The mushonga "Amiodarone": analogues, mirayiridzo, wongororo

Heart, sezvamunoziva, muviri wedu mukuru, asi kazhinji rotsva. Kuti kudzorera zvarakanga inoshanda kushandisa dzakasiyana-siyana zvinodhaka. Mumwe wavo ari "Amiodarone". Analogs vari zvikuru anodhura, sezvo anobudiswa kunze uye havasi inoshanda nguva dzose.

The Kuronga zvinodhaka uye chimiro

The medicament "Amiodarone", iro akaongororazve siyana unotora mune imwe pahwendefa 200 MG ose vanoshingaira chirungiso - amiodarone hydrochloride. Kugadzirira anoitwa mamwe sezvo kugadzirisa, apo 3 Rine mamiririta ndiyo 5% kubva vanoshingaira chirungiso.

Ebetsero zvinoriumba anoumbwa rimwe piritsi vari: mbatatisi starch, crystalline microcellulose, lactose, maltodextrin, primelloza, polyvinylpyrrolidone, magnesium stearate.

Mahwendefa akafukidzwa kuri pachimedu vachena ruvara ane zvishoma, anokunyengedzera ruomba mimvuri. Vane chimiro Valium uye chinhu uye Valium. Naizvozvo, kana zvichikodzera, vanogona kuonekwa huviri zvakaenzana zvikamu.

Drug kutengeswa mumabhokisi makadhibhokisi, apo mumwe kana vaviri Maronda akasiyana vane mahwendefa gumi. The mushonga iri kubudiswa muna girazi, polymeric uye mapurasitiki mabhotoro, vane mahwendefa 30 kana 100.

The pharmacological mashandiro zvinodhaka chiito

Antiarrhythmic uye antianginal zvivako vanoonekwa ne "Amiodarone" analogues mune zvimwe zviitiko zvinogona kutsiva naye. Its Anti-arrhythmic richifanira inobva rutapudzo kwazvino potassium ions kana pasi Kamudzira masero - cardiomyocytes. It rinoita rutapudzo ari sinus raiva pedyo nebundu iyo inowanikwa bradycardia.

Kushandisa zvinodhaka "Amiodarone" (mapiritsi) anogona kuwedzera urefu refractory cardiac conduction mashandiro. Kunoita kuti kurwadziwa kuve conductivity kuti yechipiri makwara vari varwere zvikuru urwere pakati Wolff-Parkinson-White syndrome. Uyewo antianginal zvinodhaka kwepasi inovakwa pamusoro yokuderedza myocardial okisijeni zvinodyiwa uye kuderedza nezvainoita wayo arterial netsandanyama. Rinoumbwa ayodhini, riri kushandiswa quantitative anochinja zviri thyroid kemikari, zvichiguma mwero kukanganisa kwavo myocardium ipfupi.

"Amiodarone" ane tinofanira kugara zvazviri, uye raidudzwa sei chikumbiro chacho kunoitika chete pashure vhiki rimwe kushandiswa kwezvinodhaka dzose, uye kufadza zvasvika pashure maviri-nhatu.

Inside raisangoita vanenge 40% yokunwa munhu dose, Cmax yeplasma sokuti pashure maawa 3-7. Kuvhiringidzwa anokwanisa zvikaramba kwevhiki dzinoverengeka. metabolic pezvakaitwa kuitika kunyanya chitaka, apo kushingaira maatomu akafanana aumbwa dezetilamiodaron, inova huru metabolite. Dzokerai secreted bile uye weti, T1 / 2 - pashure chete dose zvinodhaka 3,2-20,7 H, pamwe kwenguva refu kurapa - pashure 53 ± 24 maawa.

Medicine "Amiodarone": zvairatidza yokushandisa

Taurira mushonga nokuda kudzivirirwa uye mabatiro arrhythmias, izvo zvinogona nechirwere pangozi upenyu hwevanhu, uyewo ventricular arrhythmias, ventricular flutter mune kusagadzikana emuchina rinoshandiswawo zvinodhaka "Amiodarone."

Zvairatidza kubvumira kushandisa mushonga chete:

• atrial flutter;
• supraventricular arrhythmias;
• Wolff-Parkinson-White urwere;
• panowanikwa tachycardia;
• fibrillyatsionnogo vanokwanisa ventricles;
• arrhythmia anomuka nokuda cardiac uye coronary insufficiency;
• chisingaperi siyana nechirwere chemwoyo;
• myocardial infarction.

