Antibodies kuna TPO antibodies

To musi, dambudziko romunyika yose thyroid shwanu hakuiti rirasikirwe kwayo. Kushaikwa ayodhini mu muviri kuchengetwa 40% vakuru uye 50% nevana. Izvi imhaka kwete chete kune nhaka chinhu, asi pakufurira kwezvakatipoteredza. Panyaya iyi, iyo inorganic ayodhini nokuda kwetunhu mahormone akadai T3 uye T4 ndiro novimba uwandu pituitary thyroid anotokonya kemikari (TSH), thyroid kuzvidzora basa.

Zvinofanira akati kuti kana thyroid shwanu haasi zvakakwana mukuzadzikisa mabasa ayo, zvimwe zvirwere (autoimmune) kuva mumuviri. Saka, kuonekwa kudzidza AT TPO antibodies zvingaratidza hwehasha zvirwere chinzvimbo panyaya muviri. Ndokusaka-siyana zvirwere thyroid riri basa kuti kudzidza ropa TSH sandara uye kuvapo antibodies kuna AT TPO. Kana zvapedzisira achiri wakacherechedza, ipapo munhu anotaura chinhu autoimmune chirwere.

AT TPO inomirira enzayemu munyaya kwetunhu hormone SHCHZ panguva iodization mahormone. Ndiye nhengo tireyodnogo antigen.

Chikonzero ongororo inogona chirwere zvirwere zvakadai goiter, hypo- uye hyperthyroidism, Graves chirwere, tireoinid drumsticks edema. Uyewo, kuti ongororo iri ushandiswe panguva yepamuviri kuona ngozi tireoinita pashure kusununguka (10% yevakadzi vane chirwere ichi).

Zvinofanira kucherechedzwa kuti TPO antibodies, mwero panguva iyo munhu mukuru ari 5.6 U / Rine mamiririta, mumuviri zvinopa kushingaira ayodhini inotungamirwa. Antibodies kuti enzayemu ichi chinonditadzisa kwayakaita, saka zvinoderedza ari secretion pamusoro hormone T4 uye T3. Asi kwete nguva dzose, thyroid peroxidase inoratidza kuvapo imwe autoimmune chichingoitwa.

Kudzidza uku rinokosha kuti chirwere zvirwere thyroid. Chimiro kutyorwa mubasa rayo ndicho chiratidzo hypothyroidism rokutanga. Kana kushandisa zvikuru kugumbuka nzira diagnostikiAT TPO, ipapo chirwere chinowanikwa muna 94% varwere Graves 'chirwere - 84%, thyroid chirwere neautoimunnye - 15% yevanhu. Low kwevari imwe enzayemu kakawanda kuwanikwa vanhu utano, saka iri kana mubvunzo pamusoro pokumuka zvirwere zvakasiyana-siyana zviri havaratidzi kunzwisisa.

Zvinofanira kucherechedzwa kuti panyaya apo AT TPO yakawedzera, izvi kunoratidza muitiro akadai hypothyroidism. mhando iyi kutyora anooneka semubairo deceleration antibody TPO basa, ayodhini oxidation zvazvingava, uye, naizvozvo, kuitwa chacho vanoshingaira chimiro. Panyaya iyi, iyo thyroid mahormone havasi synthesized.

Kudzidza inoenda mumatanho akawanda. Muvanhu, ropa rakundwa, maererano izvo vakatsunga pamwero TSH uye T4. Kana kwomuzvarirwo T4 kuita uye pasi TSH, akaita kudzidza T3. Mukupera nyaya, unofanira kupedza imwe ongororo yakaitwa musi AT TPO antibodies.

Nokudaro, zviratidzo chidzidzo inogona vanofungidzirwa goiter, hypothyroidism uye Hashimoto kuti thyroiditis. Asi zvinofanira kuyeukwa kuti kusavapo antibodies kuti thyroid peroxidase Ait haadi runosanganisirawo kusashandisa kuvapo mumuviri. Kuwanikwa enzayemu ichi muropa haapi chivimbo chakakwana pamberi ane autoimmune chirwere, sezvo kakawanda kuti AT TPO ari vanhu zvimwe hwakanaka.

Kubva izvi zvose zvinoreva kuti kuziva miedzo enzayemu ichi zvinokosha kuti tiite misoro kuongorora nechinangwa chokubvisa mukana Ait.

Zvisinei, Saka, pasinei nemamiriro ezvinhu, thyroid peroxidase iri zvakakwana kugumbuka bvunzo autoimmune abnormalities mu thyroid, kudzidza kwakadai zvinoshandiswa sangano dzinenge dzose dzokurapa.