Inorwisa mabhakitiriya "Worufu": mirayiridzo kushandiswa, chaicho dzomuzana

Current kurapwa kwezvirwere zvakawanda zvinotapukira urongwa, hazvibviri pasina kushandiswa antibacterial zvinodhaka. The kuramba nemishonga zvigare kunoita kutsvaka nezvinodhaka zvitsva kana kushandisa mubatanidzwa kare, rikaratidzwa inorwisa mabhakitiriya. Kwete nyasha ouchenjeri kushandiswa tupukanana runoratidzwa kugadzwa unotungidzwa mishonga inorwisa mabhakitiriya, pachinzvimbo chokutanga kunyatsoongorora zviri nehanya pakati kasvisto kune zvinodhaka muboka iri. Drug "Worufu", tinazvo zvinokosha pharmacokinetic uye pharmacodynamic zvinobatsirawo dzinoverengeka fluoroquinolones vari kuwedzera kushandiswa pakurapa zvirwere zviri etiologies siyana.

Clinico-pharmacological unhu

The medicament "Worufu" kana "levofloxacin" (International Nonproprietary Name) chiri mushonga pane dzakanzi fluoroquinolones, aida kuti enteral uye parenteral migwagwa chourongwa.

By yayo chaiye "Worufu" (mirayiridzo Chinyorwa anopa mashoko chaipo vakadaro) ndiyo monoftorhinolonom - isomer pamusoro ofloxacin, uye tichienzanisa nedzimwe zvinodhaka, ane zvinokosha pharmacokinetic nezvazvinobatsira:

• zvokuudzwa bioavailability iri 100%, ukuru ukama mapuroteni eplasma yakakwirira sezvinoita 40%;
• kunonyanyisa ropa serum zvinodhaka riri kuchengetwa maawa 1-2 mushure nomumukanwa Kutarisirwa akafanana kuti zvinotevera intravenous Kutarisirwa;
• "Worufu" iri ichazivikanwa noku rakawedzerwa nokuparadzirwa pamuviri, nokuda ndichibvunza kupinda mukati tishu;
• It ane refu hafu-upenyu muviri hunokonzera chete chete dose zvinodhaka pazuva.

Kupiwa kuti chinokosha kuchirapa mugumisiro fluoroquinolones hunokonzera mwero nokukurumidza kuti kuwedzera ropa wevasungwa iri mishonga chinodhaka, yambotaurwa pharmacokinetic parameters zvinopa zvakanaka ezvinhu kuti zvakakwana kubviswa tusingaoneki.

Maererano kwavo mhando chiito pamusoro kukura uye kubereka mabhakitiriya, "Worufu" ane bactericidal zvazviri impacting kwete chete pane vanoshingaira siyana pathogenic utachiona, asiwo vegetative uye vakaneta.

Muviri nezvimwe zvinodhaka unowanikwa hepatocytes nokuda deacetylation kana oxidation. Zvisinei, vanenge 5% zvinodhaka riri yabudiswa ne netsvo sezvo metabolites, uye zvasara asunungurwa kuburikidza glomerular filtration uye tubular secretion. Zvinofanira kucherechedzwa kuti pashure nomumukanwa kwokubatsira chinokosha chikamu zvinodhaka (anenge 70%) iri yabudiswa kubva muviri mukati maawa 24 kubva weti, uye vanenge 80% of dose panobviswa pashure pemaawa 48. Mugove excretion zvinodhaka kuburikidza nemudumbu yakaderera uye ndiyo chete anenge 4%.

Kana kushandisa zvinodhaka pane mishonga anopfuura 1000 MG pazuva (Mahwendefa kaviri-zuva nezuva 500 MG) hapana mukana wokuita nekukudziridza tinofanira kugara maturo.

mashandiro chiito

The mashandiro zvinodhaka chiito kwakavakirwa chinovhiringidza nezvevamwe enzayemu inonzi DNA gyrase, iyo rinobatanidzwa kuberekana dzinotsanagura masero acho stitching Coils akanaka kunaka akamonyoroka DNA. Somugumisiro chinovhiringidza of enzayemu akambokanganiswa pezvakaitwa DNA kuberekana, sero nokupesana, sero rufu kunoitika.

