"Ursofalk": zvakafanana, mirayiridzo yekushandisa uye kusunungura mafomu

Mushonga we "Ursofalk" mirayiridzo yekushandiswa inotsanangura sechirwere ine mhando dzakawanda dzezviito, izvo, pakati pevamwe, hepatoprotective, cholelitholytic, immunomodulatory properties. Uyewo, chirwere ichi chinoderedza zvakanyanya kuwanda kweklesterolori muropa.

Active substance

Izvo zvinoshanda zvechirwere ursodeoxycholic acid. Iyo iripo mune imwe chiyero mu bile ye munhu, asi semugumisiro wehumwe hupombwe hwekushanda kwechiropa, kufanana uye, maererano naizvozvo, zvinyorwa zvechirwere mu bile zvinogona kuderedzwa.

Ursodeoxycholic asidi sechinhu chikuru chikuru chiripo kwete kwete mukugadzira Ursofalk. Analogues pamusoro pehutano uye pharmacological michina mishonga yakadai seUriosan, Ursoliv, Urdoksa. Ngatitaure pamusoro pavo pasi.

Zvirwere zvinokonzerwa ne "Ursofalk"

• Icho choleretic effect inoratidzwa mukuderera kwehuwandu hwehydrophobic acid mu bile uye kuwedzera mukuvhara kwadzo mukati memwenje wemukumbo. Mukuwedzera, chirwere ichi, nemhaka yekubatana kwayo neyakagadziriswa mueileum, kunoderedza kusvuta kwehupfu hwe hydrophobic acid.
• Izvozvo zvinokonzerwa nehutachiona hunokonzerwa nekuti ursodeoxycholic acid inokwanisa kuderedza kudururwa kwema mole molemba ekirasi yekutanga pa hepatocytes, uye yechipiri-class HLA mamolekemu pane cholangiocytes. Uyezve, mishonga inoderedza kushandiswa kwepro-inflammatory cytokines.
• Irotoprotective effect inyanzvi yehutachiwana hunobudirira kupinda mukati mehutsetse yakatsetseka ye membrane yesero, semugumisiro wekuti membrane yechipfuva inomira, zvidziviriro zvayo zvinovandudzwa.
• Hypercholesterolemic action inobva pakuderera kwekudyiwa mueileum uye kuderera kweklesterterol mukati muchiropa, pamwe nekuparadzwa kwayo ne bile.

Pamusoro pemigumisiro yakataurwa pamusoro apa, mushonga we "Ursofalk" (mirayiridzo inoshandiswa pane ino inopupurira) inoshandisa makirasi emvura necholesterol molecule yakagadzikana, izvo zvinoderedza lithogenicity ye bile. Pamusana pekushandurwa kwemakemikari emakemikari, kuumbwa kwematombo kuderera uye kuparara kwavo kunoitika.

Pharmacokinetics

Mushure mokutaura nemuromo kwechirwere mumudumbu mutsva, kubatwa kwe ursodeoxycholic acid inowanzoitika, nekunyorera nekushanda kunoshandiswa kunowanikwa mueileum muimba yekupedzisira, uye nekufamba kwekutakura mu jejunum uye iriac kumusoro. Inenge 60-80 muzana yezana rakagamuchirwa rinowira muhuwandu hwekubuda ropa.

Izvo zvinoshandiswa zvinoshandiswa muropa mukati mechiropa uye zvishoma nezvishoma zvinoputika mumatumbo, izvo zvinotungamirira pakuumbwa kwezvinokonzera zvinomwe zvinomwe-keto-lithocholic acid, iyo inotorawo, iyo inopinda muhutano hwehuwandu hwemvura kusvika kuhuwandu husingaverengeki uye hunobudiswa pachiropa. Ihafu-hupenyu hwemishonga iyi mazuva matatu kusvika mashanu. Chaizvoizvo, iyo yakanyongedzwa nemasese mune maitiro e metabolites.

Zviratidzo zvekushandiswa

Mushonga we "Ursofalk" murayiridzo wekushandisa unoratidza kushandiswa kwezvirwere zveguruvladder, chiropa, pamwe chete nekuwedzera muropa rekutsvaga kweropa, cholestasis, kuderera mune rimwe basa reropa. Pakati pezvirwere zvakadaro, biliary cirrhosis yechiropa (primary), biliary reflux-gastritis, sclerosing cholangitis (primary), biliary reflux-esophagitis, hepatitis ye etiology yakasiyana, cystic fibrosis inogona kutaurwa.

