Mishonga 'MabThera'. Mirairo yekushandiswa

Nhengo yevanorwisa zvinodhaka zvinosanganisira mishonga "MabThera". Kutsanangurwa kwemishonga kunoratidza kukwanisa kwayo kusungirirana zvakananga kune transmembrane antigen inowanika mu 95% yezvisiri zveHodgkin's lymphomas yeB-cell form. Iyo inoshandiswa inoshandiswa is rituximab.

Mushonga "MabThera". Mirayiridzo: zviratidzo

Mishonga inorayirwa B-cell kwete Hodgkin's lymphoma:

- chemo-resistant kana kuti yakadzoka, CD20-positive nechokuita chidimbu chekurwara kana follicular;

- follicular chechitatu-yechina danho rekubatana ne chemotherapy mune varwere vasingateereri;

- follicular after reaction to induction therapy sekusimbisa mumiririri;

- CD20-positive B-huru sero inosanganiswa neCOP chemotherapy.

Icho chishandiso "MabThera" murayiridzo inokurudzira kushandiswa kwechirwere chekurwara chekurwara kwemaperembudzi:

- pamwe chete nechemotherapy muvarwere vasingateereri kurapwa;

- Kudzokororazve kana chemo-resistant pamwe chete nekemotherapy.

Chirwere ichi chinoratidzwa kune vanhu vakuru vane maitiro anoshingaira ekuratidza rheumatoid arthritis pamwe chete nemishonga "Methotrexate" nemhinduro dzisina kukwana kana kusagamuchirwa kwemitemo yekurapa inoshandiswa.

Contraindications

Icho chinyorwa "MabThera" hachikurudziri murayiridzo wekusagadzikana kwevanhu.

Kuchenjerera kunofanira kuonekwa pachinoronga mishonga kune varwere vane chirongwa chemahythmia, angina, chisingaperi chemwoyo kusakundikana, kukwirira kwepamusoro kana kuderera kweropa, thrombocytopenia, neutropenia, COPD (nemhaka yemukana we bronchospasm).

Migumisiro Yechiri

Nekushandisa kwechirwere "MabThera", kufungidzira, kurwadziwa mumimba, kurutsa kunogona. Zviratidzo zvisina kunaka zvinosanganisira orthostatic hypotension, arrhythmia, tachycardia, bradycardia, renal function disorder, edema yeropa, kurwadziwa mubhokisi uye lumbosacral musana. Iyo mishonga "MabThera" inogona kukonzera mhirizhonga yeuropathy, neuritis, kugona kana kusuruvara, kushungurudzika kana kuora mwoyo, kuzvidya mwoyo, kushaya simba, chirungu, musoro. Zviitiko zvakashata zvinokonzera kugadzirisa. Mirayiridzo iyi inosanganisira rhinitis, kupfurikidza kwemafuta kana kuti rurimi, kufema kwemhepo, bronchospasm, kuchenesa kweganda, kurasikirwa, kuora kwehutano, kudengenyeka, chills, fever, marwadzo mumutsipa uye munzvimbo yekumarara kwemahara Zvirwere.

Dosage

Chirwere ichi chinoshandiswa zvishoma nezvishoma mukana wekudzivirira. Apo monotherapy inoshandiswa kamwechete pavhiki kwe 375 mg kwevhiki ina. Nhamba yekutanga yekutanga yekufambisa is 50 mg / h. Kuwedzera kusvika pahupamhi (400 mg / h) kukurumidza kunofanira kuitwa zvishoma nezvishoma.

Special instructions

Kwemaminitsi makumi matatu kusvika makumi matanhatu isati yasvika, kupedzisira (kugadzirira) ne analgesics uye antihistamines inokurudzirwa.

Panguva yekurapa uye mukati memwedzi gumi nemaviri mushure mekupedzwa kwayo, vakadzi vezera rekubereka vanofanira kushandisa mazano ekudzivirira vana.

Zvinodhaka zvinodhaka zvinofanira kuregererwa pasina maawa gumi nemaviri vasati vauya mishonga "MabThera."

Kubudirira uye kuchengeteka kwemishonga muvana hazvina kugadziriswa.

Nezvechirwere "MabThera" tsanangudzo dzeyanyanzvi dzakanyanya kunaka. Uyezve, panguva yekutsvakurudza kwakawanikwa kuti kushandiswa kwekushandisa kwechirwere se monotherapy, uyewo kushandiswa kwaro kwaro sekusimbisa mumiriri wemakore maviri, kunoderedza mikana yekuderera kwekuyerera kwe follicular lymphoma.