"Budesonide": mirayiridzo kushandiswa uye analogues. "Budesonide" inhalation: wongororo, mutengo

Asthma pokutanga kutanga munyika pakati zvirwere chokuita wokusagadzikana of zvirwere. Kurapa nayo anosika guru mari zvinodhaka. Chimwe chishandiso ndehwevakadai "budesonide". Analogs zvinodhaka ichi chiri anowanzoshandisirwa kurapa broncho-obstructive syndrome. Saka chii mushonga uyu?

Chii chinonzi "Budesonide"?

mushonga uyu ndera boka inhaled glucocorticoids. chokushandisa uyu chakaita zvokugadzirwa analoginen synthesized mumuviri wedu (ari adrenal cortex) mahormone. Imhandoi Basa "Budesonide"?

Mirayiridzo kushandiswa zvinodhaka kunoratidza kuti pomutumwa kunowedzera uwandu tichishingaira Beta-adrenergic receptors ari Airways.

Uyezve, mushonga kutigumbura kuitwa anogumbura prostaglandins uye leukotrienes, nokudaro zvichiita kuti kukura kuzvimba mune Árbol mucosa.

Kunochinja Migumisiro yacho pashure nehurumende zuva pamusoro mazuva akawanda (kakawanda anenge 5-7 mazuva).

Zviri imwe huru mishonga chokubata zvakakomba Árbol asima uye chisingaperi obstructive pulmonary chirwere. In kwokutanga nzendo kukura zvirwere izvi hazvirevi kushandisa.

Saka, "Budesonide" Ane zvainoita chipfuro masero?

pharmacodynamics

The mushonga kuburikidza inhalation chikumbiro, zvakanaka woga kubva pemvura zvemapapu (kubva pemvura nasal mucosa rinenge anosvika systemic kutenderera).

Kunonyanyisa yeplasma wevasungwa zvinodhaka riri akacherechedza mukati maminitsi 45 pashure inhalation. 85 muzana zvose kuuya zvinodhaka anosunga kune sealbumin ropa dzasara inenge yabudiswa kuchinja.

It chinogadzirwa ne chiropa. Yabudiswa kubva muviri kuburikidza nemudumbu (ari bile) uye weti.

Varwere izvi miviri zvokurwara vakachengeta refu kunonotsa mushonga muropa, chii zvakonzera kukura vakawanda yematambudziko uye ovhadhozi pakati glucocorticoid mahormone.

Zvinokwanisika kushandisa mushonga mu piritsi muchimiro nokuda pakurapa systemic connective zvinyama (asi muzana chete 10 yaipedzerwa mushonga anenge vakapinda nemudumbu angava muviri chaizvoizvo).

It rinogona kushandiswa kurapa non-anogumbura zvirwere nasal mucosa nokuda kwenguva refu omunharaunda chiito.

zvairatidza

Zvisinei, mune zvimwe zviitiko, unogona kuvapa "Budesonide"? Mirayiridzo yokushandisa mazita huru zvirwere iyo zvinodhaka izvi zvinogona kushandiswa:

• Árbol asima. The mushonga akava akakurumbira nekuvongwa yaro Anti-anogumbura zvazviri uye kukwanisa tunodzivisa basa kuti anogumbura nevamiririri.
• chirwere Crohn vake. Nokuti kurapa chirwere kushandisa tableted chimiro zvinodhaka. The mushonga anopiwa kufurira rokuregererwa nepakati siyana chirwere.
• Mabatirwo rhinitis. Anoratidza basa iri intranasal chimiro budesonide kusunungurwa kubva zviratidzo nouswa uye sema rhinitis. Rakanakisisa mutumwa kurapa chirwere ndiye "Budesonide Formoterol".
• Kudzivirira dzokororo ine polyposis, nasal mucosa. The mushonga rinoshandiswa mukuvamba postoperative nguva. Vanenge 95 muzana kacho kunodzivisa kuti kunenge kukura polyposis.