"Amiodarone": mirayiridzo kushandiswa

Mahwendefa kurehwa kuti mukanwa yaitonga pashure maminitsi 15 pashure zvokudya.

Munguva ventricular chipimo chemushonga fibrillation chirwere ndakarumbidzwa chiremba, ndizvo 800-1200 MG pazuva. Zvinofanira kukamurwa 3-4 yemichato. The kunorapwa iyi kunotora anenge 5-10 mazuva kuitira yakatsiga ezvinhu omurwere inogona kuwedzerwa, uye mwero inogona akatura kuna 600-800 MG pazuva. Ichi ndichibvunza kurapwa, vakazochinja mberi chokudzivirira, yakaderera dose zvinodhaka tigutsikane.

Kuchirapa Nokuraramisa kumwedzi mazuva 7-14, munguva ino zvinodhaka kutora 200-400 MG. Kwakadaro mushonga vhoriyamu basa kudzikamisa murwere ezvinhu mune poslereabilitatsionny munguva.

Kazhinji mushonga "Amiodarone" ushandiswe kana murwere ari muchipatara, uye unyanzvi hwake anogona kudzora chiremba. Izvi zvinoita kurerutsa nemishonga uye mumwe nomumwe kuchinja dose zvinodhaka.

Kana medicament chirwere angina kushandisa kaviri pazuva pa 200 MG. Pashure pevhiki mbiri, chipimo chemushonga wacho wakaderedzwa kusvika kamwe pazuva. Kufadza kuroorwa dose dose haafaniri kupfuudza 400 MG uye chamazuva - 1200 MG.

Pakugadza zvinodhaka izvi kuvana zvinofanira kurangarirwa kuti piritsi kukanganisa mwana nokukurumidza zvikuru pane mukuru. Naizvozvo, kuti dose rinowanikwa inobva kurema mwana. Saka, mumwe kilogram kurema ruchawa 10 MG ose medicament. dose ichi anofanira kuchengetedzwa yose kuchirapa mumazuva gumi kana kusvikira murwere ezvinhu akavandudzika. Hereinafter, Specification ichi kuderedza nhamba 5 MG por kilogram muviri kurema mwana. Okudzivirira Nokuraramisa dose rakundwa uye kunobva imwe kilogram pamusoro 2.4 MG zvinodhaka "Amiodarone."

Zvairatidza kuti mushonga waakaudzwa kushandisa mhinduro kunobva tichishingaira wemafuta amiodarone hydrochloride mu chakasimba cardiac arrhythmias. Panyaya iyi, kuti mushonga chinotarisirwa nomutsinga, zvishoma nezvishoma jekiseni kupinda muviri ane dropper. Kuti aite izvi, 250 ml 5% shuga mhinduro kuti 1 kana 2 rakatora jekiseni zvinodhaka dose 5 MG paminiti uremu kilogram muviri. Panguva ino, murwere kuongororwa pachishandiswa ECG uye BP chipimo kuverengwa.

nemishonga

Saka vazhinji mushonga zvinodhaka "Amidaron" munyika yedu. Analogs havagoni vomutsiva nguva dzose. Asi pasinei zvakanaka zvinokonzerwa mushonga uri muviri womunhu, vave kuzivikanwa uye marwadzo.

Negative zviratidzo zviri kunyanya nokuda zvinodhaka ovhadhozi. kutyora iyi kumwoyo, akadai bradycardia, sinus raiva pedyo nebundu basa kukundikana, mwoyo chidhina, kurasikirwa Kufambisa kufamba. Uyewo ari chikamu kufema hurongwa wakaonekwa diffuse interstitial pulmonary fibrosis, interstitial mabayo, Hamm chirwere - Rich, muchipfuva marwadzo, pulmonary fibrosis, tachypnea, bronchopulmonary kurwadza kwacho. Hepatic kukundikana yaiitwa kana kugamuchira "Amidaron" gadziriro. Mahwendefa zvisingawanzoitiki nyaya vanokonzera jaundice, hepatitis, cirrhosis dzimwe nguva.

