"Plagril": mirayiridzo kushandiswa, vanachiremba chaivo. Drug analogues "Plagril"

Zvirwere kumwoyo vari mushonga ano zvichida pakutanga. Mwero wokufa kwevanhu nezvirwere izvi ndizvo soro. Pane matambudziko munzvimbo iyi kuti anogona kutambudza munhu kubva pakuzvarwa. Zvisinei, pane avo umo munhu pachake pakukura kunounza wandei "mupiro". Mumwe chirwere chakadai - atherosclerosis. Kana dambudziko iri chinobata kunyanya arteries kuchinja uye kwakavharwa nenyama tsandanyama-mhando. Musimboti hosha iri kuti, nokuda kutyorwa mapuroteni uye lipid muviri uchingounganidza ari arteries pakati remafuta akawandisa deposits uye vamwe vomumatunhu pakati lipoproteins. Saka kuumbwa atherosclerotic plaques. Nokufamba kwenguva, mashoko connective zvinyama mudziyo masvingo ari plaques izvi rokuwedzera, zvichiguma aienda pamusoro lumen ari tsinga kusvikira occlusion.

Kuti vabatsire varwere izvi, vatsvakurudzi zvakagadzira mazita zvinodhaka kuti anogona sipidhi kana zvachose kudzvinyirira aggregation muitiro (yeimwe, chokuedza) of maplatelet. Zvinhu pamwe nezvaanogona dzakadaro dzinonzi antiplatelet (antithrombotics). Mumwe mushonga zvakadaro "Plagril".

Mamiriro uye Kuronga

The mushonga inowanika mahwendefa zvemapuranga aine firimu unhani vaaleanpunainen. Mahwendefa dzakaripoteredza, biconvex. Rimwe divi vakatutirana nekusimbisa, nebefu "C 127". The chikuru vanoshingaira wemafuta mushonga - clopidogrel. Sezvineiwo, panzvimbo zvinodhaka "Plagril" INN (International Nonproprietary Name) ndiyo akafanana kuti zita huru zvinoriumba - clopidogrel. The vhoriyamu kugutsikana pa piritsi - 75 MG. Kunze huru zvinoumba ari medicament vari Excipients: microcrystalline cellulose, mannitol, croscarmellose yavaibvisa, colloidal nesilicon dioxide, magnesium stearate. Manufacturers pave mushonga mu mhoni packs it zvezvimedu 10.

The mashandiro zvinodhaka

The mushonga ndiwo chaiwo inhibitor (tunodzivisa - tunodzivisa, kudzvinyirira chero muitiro) aggregation (remubatanidzwa) maplatelet. Rine koronarorasshiryayuschee chiito. Process deceleration platelet aggregation (anenge 40%) anogona kuonekwa mushure 2 maawa pashure ingestion zvinodhaka ari chipimo chemushonga 400 MG. Kuti vawane kunonyanyisa kunyatsoshanda (60% chinovhiringidza kuti aggregation) migumisiro kubva mapiritsi "Plagril", mirayiridzo kushandiswa maererano kudiwa kurapwa kwemazuva 4-7. Vose dose pazuva kunofanira kubva 50 kusvika 100 MG. Muchiitiko chino, antiplatelet mugumisiro kuchapedza yose kutenderera upenyu maplatelet (7 kusvika 10 mazuva). Mukati 5 Mazuva pashure zvinodhaka kushaya yevanhu platelet aggregation, uye nekudeura ropa nguva shure kutanga kuita.

Yabudiswa "Plagril" itsvo uye ura (50% uye 46% azvaitwa). deducing Period - maawa 120 pashure kutarisira.

The chikuru vatengi kuti "Plagrila"

Kune chaiyo boka moyo varwere vanoonekwa kushandisa mushonga "Plagril". Mirayiridzo vanofanira kutora mushonga vanhu chirwere atherosclerosis. Mishonga unoshanda kuzvidzivirira chipimo yekuzvidzivirira yematambudziko chokuita thrombosis vanhu vakambova myocardial infarction kana ischemic sitiroko. Ichokwadiwo kuti varwere kutambura occlusion (kuderera kwezvirongwa permeability) peripheral arteries.