Mushonga wacho unorayirwa muhupo hwematombo mujeri, asi chete kana iine X-ray isina, muhupamhi hukuru hwahwo hahupfuuri mamita gumi nemashanu, uye murwere haana kukanganisa kushanda kweguruva. Mishonga inoshandiswawo kana yakaipisisa chechiropa (somuenzaniso, nedoro rinouraya), chirwere chechirwere ichi pamwe chete necholestasis (muvana), dyskinesia yebhariyariyiti, atresia ye intrahepatic bile ducts. Inotorwa nevarwere avo vari parenteral nutrition, kubvisa kuparara kwe bile, uyewo nevanhu vane chirwere chekuvhara chiropa.

Sangano rekudzivirira rinorayira mushonga we "Ursofalk" (zvakafanana nemishonga inogona kushandiswawo mumatambudziko aya), uchishandisa mishonga inogona kukanganisa basa reropa (hormonal contraceptive, madhiragi ane cholestatic effect).

Mukana wekubudisa uye kuumbwa

Mhando mbiri dzokusunungurwa dzine chirwere "Ursofalk": kusungurudzwa (zvakafanana hazvipo, zvakabudiswa muSwitzerland) uye capsules (zvakafanana zvinowanika, inogadzirwa muGermany). Shanduro yekutanga yemishonga inoshandiswa kunyanya kuvana kana vanhu vane ruzivo rwokumedza. Capsules iine gelatinous, opaque, yakasimba, chifukidzo nemuviri zvakavezwa vatsvene, mukati-machena granules kana pfu. Yakabudiswa mumaphaketuru e10, 25, 50 kana 100 zvidimbu. Kuvhiringidzwa kunewo muchena mutsvuku, unoratidzirwa nekushandurwa kweunifomu, ine mhepo inoputika, uye ine unyanzvi hwemononi. Yakagadzirwa mu 250 ml mudziyo, kapu yokuyeresa inosanganiswa.

250 milligrams ye ursodeoxycholic acid inowanikwa mune rimwe capsule yemishonga, muchiyero chimwechete icho chinoshandiswa chiripo chiripo mamiriyoni mashanu (imwe yezviyero) ye Ursofalk kumira. Iyo sira inosanganisira zviyamuro zvekubatsira: glycerol, lemon anhydrous acid, xylitol, propylene glycol, sodium chloride, microcrystalline cellulose, benzoic acid, marimu aononi, sodium citrate, mvura yakachena, sodium cyclamate. Zvimwe zvinoshandiswa muzvikamu zve capsules zvinonzi colloidal silicon dioxide, titanium dioxide, sodium lauryl sulfate, starch yegorosi, magnesium stearate, gelatin, mvura yakachena.

Nzira yekutora Ursofalk

Mishonga kana pakatarwa imwe nhengo inofanirwa kutora maawa manheru. Capsules inomedzwa isina cheku, uye yakashambidzwa pasi nemvura inenge yakawanda. Sezvatatoona, chirwere "Ursofalk" yevana chiri nani kushandisa sekumiswa (sirasi). Nhamba inofanira kuverengwa nechiremba, zvichienderana nehutano hwechirwere uye hunoita muviri wevarwere. Vana vacheche (pakurema kwechirogiramu mashanu) vasati vavata vanofanira kupiwa chechina chekusimudzirwa kwekapu.

Kazhinji, nehutachiona, chirwere chemazuva ese chechirwere chevanhu vakuru ndeche 10-15 mg kilogram yehuremu, iyo nzira yekurapa inosvika pamwedzi mitanhatu kusvika kumakore maviri, asi kutora mishonga yemishonga haifaniri kukurudzirwa. Kune vanhu vane biliary reflux esophagitis kana biliary reflux gastritis, chirwere chezuva nezuva chemishonga ursofalk is 250 mg, iyo nzira yekurapa ndeyegumi kusvika gumi nemana mazuva. Ne sclerosing cholangitis uye biliary cirrhosis, chirwere che 10-15 mg kilogram yehuremu chinowanzotaurwa pamusoro pezuva, asi kana zvichidikanwa, chirwere chacho chinowedzera kusvika 20 mg pa1 kg. Therapy inowanzobva pamwedzi mitanhatu kusvika kumakore maviri. Varwere vane cystic fibrosis vanotora mishonga zuva nezuva pamutengo we 20-30 mg pa kilogram yehuremu pamusoro pemwedzi mitanhatu kusvika kumakore maviri. Muchiitiko chekutyisa kwechiropa chekutyisa, zvinoratidzirwa kuti mushonga unofanirwa kutorwa pamushandi wezuva nezuva we 10-15 mg kilogram yeuwandu kwemwedzi mitanhatu kusvika gumi nemaviri.

Mushonga we "Ursofalk." Analogues

Ngatitorei tsananguro inofananidzwa yezvinodhaka nemishonga iyo yakafanana mukugadzirwa uye pharmacological properties.