Zvirwere dzakanyorwa ndivo mukuru urongwa, umo yakatarwa "budesonide".

Dzimwe nguva, mushonga unogona kupiwa kudzivirira kukura obstructive zvemapapu chirwere. Muzviitiko zvakadaro zvinosanganisira varwere Occupational nezvirwere kana basa iri ngozi rinobudirira ezvinhu. Asi tinofanira kurangarira kuti kunyange kushandisa zvinodhaka nokuda kudzivirirwa, hatifaniri kukanganwa kungwarira dosing zvinodhaka, sezvo zvimwe yakakwirira ngozi kuti nezvinetso adrenal omumuviri, uye kushaya hanya chirwere glucocorticoids.

Zvisinei, mune zvimwe zviitiko, kushandiswa wayo contraindicated?

Contraindications

Under chii pezvakaitwa uye zvirwere, regai kushandisa "Budesonide"? Mirayiridzo kushandiswa zvinodhaka kunoratidza zvinotevera zvirwere:

• Yakawedzera aikanganiswa mushonga kana yenhengo dzayo. Pangozi yokuita angioedema.
• The vanoshingaira muchimiro tibhii.
• Zvirwere kufema fungal mavambo.
• Chenjera kutapuriranwa pezvakaitwa ari nemudumbu.
• Zvakakomba hepatic insufficiency.
• Children zera.

In zvirwere zvose izvi, kushandisa corticosteroids hakubvumidzwi. Izvi imhaka yokuti mushonga kana unokurudzira muitiro kuwedzera kana achiipa ayo kosi. Vana havagoni kushandisa mushonga uyu nekuti aigona kukanganisa vasiri kugadzirwa glucocorticoid mahormone nokuda insolvency ari adrenal cortex.

Kune zvimwe zvatisingagoni, umo kungwarira ngozi inofanira kushandiswa "budesonide". Instructions ari kushanda inonyevera kuti vanyatsohuongorora vanofanira kushandisa zvinodhaka nokuda vanhu vane BP, chirwere cheshuga, pheochromocytoma, utsinye gastric urikanwi uye duodenal urikanwi.

divi kushanda

Parizvino hakuna zvinodhaka, kushandiswa vasingadi zvakagadzira chaiyo divi maturo. Zvinosuruvarisa "Budesonide" ndiyewo mushonga ane kumbonyanya guru chakarondedzera yaivhuvhuta zviitiko vayo chiito.

Kana kushandisa "budesonide" inhalation, chikuru divi migumisiro kushandiswa chayo chichava kutaura zvirwere (dysphonia), hoarseness, muromo yakaoma, chikosoro, gangaidzo bronchospasm kukura.

Kana ikatorwa nemuromo zvingamuka mwoyo, dzungu, uye kushatirwa.

Kumwoyo anogona sei pakatanga "Budesonide" kukura vasculitis, kuwedzera systemic BP, tachycardia.

The mushonga kungaita uye kusembura pamusoro gastrointestinal zvirwere - maronda, pfungwa nomuviri zvemwana asati. Uyezve, kunomutsa pave dyspeptic zvirwere.

It isakarurama kunokanganisa zvetsandanyama nemapfupa hurongwa. Zvichida kukura osteoporosis, myasthenia gravis, kurwadza kwemajoini.

Wakakura zvikuru divi nezvinozoitika Cushing kuti syndrome. It kunoitika nokuti kuti panguva yokuwana glucocorticoids zvinoderedza kubatana kwetunhu yayo mahormone. Kana corticosteroids inoshandiswa kwenguva refu, iyo adrenal mumasero angangova kurega synthesize vasiri nenhumbi kuti hazvo kukanganisa utano murwere. Ndokusaka zvichikosha kuti nokungwarira kuongorora dose vagamuchira mahormone, uyewo kodzero kurega kutora kwavari.

chipimo chemushonga kuchinja

In chii mishonga anofanira kuzviita "Budesonide? Instructions varwere anonyaradza zvinotevera dosing zvaiitwa.