In tandem pamwe acetylsalicylic asidhi (asipurini) angashandiswa "Plagrila" kuitira kudzivisa thrombotic yematambudziko vaya vanotambura chakasimba coronary syndrome. Izvi zvinogona kusanganisira vanhu vane angina (kusagadzikana chimiro), pamwe myocardial infarction pasina chinozunguzirwa inotungamirwa Q. Unogona kushandisa mushonga mu varwere vakanodzidziswa stenting. Musimboti kuvhiyiwa - kugadzwa zviri njodzi mudziyo stent (mutete wakanaka-meshed simbi chubhu), iri vakabva inflated chaiwo chibharuma, nokudaro kuwedzera permeability ari mudziyo uye matauriro ropa riyerere pamwoyo.

Chipimo chemushonga: Chikumbiro modes

Medicine "Plagril" varwere inogona kutorwa nemuromo zvisinei zvataidya. In varwere kuwana myocardial infarction, ischemic sitiroko kana kusimbiswa chirwere pamusoro patency ari arteries kudzikira, ari dose pamusoro 75 MG akatorwa kamwe pazuva. Period kurapwa mishonga pashure Q-wave myocardial infarction agare kusvikira mazuva 35. In ischemic sitiroko, zvichienderana kwokuomerwa mamiriro, mushonga Ingasiyana kubva pamazuva 7 mwedzi mitanhatu.

Kana shamhu nenzira isina chimiro, uye myocardial infarction pasina inotungamirwa Q-wave yemanyorero mureza zvaiitwa mahwendefa riri sezvinotevera: kutanga, imwe-nguva vachizvitakudza dose 300 MG, ichiteverwa 75 MG pazuva pamwe asipurini (75 kusvika 325 MG pazuva). Nokuti yaunodya kuti asipurini kunowedzera ngozi ropa, kufadza kuroorwa dose haafaniri kupfuudza 100 MG. Drug kurapwa - kusvika 1 gore.

kugamuchirwa "Plagril" antiplatelet ARV Akaratidzawo kuti rikwanise myocardial infarction. Taurira mapiritsi kutora panguva dose pamusoro 75 MG, muzuva rimwe chete. Zvinokurudzirwa kutanga kurapwa pamwe kwokutanga vachizvitakudza dose akabatana acetylsalicylic acid. Zvichida yakafanana richiita thrombolytics (kana murege kutora).

Kana varwere mayambuka nemakore 75 muganhu, "Plagril" (rakafanana clopidogrel uyewo zvinobvumidzwa) anogadzwa pasina kwokutanga vachizvitakudza dose. Mushure pakuonekwa wemishonga pakurapa zviratidzo zvinofanira kwakatanga kare zvichibvira. The kosi anofanira kugara zvinenge 4 mavhiki.

Possible divi migumisiro

Munguva yawapiwa pamwe nekugadzirira "Plagril" mirayiridzo Chinyorwa anoudza kuti dzakasiyana-siyana zvingakonzerwa nemishonga kubva siyana hurongwa nenyere.

kazhinji kweropa hurongwa anogona kupindura chimiro gastrointestinal kubuda ropa. Zvishoma kazhinji vanogona kuva Hemorrhagic sitiroko, ropa mumhuno uye, vose zvavo, kuwedzera ropa nguva. Mune zvisingawanzoitiki Muzviitiko, kuoneka hematomas, hematuria.

Various anoratidza kubva hemopoietic hurongwa. Izvi zvinosanganisira eosinophilia, neutropenia, thrombocytopenia. Sezvineiwo kashoma kutanga granulocytopenia, nyore kana aplastic kupererwa neropa.

Pamusoro chikamu nechepakati uye peripheral tsinga angava nemusoro, dzungu, paresthesia, vertigo (kurasikirwa nepakati, achiperekedzwa nepfungwa majana zvinhu kumativi muviri, kana vakutarisire - muviri kutenderera), aone zvinhu zvisipo, kuvhiringidzika. Zvisinganyanyi kuitika, asi zviitiko yaivhuvhuta zvinoitika pamwe kumwoyo, maererano kunoderedza BP, vasculitis kukura. Bronchospasm uye interstitial pneumonitis - ichi chive maitiro kufema hurongwa kugamuchira zvinodhaka.

