Purotoni pombi FIs: mazita nezvinodhaka, mashandiro basa, wongororo

Kubva matambudziko zvomudumbu, chirungurira uye gastritis anotambura vanopfuura 90% yevanhu, asi vanhu vashoma vanoziva kuti zvinodhaka zvakagadzirirwa kuderedza mamiriro, uye yagara zvikuru kushandiswa ikoko okurapa muzviitiko apo antacids regai kubatsira. Ngationgororei zvinhu hwepurotoni pombi inhibitor, mazita zvigadzirwa kuchaitawo funga.

Ndokupi womunhu anouya kubva pombi?

Purotoni pombi, hunonziwo Purotoni pombi - ichi enzayemu mapuroteni inosimudzira kugadzirwa hydrochloric asidhi mudumbu. Uyu inodiwa uye nhano inokosha nedanho kugaya. Zvisinei, kazhinji zvinoitika kuti asidhi anotanga kubudiswa zvizhinji huru, iyo rinobatanidza risingafadzi kana kurwadza manzwiro mudumbu.

zvairatidza

A hwepurotoni pombi inhibitor (zvinodhaka mazita kucharatidzwa pazasi) rinoshandiswa kazhinji.

FIs, blockers kana hwepurotoni pombi - zvinodhaka inotumirwa izvo kurapwa kwezvirwere ari nemudumbu chokuita yakawedzera acidity:

- gastritis, kusanganisira erosive;

- nemaronda mudumbu uye duodenum;

- duodenitis - duodenal mucosa kuzvimba;

- Gerd - reflux chirwere, umo mudumbu zviri kugara kukandwa akakwidzwa yegurokuro, ndokusaka pamusoro nguva zvinoputsa ari mucosa pakati yegurokuro, trachea uye pharynx;

- dyspepsia - nomudumbu muitiro umo pane kutekenyedzwa kubaya / achicheka epigastric marwadzo (rezuva plexus nharaunda) pashure ingestion;

- Migumisiro vasiri steroidal Anti-anogumbura mishonga (yakadai se "Diclofenac") kutsvinyira gastro-intestinal turakiti;

- Zollinger-Ellison Syndrome - gastrinoma - akaipa bundu, zvichikonzera zvakawedzera secretion pamusoro hydrochloric acid.

Muzviitiko zvose izvi zvinoratidzwa kugamuchira hwepurotoni pombi FIs.

mashandiro chiito

Mahwendefa kana capsules IPP anwa zvokuvataurira nomuromo, mudutu ura diki uye akatakura neropa kuburikidza chiropa kupinda secretory canaliculi, apo vanotanga kuunganidza. Nokuda matambudziko zvakananga pamusoro tubules, izvo zvibereko hydrochloric iine acid secretion FIs kuderedza ayo akagamuchirawo zvinoderedza kuti utsinye kuti gastric muto.

A hwepurotoni pombi inhibitor (zvinodhaka mazita anowanikwa chero chemishonga) riri basa chiremba.

The mashandiro zvinodhaka zvose izvi mhando ndiyo chete, asi siyana wevasungwa ose basa venhumbi anoramba ari ph uye matambudziko nokukurumidza. Kusarudza chiremba wavo anogona chete pashure kuyerwa acidity, zviri akaita masikati. Uyezve dzakakodzera mushonga iri basa, uye ayo waivako kuongororwa. Kana kusunungurwa haauyi, asi zvinokwanisika kune kurapika uyu mutsa, zvakakodzera kutsvaka yokutsiva.

In mashoko ph vanotungamirirwa mamiriro ari acidity ari nemudumbu. Total anokwana zviyero 14, mvura kwazvakarerekera, riri pakati asidhi-nechigadziko mwero uye ane ph pakati 7. Panguva yepazasi divi mvura acidic dzatinoshandira rokumusoro - alkaline.

For-siyana zvirwere chokuita zvakawedzera kugadzirwa hydrochloric acid, dzinoratidzwa yakasiyana ph ukoshi mitemo. Somuenzaniso, duodenal urikanwi vanokwanisa vanga ari ph kupfuura 3 masikati, uye kuuraya utachiona Helicobacter pylori, zvakakodzera zvakaneta iine acid svikiro chine ph mukuru 5.