"Worufu": mirayiridzo kushandiswa uye zvairatidza

Pari, chikuru zviratidzo kuti varwere pezvakaitwa vari rwarisa kwemabhakitiriya etiology, kunokonzerwa muvamwe utachiona zvigare mushonga pavarwere vakuru makore 18.

Kugadzirira "Worufu" yakanakisisa nzira akaratidza pakurapa kufema zvinokonzerwa noutachiona ose okumusoro kufema turakiti zvirwere zvakadai rikwanise bronchitis, sinusitis, anogumbura zvirwere zvemapapu tishu. Izvi wakakodzera, kupfuura zvose, rakaisvonaka zvinodhaka kupinda mukati epithelium pakati principales nemapapu apo kunyange pashure yokutanga zvinodhaka kutarisira pave kunobudirira yevasungwa.

Chete Pfungwa zvinobudirira anoshandiswa kurapa Urinary turakiti chirwere (pyelonephritis, cystitis, urethritis, etc.), Biliary turakiti zvirwere, prostatitis, ganda zvirwere, intraabdominal utachiona uye sepsis.

Kuti vabate zvirwere zviri Airways "Worufu" riri basa (zvichienderana chirwere kwokuomerwa) 1-2 kanomwe pazuva 500 MG pa piritsi, kana injectable kugadzirira.

Nokuti pakurapa Urinary turakiti zvirwere ndiyo dose rokugadzirira 1, 250 MG kamwe pazuva yakakwana, uye mune Muzviitiko zvakaipisisa, nezuva dose kunogona 500 MG ( "Worufu 500"). Mirayiridzo dzokushandisa akati dose kaviri-zuva nezuva MG 250 inogona kutsiviwa rimwe 500 MG zvichienderana chirwere zvakaoma.

Nokuti pakurapa zvirwere ganda uye mucous "Worufu" riri basa iri chipimo chemushonga pamusoro MG 250 kaviri pazuva.

Contraindications

NeMhedziso contraindication kugamuchira zvinodhaka ndiko hypersensitivity uye neutachiona pamberi nhoroondo mishonga fluoroquinolones.

Zvachose Data maererano kwokubatsira zvinodhaka panguva pamuviri, kwete, sezvo aidzora zvidzidzo zviri teratogenic kana embryotoxic kushanda haina inoitwa.

Tichifunga kugadzwa "Worufu" ichi kuvakadzi vane mimba kunofanira kudziviswa, kunze zviitiko apo zvinogona ngozi kwokubatsira nefuma dererei pane kubatsirwa nayo.

Kana mushonga mu varwere vanenge porphyria, zvingakonzera kusembura chirwere chacho.

With chinokosha Yambiro aizomupa mhinduro inofanira kushandiswa varwere risati maronda ari nechepakati tsinga (sitiroko, yomwoyo, dzechimwe kukuvara uropi), nokuda kudunhu mukana wokuti convulsive inoti.

Varwere anoshanda zvigadziriswe dzakaoma kubasa kana kutyaira motokari, hapana mirayiridzo inokosha, asi funga mukana nemishonga nechepakati tsinga muchimiro nehope, kuvhiringidzika, uye vamwe. Nekuda kwechikonzero ichi haafaniri basa rakadai.

nemishonga

Mumwe rinonyatsooneka nemishonga kuti kuva varwere kugamuchira fluoroquinolones, ndiyo kukanganisika shwashwa kukuvara yakafanira epiphyseal chondrocytes uye tishu pacharo. Tichifunga zvinodhaka izvi contraindicated muvanhu pasi pemakore 18 nevakadzi vane pamuviri. Zvinofanira kucherechedzwa kuti varwere anopfuura 18 makore pamusoro colour kuti kushandisa zvinodhaka kwenguva refu akanga aona panowanikwa arthralgia kana dysfunction mapfundo. Pakati mhiri Marwadzo zvinotevera.

