Glycosylated hemoglobin: inowanzova vakadzi, kukodhidza uye zviratidzo zvinokosha

Iroji yehemoglobin protein uye glucose ndiyo hemoglobin imwe yeglycosylated. Chimiro chevakadzi mumuviri chinofanira kuchengetedzwa zvakanyanya nekuda kwekukosha kwaro panguva yekuzvitakura. Uyewo, chiratidzo ichi chinogona kunyatsoziva kuti kune chirwere cheshuga mumuviri womunhu.

Chii chinonzi hemoglobin?

Izwi rokuti "hemoglobin" rinoshandurirwa sezwi reropa. Zvechokwadi, ichi chinopa ruvara rutsvuku rwevanhu uye zvakakosha zvikuru kune humwe huripo hwemhuka.

Zvakakosha kuziva kuti vanachiremba vanoshevedza hemoglobin chinhu chinoputika mumuviri wemunhu chero upi zvawo kana mhuka. Inosanganisira zvinhu zviviri, iyo iron porphyrin uye protein. Hemoglobin ndiyo chete chinhu muropa romunhu anoshanda semutakuri wemamolekemu eokisijeni. Murumbidze kwaari, matese ose mumuviri anodya O ₂ .

Mukuwedzera, iyo masero matsvuku eropa anotakura okisijeni, hemoglobin inokwanisa kubvisa kubva mumuviri unopfuura carbon dioxide. Gare gare inobva kuburikidza nehutano hwevanhu. Hazvishamisi kuti chinhu chinonyanya kukosha kune munhu glycosylated hemoglobin. Zvinowanzoitika kuvakadzi zvikurukuru zvinofanira kuremekedzwa.

Zviratidzo: hemoglobin glycated

Glycosylated hemoglobin chinhu chinokosha zvikuru. Maitiro ayo ekugadzira anowedzera zvishoma nezvishoma. Nhamba ye glycohemoglobin inobatana zvakananga nehuwandu hwehuga muropa uri mumunhu. Sarudza kuti zvinyorwa zveiyi iri muropa remunhu zvinogona kuitwa nekuongorora kwezvinhu zvehupenyu.

Kugadzirisa kwehutano hweglycohemoglobin kunoitwa kunyanya kuziva murwere ane chirwere cheshuga mellitus, pamwe chete nekuwedzerwa kwarwo. Zvinonyanya kukosha kudzora huwandu hweiyo zvinhu mumadzimai ane pamuviri.

Kana murwere ane zvinetso nehuga muropa, vanachiremba vanokurudzira kuti kuongorora kwehupenyu hwemagetsi kuitwe kanenge kamwe pagore. Kana pane kukanganisa kunoonekwa, chiremba anofanira kupa mishonga inogadzirisa shuga yeropa. Murwere anorayirwawo kudya kwakakodzera.

Glycosylated hemoglobin. Kazhinji kuvakadzi

Kune mumwe mukadzi aiva nehutano pazera ripi neripi, anofanirwa kamwe kamwe pagore kupa ropa nokuda kwehupenyu hwehupenyu. Munguva iyi, zvinyorwa zve glycoglymoglobin muropa zvinoratidzwa. Kunyanya kukosha kwayo kunokosha kumukadzi wemakore ekubereka. Nekutsvakurudza kwakajeka, mukadzi anogona nyore nyore kuziva kana ane chikonzero chekurwara nechirwere cheshuga, uyewo kudzivirira migumisiro isingafadzi.

Zvakakosha kuziva kuti yakawanda sei glycosylated hemoglobin inofanira kuva muropa. Chimiro chevakadzi: mmol (mol) - 1.86-2.48. Ichi ndicho chiratidzo chekugara kwehemoglobin. Glikogemoglobin in the norm haifaniri kudarika chiyero ichi zvinopfuura 6.5%.

Overestimated glycohemoglobin

Kana zvakasimbiswa kuti mumudzimai wechikadzi chinhu ichi chiripo zvakanyanyisa, saka pamusana pekuongororwa, kuongororwa kungave kwatoitwa. Izvo zvinoenderana nenhamba yehmoglobin isina ropa muropa iro rakakwirira kwazvo kupfuura glycohemoglobin.

1. Kana glycohemoglobin inopfuura 7% yemazuva ose, saka kuongororwa "chirwere chechirwere cheshuga."
2. Kupfurikidza ne8% kunoreva kuti munhu akabhadhara chirwere cheshuga zvakanaka.
3. Kupfurikidza ne10% ndiyo chirwere cheshuga chakakwana.
4. Kuwedzerwa kwe12% ndiko kuongororwa kwe "chikamu chinokonzerwa nechirwere cheshuga."
5. Kuwedzerwa kwepamusoro pe12% ndiko kuongororwa kwe "kusabhadharwa nechirwere cheshuga".

Uyezve, pamwe nechirwere cheshuga, chiremba anogona kuisa uye kumwe kuongororwa, kunonzi anemia. Muvanhuwo zvavo anemia inonziwo "kusina kwesimbi muropa."

Nenzira, dzimwe zvirwere zvinogonawo kuwedzera glycosylated hemoglobin. Kugadziriswa (tsika yake kana kupotsa) kunogona kutaura pamusoro pezvirwere zvepleen. Kuwedzera kweglycohemoglobin kunogona kuonekwa kunyange kana chikamu ichi chibviswa.

