"Trimetazidine-Biocom MV": mirayiridzo kushandiswa, akafanana, analogs uye wongororo

The medicament ane mugumisiro iyo hworatidza wakakurumidza metabolic pezvakaitwa kuitika neurosensory mapazi uye myocardium. Usati watanga kurapwa, unofanira kuziva kuti chii chinoumba mushonga "Trimetazidine-Biocom MV". Mirayiridzo kushandiswa, murwiyo zvinodhaka - chinobatsira mashoko, izvo tiriverenge.

Form kusunungurwa mushonga, yenhengo dzayo

The mushonga yedzinza dzakachinjwa kusunungurwa kunoreva iri asunungurwa muchimiro Coated mapiritsi, anogadzirwa pachishandiswa trimetazidine dihydrochloride. Mhoni rine Mahwendefa 10 ari rongedza zvinogona kubva 1 kusvika 6. Mumwe piritsi rine 35 MG huru zvinoriumba. Zvinoumba vaisanganisa pamwe magnesium stearate, povidone, aerosil, hypromellose uye calcium yakawanda rehydrogen phosphate dihydrate.

Titanium dioxide, Macrogol vari musimboti goko Hwendefa "Trimetazidine Biocom-CF". Mirayiridzo yokushandisa nezvembiri mukuwedzera zvinhu izvi goko chinosanganisira hypromellose uye tsvuku simbi oxide.

Pharmacological migumisiro

Antihypoxanth chishandiso unokubvumira kudzorera chakaipa muviri masero, iyo kwakaitika somugumisiro yaivhuvhuta kuchinja kukura kuva pathological mamiriro (ischemia, hypoxia). Mahwendefa runosanganisirawo kusashandisa kuderedza huwandu ATP ari mumasero kubatsira kuvandudzika kuti Kamudzira Ion migero, transmembrane kufamba yavaibvisa uye potassium ions. Kuramba cellular homeostasis munguva kurapwa kushandisa medicament "Trimetazidine Biocom-CF". Mirayiridzo yokushandisa akashuma kuti chinodhaka kunoderedza mwero uko oxidation nedanho mafuta acids, nokudaro mukuru shuga oxidation rinoitwa kudzivirira myocardial pamusoro ischemia. Zvakaitwa zvinodhaka kunobva Nokuchinja kubva oxidation kwacho pamwe zvakakora acids kuti shuga.

chokwadi chinodhaka, tiine chakaipa mararamiro metabolic urongwa, paupenyu neurosensory mapazi uye mwoyo, akazoita kwokuomerwa kutyorwa mu transmembrane Ion aibuda kukura ischemia. Zvinoenderana mwoyo rinenge mushonga kunoderedza kuti zviratidzo zvakadai yokutama, infiltration kuti polynuclear neutrophils. Pamusoro zvinodhaka kwepasi "Trimetazidine-Biocom MV" mirayiridzo Chinyorwa zvinosanganisira mashoko kuti vanomiririra kunobatsirawo pamusoro myocardium kwave damage ischemia. Hemodynamic mushonga une zvachose hapana simba.

Pharmacokinetics

Absorção de Água anotora nzvimbo dzinenge zvachose uye nokukurumidza. Kukurukura mapuroteni eplasma haikoshi (16%), mwero bioavailability 90%. By kuitwa mahwendefa kusvikira nhambo apo huwandu basa fuma pamuviri kunova kunonyanyisa, izvozvo anotuma anenge maviri maawa. Zvinozivikanwa kuti mushonga inopfuura nyore neropa-tishu ematongerwo. Hafu-upenyu rinoitwa mumaawa anenge mashanu. The mushonga mumuviri yabviswa ne itsvo, vakawanda izvozvo haachinji chimiro chayo.

umboo

"Trimetazidine Biocom-CF" (Mahwendefa) kudzidziswa inogona kushandiswa kushandisa CHD kurapwa refu. Chinangwa chawo unoratidzwa zvinotevera nyaya:

• kudikanwa dzika matanho pakuparwa panowanikwa angina kurwiswa;
• dzungu, kuvapo uko chokuita vascular maronda;
• cochle-vestibular zvinetso kuva ischemic hunhu (Kuipa kunzwa);
• chorioretinal vascular zvirwere, achiperekedzwa ischemia.

angina prophylaxis kunogona kuitwa kushandisa rimwe mushonga kana pakutevedzera zvakaoma kurapa.

Contraindications

Achitaura zviitiko apo pamamiriro paakatora mishonga "Trimetazidine-Biocom MV" mirayiridzo manual, wongororo ane mashoko inotaridza hazvibviri kurapa nemishonga iri rinoti izvi:

• kunyanya aikanganiswa huru zvinoriumba uye zvimwe zvinhu nzira;
• achiyamwa;
• panguva vana.

Sezvo kuchengeteka kushandiswa kwezvinodhaka muvana (Makore asingasviki 18) uye kubudirira kurapwa pamwe kushandiswa kwayo vasina yatangwa, varwere kwakadaro ichi kunoreva harigadzwi.