Kutadza kutevedza chipimo chemushonga kunogona kukonzera kuchikosha kusaenzana kwezvinhu thyroid hormone, distireoza uye hypothyroidism, uye iine mamwe kilos. Ovhadhozi kungaita kuti nokuvhiringidzirwa ari kutarisana midziyo, achiita kuunganidza lipids ari cornea kuti mboni. Uyewo, pane raidudzwa pigmentation ganda, photosensitivity, urticaria kana erythema. rashes Minor yakaonekwa chiso, alopecia, dermatitis. Side migumisiro uyewo zvakakanganisa okubereka basa nevanhu. Muzviitiko izvi pane orchitis, kusabetsera, uye epididymitis. Zvisinganyanyi kuitika thrombocytopenia, renal kukundikana, kana angioedema vasculitis.

Contraindications pakushandisa

"Amiodarone" (inofambiswa haana akanaka nguva dzose) anosarudzwa zvachose nomumwe. Kune vanhu kuti zvinodhaka izvi hazvina kubatsira kana havana vakaona zvachose havashanduki utano mamiriro, vamwe vakatanga kuvhunga iwe pashure torishandisa, akanzwa mwoyo palpitations. Mumashoko avo, Propafenone zviri kukwanisa kuvhiringidza kwemakemikari anobudiswa hurongwa mahormone vawedzere. Saka, asati kutora ichi somushonga chigadzirwa havafaniri chete kunyatsoongorora kuverenga rairo, asi kuteerera zvairatidza, nemishonga uye contraindications.

Saka, mushonga haafaniri kuiswa kana paine atrioventricular chinogumbura giredhi 2-3, iri cardiogenic nehana, hyperthyroidism. Kugadzirira "Amiodarone" harishandiswi kwaro yakakwirira aikanganiswa yezviri mumiririri uye iodo. Ban vari zvakakomba kutyorwa cardiac conduction uye Zvikamu zviri bradycardia pamwe syncope. Havashandisi zvinodhaka panguva yepamuviri uye lactation. Lactation, panguva kurapika ngaanyarare achiyamwa.

chaizvo kurumbidza

Inofanira nokungwarira raitarisirwa chiremba yokurapwa zvinodhaka "Amiodarone". Mirayiridzo dzokushandisa anokurudzira kushandisa mapiritsi mushure X-ray kudzidza chiropa, mapapu uye unonzi, electrocardiograph. kuongorora kwakadaro kunofanira kuitwa ramangwana, kana murwere inoramba kutora mushonga.

Kwokuomerwa yaivhuvhuta zviitiko kazhinji kunobva dose, iyo inoshandisa murwere. Vanofanira kuedza kushandisa zvinodhaka sezvo Kazhinji sezvinobvira uye usingashandi akawanda. Kunowanzokonzera mugari kwemwoyo kukanzura "Amiodarone" chinodhaka.

Mirayiridzo dzokushandisa - wongororo vanoti, pasinei nemishonga, mushonga uyu akatiponesa vanopfuura mumwe upenyu - inoti pharmacological zviito zvinodhaka anodzokororwa kwemamwe mavhiki maviri pashure ayo kukanzura.

Mahwendefa ane ayodhini, izvo zvinoita kuti ikwanise kuwanika pamwero wenyika radioiodine ari thyroid shwanu. Saka, pakutanga pamusoro yokurapwa, panguva uye pakupera unofanira kugara kuongororwa kuti uwandu thyroid mahormone.

Munguva kuchirapa kupindira zvinokosha kuti vasangoramba zuva dzokupisa, hazvina zvakakodzera kutora rakavhurika zuva. The mushonga anofanira kuzviita nokungwaririra kuvanhu vakwegura vakawanda yokutindivadza kana paaiita yakachena kurapwa. Nokungwarira zvinofanira kushandisa vatyairi motokari uye vanhu vane basa rine chokuita imwe pfungwa.

Muzviitiko ovhadhozi vanogona kuwedzera pamusoro nemishonga, uyewo hypotension, arrhythmia. Zvingaitika bradycardia kana kukundikana AV conduction. An overabundance kungatungamirira chiropa dysfunction.

Muchiitiko chino, tinoratidza nokukurumidza gastric lavage, zvenhoroondo neactivated charcoal, sesaline laxatives inokurudzirwa mhinduro. Kana bradycardia majekiseni atropine, vakashandisa agonists ose Beta-adrenergic receptors, yakabereka pacing.

