"Enalapril": mirayiridzo kushandiswa uye dzinovaka. Analogs "Enalapril"

Kana uine matambudziko BP, vakawanda kubva vanachiremba vanorumbidza kutora zvinodhaka "enalapril" (Mahwendefa). Kubva chii chinobatsira kubvisa mushonga uyu? Kubva migumisiro chirwere (kureva, zvakananga kubva cheBP), kana riri kuita pamusoro fronts akawanda, kudzorera chakaipa basa kumwoyo, zvichiita kuti BP rinodzokera dzose? Kuti tinzwisise kuti mahwendefa vari "Enalapril" kumanikidzwa zvakakodzera tinyatsoziva pamutemo mazano kushandisa mishonga iyi. Uyezve, isu funga wandei analogs zvinodhaka uyu tichishingaira chirungiso uye ane kushanda.

Description rekugadzirira, rokusunungura chimiro, kunyanya okuchengetera uye pakupa zvemupiro Pharmacies

Mapiritsi "Enalapril" kumanikidza zvinoberekwa zhinji nemakambani anogadzira mishonga munyika yose. The chikuru vanoshingaira wemafuta zvinodhaka ndiko enalapril maleate, izvo neDare boka chavanopinda zvinoreva ACE-blockers. Pari zvino pane mahwendefa ane inoshingaira chirungiso zviri 5, 10 uye 20 MG. Nokuti kuti kugadzirira "Enalapril" nevezera zvakananga zvarinoita kushanda CCC uye vanoverengeka dzimwe gadziriro iri mumuviri, abudiswa Pharmacies zvinoitwa mushonga.

Nguva iyo Implementation uye kushandiswa kwezvinodhaka ichi vari achingopiwa 3 years kubva musi kwayo kugadzirwa. Saka mahwendefa usaora kuchirapa ehupfumi dzavo kana zvakachengetwa mitemo. Manufacturers dzinorumbidza kuchengeta medicament rakaoma, yakadzivirirwa kubva zvakananga chezuva, pane imwe tembiricha kwete asingasviki 15 uye kwete kupfuura 25 inegumi.

Analogs "Enalapril" vane ehupfumi, saka kunenge kushanda mushonga, uye anogona kuchengeta panguva okuchengetera yavo.

Pharmacodynamics medicament

Enalapril maleate (active chirungiso pamahwendefa) roga haadi kukanganisa vanoita ari munhu urongwa muviri. Chokwadi chokuti remubatanidzwa ichi chinonzi kuva rudzi "prodrug" ndiko nemhaka vashoma hydrolysis siyana pokubatana fuma zvachose itsva - enalaprilat.

Zviri mwoyo sei ACE basa pane kutsamwisa kuchikosha kudzikisa huwandu aldosterone mumuviri womunhu. Muchidimbu, migumisiro "Enalapril" kunoratidzwa BP (zvose diastolic uye systolic) uye kudzikira mutoro pamusoro pomwoyo (myocardium).

Somugumisiro, refu zvakawanika takazoziva kuti, pasinei zvinoderedza BP pashure kutora zvinodhaka "enalapril" varwere pasina kushaya pamwero kweropa muuropi. Uyezve, mapiritsi kugamuchirwa akanatsiridzwa ari renal uye coronary ropa riyerere.

kushandisa zvinodhaka refu akaratidza yakakwirira efficacy mu hypertrophic zvinyama, vemunyika mu rworuboshwe ventricle mwoyo tsandanyama, pane rubatsiro kudzivisa mberi nomwoyo kukundikana. Mukuwedzera, kurapa "enalapril" nokuti 6 mwedzi kuvandudza mamiriro varwere rworuboshwe ventricular dilatation uye kufamba kweropa iri myocardium, kunobva ischemia.

The rinoita mushonga fuma inowanikwa plasma pashure 1 awa pashure negashiro mahwendefa uye kunosvika kunonyanyisa rayo pashure pemaawa 4-6. The hypotensive kushanda kunogara kusvika 24 maawa.

Chete pharmacological zvivako uye nhaka analogs "Enalapril" yezviri pomutumwa.

Pharmacokinetics

Sezvakakurukurwa munyaya apa, Absorção de Água yezviri zvinodhaka fuma zvinoitika zvakakwana nokukurumidza. Raisangoita chete anenge 60% kubva enalapril maleate Bhuku substantially yose anosunga kuti mapuroteni eplasma. Nyanzvi vaswedere vatengi 'pfungwa ndechokuti Absorção de Água pakati mukomboni hakutsamiri chikafu yaunodya.

