Low samolecular uremu heparins: zvinodhaka, zvairatidza kuti kushandiswa

Zvipatara zviri thrombosis uye thromboembolic zviitiko haisi pasina anticoagulants, izvo zvinosanganisira pasi samolecular uremu heparins. zvinhu izvi zviri murwiyo mishonga anoshandura kweropa, nokudaro vavezve patency.

Mhando dzakasiyana-siyana yakananga anticoagulants

Tichitarisa mashandiro ari mugumisiro antithrombotic yeimwe zvinogona kucherechedzwa kuti havana zvakananga uye zvisina kunanga chiito. The anowanzodanwa kushandiswa boka rokutanga zvinhu.

Anticoagulants zvakananga simba pamusoro mamiriro vari rakakamurwa yakaderera samolecular uremu heparins uye unfractionated. Vanogonawo kuva yakananga thrombin inhibitor, zviri sei, somuenzaniso, hirudin.

Low samolecular uremu heparins Feature

Zvavo zvakasiyana kunzi fractionated yeimwe vane avhareji samolecular uremu anoda kubva 4000 kusvika 6000 daltons. mabasa avo vari chokuita isina kunanga chinovhiringidza pamusoro inotungamirwa uye basa enzayemu thrombin. Zvakadaro zvakaitika heparin rine pamusoro ropa coagulation chinhu Xã. Mugumisiro ane anticoagulant uye antithrombotic kushanda.

Low samolecular uremu heparins vari vakawana kubva unfractionated zvinhu kure renguruve intestinal epithelium, panguva muitiro kwemakemikari kana enzymatic depolymerization. Somugumisiro ichi kuita polysaccharide cheni iri pfupi mumwe pavatatu yaro yepakutanga urefu, izvo zvinobatsira kuderedza anticoagulant Morekuru.

Pane siyana pasi samolecular uremu heparins, uye kupatsanura ichi inobva nzira yokuwana munyu-tune yeimwe.

issuance

Formulations yavo injectable negadziriso subcutaneous kana intravenous yaitonga. Dzinowanzotanga rakazara muna ampules kana kuraswa syringes.

Low samolecular uremu heparins hadzina kugadzirwa pamahwendefa.

mishonga Intramuscularly haina kushandiswa.

Description "Gemapaksan" chinodhaka

Rinoreva zvinodhaka zvakananga anticoagulant migumisiro. The achishingaira chinoita ari muchimiro enoxaparin yavaibvisa munyu, izvo vaiona rinobva kuna heparin. nadzurudzo iyi inopa yakakwirira adsorption kana achiita subcutaneously uye munhu pasi nehanya.

Zvinonzi neve Italian kambani "Italfarmako Spa" sezvo yakajeka, Hauoneki kana chiedza-yellow mhinduro kuti jekiseni mumapepa ari syringes pamusoro 0.2, 0,4 kana 0,6 Rine mamiririta.

enoxaparin yavaibvisa chipimo chemushonga kune 2000 Iu 20 MG; 4000 Iu kusvika 40 MG uye 6000 MG 60 Iu. The rinoita chinoita yakanyauka mumvura zvinodhaka jekiseni.
Enoxaparin yavaibvisa kunooneka mune chipimo chemushonga 100 Iu pa 1 MG mukuru inhibitory zvainoita ropa coagulation chinhu Xã uye pasi zvazvinoita antithrombin ari dose 28 Iu pa 1 MG.

Kushandiswa kuchirapa zvinodhaka kuwanda mu zvirwere siyana haitungamiriri nokuwedzera nguva kwokurasikirwa ropa.

Prophylactic yavaibvisa enoksaparinovaya chipimo chemushonga asingadi kuchinja kusashanda thromboplastin nguva zvishomanana, hakupesani munhu platelet clumping dzavo kubatana kwacho kune fibrinogen mamorekuru.

Low samolecular kurema heparins ari mukuru zvinodhaka wevasungwa (6000 Iu muna 0,6 Rine mamiririta) anoshandiswa:

• nokuti kurapa ose thrombosis ari mutsinga yakadzika;
• kuumba kusagadzikana angina uye myocardial hunoshamisa infarcted tsandanyama ezvinhu akabatana acetylsalicylic asidhi;
• nokuti kudzivirira coagulation yakawedzera kuti nguva yacho hemodialysis nzira.

Nhanganyaya subcutaneous dosing mhinduro 2000 uye 4000 Iu pamusoro 0.2 uye 0,4 Rine mamiririta ukuwo, rinoshandiswa kudzivirira thrombosis uye venous thromboembolic ezvinhu hurongwa:

• munguva vachibatsira zvomusejari akavhiyiwa unhu;
• mubhedha varwere vane chirwere kufema insufficiency kana cardiac hurongwa chikwata 3 uye mhando 4;
• chenjera zvinotapukira kana rheumatic zvirwere, apo pane ngozi yokuti ropa clots;
• Varwere vakwegura;
• pamwe zvakawandisa mafuta deposition;
• kana kemikari mushonga.

