"Artrozan": mirayiridzo kushandiswa

"Artrozan" mirayiridzo kushandiswa zvinoreva kurapwa uye pharmacological chikamu oxicams. The chikuru vanoshingaira zvacho gadziriro - meloxicam kuti unoshanda zvokusarudza Cox-2 inhibitor. Vanoda "Meloxicam" chinodhaka ichi rinonyoreswa zviri mazita INN.

Hwendefa chimiro mushonga unoitwa mukati mahwendefa achirema 15 MG kana 7.5 vakatutirana muimba Maronda akasiyana metering gandiwa.

By pharmacological ehupfumi mushonga "meloxicam", vari rakabva enolievoy iine acid fuma, senzira Anti-anogumbura uye marwadzo chiito. mashandiro Izvi zvinobva nekugona zvinodhaka tunodzivisa muitiro synthesizing prostaglandins. Pasi pokudzora kwomudzimu zvinodhaka kuita kunoitika, panguva iyo zvokusarudza tunodzivisa basa Cox-2 makemikari, izvo kutora chikamu mune huru biosynthesis.

Nepo kutora zvinodhaka, "Artrozan" muperekedzi anotsanangura chiito chacho nenzira iyi. Kana mushonga chinotarisirwa pamatunhu mishonga, ipapo munguva yakareba zvavo kushandisa chinhu vasanyanye selectivity nokuda Cox-2. The mushonga zvishoma chinobata Cox-1, iyo chinodzivirira nemudumbu. Ndicho nokuda chiito ichi kusarudza uye waidzivirira nemudumbu kubva erosive uye maronda maronda.

Anti-anogumbura zvinodhaka maturo "Artrozan" mirayiridzo Chinyorwa rinobatanidza pamwe kudzvinyirira pakati enzayemu basa Cox-2, iyo anoita nzira kushoma.

Pharmacokinetics "Meloxicam" kunoratidzwa sezvinotevera. Distribution "Artrozan" kukunda muviri-zvinyama zvipingamupinyi, nokuda remubatanidzwa iyi mapuroteni eplasma yakakwirira sezvinoita 99%. The Zvinoumba synovial mvura mumisasa ukoshi hazvisi 50%.

Muviri: The mushonga rinoita zvinenge zvakazara chiropa mumasero, saka pane paumbwe anoverengeka pharmacologically kwazvakarerekera nomukaka.

Excretion: The chigadzirwa "meloxicam" kunoratidza kuda vakaenzana migove kunyanya weti uye mutsvina yadzo muchimiro metabolic zvigadzirwa. 5 chete% of zvinoriumba ndiyo goho kubva ura.

The pharmacokinetic ehupfumi zvinodhaka "Artrozan" mirayiridzo Chinyorwa uyewo chinoita kuti rinokosha zviitiko. In varwere Kunyanya, vakwegura kana kugamuchira kwakaderedza Clearance zvinodhaka, uye panyaya zviratidzo hepatic uye renal kukundikana, mushonga uri chisingaoneki zvainoita pharmacokinetics.

Kugadzirira "meloxicam" iri kwazvo woga kubva nemudumbu, ari bioavailability kwayo chechetere inosvika 89% uye haina kukanganiswa chikafu yaunodya. Womuchato pa mishonga anobudiswa dose kunopa Proportional wevasungwa zvinodhaka mumuviri.

Distribution: Kazhinji, Zvakanyanya Kunaka Panguva Yepamuviri kuita CSS kuitika pazuva rechitatu rechishanu zuva kurapwa, apo ayo kushandiswa kwenguva refu anopiwa akatsiga kuwanda akafanana kwokutanga pharmacokinetic parameters.

The chipimo chemushonga zvinodhaka "Artrozan 'mirayiridzo kushandiswa akatsunga sezvinotevera.

Shandisa mushonga mu kukabatanidzwa muchimiro inokurudzirwa. Zvavakabvumirana zvaiitwa:

- ari kutanga kwekupwanyiwa kurapwa, mazuva 2-3, akashandisa "Artrozan" -ukoly;

- pashure matatu kana mana mazuva intramuscular Kutarisirwa kunofanira kugamuchira mushonga - dziri mahwendefa.

The chipimo chemushonga nokuti intramuscular kutarisira uye kunanzvana Kutarisirwa hamushanduki uye akaenzana mureza (7.5 kana 15 MG) kamwe zuva nezuva kwemazuva. The dose uye paanowedzera chikumbiro pakutsvaga kusimba marwadzo uye ukuru kwokuomerwa kuzvimba. Pakusarudza dose anofanira kunyatsoongorora aendeswe nezvenhoroondo zvingakanganisa yematambudziko kubva nemudumbu.

In pamberi renal kukundikana, nezuva kunonyanyisa dose kwete kupfuura 7.5 MG.

Aiita zvimwe zvinodhaka anogona kuoma kubudikidza panowanikwa erosive-ulcerous anokonzerwa ari nemudumbu. Regai kutora zvinodhaka panguva yepamuviri uye achiyamwa.

Product "Meloxicam" zvinofanira kuchengetedzwa munzvimbo ine rima kwemakore anopfuura maviri.

Drug achitengeswa mushonga chete.