Zvinodhaka Antileukotriene vorudzi chitsva: mazita akanakisisa

zvinodhaka Antileukotriene vanomiririra boka itsva nevasori kuti kuderedza anogumbura pezvakaitwa kuti vari sema kana rwarisa etiology.

Kuti tinzwisise pfungwa chiito zvinodhaka izvi, zvinokosha kunzwisisa chii vari leukotrienes.

leukotrienes

Ndivo nevamiririri venyika kuzvimba. Maererano zvavo nemakemikari yakarongeka, vane mafuta acids, izvo aumba kubva arachidonic acid.

Leukotrienes zvinobatanidzwa kukura asima. Uyewo histamine, ivo nevamiririri venyika neutachiona yacho pakarepo mhando. Histamine kunogona kukonzera nokukurumidza asi pfupi bronchospasm uye leukotrienes kukonzera kunonoka uye hwakareba spasm.

Sezvo Classified antileukotriene zvinodhaka?

Pari, leukotrienes dzinoiswa sezvinotevera: A _4, B _4, C _4, D _4, E _4.

Kwetunhu leukotrienes zvinobva arachidonic acid. Zviri pasi pokudzora 5-lipoxygenase anopfuuura kuti leukotriene A _4. Pashure paizvozvo pane Pazvinoitika maitiro, zvakazoita zvinotevera muchimiro leukotrienes B ₄ -C ₄ -D ₄ -CA _4. The pagoho rokupedzisira iri kuita - LTE _4.

Rinogadzwa kuti LTE _4, D _4, E ₄ zvinogona kukonzera bronchoconstrictor Chaizvoizvo, nokuwedzera madzihwa secretion kungawedzera kutanga edema, tunodzivisa mucociliary Clearance.

B _4, D _4, E ₄ vane chemotactic basa, i.e. kungakwezva neutrophils uye eosinophils mu kushoma wongoramba.

Masayendisiti dzakaratidza kuti leukotrienes anobudiswa neZvapupu macrophages, rechikepe masero, eosinophils, neutrophils, T-lymphocytes, izvo dzinoshanda anogumbura siyana. zvinodhaka Antileukotriene mu asima inowanzoshandiswa.

Mushure masero kupinda kuonana ane allergen uye kutonhora chakaitika Airways kana pashure mumuviri nesimba, kusashanda LT usage. Kureva kwetunhu kunotanga apo osmolarity pamusoro Árbol kugutsikana inowedzera.

mapoka Four zvinodhaka

Iye zvino kuzivikanwa mumapoka ose mana antileukotriene zvinodhaka:

1. "Zileuton", inova zvakananga inhibitor 5-lipoxygenase.
2. Formulations dziri FIs floppy, unonyevera basa tichisunga puroteni pamwe arachidonic acid.
3. "Zafirlukast", "Pobilukast", "Montelukast", "pranlukast", "verlukast" dziri mhandu pamusoro leukotriene receptors sulfidopeptidnyh.
4. Zvinodhaka kuti muri mhandu kubva leukotriene B ₄ Kanotokonya.

Chinonyanya vakadzidza ndivo zvinodhaka antileukotriene wokutanga boka uye boka mari rechitatu. Funga mapoka aya zvizere.

"Zileuton"

"Zileuton" riri reversible inhibitor 5-lipoxygenase. It anokwanisa tunodzivisa paumbwe sulfidopeptidnyh The LT uye RT _4. The mushonga angava bronchodilator migumisiro zvisingaperi maawa mashanu. Uyewo zviri kudzivisa panowanikwa Árbol spasm, inova mugumisiro yokuwana mhepo inotonhora kana "asipurini".

zveBhaibheri zvakawanda zvinoratidza kuti "Zileuton" basa varwere vanenge Árbol asima mumwe kusvikira kumitanhatu, anogona kuderedza kudikanwa murwere kuti inhaled β2-agonists uye corticosteroids. A chete dose "zileuton" Anonyevera panowanikwa sneezing uye kupfupika nasal kufema pavarwere vanotambura sema rhinitis pashure nasal kwokubatsira allergen.

The-vhiki nhanhatu kurapa ne "zileuton" atopic asima akaratidza chinokosha mugumisiro. Doctors vanoti yepamusoro richikwidibira pamusoro eosinophils uye neutrophils. Uyewo ungaderedza bundu necrosis chinhu bronchoalveolar lavage zvinwiwa pashure allergen mhando bvunzo. Ndizvo rakasiyana antileukotriene nezvinodhaka, mashandiro chiito kunoenderana ichi.

"Zileuton" kunoratidzwa pfupi nguva, umo mune yayo hafu-upenyu. Izvi zvinoratidza kuti mushonga anofanira kutorwa kakawanda yakakwana nguva vana pazuva. Uyezve, "Zileuton" inogona kuderedza Clearance kuti theophylline. Zvinofanira kufungwawo, kana zvinofungirwa yakafanana kugamuchirwa theophylline uye "zileuton". Kureva dose wokutanga anofanira kuderedzwa. Kana "Zileuton" iri hurukuro refu-refu, zvinokosha kuongorora padanho chiropa makemikari.

Asi pane antileukotriene chizvarwa chitsva zvinodhaka, ravo mazita ari pasi apa.

Agents dziri mhandu pamusoro leukotrienes sulfidopeptidnyh, vakwikwidzi vane zvikuru kusarudza uye reversible blockers LT D ₄ receptors. zvinodhaka izvi zvinosanganisira "pranlukast" "Zafirlukast", "Montelukast."

"Akolat" ( "Zafirlukast")

"Zafirlukast" aka "Akolat" ndiro kudzidza pamusoro boka iri antileukotriene zvinodhaka zvinhu. Uyewo kushingaira bronchodilator dzidziso. Kuvhiringidzwa kunogara kwenguva refu, kusvikira maawa mashanu. "Zafirlukast" muitiro anokwanisa kudzivirira kukura ane asthmatic nezvinoita zvakaitika allergen inhalation. Kugona kwaro riri nekusimba, uye kudzivirirwa Árbol spasm, izvo atsamwiswa nendege chando, aspirin, kurovedza muviri, Zvinosvibisa. Active mushonga, uye kugadzirira "Montelukast" anogona kusimbisa bronchodilator basa β2-agonists.

"Akolat" ( "Zafirlukast") vane zvakanaka absorbability, Parainge wevasungwa muropa kunoitwa pashure maawa matatu pashure kutarisirwa kwaro. Its nguva hafu-upenyu zvishoma kunopfuura "zileuton", uye ndiyo maawa 10. Uyezve, hakuna zvainoita Clearance kuti theophylline. Gamuchira basa mushonga inofanira kunge awa pamberi kudya kana mukati maawa maviri pashure, sezvo zvokudya zvakati kunoderedza ayo Absorção de Água chinzvimbo. Zvinoreva Akashivirira kwazvo.

mhedziso

Antileukotriene zvinodhaka nokuti Kurwara inogona kushandiswa vana, asi kwete vasati vasvitsa makore maviri. Achibatsirwa mishonga izvi muvana kubatwa idzokororo bronchitis, sema rhinitis, munyoro asima.