Prolactinoma pituitary shwanu: zvinokonzera, zviratidzo, chirwere uye kurapwa. The pituitary shwanu iri anokonzera chii?

Kana munhu angatarisira zvokurapa rokuti yakaoma, rwunotanga nekukatanura kuva yenhengo dzayo kuti kunzwisisa chirwere yavo. Saka, mubvunzo wake pachako wokutanga: "Chii remhosva pituitary?". Mushure anotsvakisisa mashoko akariwana kuti ichi kwemakemikari anobudiswa shwanu, izvo anoita kushanda mamwe omumuviri zvose mumuviri. Kumwe kutsvakurudza kuchatungamirira murwere pamazita zvinoberekwa hormone dzavo uye chipfuro nenyere. Uye chete pashure akasarudza pakupedzisira kuwana chii rinoreva mashoko okuti "prolactinoma pituitary." Ichi bundu inobereka kemikari akawandisa, muviri anogona kugadzirisa navo. Zvakawandisa prolactin uye chinokonzera maitiro zvekuchipatara zviratidzo. Asi zvinhu zvokutanga pakutanga.

Chii pituitary shwanu?

The pituitary shwanu iri anokonzera chii? Pituitary shwanu - ari chikamu midbrain, riri pamusoro basal pamusoro mu mapfupa inotungamirwa, inonzi "Turkish Chigaro." shwanu ichi secretes mahormone yokudzora kukura dzevanhu, mwero muviri uye kubereka revana. Pituitary shwanu - muitisi of kwemakemikari anobudiswa hurongwa. Kutaurirana pamwe hypothalamus, pamwe chete ivo kudzora muviri, ichipa wayo anokosha.

Muna pituitary shwanu vari zvikamu zvitatu kana mugove:

1. Anterior akafukidza unobereka tropic mahormone. Vari atumidzwa nokuti kukanganisa dzimwe nhengo uye mishonga kuti zvirire munyama yavo. Idzi dzinosanganisira:
   - thyroid anotokonya kemikari (chokuita thyroid gland);
   - adrenocorticotropic kemikari (zvinoita adrenal mumasero);
   - follicle-anotokonya kemikari (chidhiraivho pabonde basa, kufurira kuibvisa pamusoro oocytes);
   - luteinizing kemikari (zvinosimudzira ovulation);
   - Growth kemikari anokonzera kukura;
   - luteotrophic kemikari kana prolactin (anoita chitarisiko colostrum nomukaka vakadzi vane pamuviri, ndiye mwana nema hwokuzvarwa nahwo). Prolactinoma pituitary iri kukura Anterior akafukidza, izvozvo "kunokanganisa" basa luteotrophic kemikari.
2. The posterior akafukidza secreted vasopressin (anokonzera tiine inowanzotorwa ropa uye zvinyama mvura kufurirwa), uye oxytocin ndiro saka zvakafanira panguva mwana nepamuviri uye ukoti. It anoita pamusoro wakatsetseka tsandanyama, achidzikisa nayo.
3. Avhareji Kuwanda synthesized mahormone inotokonya ganda masero - melanocytes.

Mabasa sezvo nyore zvokufungidzira, pituitary zvakasiyana-siyana. Unotonga Sero kupesana uye mapuroteni synthesizing kuvaka tishu itsva. Uyezve, anoita kuibvisa mazai uye urume, uyewo muviri apindura pabonde mahormone. It chacho zvirwere nokuita kuti masero kana zvichivhiringidza mashandiro ari thyroid. Unotonga BP yomuropa nemidziyo ropa, uwandu mafuta zvakawanda uye unhu hope. The pituitary shwanu haasi kuwanika maawa pazuva 24, 7 days pavhiki, zvose hwedu.

Prolactin - chii?

Little kunzwisisa anatomi uye physiology pamusoro kwemakemikari anobudiswa ezvinhu, unogona mberi kwayo uwane kuongorora. Chokwadi, akakurumidza, pasina dzidzo chaiyo hazvisi nyore, asi unogona zvinenge edza. In nechirwere, kuwedzera shoko "pituitary", zvakanga zvichiri prolactin. Chii?

Prolactin - mumwe mahormone secreted kubudikidza acidophilic masero ari Anterior pituitary. With kwayo makemikari marongerwo rinoreva mapuroteni zvivako. Masayendisiti ega mhuri yose zvinhu vane samolecular maitiro akafanana. Idzi dzinosanganisira:

- prolactin;
- proliferin (chidhiraivho weboka connective zvinyama masero);
- kukura kemikari;
- placental lactogen (secreted panguva yepamuviri).