Kushandisa inhalation siyana "budesonide" inobva kwokuomerwa chirwere. The optimum dose nokuti mukuru ari 200-800 micrograms pazuva. Kufadza daily dose haafaniri kupfuudza 1.5 MG. In vana, mushonga wacho contraindicated kushandiswa, uye analogs dzayo basa maererano kwokuomerwa yacho.

The zvokuudzwa chimiro zvinodhaka rinoshandiswa kwemaminitsi 30-60 pamberi kudya. Kushandisa anosvika 3 MG ka3 pazuva. Yawapiwa ndiyo mishonga nemumuromo inenge 2 months. The kuramba zvinodhaka rinoitwa zvishoma nezvishoma kudzivirira ucharwadziwa.

Intranasal Kazhinji basa "Budesonide Iziheyler". The dose anosarudzwa mumwe nomumwe nomumwe munhu, zvichienderana kwokuomerwa kwacho. Paavhareji, vanoshandisa 2-3 madonhedza mushonga neimwe pamhino kaviri daily. In vana, chimiro ichi zvinodhaka riri contraindicated. Yawapiwa nekuti 2 weeks.

Kudyidzana nevamwe zvinodhaka

Zvimwe zvinodhaka kana kushandiswa pachiimbwa "Budesonide" anogona kukanganisa Absorção de Água kwayo. zvinodhaka izvi zvinosanganisira FIs ose cytochrome P450. Somuenzaniso, kana uchishandisa zvose "budesonide" ( "Pulmicort" - somunhu analoginen) uye zvinodhaka zvakadai "Ketoconazole" "Erythromycin" anogona kuderedza excretion kubva ropa glucocorticoid, iyo hwakazara pave hormone kudhaka uye chitarisiko nemigumisiro yacho zvinodhaka.

Panguva anogamuchira "Budesonide" uye dzimwe diuretics ( "Indap") chinowedzera kukura hypokalemia murwere, izvo Achawedzera sei basa mwoyo.

zvinodhaka zvakawanda (semuenzaniso, antacids - "Almagel") apo achishandisa "budesonide" kushanda pane mumwe anopikisana zvazviri, i.e. usarega mumwe richiva ayo kuchirapa kushanda. Nokuda kwaizvozvi, Zvinokurudzirwa kushandisa zvinodhaka izvi panguva kwamaawa zviviri (rinongoshandisirwa dzaiita zvokutaurwa chimiro zvinodhaka).

Kushandisa zvinodhaka nokuda inhalation

Sezvo mushonga wakasikwa zvikurukuru nokuda kurapwa kwezvirwere ari kufema turakiti, zvinokosha kunzwisisa sei zvinofanira kupiwa kwavari.

Inhaled chimiro zvinodhaka wakasika chaizvo chaizvo, asi avo unoshandiswa kazhinji converges nenzira dzakawanda.

Chekutanga, mishonga iyi kazhinji raitongwa vachishandisa nebulizer. muchina uyu unokubvumira kupinda Airways zvachose vachiwirirana dose kurapwa. Kazhinji kunyorwa chikamu upfu kuti inhalation, kusunga zviratidzo asima kana COPD.

Nokuti chinangwa ichi, yaiwanzoshandiswa "Budesonide-chizvarwa." mushonga uyu patented nokuda Russian yakasimba. In kwayo sezvamunoita zvinodhaka kutakura kuturika kuti (kana upfu) "Budesonide". The nebulizer dzakatakura mumwe kukaseti pamwe mushonga, ipapo inspiratory mumiririri anopinda principales uye nemapapu.

zvinodhaka zvakawanda zvinowanikwa muchimiro ane aerosol, iyo rinewo "budesonide". Trade zita vave vakasiyana mumwe, asi rinoita chirungiso ichiri chete glucocorticoid. Kana kutora mushonga wakadaro, tinofanira kuyeuka kuti mumwe dose pakati aerosol rine 0,05 ml ari budesonide (zvakakosha kuziva kuti varege kuita kuti ovhadhozi kuti glucocorticoids).

