Antiparkinsonian drug "Nakom": mirayiridzo yekushandiswa

Mushonga we "Nakom" murayiridzo unofananidzwa sechibatanidza antiparkinsonian agent. Kushandiswa kwechirwere ichi pane dzimwe nguva kunowedzera dopaminergic kutapudza uye kunowedzera kuderedza kuratidzwa kwezviratidzo zvinorwadza nokushandura chikamu chinoshanda mu dopamine ne decarboxylation muuropi. Muchiitiko ichi, mishonga yekurapa kwekushandisa chiremba "Nakom" (murayiridzo unopupura izvi) inoratidzwa munguva yekutanga maawa makumi maviri nemaviri mushure mokunge vapinda. Chigumisiro chikuru chinopedzwa mazuva manomwe mushure mekutanga kurapwa. Kana iri hafu yehupenyu, iri pakati pematatu nemaawa gumi neshanu mushure mekushandiswa kwe-anti-Parkinsonian drug "Nakom". Nhoroondo dzechirwere ichi - capsules "Duellin", "Tremonorm" uye "Sinemet" - vane nzira yakadaro yekuita.

Iri kugadzirira rinobudiswa muchimiro chevhiriki biconvex mahwendefa emuvara webhuruu. Kuumbwa kwemhando imwe neimwe sezvinhu zvinoshanda zvinosanganisira mazana maviri nemakumi mashanu emamiriyoni evevodopa uye makirigiramu makumi maviri nemanomwe e carbidopa monohydrate. Zvimwe zviyero zvinobatsira zvinonzi microcrystalline cellulose, stalkatinized starch, magnesium stearate, starch yegorosi uye indigotine yebhuruu.

Tora mapiritsiti eNakom mirayiridzo yekushandisa inokurudzira kurapa kwevanhu vane Parkinson's syndrome uye zvirwere. Mukuwedzera, nyanzvi dzinowanzopa chirwere ichi kune varwere vanoshandisa multivitamines ine pyridoxine hydrochloride nevakaumbwa.

Tora anti-Parkinsonian zvinodhaka "Nakom" mirayiridzo haisi kurumbidza vanhu vane kusawirirana kweevodopa uye monohydrate carbidopa, uyewo zvinokonzera kushandiswa kune chero zvimwe zvikamu zvinoshandiswa. Mukuwedzera, urongwa hwezvinyorwa zvinosanganisira kona-kuvhara glaucoma, kukundikana kwechirwere, melanoma, pamuviri uye chiropa kusakundikana. Uyewo, usatora ichi chirwere panguva imwechete uye kwete-selective monoamine oxidase inhibitors. Mukuwedzera kune zvimwe zvose zvinopesana ndezvezera remakore gumi nemasere uye nguva yekuvigwa.

Pakati pezvakaitika zvinowanzovhiringidza zvinokonzerwa nemishonga "Nakom", nyanzvi dzinosiyanisa ganda rekuya, leukopenia, angioedema, anemia, agranulocytosis uye thrombocytopenia. Uyezve, kune ngozi yehutachiona hwema melanoma, arterial hypertension, tummy ulcers uye hematuria. Anorexia, kusuruvara, kuvhiringidzika, bruxism, kukanganiswa kwehope, kukanganisika kwepfungwa, kuparara kwepfungwa, kuora mwoyo, kuora mwoyo, dyskinesia, kugumbuka, ataxia uye chorea zvinogonawo kuonekwa semagumisiro eNakom. Iyo murayiridzo inoratidzawo njodzi ye dyspnea, shungu kana kuoma mumuromo, kunonoka kwekuzora, kurasikirwa kwekuziva, kuputika nekutuka.