Beta-agonists: tsananguro, chiito mazita zvinodhaka

Mumwe mushonga rinoreva zvimwe pharmacological boka. Izvi zvinoreva kuti zvimwe zvinodhaka zvakafanana mashandiro basa, zviratidzo uye marwadzo. Chimwe chikuru mishonga mapoka - iri Beta-adrenergic agonists. zvinodhaka izvi zviri zvikuru kushandiswa pakurapa kufema uye zvemwoyo pathologies.

Chii In-agonists?

Beta-agonists - boka yokurapa namano zvinoshandiswa kurapa zvirwere zvakasiyana-siyana. Mumuviri, vanosunga kune dzakananga receptors riri anotsvedzerera tsandanyama ari principales, dumbu, mwoyo uye vascular munyama. kudyidzana kwakadaro rinoita kweiyi ari Beta masero. Somugumisiro ari activation-siyana vasiri kwendangariro. Pamusoro nokusungwa B-agonists kuti receptors kunomutsa kugadzirwa utachiona, kufanana dopamine uye adrenaline. Chimwe zita yeimwe izvi - beta-agonists. Major Migumisiro dzayo - kumhanyisa nomwoyo zvazvingava, wakawedzera BP uye kuvandudza Árbol conductivity.

Beta-agonists: Zvakaitwa mumuviri

Beta-agonists akakamurwa V1- uye B2-adrenergic agonists. Receptors nokuti izvi zvinhu vari zvomukati. Pamusoro ndichisunga yavo Beta-agonists kutungamirira activation pamusoro pezvakaitwa zhinji pamuviri. Pane zvinotevera migumisiro B-agonists:

1. Kuwedzera cardiac automaticity uye conductivity kuvandudzika.
2. Inosimudzira kwemwoyo.
3. Kumhanyisa kuti lipolysis. Kushandiswa, B1-agonists kuonekwa muropa akasununguka mafuta acids ndiyo zvibereko disintegration ose triglycerides.
4. Inosimudzira BP. Izvi ndizvo nokuda kweiyi ari renin-angiotensin-aldosterone hurongwa (neRAAS).

Kuti dzakanyorwa kuchinja mumuviri inoenda nokusungwa agonists B1 receptors. Ivo dziri mumwoyo tsandanyama, tsinga, adipose rinenge uye juxtaglomerular midziyo yose itsvo masero.

B2 receptors dziri muna principales, dumbu, skeletal tsandanyama, musimboti tsinga. Uyewo, ivo ndivo mwoyo uye ropa midziyo. Beta-2-agonists kukonzera zvinotevera migumisiro:

1. Improvement pamusoro Árbol conductivity. Izvi imhaka kuti kutandara kuti mvere tsandanyama.
2. Kumhanyisa kuti glycogenolysis mune tsandanyama. Somugumisiro skeletal tsandanyama nokukurumidza uye zvakawanda kuderedzwa.
3. The kutandara of myometrium.
4. Kumhanyisa glycogenolysis mu chiropa mumasero. Izvi zvinotungamirira vawedzere ropa shuga yomuropa.
5. Inosimudzira kwemwoyo.

Ndezvipi zvinodhaka ndivo boka B-agonists?

Doctors kazhinji mishonga Beta-agonists. Drugs Kuva ichi pharmacological boka, rakakamurwa pfupi uye kutsanya-kuita mishonga. Uyezve, mishonga kure chete kuva nomugumisiro zvokusarudza pane dzimwe nhengo. Vamwe zvinodhaka vanoita zvakananga pamusoro V1- uye V2-receptors. The inozivikanwa mishonga kubva boka Beta-agonists vari zvinodhaka "Salbutamol", "fenoterol", "Dopamine". The agonists inoshandiswa pakurapa pulmonary uye cardiac zvirwere. Uyewo vamwe vavo zvinoshandiswa ezvinhu enyika yevanenge (zvinodhaka "Dobutamine"). zvinodhaka ishoma muboka iri zvinoshandiswa gynecological tsika.