Pari dzainyatsofunga prolactin zvakananga kana kuti zvisina kunanga anokonzera pabonde nerevane kubereka. Target Nhengo vari, sezvo zita rinoreva kuti mammary mumasero. Kemikari kunomutsa kugadzirwa colostrum wayo kutendeuka kupinda mukaka. At pakuyaruka uye panguva pamuviri ndiye anokonzera kukura uye kusimudzira mammary omumuviri, uwandu lobules uye ducts. Interesting chokwadi: The receptors kuti prolactin zvinowanika mumarudzi anenge nhengo zvose uye nyama dzemuviri, asi chii chaizvoizvo rine pamusoro pavo achiri kuzivikanwa.

prolactinoma pituitary unovapo nokuda kunotouraya ari mumasero Anterior pituitary. It chinokurwadzai nokunyanyisa pakuburitswa prolactin uye runogonesa zvivako zvayo, izvo kunokanganisa zvakanaka uye chitarisiko murwere. Sezvineiwo, chirwere uye kurapwa chirwere ichi vari kare anozivikanwa uye zvinobudirira vaedzwa, saka chirwere - kwete mutongo.

prolaktinoma

pituitary prolactinoma rinoreva kakawanda benign chirwere ari Anterior pituitary (statistically, 30 muzana chirwere anomera zvose). Common mune vakadzi zera rokubereka. The reshiyo pakati simba uye akanaka pabonde - 1 kusvika 6.

Kukura kwayo, sezvinoita mutemo, haapfuuri millimeters maviri kana matatu, asi vanhu vanogona kusangana uye dzidzo zvikuru - kupfuura sendimita mu dhayamita. namamota ava hormonally kushingaira, sezvo ivo inongomutsa prolactin. Kazhinji zvakafanira synthesized mu aroorane. Prolactin vatingakurudzira zviremera roga kana pachiimbwa luteinizing uye follicle-mutange kemikari. Kunyanya kuita kwavo kunoratidzwa panguva yepamuviri uye lactation. Asi mhiri kuti, ivo waidzora kuenda kumwedzi uye ovulation.

Yakawandisa kemikari ine vanetsane. Mukadzi anova mbereko kureva havagoni nemimba, nokubereka mwana. Varume vane titers pamusoro prolactin vane matambudziko potency uye erection chiratidzo kuzviitira uye chinangwa zamu nedumbu.

zvikonzero

Masayendisiti haana afunga kuti chokwadi nei munhu ari neoplasm, asi akaona zvimwe zvinhu, zvakajairika varwere vose vane chirwere chakadai.

Mubvunzo wokutanga, Chokwadi, munhu vachiberekwa nemagene nepfungwa yacho kwemakemikari anobudiswa hurongwa. Kazhinji, izvi vakawanda neoplasia (kureva, bundu ane anenge zvose omumuviri yomunyika secretion). Pane zvakawandisa kugadzirwa prolactin, kwete chete, asiwo hormone ose thyroid uye parathyroid omumuviri, rwatata, adrenal omumuviri, pituitary shwanu uye kuvapo nemaronda mudumbu.

Zvinozivikanwa kuti hama mukana kuti zvokurwara iri kupfuura avhareji nokuda kwevanhu. Modern genetics haasi kurega uye ari kutsvaka majini kuti achinje zvechadenga Anterior pituitary masero, asi kubudirira saka kure mumunda uyu haamo.

kupatsanura

Pituitary adenoma (prolactinoma) anogona siyana ne nzvimbo mukati sella. Namamota secrete mapoka maviri:

1. Intrasellyarnye prolactinomas kuti haapfuuri rimwe sendimita kukura uye Havapfuuri miganhu yacho pituitary fossa mafupa.
2. Ekstrasellyarnye prolactinoma makuru uye vaizvambarara mhiri sella.

Kukura bundu kunoenderana kwokuomerwa zviratidzo. Izvi zvinoshandawo kwete chete kune chaiyo zviito kemikari. The volumetric kuzvimba akakudzvinya dzimwe pfungwa zvivako, zvichikonzera rwevanhu uye zvatichiri chetsinga symptomatology. Izvi zvinogona kuva upofu, kurasikirwa kunhuwidza, kurasikirwa nezvimwe cranial tsinga (trigeminal, chiso, oculomotor). Common zviratidzo zvinosanganisira nemusoro, akaora mwoyo, kufunganya, kushatirwa uye mupfungwa lability.

