The mushonga "Celebrex": wongororo, analogs, mirayiridzo kushandiswa, mutengo

The kukundwa vari nomuzongoza, kurwadziwa ari mapfundo connective zvinyama shanduko Unoshanda pamusoro pakanyorwa kuzvimba - zvinosuruvarisa zvirwere izvi zvaiva rakajairika munguva yedu. On mamiriro ezvinhu aya kunokanganisa mararamiro, kushaya zvakajairika kurovedza muviri, masero okutodza. Kuwedzera marwadzo zvikuru kuti vanhu vatambure ichi, chirwere anokwanisa kuparadza muviri wose, rinochinja ropa kemisitiri uye kukanganisa chakaipa nokushanda kwenhengo nhengo dzomukati.

Saka zvinokosha kuti kuongorora utano uye nguva kurapa chirwere. Mumwe inonyatsobudirira zvinodhaka, raiva boka asiri steroidal zvinodhaka anonzi medicament "Celebrex". Reviews vanachiremba asimbise kushanda kwayo tichienzanisa imwe yokufunga Anti-anogumbura zvinodhaka.

The chikuru mugumisiro mushonga

An mukana zvinodhaka anganzi kugona rayo tunodzivisa kushoma basa panguva yakasiyana zvokukura chirwere. Kamwe muropa, mushonga anokwanisa tunodzivisa TSOG2 muitiro inotungamirira Mufananidzo kuzvimba. "Celebrex" The mushonga ane simba unonyaradza marwadzo pfuma antipyretic basa. Saka, hazvina chete anobvisa chokutsva foci, asiwo zvakakwana inobvisa kunyange marwadzo makuru, zvinoderedza fivha.

Zvakanakira chigadzirwa ichi zvinosanganisira kwayo zvishoma zvainoita maplatelet, ndiwo mushonga haakonzeri matambudziko neropa pakugwamba. Kana ukapiwa asiri steroidal mumiririri kuti hapana kutsamwa mudumbu uye ura, akaderedza mukana nemaronda uye gastritis varwere.

Saka, kuti "Celebrex" mapiritsi anoshandiswa zvakawanda chaizvo kupfuura vamwe NSAID zvinodhaka, "naproxen", "asipurini", "ibuprofen".

achitaura

"Celebrex" capsules anokwanisa kuderedza kwokuomerwa kurwadza kwemajoini, kuomarara kuvabvisa kutsungirira kwazvo kuzvimba. Kushamwaridzana kwakadaro zvinogoneka kurapa varwere nechirwere dzinonzi rheumatoid arthritis, osteoarthritis. Zvazvakaita zvinodhaka zvasvika kunonyanyisa mugumisiro yakanga maawa 24-48 mushure yokutanga dose. Dysmenorrhea mushonga zvinobudirira hakubvisi marwadzo, kunyange chakasimba. Uyewo, zviri kushandiswa zvinobudirira nokuti kuzorora kurwadziwa pashure kuvhiya (maxillo-chiso uye vachibatsira kuvhiyiwa).

Varwere ankylosing spondylitis zvinodhaka "Celebrex" haambotauri kuti pathological pezvakaitwa uye anovandudza muviri anogona kushanda. Kana kuchengeta simba pamusoro rwapedyo adenomatous polyposis kushandiswa zvinodhaka zvakaita kuti chinokosha zvinoderedza kukura polyps ari muura uye duodenum: achidzikisa zvavo nhamba uye kukura. Vanachiremba vanoti zvakakwana mishonga mishonga uye kurapwa regimens anogona kuzadzisa nemigumisiro yakanaka nokushandiswa kwe "Celebrex" chinodhaka. Testimonials vanoratidza usingashandi nemishonga apo kutora mishonga iyi.

The chimiro uye Kuronga zvinodhaka

Zvikuru inhibitor vanosarudza munhu gelatin Kamudzira anenge chena kana chichena, havana yakajeka uye anozivikanwa ne yebhuruu rinoparadza akanzi "7767" kurutivi rumwe uye "100" uye "200" rumwe. Kamudzira mukati: granulated chena coloring.

The Kuronga zvinodhaka zvinosanganisira: celecoxib (dzinokosha vanoshingaira chirungiso), lactose, povidone K30, yavaibvisa lauryl sulfate, magnesium stearate, yavaibvisa croscarmellose. The goko chakagadzirwa titanium dioxide, uye dzinodyiwa gelatin. Kana Hurumende zvakakodzera zvinodhaka intramuscularly majekiseni vanogadzwa "Celebrex". Izvi rworudzi mishonga iri asunungurwa muchimiro mhinduro kuti jekiseni 2,2 Rine mamiririta ampoules - inokosha fuma celecoxib.