Mukuru kupinda yevanhu enalapril kuburikidza-GHB zvipingamupinyi nokuda samolecular maumbirwo yezviri chirungiso. Uyewo hazvina kugona kukunda placental mechidziro rinowanikwa zamu rinenge uye mukaka vakadzi lactating.

Excretion zvinodhaka rinoitwa kunyanya nokuda itsvo (60%). Saka unaltered goho vanenge 20% uye 40% - somunhu metabolite. Anoramba achishingaira fuma kunze kuburikidza ura, sezvamakaropafadzwa nhamba enalapril / enalaprilat ane zviratidzo 6-8% / 25-27%.

Zvairatidza uye contraindications

The zvairatidza kuti Kushandiswa medicament "Enalapril" ndiwo kuwedzera kwakuri BP kunokonzerwa nezvirwere zvakadai scleroderma uye CHF. Mukuwedzera, mushonga rinowanzoshandiswa prophylactic kurapa pavarwere vane chirwere coronary ischemia, akasiya ventricular dysfunction (kusanganisira asymptomatic). Kuti ndehwevakadai zvinodhaka "enalapril" zvairatidza yokushandisa, asi kuzvinzwira medicate chero nyaya haisi inokurudzirwa. nyanzvi chete anogona kuita zvakarurama kurapwa zvaiitwa uye kuziva uwandu husingakuvadzi.

Munguva bvunzo, chiremba wakowo kukwanisa kumisa kuvapo kana kusavapo zvichibvira contraindications. Izvi zvinosanganisira zvirwere uye kusagadzikana kushanda nhengo:

1. Yakawedzera aikanganiswa yezviri wemafuta mushonga (akafanana "Enalapril" panguva iyoyo kuda kukanzura, sezvo ivo vari kakawanda yakafanana iyi mushonga Pfungwa).
2. Pamuviri, lactation uye vana pasi pemakore 18.
3. Previous nyaya angioedema panguva kurapwa gadziriro kubva boka ACE-FIs.
4. Cerebrovascular insufficiency, uye zvimwe zvirwere cerebrovascular.
5. Cerebrovascular hematopoiesis.
6. renal zvirwere, kusanganisira renal tsinga stenosis (yaitsigira divi kana bilateral), renal kukundikana, kuvapo wakasimwa nenyere.
7. chiropa chirwere.
8. Zvirwere nemudumbu, achiperekedzwa manyoka uye kurutsa.
9. Scleroderma nezvimwe autoimmune zvirwere kukanganisa connective munyama.
10. Kutyora metabolic pezvakaitwa pamuviri, kusanganisira hyperkalemia.
11. Diabetes mellitus.

Rubvumo "Enalapril" ose ezvinhu pamusoro apa rinofanira repealed, kana kurapa rinoitwa pasi kuramba pokudzora unyanzvi.

The mushonga "enalapril": mazita nemishonga

Pasinei guru zvikomborero chinodhaka, kana negashiro varwere vanogona zvakasiyana nemishonga kuti kukanganisa anenge zvose nenhengo dzawo. Information pamusoro yaivhuvhuta zviitiko zviri muna tafura pazasi.

Zvikurukuru, zviitiko izvi kushatiriswa rakananga kuchinja muviri huru vanoshingaira zvinodhaka fuma "Enalapril". Analogs (mirayiridzo zvishandise rine ruzivo hwakadzama panyaya) anogona kukonzera zvinetso zvakafanana. Murwere uye chiremba wake kunokosha kuona zviratidzo nemishonga, sezvo vachifuratira navo kungaita kuti zvakakomba kuvhiringidzika nokushanda kwenhengo dzomuviri.

Sei kutora mapiritsi "enalapril": nzira uye chipimo chemushonga

Kudzikamisa BP nyanzvi vanokurudzira kushandisa zvinodhaka kwenguva refu (kusanganisira analogues yayo, somuenzaniso, "hexane Enalapril" chinodhaka). Panguva kutanga kwekupwanyiwa kurapa neBP Zvinokurudzirwa kutora mushonga ari dose 5 MG pazuva. The hurongwa Zvakawanikwa kumanikidzwa muvhiki mbiri kurapa iri chipimo chemushonga iri yakawedzera 5 MG. Zvinokosha kucherechedza kuti maawa 2-3 mushure pakutanga kurapwa rokutanga, murwere inofanira kuva pasi zvokurapa achitarisirwa. Izvi zvinobatsira kuziva divi anokonzerwa kumavambo kukura kwavo. The kunonyanyisa dose haafaniri kupfuudza 40 MG rimwe zuva, asi kunyange kushandisa mari yacho zvinodhaka zvinoita chete kana zvakakodzera chaizvo uye inogutsa tolerability yacho medicament.