Usingazivikanwi glycohemoglobin

Mukati yekuongorora kwezvinhu zvipenyu, inogona kusimbiswa kuti kuderera kwehuwandu hwezvinhu "glycosylated hemoglobin" yakaitika mumuviri. Chimiro chevakadzi hachifaniri kunge chiri pasi pemakiromita 4,5 kubva muzana nemagetsi ehemoglobin. Kubva pane izvi, chiremba anogona kuita zvinotevera:

• Hypoglycemia;
• Hemolytic anemia ;
• Fragility yemidziyo yeropa.

Kuderedza mu glycoglymoglobin kunogona kuonekwa muvakadzi mune chinzvimbo chinonakidza. Muchiitiko ichi, kukanganisa kwakadaro hakusi kuonekwa sehutachiona, nokuti panguva yekuzvitakura muviri unoda simbi unowedzera zvakanyanya, kureva 18 mg pazuva.

Mukuwedzera, kuderera kwakafanana kwechinhu muropa kunogona kuonekwa nekushaya kukanganisa.

Ichokwadi, pamusana pekutsvaga kumwe, hapana chiremba ane ruzivo achaongorora chero upi zvake hunoongorora. Kuti aratidze izvi kana kuti hutachiona, chiremba anofanirwa kugovera kumwe kuongororwa kwemurwere.

Chii chinokanganisa glycated hemoglobin muvakadzi vane pamuviri?

Munhu wese anonyora nokuziva anoziva kuti chirwere chacho chiri nyore kudzivirira kana kuporesa panguva yekutanga pane kutarisana nevekutanga kutaridzirwa. Kutonga kwekutanga kwehutachiona hweglycated hemoglobin, kunyanya mumadzimai ane pamuviri, kunobatsira kudzivirira migumisiro yakasiyana-siyana inofadza uye zvakakosha kugara uchiyeuka.

Mumwe chiremba ane unyanzvi achangotumira murwere ane pamuviri kuenzana rekuongorora ropa kuzviratidzo zvakadai se:

1. Matambudziko emagetsi.
2. Gestational chirwere cheshuga, chinozviratidza mumwedzi yakawanda yekuzvitakura.
3. Kuberekwa kwemukadzi anototambura nechirwere cheshuga.
4. Zvirwere zvekuvhenekera.
5. Hyperlipidemia.
6. Nzvimbo dzakagadziriswa nehutachiwana hwechirwere cheshuga.
7. High blood pressure.

Mukuwedzera, kuongororwa kweglycated hemoglobin kubudirira kunobatsira kuziva muvakadzi vane pamuviri zvirwere zvakasiyana-siyana zvemuviri wemutsipa, kukura kusina kunaka kwemwoyo mutsva mu fetus neuropathy.

Kana mukadzi ari mumamiriro ezvinhu anofadza anonzwa akaipa, saka anofanira kufanirwa kuzivisa chiremba izvozvi zvakaitika.

Glycosylated hemoglobin: zvinowanzoitika kune vakadzi vane pamuviri

Munguva yepamuviri, huwandu hweglycohemoglobin haufaniri kudarika huwandu hwakanaka. Kana amai vane ramangwana vakatarisira mwana wavo, ipapo anofanira kuziva kuti glycosylated hemoglobin chii. Chimiro mumadzimai ane pamuviri haafaniri kunge chinopfuura 6.5%.

Kana mukadzi atova nechirwere cheshuga, ipapo kuongorora kwakadaro kunongodikanwa, nokuti kutakura shuga inzvimbo inokosha zvikuru pakubereka mwana. Vakadzi vane utano vanofanirawo kupa ropa re glycohemoglobin mwedzi imwe neimwe. Izvi zvinodiwa kuti uchengetedze muviri wemakrohydrate metabolism mumuviri.

Kana mukadzi ane pamuviri anetseka pamusoro pehutano hwake uye nguva dzose anoshanyira kubvunzurudza kwemukadzi, ipapo nhengo yemagetsi ichagara ichimutumira kune zvose zvinoedzwa. Kana mukadzi asina hanya nekushanyira vanachiremba, iye zvino achafanira kudzora mamiriro ake ari oga.

Inofanira kuonekwa kuti high helyogated hemoglobin in pregnant women is rare. Kunyanya kakawanda pane kushayikwa kwaro, nokuti vakadzi vari munharaunda inofadza vanowanzotambura nekushaya ropa, pane chirwere cheshuga.

Glikogemoglobin kune tsanangudzo yechirwere cheshuga mellitus

Kuongororwa kweglycohemoglobin kunokosha zvikuru kune avo avo vanoziva kare nezvekutsvaga kwavo. Vanachiremba vanotsanangura kuti pasinei nemutengo mukuru wekufara uku, chidzidzo chakadaro chichabatsira kuvepo kuvapo kwechirwere cheshuga uye danho rayo. Kuongororwa kwemashuga eropa kusinganzwisisi hakutauri zvakajeka mufananidzo, asi izvi zvinobvumira kudzidza kune glycosylated hemoglobin. Chimiro chevanhu vane chirwere cheshuga hachisi chakasiyana nedzimwe tsika dzevanhu vane utano.

Nenzira, inowanzoongororwa pamusoro pekudzidza shuga muropa inogona kuva yenhema. Chiratidzo chacho chinokonzerwa nezvikonzero zvakawanda, kureva kushandiswa kwezvimwe zvokudya, kushungurudzika mamiriro uye kushushikana mupfungwa. Kuongororwa kweglycohemoglobin hakubvi pane zvose izvi. Ndicho chikonzero chinokurudzirwa navanachiremba kune vanhu vane chinangwa chechirwere cheshuga, uyewo avo vakadzi vanozvironga kubereka vana.