Pharmacokinetics

The mushonga zvakanga wefodya unopinda muropa riri nokutsanya wehurumende uye rinosvika vaifanira kuita pashure maawa anenge 2-3. Zvisinei, kushandiswa pachishandiswa pamwe chete nemafuta zvokudya anogona kunonotsa kuwanda kwayo kwemaawa 1-2. Naizvozvo zvakafanira kuti chiremba nenguva kutora mishonga.

Kamwe muna muropa, zvinoshingaira zvinhu regai kusungira kuti masero matsvuku eropa, asi mashandiro anoita vasakanganise kubudirira pakati achida wevasungwa zvinodhaka mumuviri. Drug rinoita ari chiropa kubudikidza oxidation uye glucuronidation nechokuita CYP2C9 enzayemu. Output zvinoreva ne weti uye mutsvina yadzo muchimiro nyore metabolites, uye 3 chete% yezviri fuma anoramba kuzochinja.

Drug "Celebrex", analogues zvacho zvakafanana sezvamunoita, akawana nzira, zvichiita kuti utano usingashandi kukuvara, nokuda kugona yaro nyura yakawanda sezvingabvira uye akapotsa zvachose chose kubva mumuviri. Aine muviri uremu pasi vakachengeta wakakwirira wevasungwa zvinodhaka muropa, uye chiitiko ichi chiri kuchengetwa kupfuura vakadzi. Hazvizivikanwi sei, asiwo vanhu vatema vakachengeta chete simba. Saka, mapoka aya wevarwere ushandiswe yakaderera dose kurapwa pakutanga yokurapa.

zvairatidza

Sezvo asiri steroidal Anti-anogumbura vamiririri nokuda symptomatic kurapwa waakaudzwa zvinodhaka "Celebrex". Zvairatidza kuti kushandiswa:

• dzinonzi rheumatoid arthritis;
• chemajoini;
• spondylitis;
• algomenorrhea;
• kurwadziwa (post-kushanda nguva, musana marwadzo, zvetsandanyama nemapfupa zvirwere);
• anoshandiswa pakurapa adenamotoznogo polyposis.

Zvinofanira kucherechedzwa kuti zvakakwana kunokwanisa chete kurongera chiremba pahwaro pakutsvakurudza.

Nzira chourongwa zvinodhaka

Kutora mushonga unofanira kuva mukati, pasinei kudya. Chewable mahwendefa hazvifaniri, unofanira kunwa mvura pachena. Zvinofanira kucherechedzwa kuti zvemwoyo yematambudziko anogona kuitika pamwe chirwere kwokubatsira chezvinodhaka. Naizvozvo, vanachiremba akarayira "Celebrex" pfupi yawapiwa. Nyanzvi Guest zvinoratidza kuti kufadza dose kunorapwa kwenguva refu haafaniri kupfuudza 400 MG pazuva!

• Mabatirwo chemajoini - zvakakwana dose iri 200 MG pazuva. Mukana chete dose kana huviri (dzimwe nguva).
• Dzinonzi rheumatoid arthritis - vaitarisira dose 100 kana 200 MG 2 nguva pazuva. Kana wakakura zvikuru siyana - kusvika 400 MG kaviri pazuva.
• Ankylosing spondylitis - MG 200 pazuva, nokuti 1 kana 2 yakakamurwa mishonga. In chiremba kungwara ari dose anogona ngazviwedzerwe zvakakwana chengetedzo
• Dysmenorrhea uye kurwadziwa simba - anotanga kurapa pamwe 400 MG pazuva uye akawedzera imwe MG 200 pazuva yokurapa rokutanga, kana zvichidikanwa. In zvinotevera mazuva, unofanira kutora 200 MG kaviri pazuva.

Duration kurapwa iri pakutsvaga kupinda chiremba.

Contraindications kuti kushandisa zvinodhaka

Kuwedzera zvichibvira neutachiona kuti vomumatunhu zvinodhaka, pane mitemo pasi zviri wairambidza kushandisa zvinodhaka "Celebrex":

1. Árbol asima, urticaria, sema kune dzimwe NSAIDs.
2. The postoperative nguva pashure aortkoronarnogo yokunzvenga.
3. Peptic urikanwi (exacerbation).
4. GI ropa.
5. Anogumbura bowel chirwere.
6. Heart kukundikana.
7. Zvakakomba hepatic insufficiency.
8. Renal insufficiency.
9. Pamuviri uye lactation.
10. Not pachii kushandiswa pasi 18.
11. Hypersensitivity kuti vomumatunhu zvinodhaka uye sulfonamides.

