"Propranolol": analogues, mirayiridzo kushandiswa, tsananguro uye wongororo

"Propranolol" - mumwe mushonga kungova boka blockers anyatsosarudza. The mushonga une antianginal zvinokonzerwa, antiarrhythmic uye hypotensive. The medicament raitongwa nechinangwa Mabatirwo ischemic mwoyo chirwere, thyrotoxicosis, BP. Mushonga kubudirira neuro dystonia, migraine. Rinoshandiswa nenzira Implementation kurapa mwoyo kukundikana, angina pectoris. The chinodhaka vanobatsirwa muviri myocardial infarction. Vanobatana arrhythmia uye cardiomyopathy hypertrophic. Kana murwere haasi akakodzera "Propranolol" dzomuzana vanoonekwa nyanzvi prescribers kuti nokuti murwere Zvakanyanya Kunaka Panguva Yepamuviri.

kusunungurwa Form

Unogona kutenga mhando mbiri zvinodhaka - zvinodhaka "Propranolol" uye zvinodhaka "Propranolol Nycomed". Ndicho mishonga chete kuti anobudiswa neZvapupu zvakasiyana vagadziri zviri pamahwendefa.

The zvinoumba mushonga

Kugadzirira yakaitwa pachishandiswa yezviri fuma propranolol. Dose chikuru chinoumba angava akasiyana - 10, 40, 80 uye 160 MG zviri murwiyo nerimwe piritsi.

Ebetsero zvinhu zvaishandiswa kugadzirwa mahwendefa akasiyana uye kuvimba Vagadziri. Kuziva chaizvo zviri mushonga asati kushandisa zvakafanira kuverenga redzidziso.

The kuchirapa mugumisiro mushonga

Zvinoratidza kukwanisa adzikatidza Beta-adrenergic receptors rinoreva "Propranolol" mirayiridzo Chinyorwa. Analogues pane muviri akafanana chiito. Mahwendefa sei pamusoro vascular Beta receptors masvingo 1 uye 2. inhibitory nomugumisiro receptors izvi inotungamirira kuti kutandara pakati vascular masvingo, nokudaro kubvisa zvinetso zvakawanda - BP, zvakawedzera cardiac kudiwa chokuwana okisijeni, murombo kugoverwa zvinovaka muviri uye okisijeni kuti nyama uye nhengo dzomuviri.

Antiarrhythmic zviito zvinodhaka inosimudzira chitarisiko zvakanaka kuchinja pamuviri, dzakadai sinus raiva pedyo nebundu automaticity normalization, kuderera conduction atrioventricular raiva pedyo nebundu, kubviswa yakawedzera excitability masero kuti vanoumba iri myocardium. Nemhaka "Propranolol" akadzorera chakaipa mashandiro kwomwoyo, hapana kwomusikirwo zviwane, izvo zvinogona kukanganisa mutinhimira waro.

"Propranolol" analogues vanotsigira kukura Anti-anginal mugumisiro iyo akava nani ezvinhu cardiac tsandanyama, kuderedza okisijeni inodiwa huchishanda. Izvi zvinoreva kuti moyo inoda zvishoma oxygen kuderedzwa, uye kakawanda sunga izvi ipfupi zvakare.

Hypotensive richifanira inobva kuwedzera lumen midziyo ropa uye kutandara zvavo masvingo. Kushandisa chimwe dose mahwendefa kunotungamirira zvinoderedza ropa nevezera, kunoguma kushanda iri rakaramba kwemaawa dzinenge 20 usiku hwese. Kugadzikana hypotensive chaizvoizvo akanga aona pashure pemavhiki maviri kushandisa mapiritsi dzose. The mushonga haasi akakodzera zvakazorodza ezvinhu achiperekedzwa unopinza kuwedzera kumanikidzwa, zvinonzi inoratidzwa kuti kurapa-refu kuti BP.

