The mushonga 'Diovan'. Mirayiridzo dzokushandisa uye tsanangudzo pfupi

"Diovan" ndiwo chaiwo vanoshingaira angiotensin II Kanotokonya antagonist. Mwari akaronga kuti nomumukanwa yaitonga. Nokuti kuti vasiyana mushonga 'Diovan' mirayiridzo, inodzidzisa vanogona kudzidza pamusoro nzira chiito. chinodhaka ichi Zvidhinha ari AT1 receptors, anokonzera angiotensin II. Somugumisiro, plasma wevasungwa pamusoro angiotensin II, iyo kunomutsa kukiyiwa AT2 Kanotokonya subtype, kunowedzera.

Pane zviratidzo zvakawanda kushandiswa "Diovan" chinodhaka. Mirayiridzo kushandiswa kunoita kuti aaverenge. Ivo:

- mwoyo kutadza (refu);

- neBP.

"Diovan" Mahwendefa vari raitongwa kuti kuwedzera mukana yokupona pavarwere vane chakasimba myocardial infarction, izvo rakaoma nokuda rworuboshwe ventricular dysfunction, systolic kana kuruboshwe ventricular insufficiency, geodynamic kugadzikana zviratidzo.

Kuvhiringidzwa zvinodhaka ichi kuti mwoyo kutadza kunobva kukwanisa kwayo kubvisa

- Sero kuwanda inotungamirira yagadziriswa mwoyo, tsinga, itsvo;

- Mvura chengetedzo mumuviri;

- vasoconstriction;

- dzishande kunyanya kwetunhu mahormone akadai aldosterone, endothelin, vasopressin nezvimwe catecholamine.

In kurapwa kuti BP chiito "Diovan" chinodhaka aona pashure maawa maviri. The vakaomerwa kumanikidzwa inodonha iri akacherechedza pashure maawa anenge 5. Mahwendefa chiito zvikaramba kwemaawa anopfuura 24. Akadzokorora kushandiswa "diovan" kunonyanyisa kumanikidzwa ipfupi anenge nokuda vhiki wechipiri kana wechitatu, uye akaramba panguva pamwero kwenguva yakareba. Zvinofanira kucherechedzwa kuti maererano nemashoko vakabayira vasiyana mushonga "Diovan" mirayiridzo, chimbichimbi kumira kushandisa zvinodhaka haitungamiriri pakarepo kuwedzera kuitiswa kana zvimwe kwakaomarara zvekuchipatara migumisiro.

Muzviitiko apo "Diovan" mahwendefa anoshandiswa pashure myocardial infarction, zvinoshingaira zvinodhaka fuma - Valsartan - a 25% zvinoderedza mukana rufu.

Pamberi kushandisa mishonga iyi inofanira kuva nyatsoziva contraindications kugamuchira "Diovan" chinodhaka. Mirayiridzo kuti mushonga ine mazita kwavari:

- pamuviri;

- lactation;

- rinokosha aikanganiswa chero rokuti chipo iri Kuronga zvinodhaka.

Uyewo, pamwe chakazara hanya zvinofanira kutorwa "Diovan" piritsi:

• ane zvokudya dzakamanikidzwa mune yavaibvisa;

• varwere kwakaratidza bilateral renal tsinga stenosis ;

• muna hepatic kukundikana, kwakaitika pamusoro yaitwa biliary mhingaidzo;

• Varwere renal insufficiency;

• panguva manyoka, kurutsa.

Averenga pamusoro mushonga 'Diovan' wongororo, unogona kudzidza pamusoro dzakadaro zvakafanana nemishonga se:

- kutapukirwa noutachiona,

- Neutropenia,

- postrualnoe dzungu,

- orthostatic hypotension.

Mune zvimwe zvisingawanzoitiki zviitiko zvingaitika yokumusoro kufema turakiti zvirwere, hyperkalemia, sinusitis, kushaya hope, kufenda, kwazvo huro, kurasikirwa libido, mwoyo kukundikana, hypotension, chikosoro, uye kurwadziwa mudumbu, manyoka, vertigo, musana marwadzo, asthenia, kunzwa kuneta , edema. Very kashoma, asi anogona kuitika rhinitis, thrombocytopenia, pruritus, mapundu, nomusoro, kuda kurutsa, vasculitis, angioedema, arthralgia, renal dysfunction, myalgia.

Zvinorondedzerwa pfupiso uyewo zviratidzo ovhadhozi zvinodhaka ichi. Kuti izvi zvisaitike, asati kushandisa "Diovan" gadziriro mirayiridzo kushandiswa kwayo kunofanira nokungwarira runoonekwa mutengi. Zvinoratidza nzira pakutora zvinodhaka uye dose, uyewo tsanangudzo zvose zviratidzo ovhadhozi uye rwekutanga matanho.