Pashure 2-3 mavhiki pashure ratanga monotherapy "Enalapril" chinodhaka, varwere vari kune kutsigira zvinodhaka mutambo muoti. Panguva iyi, nezuva dose ndiyo 10-40 MG zvinodhaka. Mahwendefa vanofanira kunwa 1-2 kanomwe pazuva. Akakurudzira panguva kurapwa nguva kuyera BP.

The apa kurumbidza kushandiswawo avo varwere havatamburi kubva concomitant zvirwere zvakadai hyponatremia uye renovascular neBP. In chii mishonga vanofanira kutora zvinodhaka? Kazhinji, zvinoenderana munhu zvechadenga murwere uye rwakadini chirwere. The dose kwokutanga chero zvazvingava zvinogona dzaona chete kupinda chiremba.

Duration kugamuchirwa ane medicament kunobva zvinoverengeka, kusanganisira murwere ezvinhu uye migumisiro mumarabhoritari bvunzo. Nyanzvi dzinoti kuti chimbichimbi kurega zvinodhaka kungaita kuti migumisiro yakaipa. Saka, kunyange kana kunyanyisa richikwidibira ropa nevamwe varwere pakugamuchira zvinodhaka "enalapril" vanofanira zvishoma nezvishoma kuderedza uwandu husingakuvadzi.

Zviratidzo uye mabatiro zvinodhaka ovhadhozi

Saka, isu akatarira dzinokosha zvechadenga zvinodhaka "enalapril" (Mahwendefa), kubva yavakanga kubatsira uye pamigumisiro kugamuchirwa kwavo pakupedzisira. Ndiyo nguva kuenda pane kukurukurwa nyaya iyi, imwe ovhadhozi zvinodhaka ichi. Kakawanda varwere vanowanzotevedzera kutora makuru mishonga zvinodhaka netariro kubvisa zvinoitika zviratidzo. Pakadaro, kana ruchinge mushonga "Enalapril" munhu, migumisiro zvinogona dzakakomba zvikuru. Pamwechete rutapudzo ropa nevezera dhirika kunogona kuitika munguva varwere kuti kazhinji kunotungamirira dzakakomba myocardial infarction kana chepfungwa kutenderera zvirwere.

Kazhinji, zviratidzo ovhadhozi rokutanga vari kurasikirwa pfungwa, ezvinhu wekutsumwaira kana chimiro pfari. Uyewo, pangava nezvimwe zviratidzo imwe lesion ropa kuyerera chepfungwa uye cardiac abnormalities: hapana ganda, anotemwa nemusoro, marwadzo seri breastbone.

Treatment murwere ane ovhadhozi kuti "Enalapril" symptomatic zvinodhaka. In munyoro chepfu kunoratidzwa kugamuchira sesaline uye gastric lavage. Muzviitiko zvakaipisisa kungada intravenous jekiseni sesaline uye zvinowedzera plasma, uyewo hemodialysis.

zvinodhaka kwavatori

Mahwendefa "Enalapril" anogona kuita atypically, apo mabiko pamwe nemamwe mishonga. Nonsteroidal Anti-anogumbura zvinodhaka ( "Ibuprofin" uye m. P.) Uye estrogensoderzhashie mishonga zvikuru kuderedza ayo hypotensive chiito. Blockers, nitratsoderzhaschie zvinodhaka, dzokutindivadza uye panyaya iyi zvinowedzera kubata zvinodhaka "enalapril". zvinodhaka Diuretic vanobviswa pamwe mapiritsi kuderedza kumanikidzwa, anogona kukonzera hyperkalemia kukura. Nokungwarira yokunyanyisa zvinofanira zvinodhaka kubva boka immunosuppressants, nokuti panguva vagari womuchato mishonga ine enalapril yekudyidzana kuvandudza haematotoxicity kwayo.

mishonga Reviews

Pari pamusoro mushonga inogona kunzwa zvose zvakanaka nezvakaipa dzinovaka. Chikuru nani chokutanga "Enalapril" Mahwendefa - Price (20-25 rubles pa rongedza), risingagoni anonzi mukuru. Uyezve, akaonga zvikuru mukugadzirwa uye kubudirira kwayo. Basa huru zvainovhiringidzawo ndivo vazhinji divi siyana uye yakakwirira mukana yematambudziko pamberi concomitant zvirwere.