Zvokungwarira vanofanira kushandisa mushonga pamwe mvura chengetedzo mumuviri, zvirwere kumwoyo, chirwere cheshuga.

nemishonga

Pasinei mukuru potency zvinodhaka, kwenguva refu kana zvisiri kugamuchirwa muoti uye chipimo chemushonga zvinogona divi Migumisiro zvinodhaka "Celebrex". Testimonials vanoratidza rakajairika (kakawanda) zviratidzo zvakadai:

• Neutachiona kusanganisira mapundu, urticaria, pruritus.
• Flatulence, dyspepsia, edema, kushaya hope.
• Chikosoro, rhinitis, yokuSpain-kufanana maitiro uye kufema turakiti zvirwere.
• Urinary turakiti noutachiona.

Ndoda pane yawedzera kufunganya, kupererwa neropa, tinnitus, flushes, arrhythmia, chirwere cheBP. Vamwe varwere akanyorwa ulceration pamusoro zvomudumbu turakiti, angionevropatichesky edema, paumbwe bullae paganda, exacerbation kuti pfungwa nomuviri zvemwana asati kana ayo kukura, kuvhiringidzika. zviratidzo zvose izvi zvinogona chete kuitika kana nzira yokurapa iri muchidimbu (kuti vhiki 12, isingadariki 800 MG pa dose). Asi vairapwa kwenguva yakareba (kusvika 3 years) zvinochengetwa:

• Common: kushungurudzwa nechigaro, BP, zvirwere nzeve, angina, myocardial infarction, kuda kurutsa, dysphagia, prostatitis, vakawedzera creatinine.
• More zvisingawanzoitiki: arrhythmia, angina, ischemic sitiroko, atherosclerosis, hope, kusangana nekutsi kwemukadzi ropa, nemaronda mumuromo, dysmenorrhea, kuwedzera Chizenga, kuderera hematocrit.

The kukurukurirana pamusoro mushonga nedzimwe zvinodhaka

The medicament achishingaira biotransformed nechokuita P450 2C9 (cytochrome). Saka Zvinokwanisika zvakananga kusakarongeka zvinodhaka nezvimwe vamiririri:

1. Concomitant Kushandisa zvinodhaka "Warfarin" kunowedzera mukana dzinouraya kubuda ropa.
2. Kugadzirira "Ketanazol" uye "Fluconazole" kuwedzera wevasungwa kuti basa fuma celecoxib akapotsa kaviri.
3. Kugamuchira blockers kana ACE FIs angiotenzita NSAIDs anogona kuderedza zvazvinoita antigipertinzivny
4. Combination zvigadzirwa ine lithium, zvinogona yekudyidzana kuwedzera ropa pamwero.
5. Zvinonzi mbidzwa panguva kushandisa zvinodhaka "Celebrex" analogs ane celecoxib, dzimwe NSAIDs!

zvinodhaka analogues

Zvinokosha kucherechedza kuti "Celebrex" chinodhaka mari kwete zvakawanda, mutengo wayo uri avhareji kubva 400 kusvika 450 rubles. 10 capsules (100 MG chipimo chemushonga). Zvisinei, kurapa kwakadaro zvikuru zvinodhura kuti murwere mushonga-refu. Panyaya iyi, iyo mvumo chiremba, ngaagadze vamiririri rine celecoxib. Nokuti mushonga "Celebrex" analogues zvinotevera:

• zvinodhaka "Ranselak";
• zvinodhaka "Revmoksib";
• Mahwendefa "Flogoksib";
• Kamudzira "Artoksib".

analogs izvi zvine chete rinoita fuma uye vane substantially kufanana kuchirapa chaizvoizvo pakurapa zvirwere. Ona kuti imwe yakakwana dose ane analogue anopiwawo chete kupinda chiremba. Panyaya iyi chiremba anofunga zvakasiyana zvinobatsira sezvamunoita mu analogs, dzine yokuvirisa siyana sezvo zvichienzaniswa zvinodhaka "Celebrex". Instruction anodzokorora vanachiremba vanoti mukana ane sema maitiro kubudikidza murwere kuti Excipients mishonga yakasiyana rimwe boka.