Kugadzirira "Vasar N 160": mirayiridzo yekushandiswa, tsanangudzo, kuumbwa nekuongorora

Vanhu vazhinji vanotambura nehutachiona hwehutano. Uyezve, kuwedzera kwekumanikidzwa hakugoni kuendeswa kune zviratidzo chero chipi zvacho, asi zvinoratidzwa munzira dzisina kumira, pakugadzirisa kwayo. Kunyange mune dzimwe nguva mamiriro ezvinhu aya achiri kuendeswa nemusoro, kuputika kwembubu pamberi pemaziso uye mutsipa.

Kuti kuderedza kukwidziridzwa kwemagetsi kunokosha. Sezvo mutemo, mishonga inokosha inoshandiswa pane izvi. Mumwe wavo ndiye mushonga we "Vazar N" (160). Mirayiridzo yekushandisa, kuongorora, kuumbwa uye mari yemishonga iyi inokurukurwa pasi apa.

Fomu, kuumbwa kwemishonga yemishonga

Inorudzii iyo inobudisa mushonga we "Vazar N" (160)? Mirayiridzo yemashandisirwo ekushandisa kuti chigadzirwa ichi chinoumbwa nenzira yehwendefa ine kupfeka mafirimu. Zvinhu zvavo zvakanyanya valsartan, uyewo hydrochlorothiazide. Mukuwedzera, kuumbwa kwechirwere ichi kunosanganisira zvimwe zvinoshandiswa zvakadai se lactose monohydrate, croscarmellose sodium, povidone, silicon anhydrous colloid, microcrystalline cellulose, magnesium stearate uye talc.

Pharmacological action

Ndeipi mushonga "Vazar N" (160)? Mirayiridzo yekushandiswa, kuongororwa kunoshuma kuti iyi inosanganiswa nemishonga yakagadzirirwa kurwara neupemha.

Chinhu chikuru chechirwere chiri mubvunzo ndiyo angiotensin 2 blocker (yayo receptors). Anoshingaira kubatanidzwa mukugadzirisa kwebasa remwoyo nemidziyo yeropa. Inofanirawo kutariswa kuti mishonga iyi haidziviri uye haitsigiri kusungirirwa kweion channels uye mamwe mahomoni ekugamuchira.

Kana iri hydrochlorothiazide, inonzi diuretic (kureva, thiazide diuretic). Iyo inhengo inopesana nehutachiona iyo inoderedza reabsorption (renal) ye electrolytes, uye inowedzerawo excretion ye sodium, chlorine, bicarbonate, potassium, mvura uye magnesium. Mukuwedzera, chigadzirwa ichi chinowedzera izvo zvinyorwa muropa.

Kubatanidzwa kwezvinhu zviviri zviri pasi pekufungidzirwa zvinonyanya kufadza kune zvakataurwa zvakataurwa hypotensive kupfuura kushandiswa kwavo chete.

Zviratidzo zve pharmacokinetic

Ndeipi kupi kunwa kwechirwere "Vasar N" (160)? Mirayiridzo yekushandiswa inotaura kuti valsartan inobatwa pakarepo kubva kune imwe nzira yekudya. Uye chiyero chekudya kwayo chinoshanduka.

Kuwanikwa kwezvakaberekwa (mhedziso) yezvikamu izvi ndeye 23%, uye kubatana kweprotein ye plasma kune 95-97%. Izvozvo zvinonzi valsartan zvinouya kuburikidza nemukati uye itsvo.

Hydrochlorothiazide inokurumidza kukurumidza kubva mumuviri. Nhamba yepamusoro yekumanikidzi inowanikwa mushure memaminitsi makumi maviri, uye bioavailability iri 65-85%.

Iyo hafu-hupenyu yehupfumi iri mubvunzo inopesana pakati peawa 6 ne15 (kuburikidza netsvo).

Zviratidzo zvekutora mahwendefa emuromo

Muzviitiko zvipi zvinogona kuve nemishonga yakadai se "Vasar N" (160 / 12.5) inorayirwa? Mirayiridzo yemashandisirwo emashandisirwo anoitwa kuti mishonga iyi inoshandiswa kurapa mamiriro ekubatanidza nehutachiona.

Zviratidzo zvekutora mishonga

Pasi pemamiriro api haagoni kushandisa chirwere ichi "Vasar N" (160)? Mirayiridzo yekushandisa inoratidza zvinopesana zvakadai se:

• Anuria;
• Hypersensitivity kune chero yemishonga yemishonga;
• Refractory hypokalemia;
• Chirwere chechiropa chinoshanda chechimiro chakakomba;
• Kurwisa kwechiropa uye cholestasis;
• Hyponatremia;
• Pathology ye renal basa rekuoma kwakasimba;
• Hypercalcemia;
• Hyperuricemia symptomatic;
• Hypersensitivity kune dzimwe sulfonamide.

Mishonga yemishonga "Vasar N" (160): mirayiridzo yekushandiswa

Analogs yemudhiyo ichave yakanyorwa pasi apa.