The mushonga rinoshandiswa subcutaneously munzvimbo abdominal rusvingo, rine posterior uye anterolateral mapazi.

Mishonga iri contraindicated nokuda thrombocytopenia, ropa, pakugwamba zvirwere, maronda chirwere ari mucous Kamudzira mudumbu uye duodenum, subacute kwemabhakitiriya endocarditis, chirwere cheshuga, chirwere cheshuga, mukuru nehanya uye pamuviri.

"Gemapaksan" Medicine: mutengo

Mari jekiseni rine 2000 Iu sirinji muna 0.2 ml zvidimbu matanhatu 955 rubles.

Kuti uwane chipimo chemushonga zvinodhaka "Gemapaksan 'mutengo neeSultan kubva 1,500 rubles por rongedza pamwe syringes matanhatu.

Description "Clexane" chinodhaka

Rinoreva chete nzira nokuda enoxaparin yavaibvisa. Zvinoberekwa kambani French "Sanofi Aventis" somunhu injectable mhinduro yakajeka chinogona kuva Hauoneki kana zvishoma tsvuku tint.

Pane chipimo chemushonga "Clexane" kugadzirira 10000, 8000, 6000, 4000 uye 2000 Iu pamusoro enoxaparin yavaibvisa kusvika 1.0; 0,8; 0,6; 0,4; 0.2 ml nemvura chinodhaka, ukuwo. The kushingaira pazvokudya mushonga uri 1 MG 1,000 Iu.

Low samolecular uremu heparins anogadzirwa mune girazi syringes, izvo zvinogona mune rongedza 2 kana 10 zvidimbu.

Drug "Clexane" yokudzivirira HIV thrombotic uye thromboembolic zvirwere zviri mutsinga munguva kuvhiya kupindira chokuita orthopedics, uye hemodialysis.

Kugadzirisa raitongwa subcutaneously panguva kubviswa venous thrombotic inoti pakadzika yemapapu uye kupinda tsinga.

Drug vaitire angina kusagadzikana hunhu myocardial hunoshamisa uye myocardial tsandanyama pachiimbwa mahwendefa "asipurini".

"Clexane" Medicine: mutengo

Mari jekiseni rine 2000 Iu 0.2 ML paminiti sirinji iri 175 rubles.

Chimwe chikwata dose kuti 4,000 Iu pamwe 0,4 ml NZD 280 aizofanira kubhadhara 6,000 Iu pa 0,6 Rine mamiririta - 440 rubles 8000 Iu pa 0,8 Rine mamiririta - 495 rubles.

Mukugadzirira "Clexane" mutengo chete chairema mashekeri 10 ane dose 20 MG, 40 MG uye 80 MG riri 1685, 2750, 4000 rubles.

Description "Fragmin" chinodhaka

The kushingaira chezvinonhuwira kuti zvinodhaka rinobva heparin fuma waimiririra dalteparin yavaibvisa. Zvinonzi yaunganidzwa depolymerization kubudikidza chiito nokuda nitrous inouraya , zvichiteverwa yokuzvinatsa uchishandisa Ion Exchange chromatography. Dalteparinovaya yavaibvisa munyu unotora polysaccharide ngetani pasi sulphation, neavhareji samolecular kurema zviuru zvishanu daltons.

Upiyona hwebetsero protrude mvura jekiseni uye yavaibvisa chloride munyu. ZveBelgium medicament "Fragmin" Chinyorwa anotsanangurwa kugadzirisa kuti jekiseni subcutaneous uye intravenous yaitonga iri mvura segirazi Hauoneki kana yellowish tint.

kusunungurwa raro monodose magirazi syringes ose 2500 Iu pa 0.2 Rine mamiririta; 5000 Iu pa 0.2 Rine mamiririta; 7500 Iu pa 0.3 Rine mamiririta; 10,000 Iu muna 1.0 Rine mamiririta; 12.500 Iu muna 0.5 Rine mamiririta; 15,000 Iu pa 0,6 Rine mamiririta; 18.000 Iu pa 0,72 Rine mamiririta.

Drug "Fragmin" Chinyorwa anokurudzira kushandisa kuzvidzivirira nechiyero kuti kudzorwa kweropa mashandiro ari hemodialysis uye haemofiltration mabasa zvainanga kurapa itsvo kukundikana, kudzivirira paumbwe clots vari kuvhiyiwa.

The medicament chinotarisirwa kubvisa thromboembolic maronda varwere akangorara.

Solution vaitire angina, kusagadzikana uye infarct myocardial hunoshamisa ezvinhu tsandanyama, symptomatic venous thromboembolism.