Prolactinoma pituitary: Zviratidzo vakadzi

Kwenguva refu, mukadzi arege kuona yambira kuchinja muviri wako, kunyanya kana ane, uye denda vaiva nedambudziko kuenda kumwedzi. In varwere vakachengeta zvinoderedza uwandu mazuva kumwedzi, kushomeka kwezvakanyorwa secretions kana kunyange zvavo vasipo. Ladies vanoda kuva mwana asingakwanisi kuita izvozvo, sezvo ovulation hakuitiki.

Ndezvipi zvimwe zviratidzo kuitika mune vakadzi? prolactinoma pituitary kunomutsa kugadzirwa colostrum uye mukaka, kunyange avo akanaka pabonde vasiri vakagadzirira vanova vanaamai. Liquid mumate hungabudiswa nomuviri compression pamusoro munyatso kana chokumisa oga (kazhinji nokuda yakawanda mukaka). Women pamwe chimiro zviratidzo izvi pakutanga kufunga kenza yemazamu kana zvimwe kuchinja omunharaunda, asi yokunyatsoongorora angawana pamudzi dambudziko.

Zviratidzo pituitary prolactinoma vakadzi - hakusi chete pakusarudza colostrum uye mukaka, zviri zvakare kuwedzera mapfupa fragility kusvikira osteoporosis. Uyezve, pokuperevedza mune mamwe mahormone, akadai inonzi estrogen kunokonzera mvura chengetedzo mumuviri, uye kukurumidza kufuta. Chitarisiko anogona zvachinja - polymorphic mburwa mapundu, vakawedzera hairiness pamusoro yokumusoro muromo uye pamisoro hura. izvi zvose zvinofanira kubata pamusoro chiremba pfungwa pituitary bundu.

Zviratidzo zviri varume

pituitary prolactinoma nevanhu kunooneka vasanyanye testosterone mumatunhu uye havachanyatsogoni utachiona sero inotungamirwa. Izvozvo anokonzerawo kusabereka. Asi aspermia vakarasikirwa ane erection, akaderedza zvepabonde nemotokari, potency kunoderedza.

Mukuwedzera, vamiririri simba hafu akaona kuwedzera uye shanduko chimiro mazamu - gynecomastia. Kazhinji, chinoremedza mu vatambi vari nyanzvi, rinotarisa kutaridza kwetsandanyama, uye munhu asina kugamuchira steroids, inofanira kuva chiratidzo ngozi. Dzimwe nokuda yakawedzera nechityu anogona achigarira maoko mukaka.

Uyezve, varume pakupedzisira atrophy pamusoro bonde omumuviri, vasisina yechipiri pabonde vatambi, rinowanika kunyanya fragility mapfupa uye tsandanyama simba.

Diagnostics

Pituitary bundu (prolactinoma) kakawanda vakatsunga pashure neuroimaging kuongorora (rinobva resonance kuri). Uye ngaarege kutarira Panoramic bara, uye zvakamubaya kutsvaka pituitary zvokurwara uchishandisa musiyano mumiriri - gadolinium, tropic neuroendocrine tishu. MRI anogona kuona kukura uye nzvimbo yacho anomera.

Kana uwandu bundu duku, kusvikira mumwe sendimita, zvakakodzera kushandisa computed tomography, nokuti zvavataura. CT pachena zvinoonekwa pfupa marongerwo uye yavo ichichinja mukufamba kukura adenoma.

Asi kuwedzera paku nzira kuti inodiwa kuti zvakajeka kusimbisa chirwere uye kugadzirira kuvhiyiwa, kune mumarabhoritari chirwere nzira. Rokutanga kuona padanho prolactin muropa. The kuongorora yaifanira katatu, pamazuva siyana kumwedzi kutonga kunze dzenhema-akanaka kana nhema-nemigumisiro yakaipa anokonzerwa kushushikana kana vasiri nokufamba. Result kuratidza nanograms anopfuura 200 paminiti milliliter, anenge zana rimwe muzana inoratidza kuvapo bundu.

Kana prolactin yomuropa ranged kubva 40 kusvika 100 nanograms, zvingangoita kuti nhamba idzi zvinokonzerwa vasanyanye thyroid basa, muchipfuva kunotevera, kana renal dysfunction. Chokwadi, diagnoses aya uyewo havana zvinokurudzira.

The kupfuura kuratidzwa bvunzo thyrotropin. Pashure intravenous Kutarisirwa hafu yeawa ipapo yave ichiwedzera prolactin. kemikari wevasungwa uri kanenge kaviri Muongororo yekutanga. Kana varwere prolaktinome yakawanda prolactin muropa haachinji kana yakawedzera zvishoma. Kana kemikari pamwero zvemamiriro kuwedzera kushaya bundu, uye zvimwewo, nezvinoita kuti thyroliberine achava pedyo dzose.