Kakawanda iri mishonga "Plagril" (wongororo kuvarapi uye varwere zvinoratidza chokwadi ichi) zvaanoita zvomudumbu hurongwa. Maitiro muviri kunoratidzwa kukura manyoka, dyspepsia, abdominal marwadzo. Ishoma zvinogoneka siyana akadai kuda kurutsa, kurutsa, kupatira, rikwanise gastritis uye gastric uye duodenal maronda, flatulence. Rare asi zvinoita panowanikwa zvirwere zvakadai colitis, pfungwa nomuviri zvemwana asati, stomatitis, hepatitis, zvakachinjwa kuravira, kuvandudzwa rikwanise chiropa kukundikana.

Osteo-tsandanyama hurongwa angataura pacharo arthritis, myalgia. Kunyange zvazvo zvinoitika kazhinji. Glomerulonephritis kungakonzerwa maitiro Urinary hurongwa. Dermatologists zvinoratidza kuti zvinobvira mugumisiro mumwe "Plagrila" ndiko kuvaviwa, bullous mapundu, erythematous mapundu, lichen planus, eczema. Zvichida kukura neutachiona muchimiro angioedema, anaphylaxis, serum kurwara. Of vanhuwo nemishonga zvinogona kucherechedzwa fivha, yakakwirira serum creatinine.

Kushandiswa "Plagrila": chii kunotsvaka

Kana kuti mamwe mamiriro ezvinhu ari pamamiriro antiplatelet simba, kana zvinofanirwa kuvhiyiwa, unofanira kubvisa kurapwa ne "Plagril". Mirayiridzo dzokushandisa anokurudzira kuita kudaro kanenge 7 mazuva asati kuvhiyiwa. Mushure abolition zvinodhaka kumisa pakarepo atanga kubuda vanoda nguva yakawanda. Varwere vanofanira kunyeverwa nezvazvo uye zano kuti azivise chiremba pamusoro kujairika ropa ose. In kufarira murwere kuti azivise chiremba pamusoro pakurapa "Plagrilom" idzodzo nguva, kana kuti chero kuvhiyiwa, kana murwere basa chero mushonga mutsva.

Nokufamba zvokurapa kurapa kunokosha kuti tirambe kudzora hurongwa parameters pakati homeostasis (platelet kuverenga, miedzo dzichipfekeka basa, APTT). The dzichipfekeka basa chiropa uye dzinofanira kugara kuongororwa uye dzinoongororwa sezvo kwazvo zvarakasiya mubasa rayo aigona kuwedzera ngozi Hemorrhagic diathesis.

Medicaments, ane chikuru vanoshingaira chirungiso ndiyo clopidogrel ( "Plagril" analogs), hauna varumbidzwa vaya vakatambura kusachengeteka kukuru myocardial infarction, panenge panguva yokutanga mavhiki mashoma pashure Pazvinotanga. Vanachiremba regai kuvakurudzira "Plagrilom" kurapa kana murwere ane kusagadzikana angina, pamwe ischemic sitiroko mu coronary ndavhiyiwa.

With imwe mari renyevero vanofanira kutora mushonga kuti vanhu vakaremara vari kushanda neitsvo.

Kuti tidzivise-kugamuchira "Plagrila"?

"Plagril" (Mahwendefa) kudzidziswa unorambidza varwere hypersensitivity kana kusashivirirana anozvisarudzira chikuru uye ebetsero zvinoumba ari medicament. Regai kutora mushonga chero zvirwere predisposing kuti ropa (gastric uye duodenal maronda, hyperfibrinolysis, kenza yemapapu, tibhii, etc.). A simba umbowo asiri kushandiswa "Plagrila" vari chakasimba hepatic kukundikana, Hemorrhagic syndrome. Kuwedzera pane zviri pamusoro apa, zviri contraindicated kutora mushonga kuvakadzi vane mimba navaya vanoyamwisa. Kwete kuti taurira mushonga kuvana pasi pemakore 18.