Maererano chakaipa ph uye nechirwere, chiremba prescribes imwe mushonga kubva boka hwepurotoni pombi blockers mune zvimwe chipimo chemushonga kuti imwe nguva.

Duration pamusoro

Yawapiwa agare inoverengeka kana kunyange kwemakore. Somuenzaniso, mumwe mushonga, "Rabeprazole" mutungamiriri uye rinotsanangura ya mabiko. Purotoni pombi FIs vakachengeteka nokuti muviri, nokuti unoshanda munharaunda uye havasi muropa, zvinokwanisika kuti Musatya vanonzi "kushaya chirwere" mushure kosi. Izvi mhando zvinodhaka regai zvinovhunga chirwere, uye chose anoporesa.

Zvino zviri pachena kuti vakadaro hwepurotoni pombi inhibitor. The pamazita zvinodhaka kukuru kwazvo.

Group hwepurotoni pombi blockers

"Omeprazole" ndiwo rinozivikanwa zvinodhaka. Sale ndiko:

- "Omeprazole Acre."

- "Omeprazole-Richter" - simba kupfuura shanduro.

- "Sandoz Omeprazole". Combined turusi rinoshandiswa zvikuru kugadzirisa kugadzirwa hydrochloric acid, uye nemudumbu.

Kwenguva yakareba zvave kuzivikanwa kuti "Omeprazole" - hwepurotoni pombi inhibitor, asi nhasi nayo Zvinosarudzwa kuti ndipe zvishoma, nokuti chizvarwa chitsva mishonga yakasiyana nani zvose kubudirira uye marwadzo.

It akabvumira kusuma kwete nomuromo chete asi nomutsinga, izvo zvinoita kuti kukurumidza mugumisiro. Dzokororo chirwere kwaicherechedzwa mumakore 10 arambe wevarwere.

"Pantoprazole"

Mumwe pasuru inowanikwa kune zvinodhaka "Pantoprazole" mirayiridzo Chinyorwa. Mutengo zvinodhaka ndiko avhareji 130 rubles.

"Pantoprazole" nokungwarira kukuru, asi ari nachiremba 2 uye 3 trimesters pamuviri kana kubatsira kungaita Vanzveri kure kupfuura njodzi kumwana. Miedzo vakadzi vane pamuviri vasina kuitwa, asi mhuka Migumisiro pamusoro mudumbu kunge vakaudza.

Asati nokushandisa "omeprazole" uye "Pantoprazole" vanofanira kunyatsoongorora kuverenga rakakura mazita zvinodhaka-zvinodhaka mukukurukurirana uye bvunza chiremba kana negashiro upi kurapwa pachikwata iri kurongwa pachiimbwa nemimwe mishonga. Analogue - "Nolpaza".

Sei taurira mushonga uyu? Izvi zvakare hwepurotoni pombi inhibitor. Anouya maviri siyana - mahwendefa uye ndiro kuti jekiseni. Asi chaizvoizvo ampoules - a lyophilisate iro yakagadzirirwa mhinduro kuti jekiseni. Kakawanda nachiremba peptic urikanwi chirwere, asi rave kushandiswa zvinobudirira dzimwe hosha nemudumbu.

Nokuda mushonga, gastric muto rinobudiswa kuti muduku kumwero, zvikuru mucous hakusi ashatirwa. Kana pane maronda uye erosions, zvishoma nezvishoma zarubtsovyvayutsya. With kwazvo basa iri "Nolpaza". Sei taurira munhu mushonga, zvakava pachena. Analogs - "Lanzap", "Lansofed", "Loenzar-sanovel", "Epicure", "Akrilanz" etc. Boundedly zvaishandiswa pakurapa vakadzi vane pamuviri uye vana, kushandisa chisingadiwi kana zvimwe zvinodhaka anogona kusarudza ..

"Rabeprazole" - mumwe mushonga kubva boka hwepurotoni pombi blockers.

By zvinodhaka "Rabeprazole" mirayiridzo kunoratidza kuti kuchipesana mura antacids. Akanatsiridzwa chiito panguva iyoyowo akatora "warfarin", "diazepam" "theophylline" uye "Phenytoin". Analogs - "Zvinoda", "Zolispan", "Noflyuks" "Pariet", "Rabelok", "Hayrabezol" and said.