Long-rokuti kushandisa zvinodhaka inotungamirira chitange cardioprotective migumisiro. Ratidza kuti kuderera ndingangokuvara dzokororo ine myocardial infarction pashure kurapa kwakadaro kunoreva "Propranolol" ongororo, mirayiridzo. Sezvineiwo kwakaderedza mukana kufirwa kuitika. Zvinozivikanwa kuti mushonga kunobatsirawo panguva yakakwirira intraocular kumanikidzwa.

Pharmacokinetics

Yapinda mukati muviri chikuru chikamu wefodya zvinodhaka (anenge 90%), ukuwo Indekisi bioavailability iri kunyora nezvavo. Kutaura mapuroteni zvakafanana 93%. Drug kubva muviri abviswa weti, iyo kuwa metabolites. Constant mhando ane asingasviki chimwe muzana mishonga.

umboo

"Propranolol" analogues murayiridzo unokubvumira kupa mishonga zvimwe zvinhu uye zvirwere. Yavaiita portal neBP uye arterial, myocardial dystrophy, hyperthyroidism. Mishonga kunobatsira kuderedza ezvinhu panguva kujekesa lumen yacho yeropa, zvinokosha tremor, vhunduka, rinogona kushandiswa senzvimbo chokushandisa ari prophylaxis pakati migraine. Mahwendefa akakodzera kurapa ari musoja mwoyo, myocardial infarction, arrythmia. The mushonga chinotarisirwa kuti varwere mitral vharafu prolapse. By zvinoratidza zvinosanganisira supraventricular tachycardia uye sinus. Ronga zvinoreva anoitwa panguva kushaya chirwere, angina pectoris, akathisia, anomuka nokuda kushandisa neuroleptics. Mishonga ushandiswe varwere vane pheochromocytoma kuti mubatanidzwa mishonga. The mushonga rinoshandiswa kwokusasimba basa basa pashure kubereka kubvisa kuonekwa kunaka.

Contraindications

Pane dzimwe contraindications kuti "Propranolol" chinodhaka. Analogs zvinogona kusarudzwa muna zviitiko apo mushonga hakusi akakodzera. Contraindications dzinosanganisira:

• kusashivirirana zvinoreva zvinoriumba izvozvo;
• cardiogenic kugwinha;
• bradycardia, umo nhamba heartbeats paminiti ndiyo 55 sp.;
• metabolic acidosis;
• chirwere chemwoyo kana chakasimba siyana;
• vasomotor rhinitis;
• sinoatrial mufurati, atrioventricular (2nd, 3rd dhigirii);
• Prinzmetal angina ;
• pasi BP;
• Shandisa insulin yakakodzera;
• chirwere achiperekedzwa sinus;
• Kuvapo nguva umo chipo refu achitsanya;
• nematambudziko peripheral kuparadzirwa (decompensation danho);
• kare Kutamiswa nhungamiro chirwere umo sei Airways, asima, bronchospasm Kuwanikwa.

Panewo zvinhu apo renyevero kunodiwa. Munyaya inotevera nyaya, unogona kusarudza pachinzvimbo zvinodhaka "Propranolol" analogues, anoreva zvakafanana:

• myasthenia gravis;
• cheshuga (decompensated, subcompensation);
• cardiac tsandanyama insufficiency (asima), chiropa, itsvo;
• spastic colitis;
• kuora mwoyo;
• atrioventricular misa (wokutanga dhigirii);
• psoriasis;
• zvakawedzera kushanda thyroid shwanu;
• chisingaperi siyana bronchitis;
• ropa shoma;
• emphysema;
• kukwegura;
• Panguva pamuviri, breastfeeds.

zvinodhaka kurapwa

Varwere neBP zvinofanira kutorwa kaviri zuva zvinodhaka dose 40 MG muzana chete dose. Zvibereko zvayo zvinogoneka mukati memazuva 14-28. Kana zvakakodzera, mapiritsi anogona kunwa zuva iri chipimo chemushonga 80 kusvika 160 MG. Kakawanda kubva kugamuchira zvinoreva zvakangofanana.