Pamusoro chikamu nemudumbu - kuda kurutsa, kurutsa, kurasikirwa kudya, pakuonekwa dzamira nezvekufadza ari epigastric nharaunda, unogona kuona gastrointestinal ropa uye kukura gastroenteritis; kuwedzera transaminases muropa plasma.

Pamusoro chikamu nechepakati tsinga - uye kakawanda kuchinja manzwiro, chimiro paresthesias, aone zvinhu zvisipo, uye zvinovadadira kukura encephalopathy zviratidzo, nomusoro, dzungu, kurasikirwa pfungwa, hope zvirwere,.

Pamusoro chikamu zvirwere - kukura neutachiona akadai ganda mapundu, kuvaviwa, uye unogona kuva photodermatitis yakapa mukuru insolation.

Kubva Urinary gadziriro - kukura crystalluria.

The kufema gadziriro angangodaro panowanikwa bronchospasm uye kweropa hurongwa - unopinza kuderera BP, yomuropa kukura maitiro ne sero hemostasis (muchimiro thrombocytopenia, etc.).

Kudyidzana nevamwe zvinodhaka

zvinodhaka fluoroquinolone havana raitongwa pamwe antacids, sezvo izvi yekudyidzana kunoderedza Absorção de Água uye bioavailability inorwisa mabhakitiriya. Not akakurudzira mawa kushanda "Worufu" dzamatare kugadzirira, uyewo zvinodhaka chokuita dzichipfekeka basa epfungwa. Uyezve, pane uchapupu pamusoro mugumisiro probenecid uye cimetidine pamusoro excretion zvinodhaka (izvi zvinhu anogona kuderedza kubviswa mushonga).

Inonzwisisika chiratidzo zvinodhaka aiita levofloxacin kwete. Tichifunga yakaderera muviri zvinodhaka ari hepatic zvinyama uye kushaya nekuita pamwe makemikari ari boka cytochrome P450 «Worufu" haachinji okupedzisira basa, asi pasinei ichi, kufanana nedzimwe nhengo fluoroquinolone, mushonga havafaniri pamwe zvinodhaka teofilinovogo dzakatevedzana uye zvisina kunanga anticoagulants, nokuda zvichibvira kuwedzera kwavo wevasungwa muropa.

Kushandiswa kwezvinodhaka paanenge achiyamwa

To musi hakuna ruzivo pamusoro mano zvinodhaka zvinopfuura raamai mukaka. Kana paine kudiwa asingaurayiwi kurapa panguva uchiyamwisa, wokupedzisira vanorega nokuti nguva yakarumbidza (nguva kunoenderana kwokuomerwa utachiona uye kutarisirwa ya asingaurayiwi kurapwa). Kana zvakakodzera kuti tirambe lactation kubudisa nguva nenguva kupomba kana kumisa lactation zvachose kuburikidza zvokurapa nzira.

Muzviitiko, uchiyamwisa uye mishonga inogona kuva ngozi kuongororwa kuti mwana namai.

Release chimiro uye chipimo chemushonga

"Worufu" anogadzirwa kaviri nokuti enteral uye parenteral yaitonga. For zvokuudzwa Kutarisirwa ikoko Hwendefa fomu rine 250 kana 500 MG zvinodhaka (azvaitwa pasi kutengeswa mazita "Worufu 250" uye "500 Worufu"). For parenteral Kutarisirwa iripo aizomupa mhinduro.

"Worufu" Mahwendefa vanotorwa 1-2 kanomwe pazuva pamberi kudya kana pakati nzira ayo haisi emura, kusvinwa nemvura yakakwana. Mune chiitiko kudiwa kuti zviparadzanise dose iri hafu chinodhaka, hwendefa anogona kutyora pamusoro Chikwata muzvikamu zviviri.