Ukama nedzimwe mishonga

Zvokungwarira zvinofanira kushandiswa kwezvinodhaka panguva imwe chete nezvimwe zvinodhaka, kunyanya kana vari kubva chete boka antiarrhythmic. Hazvina zvakafanira chokubatanidza pamwe mabiko "erythromycin", "pentamidine" uye "vincamine." Pane njodzi polymorphic ventricular tachycardia akabatana "sultopride". Hazvina varumbidzwa chokubatanidza yaunodya CCB uye Beta-blockers ne "Amphotericin B" uye mishonga kunokonzera laxative chaizvoizvo diuretic. With kutarisira kushandisa mishonga akabatana corticosteroids, antidepressants, "Astemizole", "terfenadine." Kukwanisa yekudyidzana kuwedzera zvinokonzerwa mishonga yakadai se "Warfarin", "Phenytoin" "Tacrolimus" kana "Digoxin". Parinoshandiswa pachiimbwa "cimetidine" DZEMUNHU DZINODZORA chirongwa muviri mumuviri.

Upenyu uye chengetedzo mitemo

The medicament "Amiodarone", ane chimwe chinotungamirwa pamusoro kubviswa tachycardia, ventricular fibrillation, tachyarrhythmia uye atrial flutter rutapudzo, anoreva kugadzirira category "B" boka. Pasherufu-upenyu zvinodhaka idukusa makore matatu. Mahwendefa zvinofanira kuchengetwa nenzira inotonhorera, nerima uye pasigasvikirwi vana.

kushandiswa "Amiodarone" chinodhaka anofanira kunyatsoteerera kudzorwa. The resipi kurishandisa anonyora mumwe chiremba. Panyaya iyi, vaizviona inofanira kunze zvachose.

Analogs medicament

Kana iwe pakarepo haana kukodzera kuti zvinodhaka "Amiodarone" analogs anogona kuwanikwa chero chemishonga. Pakati pavo vane mishonga yakadai: "Amiodarone Belupo" uye "Amiodarone Aldaron", "Angoron" uye "Atlans" uye atsive nezvinoitika mishonga aigona "Kordaron" kana "Kordinil". Zvakafanana "Amiodarone" iri acho ari mumuviri womunhu "Medakoron" uye "Palpitin". Mune zvimwe zviitiko, mushonga kuchatsiviwa "Sedakoronom" uye "Sandoz".

zvinodhaka izvi kana ane imwe vanoshingaira fuma kana zvakafanana kwavo antiarrhythmic mugumisiro mushonga "Amiodarone". Analogues kazhinji anogadzirwa kwose uye kakawanda anodhura.

Testimonials

Varwere vakawanda vanoti Kudzikamiswa yavo ezvinhu pashure kutora mushonga, "Amiodarone". Mirayiridzo dzokushandisa - kazhinji zvinodhaka analogs vanosarudzwa kwakavakirwa nomumwe zvechadenga muviri - anopikira normalize mwoyo zvazvingava, kumanikidza. Kana inoratidza kugamuchira mune mishonga diki, kazhinji hapana dambudziko, uye zvinodhaka mabasa zvinobudirira.

Pashure kushandiswa kwenguva yakareba zvinodhaka mune vamwe varwere akaonekwa kupfupika mweya, mwoyo palpitations, kutya uye kuora mwoyo, chinja kwemanzwiro ikawanda thyroid kemikari, kukanganisika ari nemudumbu, uye mune zvimwe zviitiko, kuda kurutsa uye kurutsa.

vanhu vazhinji vanoshandisa nayo pakurapa angina, uye cherechedza kuti hapana kupfuura kupinza dzomuzana. Vamwe varume vanotya kutora mushonga, nokuti maari, anokwanisa kukonzera zvinoverengeka kenza. Zvinonzi vaidavira kuti mushonga zvinofanira kutorwa chete pasi ezvinhu angavatsugudusa upenyu hwevanhu, mune mamwe mamiriro ezvinhu zvose, anofanira kutsvaka imwe nzira. Mukuwedzera, hwendefa kunogona kukanganisa makono dzokubereka basa, riri kuti paChidzidzo mutambo wavo.

Asi nokuti vazhinji zvinodhaka "Amiodarone" waiva mushonga, nemhaka iyo hosha yaserera, asi munhu wakasara. Kwete kuti analogues Zvaizovawo vanobudirira. Saka, muna mabatiro chemwoyo, regai kunodudzwa mushonga kure, kunyanya kana chiremba hwarinokurudzira.