'Enalapril' mapiritsi varwere Most akabatsira kubvisa ari hurongwa kuwedzera BP. Nokuti vatengi vane kugadzwa kwavo kwakaita mhirizhonga munyika kushanda siyana nadzo, zvaifanira kusiya kwete chete pane mushonga, asi kubva analogues ayo, sezvo kazhinji, ane chete rinoita fuma kana zvakadai enalapril indapamide. Ndokusaka nyanzvi haina varumbidzwa kutora akawanda mishonga kuderedza BP.

Analogs "Enalapril": musiyano, zvakanakira nekuipira

On kune zvinodhaka zvakawanda kuti dzakafanana mushonga "enalapril" nyika mishonga pamusika. Kakawanda, vane yepamusoro cost, chisingazivi nguva dzose pave kusavapo nenjodzi kana yepamusoro zvinodhaka efficacy. Funga pamazita zvinodhaka kuti akaumbwa vanoshingaira fuma, zvakafanana nezvakanyorwa huri "Enalapril" Mahwendefa. Kazhinji, asi mishonga mumarabhoritari munyika dzokuMadokero rinoshandiswa senzira chikuru chinoumba amplodipin enalapril, izvo hwakasiyana enalapril maleate ndiyo chete samolecular marongerwo. Zvikasadaro ine zvakafanana maitiro uye zvivako.

Mugore Russian mishonga pamusika pane zvinotevera analogs "Enalapril":

1. Mahwendefa uye capsules nokuda injectable "Enap" by Slovenian kambani KRKA. mutengo wavo inotanga pa 280 uye wakakwira 4000 rubles nokuda kavha mahwendefa, uye 500 rubles kuti 10 ndiro pamwe mumushonga. Sezvinogona kuoneka, mukusiyana kune "Enalapril" chinodhaka, mitengo yakakwirira zvikuru, izvo zvinoita zvibereko muchiso ichi dzisingambosvikiki kune vakawanda vatengi. Panguva iyoyowo, nyanzvi dzinoti matunhu kunaka analoginen.
2. Mahwendefa "Enalapril hexane" kubva mugadziri German SANDOZ. Domestic mushonga nokuti kushanda kwayo hakuna muduku munhu akapiwa medicament. Mari analogue Saka zvishoma kupfuura mutengo "Enalapril" uye anenge 78-100 rubles por rongedza.
3. Mahwendefa "Berlipril" zvinoberekwa kambani inogadzira mishonga German, "Berlin-Chemie". The chikuru vanoshingaira wemafuta zvinodhaka ndiko amlodipine, enalapril. Nokuti kuti risiti ari yeimwe zvakawanda yakaoma uye anodhura, mapiritsi mutengo anenge 140-180 rubles por rongedza.
4. Mahwendefa "Renitek" kubva Merck, kukosha riri pakati-siyana uye riri 80-150 rubles por rongedza.

Uyewo ari Pharmacies unogona kuwana akadaro zvakafanana marongerwo uye chiito kuti zvinodhaka analogues "Enalapril" se "Kalpiren", "Miopril", "Envas", "Vazopren" uye "Miopril". Zvisinei, nyanzvi, vanoti haisi nguva dzose kutaurwa mishonga inogona kushandiswa sezvo yokutsiva asina kuswedera murwere, nokuti chero kwezvikonzero, zvipfuwo zvinodhaka. Chokwadi ndechokuti racho sezvamunoita ivo kushanda kudzokorora "Enalapril" yedu, kureva kuti vanogona kukonzera zvakasiyana siyana yematambudziko. Uyewo, vanachiremba vari zano kuteerera murwiyo yakabereka kunze mishonga. Amplodipin enalapril, izvo hwakasiyana enalapril maleate iri diki, izvozvo zvinogonawo kuita kwakakanganisa pamusoro muviri. Chero zvazvingava, risati kushandisa sezvo chikuru zvinodhaka vamwe wo analogs, zvakakodzera kubvunza chiremba.