• Mushonga we "Ursosan". Ichi chigadzirwa chinogadzirwa muCzech Republic neGermany, chinowanikwa chete nemafomu eti capsules. Iyo nzira yekuita zvinodhaka zvakafanana. Zvisinei, vanachiremba, hepatologist, vanachiremba vane chirwere chinotapukira pamubvunzo wemishonga ipi iri nani: "Ursosan" kana kuti "Ursofalk", pamwe chete anopindura kuti zvinosarudza kusarudza yechipiri. Mhedziso yakadaro inogadzirwa neyanyanzvi pamusana pekuona kwavo kliniki uye kuongororwa kwevarwere. Chirwere ichi "Ursofalk" chinoshandiswa nyore nyore kupfuura chifananidzo chiri mubvunzo, iyo inokurumidzawo kugadzirisa chinoshanda chechiropa. Asi usakanganwa nezvehupenyu hwemuviri, pane vanhu vanobatsira "Ursosan" inobatsira zviri nani. Mukuwedzera, iyi mishonga inenge iri shoma: kuvhara ne 50 capsules kunodhura 650-830 rubles, apo 50 capsules yemudhaka "Ursofalk" inofanira kubhadhara 850-1200 rubles.
• Nzira dze "Urdoksa." Mishonga iyi chirwere chinogadzirwa. Zvisinei, kambani yemishonga inobereka iyo inotenga zvigadziro zvinodiwa kune dzimwe nyika, uye muRussia chete nzira yekugadzira mishonga inoitika. Inowanikwawo mumapisisumu, mutengo wezvikamu makumi mashanu unosiyana pakati pe 440-960 rubles. Zvese zvinodhaka zvakafanana mune zvemasitoriki, hapana misiyano yakakosha mune zvakagadzirwa.
• Mushonga we "Ursoliv." Mushonga wacho, sezvakaitwa munyaya yapfuura, inobudiswa muRussia. Panguva imwecheteyo, vanhu vakawanda vanocherechedza kuti kubva kune mishonga yose yakanyorwa, ichi ndicho chinhu chakanaka chinoparadza mazai muhuro yeguru. Asi kunewo avo vakagadzirirwa kurapwa nemishonga "Ursofalk". Capsules ane zvakakodzwa zvakafanana, saka zvakaoma kupa zvakada kune izvi kana izvo zvakasiyana. Kana iwe uchitarisa pamutengo, zviri nani kutenga mishonga iyi "Ursoliv", inodhura zvishoma - 460-905 rubles makumi mashanu emapapirosi.

Zviitiko zvakashata

Zvakanaka chaizvo kutumira mushonga we "Ursofalk" kuvarwere. Nhengo dzechirwere ichi dzinoratidzwawo zvakanaka nekushivirira. Mune zvimwe zviitiko, zvinopesana nemamiriro ekurapa, calcification yegurustones inowanikwa, mushy stool inowedzera, marwadzo anoonekwa mu epigastrium. Mukuwedzera, mishonga inogona kukura nenzira yeganda kuchenesa, mikoko. Hapana nheyo dzekuwedzerwa kwezvinodhaka zvakaparidzirwa kusvika zvino.

Contraindications

Kukwirira kunzwisiswa kwevanhu kune zvikamu zvechirwere kunoshanda sechikonzero chekuramba kushandisa. Mishonga inopindirana yevanhu vane cholangitis, kuvharwa kwe cystic kana bile duct, yakaoma cholecystitis. Usaisa mishonga kune varwere vane chirwere chekushaya simba kwebasa re gallbladder, biliary colic.

Kushanda pakuberekwa uye lactation

Maererano nekutsvakurudza, ursodeoxycholic acid haina kuratidza mutagenic, teratogenic, embryotoxic basa, asi kukwanisa kwayo kupinda mukati megadziriro yehematoplacental uye kukanganisa nzira yekuzvitakura haina kunyatsodzidza. Saka, kutora mishonga iyi "Ursofalk" panguva yekuberekwa kwomwana kunogona chete kana zvichidikanwa uye maererano nechiremba chiremba. Chiitiko chekushandisa mishonga munguva yeakisi yakasipo.

Kuwirirana nemimwe mishonga

Kubvumirana kwakagadziriswa kwechirwere nemasikiriti ane aluminium hydroxide, uye nemishonga "Kolestipol" uye "Kolestyramin" inotungamirira kuderera kwekushandiswa kwe systemic inoshandiswa. Iyo mishonga inogona kuchinja kuisa muropa reropa remushonga we "Ciclosporin." Kana pane chidimbu chekushandisa pamwe chete kwemishonga yakadai, inofanira kutorwa panguva dzenguva maawa maviri.