Description of zvinodhaka "Anfibra"

Its pasi samolecular uremu heparins anonzi yokuRussia kambani OJSC "Veropharm". Pane mhinduro akajeka jekiseni, izvo zvingava Hauoneki kana yellowish tint.

Pane zvinoreva zviri enoxaparin yavaibvisa munyu, izvo zvingazivikanwa mabhati 2000 Iu muna 0.2 Rine mamiririta; 4000 Iu pa 0,4 Rine mamiririta; 6000 Iu pa 0,6 Rine mamiririta; 8000 Iu pa 0,8 Rine mamiririta; 10,000 Iu muna 1.0 Rine mamiririta. The kwakadonhera mvura inoshandiswa sezvo solvent.

It prepacked mu ampules kana syringes kuti 1ml, idzo 2, 5, uye 10 zvidimbu vari kugara mu packs it kuti makadhibhokisi.

Drug "Anfibra" mirayiridzo pachii kudzivirira thromboembolic ezvinhu apo kushanda bata uye hemodialysis pakurapa clot inotungamirwa nemidziyo yakadzika-nhema.

Solution ichitarisira kusagadzikana chimiro angina uye cardiac tsandanyama infarct mamiriro umo hapana zino Q pamusoro kwemwoyo unonzi, electrocardiograph.

Achirondedzera "Fraksiparin"

By pasi samolecular uremu heparins ndiko nadroparin calcium, iyo yakawanikwa panguva depolymerization rikurumidze. mamorekuru ayo glycosaminoglycans, avhareji samolecular yairema akaenzana 4.300 Daltons.

Kugadzirira "Fraksiparin" (subcutaneous majekiseni) ayo sezvamunoita rine karusiyamu hydroxide uye munyu nadroparin, izvo zvazvichanyungudutswa injectable mvura.

Chipimo chemushonga kuti vanoshingaira chirungiso ndiyo 2850 ME muna 0.3 Rine mamiririta; 3800 ME 0,4 Rine mamiririta; 5700 ME 0,6 Rine mamiririta, 0,8 ME 7600 Rine mamiririta, 9500 ME muna 1 Rine mamiririta.

The gadziriro iri yakajeka kana zvishoma opalescent mvura, ine chiedza yero ruvara kana zvachose Hauoneki.

Nadroparinovaya munyu wakanaka mapuroteni anosunga kuti antithrombin III, izvo chinoita wakakurumidza chinovhiringidza kuti chinhu Xã. The fuma zvaanopa simba inhibitor ichipa kusanduka zvinyama chinhu, lowers ropa viscosity ikawanda platelet Kamudzira permeability uye masero granulocytic. Saka yakatakura antithrombotic mugumisiro chezvinodhaka.

Majekiseni "Fraksiparin" ushandiswe kudzivisa thromboembolic ezvinhu apo kushanda vachibatsira kuchinja chimiro uye hemodialysis. The mushonga chinotarisirwa varwere kuva mukuru njodzi ropa clot inotungamirwa, chenjera kufema insufficiency uye mwoyo chirwere, kusagadzikana angina pectoris, myocardial hunoshamisa myocardial tsandanyama kushaya Q-wave.

Kushandiswa anticoagulants mwana inobereka

Low samolecular uremu heparins mune nhumbu dzinopiwa varwere vane ropa zvinetso kuti haana akaumba placental ropa clots kuti kukonzera pamuviri, kuti preeklampsicheskomu vane BP, peel they and and mwana nezvigaro pamwe rinorema ropa, kunonoka kukura mudumbu iri dumbu, zvichiita pasi mwana uremu.

anticoagulants vakadaro nachiremba vakadzi nzvimbo pamwe zvinokwanisika ngozi clot inotungamirwa pakadzika mutsinga Somuenzaniso dzakaderera kuviri, uyewo zvemapapu tsinga occlusion.

LMWH kurapa chinhu chinorwadza chichiitwa, umo murwere pamuviri anopinda zvinodhaka zuva pasi ganda iri mudumbu.

Zvisinei, munguva kurapwa randomized avapo pakuongororwa izvo zvinoratidza kuti kushandisa anticoagulants dzakadaro kakawanda haakonzeri zvakwakanakira. Vakawanawo kuti pasi samolecular uremu heparins mushonga vanogona kukuvadza muviri raamai chokuita rakawedzera kubuda ropa uye ungaderedza kurwadziwa anopona.

Zvidzidzo izvi zvakaratidza kuti abolition kuti anticoagulant kunokwanisa kuponesa vakadzi vazhinji kubva zvisingakoshi marwadzo zviratidzo apo akatakura mwana.

The mirayiridzo kushandisa gadziriro kwakavakirwa yakaderera samolecular uremu heparin ARV contraindicated mu pamuviri.