Mari zvinodhaka

Akapiwa ukuru ano mishonga pamusika hakuna kuoma tonotora pachavo, "Budesonide" nokuda inhalation. mutengo ayo analogues dzingasiyana, asi zvinofanira kuyeukwa kuti zvose zvakafanana kwavo maumbirwo huru vanoshingaira chirungiso ndiyo budesonide. Mari zvinodhaka achavaponesa anoita mushonga, uye kana iri patented mushonga kana zvinodhaka Generic.

The mushonga chakatengeswa chete mu Pharmacies. zvikuru sei kunzanga "Budesonide"? mutengo ayo analogues ndiyo avhareji kubva 300 kusvika 2000 rubles. Zvose zvinoenderana ndiani mugadziri uye chimiro zvinodhaka kusunungurwa. Somuenzaniso, kwakadaro mushonga se "benacort" anogadzirwa muchimiro capsules vane upfu kuti inhalation. Paavhareji, tinorasikirwa 400 rubles. mishonga British ndivo zvikuru anodhura. Somuenzaniso, "Budesonide Formoterol" kugadzira British riri mukati rubles 2,000, kuti haasi munhu wose anogona kuuya. Simply kunotenga Slovenian zvigadzirwa, izvo regai zvakasiyana vaita, uye vari isingadhuri zvikuru.

Munguva zvidzidzo zvave vakaratidza kuti zvinodhaka anodhura ndiyo inenge hapana nzira muduku wavo bhajeti dzomuzana. Naizvozvo, chii zvinodhaka kuzotenga - kusarudza mumwe nomumwe, zvichienderana zvaaida uye kuchengeteka.

Reviews kugadzirira

mishonga Glucocorticoid yagara dzinoshandiswa varwere vakawanda vane chirwere echirwere obstructive kana asima. Anenge varwere vose kwazvo chimiro chimwe zvirwere izvi zviri basa "budesonide". analogues Its nenzvimbo foni nokururamisira paupamhi ari mazita mishonga pazvirwere izvi, saka kakawanda vari kunzwiwa kwose kwose. mishonga iyi zvakadai, somuenzaniso, "Apulein" "Benakap" "Buderin", kare ambotaurwa "Pulmicort" uye "benacort" etc.

Maererano varwere vakawanda, mishonga iyi ndiyo yakanakisisa pakurapa zvirwere kufema turakiti. Wandei vanhu vashomanana havana kunge akabatsira inhalation chimiro glucocorticoid kana pamwe waro Beta-agonists.

Zvakakodzera mishonga dosing akakwanisa kuita kuchikosha nani varwere izvi. Pari, vazhinji havangagoni kufungidzira upenyu uye kurarama pasina kushandisa zvinodhaka izvi.

Zvisinei, pasinei nokuti vakawanda Wongororo, pane divi yerima zvinodhaka se "Budesonide" - mutengo.

Kwenguva refu nguva paiva tsika akasununguka kugadzwa asima mishonga varwere vanoshaya. Varwere All aigona kuuya chemishonga, uye pamusoro mharidzo kuMudzidzisi gwaro kuwana mishonga akasununguka zvavo zvavaida.

Parizvino, zviri kuita, asi contingent, vari kodzero kusunungura zvinodhaka izvi yekudyidzana kujekesa. Zvino mishonga aya pachena chete vanhu vakaremara 1 ne2 mapoka, uyewo vana; Vamwe vanhu vane kutenga mushonga nokuda mari yavo. Yandakapiwa gadziriro anotora chaizvo chaizvo, kwete munhu wose anogona kutenga mishonga yakadaro.