For parenteral Kutarisirwa, mhinduro nokuti jekiseni inowanika nokuva chirungiso kuwanda 500 MG / 100 ml mhinduro ( "Worufu 500"). Kana intravenous jekiseni, okusuma ari zvinodhaka haana nokukurumidza kupfuura 1 awa.

zvimwe yezwi pahwendefa chimiro inokurudzirwa pashure aizomupa kutarisira. Zvinotarisirwa chinguva kunobva kwokuomerwa neutachiona uye aikanganiswa pamusoro pathogenic zvigare mushonga. Zvipatara (pasinei muchimiro chourongwa) vanokurudzirwa kuramba kwemazuva 3-4 mushure normalization kuti tembiricha yomuviri. Separate kurapwa uye mangwanani kugumiswa mushonga hauna yakarumbidza nokuda mukuru mukana divi siyana uye zvinoita kukura kurwisa kuti zvinodhaka microflora.

Zvokungwarira

mushonga kushandisa "Worufu" mirayiridzo Chinyorwa Asati anoita vakabata ivhu kuti microbial kugozha aikanganiswa mushonga. Zvisinei, sezvo chakarondedzera chiito, kurapwa angadzorwa anosarudza pasina kuitisa mharidzo, kunoteverwa Kutsunga inonyatsobudirira zvinodhaka.

Rakavapa mushonga "Worufu", vainyatsotarisirwa inofanira kubhadharwa kuti ongororo kunangidzirwa kuongorora ropa aibuda renal, sezvo unorema kubva zvinodhaka riri yabudiswa kuburikidza itsvo payo. Kana kutyorwa zvinodhaka yokupedzisira dose basa anofanira kuchinjwa maererano Clearance pakati endogenous creatinine.

Aizomupa gadziriro chimiro iri zvachose hazvitenderwi hwakakanyiwa negadziriso majekiseni, izvo zvine alkaline maitiro (sodium bicarbonate), uye pamwe heparin. Nechinangwa aizomupa dilutions rasvor "Worufu" kunoenderana isotonic yavaibvisa chloride mhinduro, isotonic shuga mhinduro "Ringers".

Panguva womuchato, "Worufu" havafaniri kunwa doro, kuti runogonesa kuti hunokachidza mugumisiro levofloxacin pamusoro nechepakati tsinga uye zvakawanda raidudzwa nokuratidzwa nemishonga.

Kana, zvisinei, akasarudza pachavo kushandisa "Worufu", mirayiridzo kushandiswa, analogues, zvinofanira kuongororwa nokungwarira, nokuti kuzara mashoko uye kuvimba zvakakwana ruzivo rekugadzirira tichadzivisa blunders.

Storage uye kugoverwa Pharmacies

Special ezvinhu okuchengetera zvinodhaka hakuna kuzvireva. chengetedzo Its kunosimbiswa pana ambient tembiricha 25 Celsius. Kubva "Worufu" Pharmacies (asingaurayiwi) Hupenyu.

Kana kutenga chinhu chigadzirwa kunokosha kuti kuteerera kuvimbika uye kuchengeteka kavha, kugadzirwa musi uye pasherufu upenyu. Anofanira hazvo kuva mubhokisi wemishonga "Worufu" mirayiridzo Chinyorwa. Mahwendefa vanofanira kuva yepamusoro kavha. Unogona kutarisa tactile vanonzwa kwayo (sezvo zvingaita sezvinoshamisa). Izvi imhaka yokuti yakawanda uye kakawanda muna mishonga pamusika pane ndevokunyepedzera uye fakes, izvo panguva yakanakisisa havagoni kupa yakakwana antibacterial mugumisiro kana ikatorwa nemuromo uye akaipisisa - kukonzera zvikuru nemishonga. Naizvozvo, kuwana mushonga, regai kuva simbe yokubvunza mishonga pamusoro kuvapo unhu tsamba, achisimbisa kwakabva zvinodhaka, "Worufu" (Mahwendefa). Mirayiridzo dzokushandisa (mushonga zvinodhaka yakatengwa) anofanira ane ruzivo nezvekwakabva mari.

ovhadhozi

Kana pane mushonga hapana chaicho ovhadhozi. Symptomatology kupfuura dose ichiwanika kunonyanya kufurirwa yokupedzisira pane yaishandiswa mabasa epfungwa. Muchiitiko ichi pane nyongano mupfungwa, hope, dzungu, uye zviratidzo zviri excitation pakati tsinga muchimiro psychosis, nezvipusha, uye vamwe.