Mishonga contraindicated pamwe akaratidza chiropa kwevanhu uye itsvo kukundikana, umo nechiidzo akadai creatinine Clearance iri yekudyidzana wakaderedzwa (ndiko 15. / Maminitsi zvichidzika). Kwete chete yokuziva zvairatidza uye contraindications kurapwa zvingangoita "Trimetazidine-Biocom MV". Mutengo anewo zvimwe kukosha pakusarudza medicament kuti mushonga. Pairi ichakurukurwa pashure.

zvinodhaka kurapwa

chete dose saizi kunotemwa nachiremba (kazhinji haana asingasviki 40 MG asi kwete kupfuura 60). In maawa 2-3 kunodiwa kuita kugamuchirwa nzira. Duration yokurapa chinosimbiswa yoga zviitiko zvakasiyana.

nemishonga

Asati mushonga, zvinokosha tinyatsoziva zvichibvira nenjodzi pashure ingestion mahwendefa muviri "Trimetazidine Biocom-CF". Mirayiridzo kushandisa nzira, yakavakirwa izvo nemabatiro nemishonga zvinosanganisira chisimbwa, richiratidzwa sechinhu itchy uye ganda mapundu, mamwe maitiro havasi zvakajairika kuti muviri. Panguva kurapwa, mune zvisingawanzoitiki chaizvo nguva vamwe varwere vane kuda kurutsa, kurutsa kunoitika, izvozvo rinozivikanwa gastralgia.

Zviitiko zvikuru ovhadhozi vasina wakaiswa, uye mukana panowanikwa wavo ungangova. Somugumisiro kwazvo zvavakabvumirana dose inogona kuchengetwa chiso Flushing, hypotension.

Zvokungwarira

Marapirwo hazvirevi runosanganisirawo kusashandisa kukwanisa kudzinga uye asingauyi kupindira mabasa ari kuita izvo zvinoda anokurumidza mumuviri uye psychomotor zvavaifunga.

Mahwendefa hazvisi akakodzera kuchaitwa angina kurwiswa uye rinogona chete kushandiswa chokudzivirira zvinangwa nevarwere vanotambura kurwiswa zvakadaro.

The Kurapa varwere nechirwere chemwoyo iri vasanyanye zuva chinodiwa nitrates.

Mari zvinodhaka analogues, wongororo

Zvinofanira kudzidzwa kurapwa asati rinoreva "Trimetazidine" mirayiridzo Chinyorwa. Mutengo zvakare unokosha ruzivo uye kufungawo pakusarudza mushonga nokuda kurapwa (prophylaxis), matambudziko mwoyo (coronary tsinga chirwere). The anofungidzirwa Mari zvinodhaka ndiko 100-165 rubles. Mahwendefa 30 uye 189-208 rubles. 60 Mahwendefa.

The analogue anogona kuiswa "Preductal", "Antistius" kana "Trimethyl". Possible kurapwa zvinodhaka "Medarum", "Rimekor". Chiremba anogona kutsiviwa mishonga nokugadza "Prekard", "Angiozyme", "Trimitard MV". Pane mukana kurapa "Tridukardom", "Predizinom", "Trimektalom" kana "Metagardom". Kutonga nezvinooneka wongororo, chinonyanya dzakakurumbira analogue ndiye "Preductal" mushonga uyu unoshanda, asi ane anodhura pane "Trimetazidine". Mirayiridzo kushandiswa, mutengo rinoratidza kuti zvinodhaka kurapa kunobatsira, wongororo mbisa efficacy yokurapa ichi.

In kudzokorora medicament Zvinonzi kuti mushonga zvakanaka anobvisa kurwadziwa mumwoyo, izvozvo anoita ayo basa zvakakwana. Nokuti chipimo chemushonga sezvo kuvarwere uye vanachiremba kwakaratidzwa nokuchinja kwakanaka, semuenzaniso, muviri vanhu kugamuchira kurapa, nani kuonesesa muviri. Vanhu vazhinji vanoti kuti pashure pemazuva mashoma kurapwa vakarashikirwa dyspnea, tachycardia zvaitika, BP kudzokera dzose. Kazhinji akacherekedza kuvandudzika pazuva rechina kurapwa, kwakavakirwa kushandisa chipo mari "Trimetazidine-Biocom MV". Mirayiridzo kushandiswa, mutengo rinoratidza kuti mishonga inowanikwa kwete chete asiwo kunobudirira, mukuwedzera, ane shoma nhamba zvichiita nenjodzi kuti havawanzosarudzi kutanga. The kwaita nemishonga kuchengetwa zvisingawanzoitiki zviitiko.

Saka, isu takasiya kwemashoko akazara pamusoro zvinodhaka "Trimetazidine-Biocom MV". Analogues, mutengo, mutungamiriri, akaongororazve pamusoro mushonga yauri ikozvino kuzivikanwa. The mushonga inofanira kugadzwa nyanzvi uye akavashandisa tikaisa dose. Kudiwa yaitsiva medicament akatsunga nachiremba yakavakirwa zvinhu zvakawanda. Mirayiridzo unokubvumira kuti inonyatsobudirira kurapwa pasina kukuvara.