Kugadzirira analogues

Muna mishonga pamusika nhasi, boka zvinodhaka antiplatelet yomuchipatara ( "Plagril" anoreva zvakafanana ayo zviri huru vanoshingaira zvinoriumba) zvinowanikwa zvakakwana zvikuru. Anopfuura 3 gumi nevaviri zvinodhaka - antiplatelet vamiririri vane basa chirungiso (clopidogrel) uye panguva imwecheteyo chipimo chemushonga (75 MG). Kunze vagadziri Russian pave antiplatelet Indian nemakambani anogadzira mishonga, mabhizimisi Hungary, Israel, Marita, France.

"Dr. Reddies Laboratories" "Plagril" pacharo unobereka ane Indian kambani. By Fananidzo, tinogona kusanganisira French "Plavix" German "Clopidogrel ratiopharm," Hungary "Clopidogrel-Richter," Israeli "Clopidogrel din email," Maltese "Liporel" Macedonian "Listab 75". "Zilt" zvinogona kure kupfuura akakurumbira uye chaizvo kudiwa nevamiririri Russian.

"Zilt" - Russian "Plagril"

The chikuru vanoshingaira fuma rekugadzirira "Zilt" ( "Plagril" pakuti anonyatsokwanisa inopindirana) ndiyo clopidogrel. Mishonga ndohwaJehovha boka antiplatelet nevamiririri. The kwokutanga dose (nokuti "Zilt" - 400 MG) pashure 2 maawa pashure Kutarisirwa DZEMUNHU DZINODZORA platelet aggregation. Sezvo "Plagril", "Zilt", akapa pakugamuchira 50-100 MG pazuva ichapa kufadza kuchirapa mugumisiro pashure pemazuva 4-7.

Medicament rinoita ari chiropa. The Zvinoumba Ropa ose basa metabolites iri dzakaonekwa. Inenge 50% "Zilta" yabudiswa nokuda netsvo, dzasara 46% mukati 5 Mazuva pashure kugamuchirwa achava kutorwa kuburikidza ura.

Zvairatidza kuti kushandiswa "Zilta" vakafanana mu "Plagrila": kudzivirira thrombus inotungamirwa pavarwere kuwana myocardial infarction, ischemic sitiroko kana kutambura kubva zvinetso tsinga patency.

mutengi pfungwa

Kufanana chero mushonga, asi "Plagrila" ane kupima akanaka yevatengi, zvose zvakanaka uye kunaka wongororo. Kune varwere uyo zvinodhaka akagadzwa nokuda kurapa angina uye akaratidza kuva chaizvo zvinodhaka. With kushandiswa kwayo pamusoro kurwisa vakatora nzvimbo kana zvachose, kana vakava zvakati zvishoma. Pamwe chete makasitoma vari kunyatsoongorora mishonga "Plagril" apindure n'anga.

Zvisinei, unogona kusangana uye zvaanorumbidza pamusoro divi matambudziko anokonzerwa kushandisa mishonga. Vamwe vanhu vakanyora pamusoro chimiro mavanga, vamwe pachena akaratidza kupererwa neropa. Vaiva Varwere uye Zvikamu nokushayiwa nomusoro, uye yakasiyana chaizvo mirayiridzo zvinetso munyika zvomudumbu ino. Rare, asi unogona kunzwiwa akura ari muitiro pakugamuchira "Plagrila" gastric urikanwi kana duodenal urikanwi.

Kazhinji, zvinofanira kutaurwa kuti zvinodhaka "mirayiridzo Plagril 'kushandiswa iri papi sezvo chakakomba zvinodhaka zvakakwana haisi inowirirana mishonga yose. Ane kumbonyanya zvakawanda pasi contraindications, kunogona kukonzera yakawanda nemishonga kubva siyana hurongwa uye nhengo dzomuviri. Kusingadzoreki kushandiswa ungamutsa akaipa zvakakwana (uye dzimwe nguva kusingarapiki) nemigumisiro utano murwere.

The mhedziso kubva zvose pamusoro zvifakazira. "Plagril" nokuti mishonga kosi anofanira neMutungamiriri kupinda chiremba. Uye yakanaka sarudzo kurapwa pamwe zvinodhaka ichi - muchipatara uye pasi pokudzora nyanzvi vaitungamirira. Chete muchiitiko ichi tinogona kutarisira kunobatsirawo zvinodhaka shoma mukana nemishonga.