Anticoagulants - zvinodhaka kuti chokuita kweropa

Under kwomuzvarirwo ezvinhu, ropa imvura iyo inopa sangano wake kweropa hurongwa. In yezvirwere uye parasitic zvirwere, uyewo intoxications kuchinja physico-namakemikari ehupfumi, izvo kwakakanganisa kunokanganisa metabolic pezvakaitwa uye kushanda zvomukati. Saka chaivo ukoshi ane mwero pakugwamba. Inogona nokukurumidza uye kunonoka. Mukurapa, kushandisa yakawanda pharmacological vamiririri achibatsirwa paunogona kuchinja kumhanya kweropa. Anticoagulants - mishonga kunetesa muitiro coagulation ropa, senzira mhanyisa ichi unodzivirira mhinduro, inonzi coagulants.

The mashandiro pamusoro coagulation uye thrombus inotungamirwa - kunzwisisa nokukanganisika kwacho chinodzivirira muviri kubva kurasikirwa neropa panguva vascular kuvimbika kukanganisa. Izvi zviri kuitwa tichiregeredza prothrombin, iro synthesized muna chiropa, uye maplatelet, izvo vanoomerera kuti collagen fibers ari micheto ukama mudziyo. Muna hydrolysis muitiro dzinounzwa platelet-vapfumi yeimwe (adenozintrifosfatnaya uye adenozindifosfatnaya acid), thromboplastin uye vasoconstrictors - norepinephrine, epinephrine, kweserotonin. Ivo rakatetepa mudziyo lumen. Thromboplastin vakadhakwa calcium mapuroteni eplasma chokuita prothrombin uye thrombin nezvimiro, inova puroteni (fibrinogen) iri kutendeukira insoluble fibrin, Simbiso munhu vascular lumen.

Kweropa DZEMUNHU DZINODZORA zvirwere chokuita akaderedza karusiyamu yomuropa muropa, vasanyanye platelet kuverenga, prothrombin usage kukanganisika fibrinogen, thrombokinase kukwana basa uye vhitamini K. The coagulants inoshandiswa mukurapa, thrombin, fibrinogen, karusiyamu chloride, menadione, aminocaproic acid, muriwo gadziriro (yorukato mashizha, mvura mhiripiri).

Anticoagulants - mishonga tunodzivisa zvipenyu basa wegadziriro, iyo inopa ropa coagulation uye kunodzivisa paumbwe clots mumidziyo ropa. Ivo tunodzivisa zvose kana vamwe maitikiro ropa pakugwamba. Zvinozivikanwa kuti ropa mvura wehurumende ari nekugadzirwa dzakananga makemikari uye antitrobminom. Kuitira kudzivirira paumbwe ropa clots, anticoagulants vaishandisa zvakananga chiito. Ivo sei ropa pakugwamba zvinhu kunonoka mutoo mumuviri kana chubhu. Yavaibvisa citrate (sodium citrate) uye EDTA (ethylenediaminetetraacetate acid) kusunga ari ionized karusiyamu ropa uye kuichinja karusiyamu citrate kana complexed pamwe EDTA. Nezvokumutswa kubviswa calcium ions kubva kweropa gadziriro aumbwa thrombin uye fibrin. Heparin inactivates thrombogenic zvinhu uye kuchititadzisa kutendeuka prothrombin kuti thrombin. Anticoagulants - zvakananga kuita zvinodhaka nachiremba ropa uye hematology rabhoritari zvidzidzo kuti kudzivirira kweropa uye nekuda kurapwa kwezvirwere kuti pamwe nokukurumidza kweropa. zvinodhaka izvi zvinoshandiswa kuti kudzivirira uye vabatwe thromboembolic yematambudziko.

Anticoagulants zviri kunanga kuita - bishydroxycoumarin, coumarin, sinkumar - adzikatidza kwetunhu makemikari kuti vanobatanidzwa kweropa. Ivo tunodzivisa thrombin inotungamirwa ari chiropa. Izvi ikabuda nhengo mumaawa 12-72 uye anoratidzwa mune imwe nguva kubva maviri gumi mazuva. Uyu-refu kuita mishonga. Anticoagulants - mishonga zvisina kunanga ushandiswe nokuda kudzivirirwa uye Mabatirwo thrombosis, embolism, thrombophlebitis.