Phosphate cheshuga: zvinokonzera, zviratidzo, nechirwere, kurapwa

Munyika yanhasi inenge vabereki zvose vanoziva chirwere ichi, sezvo asina kusimba. On kudiwa kudzivisa chirwere ichi chinonditadzisa chiremba mwana mumwe nomumwe mumwedzi youpenyu mwana wokutanga. Kusimba rinoreva vawana zvirwere kusimukira nokuda kukwana cholecalciferol - imwe pfuma inozivikanwa vhitamini D.

Zvisinei, mune zvimwe zviitiko, vana vaduku chaizvo vane zviratidzo chirwere, zvisinei kuomerera matanho. Pakadaro chinofanira vanofungidzirwa chirwere chakadai phosphate cheshuga. Kusiyana kusimba, chirwere chokuita nemagene pathologies. Naizvozvo, ihosha zvikuru uye zvinoda refu kunzwisisa kurapwa.

Chii phosphate chirwere cheshuga?

Ndizvo boka nemagene zvirwere chokuita havachanyatsogoni chicherwa muviri. Mune chimwe zvokurwara inonzi vhitamini D nemishonga kusimba. Hukuru mhando phosphate zveshuga rinowanikwa munenge 1 mwana kunze 20,000 vana vachangoberekwa. chirwere yakatanga kurondedzerwa muna 1937. Gare gare zvikazooneka kuti pane dzimwe nzira nemagene abnormalities. Kakawanda, phosphate chirwere cheshuga ari kuona mu muduku. Kunokwezva pfungwa vabereki gait orega uye kukanganisa pfupa.

Mamwe marudzi chirwere vari pamwe nemamwe metabolic zvirwere. Dzimwe nguva chirwere chiri asymptomatic uye anogona chete kuziva huchibvutwa mumarabhoritari nemiedzo. The chirwere ari Classified pamwe vawana kusimba, hypoparathyroidism nezvimwe kwemakemikari anobudiswa abnormalities. Treatment anofanira revatema pazera duku.

The zvinokonzera chirwere

Kukonzera phosphate cheshuga rwakavhunika masero. Kunotouraya vari nhaka. Vatakuri zvemamiriro Gene kunogona vakadzi nevarume. The mutation rikaitika X-chromosome kwakabatana, inova kuzivikanwa. Mune zvisingawanzoitiki Muzviitiko, phosphate chirwere cheshuga chinogona kuwanikwa. Iye anova ari mapundu ose mesenchymal rinenge achiumbwa utero. In zvokurwara ichi anonzi "oncogenic kusimba."

Chirwere rinoreva boka tubulopathy - kusagadzikana neitsvo. Nekuti zvicherwa zvinoderedza reabsorption ari proximal tubule, anovandudza kushayiwa phosphorus pamuviri. Uyezve, zvakashatirisa bowel kubvisa okufunga. Somugumisiro, pane kuchinja zvicherwa Zvinoumba mafupa tishu. Pane kazhinji kutyora osteoblast chaitika. Men zvakaitika pathologically zvakachinjwa Gene vanasikana chete, uye vakadzi - vana aroorane. Kazhinji, zvikuru yakanyanya chirwere vakomana kupfuura vasikana.

Kupatsanura pakati phosphate cheshuga muvana

Kune dzakawanda nehosha, dzakasiyana muna kuvabereki uye sokuora zvinodiwa. Most kazhinji chirwere munzvimbo X-kwakabatana hypophosphatemic kusimba, ine hukuru muenzaniso wenhaka. Zvisinei, pane dzimwe mhando zvokurwara. The kupatsanura zvinosanganisira zvinotevera chimiro chirwere:

1. X-yakabatana rave mhando phosphate cheshuga. It kunoratidzwa kuchinja PHEX Gene, iyo inofananidzira ari endopeptidase. enzayemu Izvi anokonzera chokufambisa zvicherwa siyana achishandisa itsvo uye intestinal Ion makwara. Nekuti ichi Gene mutation muitiro DZEMUNHU DZINODZORA, achipa pave kukundikana kubudikidza phosphate ions mumuviri.
2. X-yakabatana recessive. Ichazivikanwa CLCN5 mutation ane Gene kuti inofananidzira imwe puroteni anokonzera nokushanda kuiisa chlorine Ion makwara. Somugumisiro ndiko kuremara kwakakanganiswa kutakurwa zvinhu kuburikidza Kamudzira yacho renal tubules. Vatakuri kwakadai zvokurwara kunogona vakadzi nevarume. Zvisinei, hosha rinowanikwa chete vakomana.
3. Autosomal chikuru anopa phosphate cheshuga. Rinobatanidzwa ane majini mutation mu chromosome 12. Nekuti osteoblasts pathological kuremara yoga mapuroteni iyo anotsigirwa kunowedzerwa phosphate kubviswa kubva mumuviri. The zvokurwara kunoratidzwa nekaupenyu vanyoro, sezvo vaipikisa kuti X-chokuita chimiro.
4. Autosomal recessive. Rova. Ichazivikanwa DMP1 chakaremara Gene iri mu chromosome 4. It inofananidzira ane puroteni kuti ndiye anokonzera kukura pfupa uye dentin.
5. Autosomal recessive, aine nokubudiswa calcium iri weti. Unomuka nokuti majini kuremara riri pamusoro chromosome 9 uye nokubatira yavaibvisa-nemataundi renal makwara.