Musakanganwa kubvunza chokuita nyanzvi uye mibvunzo kungwarira murwere. To fungira zvokurwara, dzimwe nguva zvakakwana mibvunzo zvakanaka.

mabatiro

Mabatirwo pituitary prolactinomas kazhinji mishonga. Therapies zvainanga kuderedza kwevari kemikari uye nemigumisiro yayo munoenzanisa. Selection mishonga yavo chipimo chemushonga zvaiitwa endocrinologist aita chete kutongwa mumarabhoritari nechirwere. At chiremba zvombo kune mishonga yakadai se "Bromkriptin", "L-dopa", "Cyproheptadine", "Cabergoline" uye vamwe. Varwere vakawanda anobatsira rokuti "bromocriptine". The nezvinozoitika kuoneka mukati shomanana. Asi ane zvakawanda nemishonga, saka zvakanaka nzira iri 'Cabergoline'. Uyezve, zviri nyore kushandisa (chete kaviri pavhiki).

The kurapa akaderedza bundu saizi, ari secretion kuti prolactin ikasawira shure kuipa chiratidzo, mira vhinza colostrum. In vakadzi zera rokubereka dzumbunuka kumwedzi, dzokubereka nerevane anomutswa. Varume regai kuva chena, achidzoka libido.

Kana, pashure refu mararamiro kuchinja kurapa, mamiriro ezvinhu haana kumbochinja nani, kana paiva kunaka kuitika, kuti neurosurgeon ane endocrinologist vari kufunga kuvhiya kupindira. Nokuti varwere contraindications kuti kuvhiyiwa, pane imwe nzira - radiotherapy. Asi ane zvainovhiringidzawo: kusimukira pituitary insufficiency, uye vanoda hwose yokutsiva mishonga.

Diet nokuti prolaktinome pituitary zvainanga yokuderedza yokufutisa, yakabuda pamusoro pakanyorwa hormone kukundikana. Endocrinologist kana yezvokudya kunogona kubatsira kuva kudya urongwa kuti ichange iine zvose zvakafanira macro- uye microelements, uyewo kuva mukuru kugutsikana calcium phosphorus zvaidikanwa kudzivirira osteoporosis. zvokudya zvakakodzera, unogona kunamatira uye pashure chirwere achakundwa.

Mabatirwo pituitary prolactinoma acho mishonga haisi aikosheswa zvikuru nyanzvi sezvo infusions uye decoctions musamutsa zvinozoita, asi panguva imwe chete tunodzivisa kushanda thyroid uye adrenal mumasero. Izvi zvinogona kukanganisa murwere ezvinhu utano, uyewo uprofita pamusoro pakupora. Kana uchida zvikuru rokupisa pachangu mbuya vake Recipes, musakanganwa chiremba.

Kufembera uye kudzivirira

Ndinogona pakurwara kubva pituitary shwanu prolactinoma? Migumisiro kunyanya Kugadzirwa mahormone pamuviri vari vakadaro, kuti kunyange kana bundu yaenda, vanhu vachange vachiri refu kuti apore vakarasika mabasa. Uyezve, vanachiremba regai kupa chero Zvaifungidzirwa pamusoro pakupora mwero uye kurapwa kubudirira.

Kuitazve rinowanikwa munenge hafu varwere uye pashure pokuvhiyiwa nhamba kunyange kudzika - muzana matatu chete kurapa.

Icho mutongo zvokuongorora "prolactinoma pituitary?" Zvaifungidzirwa ipai nesimba. Kunokwanisa kutora makore uye kwete kupa chero mhinduro. Ose vaviri makore, vanachiremba vari zano kutora kumbozorora pakati yamabwe kurapwa zvokusimbisa itsvo uye chiropa. Asi panguva imwe chete, nokubviswa zvinodhaka kungaita malignancy uye bundu kukura.

Varwere kumisa fanira kuongororwa nachiremba kumusoro. Gore negore vane kuita kombiyuta kana rinobva resonance kuri uropi, bvunza munhu ophthalmologist, gayinakorojisiti uye endocrinologist, uye kuti kuedzwa kuti padanho prolactin. kwazvo Kuongorora kwakadaro, kuenzanisa maitiro pamusoro nguva, uye nenguva kugadziridzwa kurapa zvinoita kuti zvimwe zvekungofungira pamusoro kuzoita varwere.