"Lansoprazole" - ane mushonga zvakabatsirawo zvirwere nemudumbu. Unobereka ichivharira kugadzirwa gastric muto. Izvi zvinosimbisa kuti mushonga "Lansoprazole" mirayiridzo. Mukuwedzera, mushonga ari kunetseka utachiona Helicobacter pylori. Dzinenge antibodies kwairi dzinokudziridzwa kuzviita nokuda Zvakaitwa zvinodhaka. Maximum kumhanya mazuva gadziriro pamwe kutanga nokugamuchirwa wokutanga shoma. Analogs -. "Emanera", "Nexium", "Losek", "Sanpraz", etc. Vamwe mishonga akatorwa Panguva ne "Lansoprazole" anogona kuwedzera ayo yeplasma wevasungwa uye kuwedzera sei. Izvi "Imipramine", "clomipramine" "Citalopram". "Diazepam" uye "Phenytoin" kuwedzera kugutsikana zvishoma, uye "ketoconazole", "Itraconazole" uye "clarithromycin" anogona kuderedza kubudirira mishonga. Rinotsanangura "Lansoprazole" mirayiridzo Chinyorwa.

"Esomeprazole" - mushonga wakanaka nemaronda mudumbu uye duodenal maronda. Rinogona kushandiswa pachiimbwa nemishonga. Yainokurukura nezvirwere exacerbation kuyaruka uye rinoshandiswa kudzivirira. Kuchititadzisa kuwandisa Helicobacter pylori. Kugadzirira "esomeprazole" (capsules uye mhinduro kuti jekiseni) inoshandiswa mwedzi ari dose 40 MG pazuva. Nokuti kudzivirirwa kubva dose zvinogona vagovane.

matanho okudzivirira

Kurapwa blockers, hwepurotoni pombi kenza zvingaratidza kuva Just kuoneka, saka vasati vatanga kurapa anofanira akadzitira kudzivisa chidzoke anomera. Uyezve, nokukurumidza tsvakurudzo kunodiwa pamwe kakawanda kurutsa, kunyanya neropa chirwere cheya, kuchinja ayo ruvara uye kunhuwidza, uyewo unopinza uremu. Saka, kungwarira zvinofanira kugamuchirwa "rabeprazole yavaibvisa."

Ichi boka zvinodhaka, maererano zvichangobva kudzidzwa, inowedzera fragility mapfupa ukuwo, uye ngozi nokutyora, uyewo wakatsamwiswa akabatanidza manyoka (kureva, anokonzerwa yaunodya nedzimwe mishonga), hypomagnesemia, nekuratidzwa dementia mune vakwegura.

Nokuda kwechikonzero ichi, chiremba anofanira kutanga kupa yakadereresa zvinoita chipimo chemushonga kana zvichida pfupi nzira kugamuchirwa uye murinde mugumisiro.

Kushandiswa mushonga

Purotoni pombi FIs (zvinodhaka ari chizvarwa chitsva) zvinoshandiswa mishonga yezvirwere anokonzerwa utachiona Helicobacter pylori, izvo zvose zvinogona kukonzera zvinetso nemudumbu, uye kutsamwisa zvazvo kunge zvinoita anoporeswa zvirwere. Muchiitiko chino, mishonga vari kuwedzera kurapwa, kunyanya tetracycline.

Iri boka simba nemishonga, saka chero zvazvingava hazvibviri akavaisa oga.

nemishonga

Kungofanana mishonga ipi, vane blockers, hwepurotoni pombi pane vakawanda zvingakonzerwa nemishonga:

• kuwedzera Kurara - saka ichi mhando zvinodhaka hazvibvumidzwe kugamuchira vanhu vane basa zvinoda kutarisirwa uye kumhanya kuita, zvakadai vatyairi;

• nomusoro, richisvika kutemwa nemusoro - protivomigrenoznye mari havabvumirwi kugamuchira panguva imwe chete chete PPI, asi chiremba kubvunza ndiko kwakanaka;

• dzungu kana simba;

• marwadzo ari makumbo, musana, majoini;

• fufune - manyoka kana kupatira, kuda kurutsa,

• kuchinja manakiro;

• muromo yakaoma;

• neutachiona - urticaria, kuvaviwa;

• kuderera paumbwe masero eropa - ropa masero machena uye maplatelet;

• wakawedzera vangadikitira, chills.