Kuwedzera kune marudzi aya phosphate cheshuga, pane mamwe marudzi zvokurwara. Vamwe akasiyana chirwere vasina kudzidza kusvikira ikozvino.

Kusiyana pakati kusimba uye phosphate chirwere cheshuga

Kusimba uye phosphate chirwere cheshuga muvana - ichi hachisi chaizvo zvimwechete, kunyange zvazvo chiremba mufananidzo hosha iri rinenge zvakafanana. Kusiyana izvi pathologies muna etiology uye mashandiro okukura. Vanhuwo kusimba - anowanikwa chirwere chokuita nokusava cholecalciferol. fuma iyi anogadzirwa ganda pasi pokudzora chezuva. Chirwere dose vhitamini D anoitwa kutora zuva nezuva vose vana 1 pamwedzi 3 years, dzakakudzingai chirimo. Nokuda kuti kukundikana cholecalciferol vachanetseka karusiyamu Absorção de Água rikurumidze. Somugumisiro dzichiri mapfupa deformation.

Kusiyana phosphate cheshuga kuti Rinoreva vachiberekwa chirwere. Kana zvokurwara ichi vachanetseka Absorção de Água zvicherwa zviri itsvo, zvikurukuru - the phosphates. Mune zvimwe zviitiko, pane karusiyamu kukanganisika. Nokuda kuti kutyorwa zvicherwa Zvinoumba pfupa rinenge pathologies akaita zviratidzo. Musiyano pavo anozvigona hwaizogadzwa chete pashure murabhoritari zvawanikwa.

Hypophosphatemic kusimba mune vacheche: Zviratidzo

Zviratidzo nehosha zvinowanzova chirwere mumakore rechipiri rokubata upenyu. Mune zvisingawanzoitiki kacho pane hypophosphatemic kusimba mune vacheche. Zviratidzo zvinogona chirwere achiri mucheche - munhu tsandanyama hypotonia uye richiripo kupfupikisa. Huru zvekuchipatara kuratidzwa ndiwo:

1. Deformation of gumbo mapfundo.
2. O-zvakaumbwa curvature repasi wamativi.
3. Kukura retardation muvana - anova kuoneka pashure 1 gore.
4. Thickening of chiningoningo uye rumbabvu shwashwa - "rachitic zvamaoko uye marozari."
5. Kurwadziwa mapfupa chiuno nomuzongoza.
6. Kuzotadzira zino enamel.

Kazhinji main chichemo vabereki ndechekuti mwana pamakumbo hwakakungwa. With kuchiita hosha pane kunyoroveswa mapfupa - osteomalacia.

Chirwere kuti phosphate chirwere cheshuga uye kusimba

Kuziva abnormalities, aidzidza kudzidza nokukanganisika Zvinoumba ropa. It rinozivikanwa hypophosphatemia. padanho calcium kakawanda kuipa, dzimwe nguva - ungaderedza. Nourefu kusimba pane kuwedzera pamusoro alkaline phosphatase. Apo maekisirei akaratidza osteoporosis uye mapfupa kukura wongoramba kukanganisa. Muna weti yakaratidza yakawanda phosphates. Dzimwe nguva pane Urinary karusiyamu.

Treatment kusimba uye phosphate chirwere cheshuga

Nokuti pakurapa phosphate chirwere cheshuga vaishandisa guru mishonga kuti cholecalciferol. Mune zvimwe zviitiko, dzakaratidza karusiyamu zvokuwedzera. Iva nechokwadi kuti kushandisa mishonga kuti ane phosphorus. Kuvandudza mamiriro ushandiswe vhitamini uye chicherwa zvokuwedzera. Izvi zvinosanganisira "Vitrum" zvinodhaka "Duovit", "Alphabet" uye zvichingodaro. D.

Kana vakaratidza curvatures mapfupa dzakaratidza physiotherapy, panyama kurapa uye kuvhiyiwa. Vanofanira kutanga podiatrist.

Matanho uye Zvaifungidzirwa

Nokuti Kudzivirira matanho anosanganisira inspections wevana uye chiremba, kufamba munzvimbo yakachena mhepo, kugadzwa vhitamini D kubva pakutanga mwedzi upenyu. Kana mhuri vanorwara kuti phosphate chirwere cheshuga vanofanira kumbotambudzika majini rokuedza utero mudumbu. Kufembera kunyanya rakanaka nenguva nokurapwa.