Kupatsanura pakati Beta-agonists: mhando mishonga

Beta-agonists - ichi pharmacological boka, rinosanganisira vakawanda mishonga. Saka, vari rakakamurwa mapoka akawanda. Kupatsanura B-agonists zvinosanganisira:

1. Non-vanosarudza Beta-adrenergic agonists. boka iri zvinosanganisira mishonga "ortsiprenalina" uye "Isoprenaline".
2. Kusarudza B1-agonists. Ivo zvinoshandiswa cardiology uye yevanorwara zvikuru vachiravana. Vamiririri boka iri mishonga "Dobutamine" uye "Dopamine".
3. Kusarudza Beta-2-agonists. boka iri zvinosanganisira mishonga inoshandiswa zvirwere kufema hurongwa. Uyewo haangotongi B2 agonist rakakamurwa zvinodhaka pfupi-kuita, uye zvinodhaka kuva zvechigarire kushanda. Boka rokutanga rinosanganisira mishonga "fenoterol", "terbutaline" "Salbutamol" uye "hexoprenaline". Long-kuita zvinodhaka - mushonga "Formoterol", "Salmeterol" uye "indacaterol."

Zvairatidza In-agonists

Zvairatidza kuti kushandisa B-agonists kunoenderana mhando zvinodhaka. Beta-agonists vari kuita non-zvokusarudza zvino asiri kushandiswa. Pakuvamba, aishandiswa kurapa mamwe arrhythmias, kuwedzera cardiac conduction, Árbol asima. Zvino vanachiremba vanosarudza taurira kusarudza B-agonists. Zvakavanakira ndechokuti vane kure zvishoma nemishonga. Uyezve, mishonga haangotongi nyore kushandisa, sezvo chete kukanganisa dzimwe nhengo.

Zvairatidza kuti B1-agonists nechinangwa:

1. Chenjera mwoyo kutadza.
2. The kuvhunduka chero etiology.
3. Richaparara.
4. Decompensated mwoyo kuremara.
5. Kashoma - ischemic mwoyo chirwere chakakomba dhigirii.

B2-agonists raitongwa mu Árbol asima, chisingaperi obstructive pulmonary chirwere. Kazhinji, zvinodhaka izvi zvinoshandiswa muchimiro aerosols. Dzimwe nguva mishonga "fenoterol" rinoshandiswa gynecological tsika yokurembedza basa, uye kudzivisa kubva kwepamuviri. Panyaya iyi, kuti mushonga chinotarisirwa nomutsinga.

Mune zvimwe zviitiko, B-agonists vari contraindicated?

Zvinofanira kurangarirwa kuti boka zvinodhaka A Beta-agonists vane uwandu contraindications uye marwadzo. Izvi ndezvechokwadi kunyanya mune dzisiri anyatsosarudza agonists. Side Migumisiro zvinodhaka izvi - .. Ko kukura hyperglycemia, muzvidimbu chakamira pakunodengenyeka zvine, mwoyo mutinhimira zvirwere, nechepakati tsinga excitation, etc. Beta-1 agonists vari zvinodhaka simba, saka anoshandiswa chete vanenge kudiwa. Ivo contraindicated pavarwere vane nhoroondo zvokurwara kwakadaro: ventricular arrhythmia, subaortic stenosis, pheochromocytoma. Uyewo, havagoni kushandiswa cardiac tamponade.

B2-agonists vari contraindicated anotevera nyaya:

1. Kurambidzwa kuenda Beta-agonists.
2. Pamuviri rakaoma ne ropa, placental abruption, vakatyisidzira kubva kwepamuviri.
3. Children pasi 2 namakore.
4. Anogumbura urongwa mu myocardium, cardiac arrhythmias.
5. Diabetes mellitus.
6. Kutsemuka stenosis.
7. BP.
8. Chenjera mwoyo kutadza.
9. Thyrotoxicosis.

Medicament "Salbutamol": mirayiridzo kushandiswa

Drug "Salbutamol" rinoreva B2-agonists pfupi chiito. Rinoshandiswa nenzira urwere pakati Árbol mhingaidzo. Most inowanzoshandiswa aerosols nokuda 1-2 mishonga (0.1-0.2 MG). Vana vaida kuti inhalation vachishandisa mumwe nebulizer. Panewo pahwendefa chimiro zvinodhaka. The chipimo chemushonga nokuti nevakura 6-16 MG pazuva.

"Salbutamol": zvinodhaka mutengo

The mushonga yaishandiswa monotherapy mune vanyoro asima. Kana murwere ane mwero kana zvakakomba pavaipfuura chirwere, mazhinji vakashandisa zvinodhaka (Beta-agonists refu-nokuita). Ndivo inokosha kurapa pane Árbol asima. kushandisa zvinodhaka "Salbutamol" kukurumidza kusunungurwa kurwiswa ose breathlessness. Mutengo zvinodhaka kubva 50 kusvika 160 rubles zvichienderana mugadziri uye dose huri chinu.