Drug "allopurinol": wongororo vanachiremba, zviratidzo, nemishonga

To musi, zvinodhaka "allopurinol" kunokosha (zvepuraimari uye pathogenetically makateyiwa) mushonga kuti rinoshandiswa kurapwa kwezvirwere zvakadai gout. Mumwe munhu usati kuedza chinhu chitsva, vachiedza kuwana kupfuura anobatsira ruzivo nezvazvo. Naizvozvo isu kupa kubata muudzame pamwe kana chete vanofanira kushandisa "Allopurinol". Reviews wevarwere uye vanachiremba zvichakurukurwa munyaya nyaya yedu uye iwe uchaziva kuti kutya apo kutora zvinodhaka ichi.

Pharmacological zvechadenga zvinodhaka

"Allopurinol" rinoreva boka protivopodagricakih kugadzirira. Huru achishingaira fuma - allopurinol uye chacho vanoshingaira metabolite oksipurinola. Izvi pharmacodynamic migumisiro nokuda kutyora kwetunhu pakati uric asidhi chete pakukura urostaticheskogo maturo. Izvi pakupedzisira inotungamirira zvinoderedza yayo wevasungwa, zvichiteverwa Kuparadzwa urate.

Nokuda zvakanaka solubility "allopurinol" ane kumusoro bioavailability. The mushonga zvakanaka woga kubva lumen yacho ura duku. Mudumbu kupinda systemic riparadzirwe arege kuwa. pamberi plasma Zvakacherechedzwa kuti hafu yeawa pashure kutarisira uye kufadza pfungwa vakachengeta pashure pemaawa 1.5. Saizvozvowo, kufadza pfungwa imwe metabolite ane allopurinol - oksipurinola vakachengeta maawa matatu pashure nomumukanwa yaitonga.

The mushonga ane refu hafu-upenyu uye sezvo anokwanisa cumulation. Varwere pakutanga yokurapa, pane zvakawanda wevasungwa zvinodhaka kuti nechokumusoro pashure munhu vhiki mbiri yokurapa. Nokuda refu kuchaitwa "Allopurinol" (wongororo vanachiremba ngaadarowo) haina pachii kushandiswa mune vanhu vane itsvo kukundikana. In varwere akachengetedzwa renal excretory nerevane cumulation haina kuchengetwa.

"Allopurinol": zvairatidza yokushandisa

Anodzokorora vanachiremba varwere ichi mushonga vanoti kuti zvinonyatsoshanda uye vanoruramiswa vanenge hyperuricemia (dzakakwirira kwevari uric asidhi chete chikwata vhoriyamu ropa) pa:

• gouty yemajoini (gout);
• urate urogenital zvirwere (nephropathy, urolithiasis);
• oncological zvirwere ropa;
• vachiberekwa anomalies of enzayemu hurongwa.

Mune zvimwe zviitiko, zvinoita kushandiswa kwezvinodhaka nokuda pakurapa vana urate nephropathy, yakabuda pamusoro pakanyorwa neleukemia mishonga iri vachiberekwa zvirwere chokuita havachanyatsogoni muviri pamusoro uric acid, yechipiri hyperuricemia yakasiyana mavambo.

Features zvinodhaka

"Allopurinol" Mahwendefa (wongororo vakanyevera kwokuoma zvaidiwa vanorumbidza kurapwa) vanobviswa pashure zvokudya, ivo hausi hazviiti kutsenga, asi zvokunwa yavo yose uye kunwa kupfuura girazi remvura inodziya.

Vanhu kunwa mushonga uyu, nguva dzose unofanira akuteerere zvokudya zvavo, uye panyaya kukanganisa ari kudya zvakakodzera kuchinja chipimo chemushonga kwayo, asi chete pasi kutarisira kupinda nyanzvi.

The zvakakodzera dose kubata "allopurinol" mushonga akatsunga zvichienderana zviri uric asidhi muropa murukova. Kazhinji, izvozvo anoda kubva 100 kusvika 300 MG por imwe nguva "allopurinol" gadziriro. Reviews wevarwere uye vanachiremba maererano dosing ichi zvakanaka, sezvo mushonga chinobviswa kamwe chete pazuva.

Gout jekiseni kutanga kugadzwa 100 MG zvinodhaka kamwe pazuva. Kana yokusava efficacy uye murombo richikwidibira uric iine acid chipimo chemushonga iri kuwedzera zvishoma nezvishoma (ne 100 MG mbiri kana nhatu dzose), zvichiita kuti inoshanda kuchirapa rabhoritari pasi kutonga uric asidhi siyana. Muzviitiko zvakadaro, paavhareji chipimo chemushonga kwaizotevera Nokuraramisa dose anoda kubva 200 kusvika 400 MG, asi mune mamwe mamiriro ezvinhu, asi dose inogona kusvika 800 MG. Muchiitiko chino, rakakamurwa kakawanda pazuva.

In agadza mushonga varwere vane renal insufficiency vanofanira omerera creatinine Clearance.