Treatment nechinangwa panguva nokukurumidza excretion zvinodhaka. Kupiwa dzakakwirira bioavailability uye kuparadzira zvinodhaka mumuviri, hemodialysis detoxification nzira hadzibatsiri. Zvakakosha kumisa kuerera zvinodhaka mumuviri uye aite symptomatic kurapwa.

Nokuda wandei kubviswa "Worufu" by filtration ari itsvo glomeruli anobudirira nzira detoxifying zviri kushandisa aqueous munyu mhinduro uye aizomupa diuretic zvinodhaka loop mhando chiito.

Reviews kugadzirira

Kumboda vaichengeta mhinduro yakanaka pamusoro mushonga nokuda kwayo yakakwirira kunyatsoshanda kuti kurapwa kwezvirwere zvinotapuriranwa-siyana etiology. Sezvinotaurwa mu "Worufu" mirayiridzo kushandiswa kwezvinodhaka wongororo vakasara varwere kwete chete, asiwo vanachiremba, uyo akaona kumusoro kunyatsoshanda yayo, kusvikira pakurapa nosocomial uye nosocomial zvirwere.

Negative Wongororo uye nokuvhiringidzika zvinodhaka vakasara varwere huru. Izvi imhaka kukura kwavo nemishonga kana kushandisa "Worufu". Zvisinei, murayiridzo, anopa misoro chaizvo mashoko chigadzirwa ichi. Negative Wongororo inokonzerwa kushandisa zvinodhaka muzviitiko apo zviri basa nokuda asiri zvaidiwa pamusoro chakarondedzera antibacterial chiito ane microbial utachiwana. Zvinofanira kucherechedzwa kuti dzinonetsa pfungwa kazhinji kusiya varwere kuzvinzwira medicate uye kutora zvokuzvigadza, kana pamusoro dzinoenda shamwari kana "Worufu" shamwari (mirayiridzo panguva imwe nguva zvichiwanzoregwa, izvo regai inokurudzirwa zvikuru). Negative inofambiswa kubva zveutano nenyanzvi ari kushanda kwete kuchengetwa. Izvi imhaka zvakarurama uye zviine musoro kushandisa mishonga (ruzivo nezve "Worufu 500" Chinyorwa rine mashoko zvakakwanira kushandisa zvinodhaka).

Drug analogues "Worufu"

Nokuti gadziriro "Worufu" mirayiridzo analogs anorondedzerwa sezvinotevera: sezvo mushonga ari fluoroquinolone asingaurayiwi levofloxacin, mukuru-mugiredhi analogues anogona kunzi zvinenge zvinodhaka ose sezvamunoita zvakafanana. kutanga yose "Levofloxacin", "Sol", "nejichidza", "Levoksimed" Pakati izvi, uye vamwe vazhinji zvinofanira kucherechedzwa. Nokuti "Worufu" (Mahwendefa) User kushanda inopa analogs zvinodhaka akadai "Leflok", "Floksium" uye vamwe.

mhedziso

The vanoshingaira rokuti "Worufu" mushonga - mushonga unorwisa levofloxacin. Ndiye rakanakisisa antibacterial mumiririri pamwe yakafara-chakarondedzera bactericidal mugumisiro. Nokuda yakaderera kuitika nemishonga uye kushaya kuramba mushonga unorwisa akasiyana kwemabhakitiriya utachiona, rave zvinobudirira kushandiswa kurapwa muitiro "Worufu". Mirayiridzo dzokushandisa anopa mashoko chinoratidza chaizvo panyaya basa zvinodhaka.