Kana tachyarrhythmia varwere mukuru vakanwa matatu kana mana nguva zuva nezuva kubva 10 kusvika 30 MG chete kugamuchirwa "propranolol" zvinoreva. Analogs zvinogona kushandiswa, kana chigadzirwa ichi hakukodzeri. varwere muduku chete dambudziko zvinodhaka raitongwa ari mari kubva 0.2 kusvika 0,4 MG muzana uremu kilogram muviri. The kakawanda chikumbiro zvinoreva - sezvo matatu kana mana kanomwe pazuva.

Somunhu chokudzivirira nechiyero pavarwere vave kuzivikanwa angina kugadza zvina kutora mushonga uyu ose zuva. A chete dose 20 MG. Zvibereko zvayo zvinogoneka mazuva manomwe. 40 MG zvinodhaka chinobviswa panguva mwero chete, 80 MG - zvishoma zvishoma kazhinji (ruviri).

Pashure myocardial infarction prophylaxis kunodiwa. Mhanyai rinogona medicament "Propranolol". Size yakakodzera chete dose ndiyo 40 MG, mushonga yemichato pazuva anofanira kuzviita matatu. Kuwedzera dose kusvikira vaifanira 80 MG.

Migraine matanho anofanira akasangana nokushandiswa 40 MG zvinodhaka kaviri pazuva. Anodei kuwedzera dose kusvika 80 MG, kunwa mushonga zuva kungava maviri kana matatu, uye vana - vatatu kana vana. Kukarukureta of dose varwere navaduku anoitwa mune kufunga kwavo uremu, paminiti kilogram pakati - kubva 1.5 2 MG.

Thyrotoxicosis - chirwere umo zvinodhaka anopiwa 10 MG asi kwete kupfuura 40 pakugamuchira matatu kana mana kanomwe pazuva.

Kana uchironga pheochromocytoma kurapa, mushonga unobatanidzwa pamwe Arifa blockers.

nemishonga

Vanofanira kuteerera chii chinoratidza parutivi migumisiro zvinodhaka "Propranolol" mirayiridzo Chinyorwa. Analogs Wongororo - haasi mashoko kukosha, kufurira kusarudza mishonga kurapwa. To nengozi nenjodzi wemuviri usingashandi, zvakakodzera nokungwarira kuverenga rairo, rinobatsirawo tinyatsoziva.

Mishonga kana ikashandiswa zvisina kufanira kunogona kukanganisa kumwoyo anokonzerwa vachivavhiringidza nechepakati tsinga, kuti kwemakemikari anobudiswa hurongwa. Zvingangoitwa kuratidzwa pamusoro chikamu zvomudumbu turakiti, anogona kunokanganisa mucous membranes uye ganda. Pakati divi migumisiro dzakanyorwa mumirayiridzo - matambudziko kufema. Pangava nemamwe marwadzo.

Analogs mutengo

Asati vanotenga "Propranolol" chinodhaka analogues, mutengo zvinowanzooneka kudzidzwa varwere. Kutenga mapiritsi anogona kuva 16-75 rubles. Price iri pakutsvaga nhamba mahwendefa por rongedza. Kutsiva mushonga anogona kuva "Propranobene" medicaments "obzidan" kana "Inderal". Unogonawo kuita kurapwa "Inderalom LA", "Inderalom".

By nezve mushonga "Propranolol" mirayiridzo kushandiswa, mutengo, analogs mashoko anokosha anobatsira kuita chisarudzo chakanakisisa pakusarudza mishonga uye kurapwa.

Reviews

Anodzokorora kunyanya akanaka. Vakaudza kuti zvinodhaka kurapa kazhinji inobudirira. Uyewo, vazhinji vanogutsikana yakaderera mutengo mishonga. "Propranolol" Vanotarisira kuchengetedza BP pane zvisingatomboiti pamwero, Kurumidza kubvisa mwoyo palpitations. Mishonga kunoita zviratidzo chemwoyo, anobvisa manzwiro evanhu. Negative Wongororo kazhinji vanhu kusiya nokuti zvakakomba nemishonga kuti munguva mushonga. Dzimwe nguva pane kwakakomba simba, hope matambudziko, kurota zvinotyisa.