Contraindications nokuti "Allopurinol" izita

The mushonga iri contraindicated mu varwere zvakakomba renal kukundikana, uyewo pamuviri uye lactating. Zvinonzi zvakare haana anokurudzirwa kuti mushonga varwere ane sema maitiro kana hypersensitivity mumwe kana kupfuura zvinoumba kugadzirira. Zvinonzi rambidzwa kushandisa mushonga pavarwere vane pamuganhu kwevari uric asidhi muropa plasma, nokuda rutapudzo raro kubudirira zvinogona kuitwa nokuchinja zvokudya.

"Allopurinol": nemishonga

Reviews wevarwere aishandisa zvinodhaka kokutanga, anoratidza kuti kazhinji ingangodaro exacerbation uye vakawedzera Zviratidzo gout pamwe kwaita vanonzi kurwisa. Asi chinhu ichi chinoshamisa pfupi, uye harisi zvakakodzera kutya zvakakwana kurega kurapa. Asi kune chinhu rashes, kusagadzikana kana kurasikirwa mangwanani zviratidzo unofanira pakarepo kuudza chiremba wako. In nzira iyi "Allopurinol" vanofanira kumiswa pakarepo, uye sezvo kunyangarika zviratidzo mukoti anogona kuzodzosera kuvapa mushonga, asi kuti muduku dose (kubva 50 MG). Rubvumo zvinofanira kuitwa pasi pedyo kutarisira kupinda chiremba uye kamuri.

Pakati nenjodzi zviri tsinga uye yakakwirira mupfungwa mabasa kungaita depression. Pamusoro pakukura kokumanikidza mumwongo hematopoietic gadziriro haawanzopiwi akaona panowanikwa thrombocytopenia, aplastic kupererwa neropa.

Kana muchigamuchira mushonga anogona kuva metabolic zvinetso sezvo cheshuga, mukuru wevakuru mafuta acids muropa plasma.

Cardio-vascular hurongwa zvingamuka neBP, bradycardia.

The kakawanda nenjodzi kuti mushonga yakawanda pamberi renal kukundikana pane murwere.

Release chimiro uye chipimo chemushonga

"Allopurinol" rinowanika piritsi muchimiro (30 kana 50 hrs. On the pasuru) pane imwe chipimo chemushonga 100 kana 300 MG kuti vanoshingaira wemafuta pa tablet. Mudzimai kumusika pane "Allopurinol Sandoz 300". Reviews izvozvo zvakanaka, sezvo mushonga ari chipimo chemushonga iri basa kamwe chete pazuva, anenge negates mukana kusuwa negashiro zvinodhaka.

Chepfu uye zvinodhaka ovhadhozi

Kusvibisa kashoma wakacherechedza, asi pane zviitiko chete dose 20 magiramu zvinodhaka. Muchiitiko chino, waunowana zvinotevera zviratidzo: dzungu, kurutsa, kuda kurutsa, manyoka. In renal insufficiency, uye kuramba kwokubatsira dzakakwirira mishonga zvinodhaka vakanga vakachengeta kwazvo Zviratidzo kudhaka muchimiro fivha, hepatitis, chenjera renal kukundikana.

Mabatirwo chenjera chepfu uye ovhadhozi, symptomatic, zvainanga kuwedzera kubviswa pakati zvinodhaka mumuviri. No chaicho mushonga. Nokuti nokukurumidza excretion zvinodhaka mumuviri dialysis nzira dzinobudirira detoxification.

Reviews

Akapiwa chokwadi kuti nguva kuunganidza zvinodhaka muropa (pa wevasungwa yakakwana kupa muviri chiito) ndiyo avhareji vhiki imwe, varwere vanenge gout, anofanira kutevedzerwa chaizvoizvo upenyu "allopurinol". Reviews kuvarapi vari inonzwisisika: mushonga vaudzewo pacharo zvakanaka. Asi ichi hachisi "chishamiso piritsi" rinogona kuva chokunwa uye kukanganwa pamusoro chirwere. Gout - ndiko kutoti nzira youpenyu pane chirwere. Asi "Allopurinol" chinobatsira kudzora pachiyero lactic asidhi uye kudzivisa kusembura chirwere uye zvakare kwayo kunoita.

In mashoko nyore, ndekwaunogumira "Allopurinol" chinodhaka apindure vanachiremba Uyewo akanaka, nekuti kakawanda murwere unofanira kutorwa mishonga kamwe zuva. Izvi waanodzikisira mukana kuti asipo negashiro medicament uye, saka, anowedzera kushanda ari mishonga.

mhedziso

Saka, mukuru mushonga gout - "Allopurinol". Reviews nyanzvi uye varwere, izvi zvinoreva kupinza, akanaka, uye izvi kunosimbisa kunyatsoshanda of medicament pamwe utsinye Gout uye uric iine acid muviri zvirwere. Nemhaka kushandiswa kwezvinodhaka, vazhinji varwere vawane tariro kuderedza matambudziko nechirwere cheshuga.