Muzviitiko izvi hazvo kuziviswa kupinda chiremba, uyo, kazhinji ibasa mumwe akakodzera zvinodhaka IPP.

Zvinofanira kurangarirwa kuti divi Marwadzo mashoma uye kazhinji vanyoro zvakakwana mune zvose, naizvozvo, pasi pokudzora chiremba pamwezve rinowanzova ingangodaro.

Kana akashandisa hwepurotoni pombi FIs (chizvarwa chitsva zvinodhaka), kurutivi migumisiro hadziwanzowaniki.

Contraindications

General contraindications vose hwepurotoni pombi FIs ndiwo:

- Nguva lactation uye pamuviri, kunyanya 1 trimester, kushandisa dzimwe zvinodhaka mune boka iri muna 2 uye 3 trimesters optionally chiremba mvumo. mishonga ava zvikuru bioavailable, kuti anokwanisa kupinda kuburikidza munyama, kusanganisira placenta uye kuunganidza mu mukaka. Kunyange pasina akasimbisa mashoko nezvengozi mari idzi kuti mudumbu, hapana inofambiswa kunze kuedza nemhuka.

- Children pasi makore 12, kubva pabasa kwemakemikari anobudiswa mumasero riri pasi kukura uye maumbirwo, saka chero chipingaidzo kunogona kukonzera atadze kushanda zvakanaka.

- sema kana hypersensitivity kuti zvinodhaka.

Somuenzaniso, inorondedzera zvose kune zvinodhaka "Pantoprazole" mirayiridzo Chinyorwa.

mutengo

Prices blockers zvinodhaka hwepurotoni pombi dzinosiyana, asi ivo vari nyore. Paavhareji, mari ndiyo 90 rubles. kurongedza "Omeprazole" kusvika 500 rubles. kurongedza mamwe chizvarwa chitsva zvigadzirwa.

The mutengo inobvawo pane nhamba capsules / mahwendefa pasuru uye nyika mavambo. Somuenzaniso, generics Russian inogona kutengwa 20-100 rubles, asi zvinofanira kunzwisiswa kuti zvinodhaka Generic -. Haisi nzira yepakutanga. Dzinowanzoitwa zvishoma inobudirira uye zvishoma kushivirira, kazhinji kuona divi anokonzerwa.

Reviews

Kugadzirira veboka iri dzinowanzotsigi- kukonzerwa nyaya dzinovaka. Ndivo here kubudirira zvirwere nemudumbu. Mari zvinogamuchirika kwazvo.

Kune Chokwadi, vamwe nemishonga, akadai manyoka. Asi ivo rwakavapo zvisingawanzoitiki nguva asi kana iwe sarudza zvakanaka chipimo chemushonga, havazovi zvachose.

mhedziso

Purotoni pombi FIs vari kuramba vari nani. Izvi zvaisanganisira masayendisiti kubva kunyika dzakasiyana munyika. zvinodhaka "Dekslansoprazol" akasunungurwa anenge 6 apfuura. Zvichigere kubvumirwa kushandiswa pasina kumanikana, asi gastroesophageal reflux chirwere achibatsirwa kubatwa zvikuru kubudirira.

Parizvino muJapan yakatanga "tenatoprazole," riri papi sezvo inonyatsobudirira blocker kuti hwepurotoni pombi.

Korean "Ilaprazol" unoshanda unotedza zvikuru uye dzichimhanya "omeprazole" Zvisinei kuRussia, US uye EU nayo chinorambidzwa kushandisa kuti asingazivikanwi zvikonzero.

Kugadzirira veboka iri vanotorwa kakawanda 1-2 kanomwe pazuva, izvo zvinoita kwavo kushandiswa zviri nyore. Asi vanofanira kugadza chiremba pashure anamnesis uye kuongorora, nokuti mumwe mushonga zvivako zvayo, uye munhu wose ane zvechadenga chirwere chavo. Takurukura zvakadzama Purotoni pombi FIs. The mashandiro chiito hunorondedzerwawo.