Tora mahwendefa aya "Vasar N" inofanira kutorwa nemuromo, kushambidzwa nechingwa chemvura, pasinei nokudya.

Maererano nemirairo, kuwedzerwa kwezuva nezuva (kutanga) kwemugadziro uyu ndi 80 mg / 12.5 mg. Kana chiratidzo chakaratidzwa chakanga chisingabatsiri (kwemavhiki 3-4), ipapo chirwere chekurapa chinoramba chichiendeswa pamushandi wezuva nezuva we 160 mg / 12.5 mg. Kazhinji zviyero zvakadaro zvegadziriro zvinoratidzwa kuvanhu vasina kukwana kuora mwoyo kweBP pamusangano wokutanga.

Kana zvichidiwa, chiyero chemishonga chinogona kuwedzerwa kusvika ku 320 mg / 12.5 mg pazuva.

Nzira yakasimba yekutora mishonga iri mubvunzo inowanikwa mushure mamavhiki maviri kusvika ku4.

Zvikanganiso (pashure pokutora mapiritsi)

Ndezvipi kukanganisa kusingadi kunokonzerwa nemishonga "Vazar N" (160)? Mirayiridzo yekushandisa inotaura kuti kutora valsartan kunogona kumutsa:

• Orthostatic hypotension, neuralgia, kurwadziwa shure;
• Zvirwere (zvinotapukira) zvehutano hwemapfupa, kusanganisira sinusitis uye pharyngitis;
• Diarrhea, epistaxis, hypotension;
• Conjunctivitis, kushaya simba, arthritis, kukohwa;
• Kunyunyuta, syncope, moyo kusakona;
• Kuora mwoyo, kurwadziwa mudumbu, asthenia, kubuda ropa;
• Myalgia, rashes, hyperkalemia, kubatwa;
• Arthralgia, misoro, gastroenteritis, thrombocytopenia;
• Vasculitis, angioedema edema, rhinitis, isina simba renal basa.

Kana iri hydrochlorothiazide, ichi chinhu dzimwe nguva chinokonzera:

• Jaundice, hyperuricemia, arrhythmias;
• Hypokalemia, pancreatitis, orthostatic hypotension;
• Edema yemapulmonary, kuwedzera kwenhamba ye lipids muropa, pneumonitis.

Nyaya dzebhetheni dzinodarika

Kuwanika kwepamusoro kwepamusoro-dhe kunogona kuita kuti kuve nekurwara kwakanyanya. Kakawanda, iyi mamiriro ezvinhu inova chikonzero chekutyisidzira kana kushaya mwoyo.

Nekuwedzeresa kwehydrochlorothiazide, murwere anogona kukudziridza manzwiro ekutsvaira, hypovolemia, kugona, electrolytic disorders inosangana nemasaisai (musisi) uye arrhythmia.

Kubatana Kwemishonga

Kufanana kwekutonga kwe "Cimetidine", "Glibenclamide", "Indomethacin", "Furosemide", "Atenolol", "Digoxin", "Hydrochlorothiazide", "Warfarin" uye "Amlodipine" haitungamiri pakubatana kukuru ne "Vasar N".

Kurapa kwenguva refu neNSAID kunogona kuderedza zvirwere zvemuviri uye zvehupenzi zvechirwere chiri mubvunzo, uyewo zvinotungamirira kusakanganiswa kwekuita basa.

Kana yakabatanidzwa ne holinoblokatorami inowedzera bioavailability ye hydrochlorothiazide.

Mazano Anokosha

Iyezvino unoziva zvinorehwa kubva pamishonga yakadaro se "Vasar N" (160). Mirairo yekushandisa, mutengo wemishonga iyi inowanikwa munyaya ino.

Nekuchenjerera kwakadai ichi chirongwa chinokurudzirwa kune vanhu vane cirrhosis yechiropa, myocardial infarction, CHF, pamwe chete stenosis yerinari renal, uyewo pamwe pamwe ne potassium, potassium-sparing diuretics uye ACE inhibitors.

Kune varwere vane chiropa kukuvadza (kwete-cholestatic), kuyerwa kwemishonga iri mubvunzo hakufaniri kudarika 80 mg (valsartan).

Ongororo, zvakafanana, mutengo

Mari inoshandiswa mubvunzo iri mubvunzo ndeye 200-600 rubles (zvichienderana neyero). Nhoroondo dzechirwere ichi dzinosanganisira: Teveten Plus, Mykardis Plus, Lorista N, Cardosal Plus, Lozap Plus, Olimestra N.

Mushonga we "Vasar N" wakaratidza kuva mishonga inobatsira zvikuru yemishonga inotarisirwa mukurapa kwehutachiona hwehutachiona. Maererano nevatengi vanoongororwa, iyi mishonga haigoni kukonzera migumisiro yechirwere, uye inogonawo kushandisa uye nyore nyore kuwana.