disulfiram, uye viloxazine, uye panguva yehutachiona .

Inosorbents uye antidiarrhoeals dzinoderedza kushandiswa kwe "Aminophylline".

Analogues uye kugadziriswa kwevatengi

Pane mimwe mifananidzo yeAminophylline here? Nyanzvi dzinopindura mubvunzo uyu muchitsigira. Mushonga uri mubvunzo unogona kuchinjwa ne "Aminophyllin-Escos", "Eufillin-Darnitsey", mahwendefa uye injection ye "Eufillina".

Chii chinoti vatengi vanoti pamusoro peimba inotaurwa? Pane zvakawanda zvekuongororwa pamusoro peiyo chigadzirwa. Vakawanda varwere vanotaura kuti chirongwa chejojo che "Aminophylline" chiyeuchidzo chinopupurirwa. Kubudirira kwayo nekubudirira hakukonzeri kusava nechokwadi, kusanganisira panguva yekurwiswa kwechirwere chechirwere.

Kana zviri zvekuongorora pamuchero we "Aminophylline", saka zvinopesana. Vamwe vatengi vanopikisa kuti chigadzirwa ichi hachina maturo. Zvisinei, panewo varwere vakadaro vanogovana zviitiko zvinonakidza mushure mekushandisa mafuta pamusoro pe cellulite.