"Ademethionine": mirayiridzo kushandiswa, analogs, wongororo

Chii fuma ademetionine? Mirayiridzo kushandiswa gadziriro, ine chimwe chezvinonhuwira achapiwa kurondedzerwa hereinafter. Nesuwo kukuudzai pamusoro zvakadini tinorasikirwa zvakafanana chishandiso kuti vanoshandisa vanoti pamusoro pazvo, uye zvichingodaro.

Chimiro chinodhaka, tsananguro yacho

In chii chimiro aripo zvinodhaka "Geptral" (INN "Ademethionine")? Mirayiridzo Dzokushandisa rinoti chokushandisa ichi rinowanika zviviri zvakasiyana siyana:

• The lyophilizate, akaronga achigadzirira intravenous kana intramuscular mhinduro. fomu uyu lyophilized guru chena, pasina inclusions wokumwe. Uyewo, ari makadhibhokisi svinga chine solvent chinokosha chine chimiro Hauoneki uye segirazi zvokunwa.
• "Ademethionine" - mapiritsi chena hamvuropu, biconvex uye denderedzwa. Uyezve homonymous vanoshingaira fuma, ichi chinomirira unotora uye ebetsero zvinhu dzakadai MSC, Na-carboxymethyl silica uye stearate MG.

pharmacodynamic unhu

Zvakaita nzvimbo yacho fuma ademetionine? Application Mirayiridzo kunopa kuti akati chirungiso Exhibits choleretic, holekineticheskoe, detoxifying, neuro- uye hepatoprotective uye Anti-depressant uye antioxidant nemigumisiro.

Saka, zvakanaka kuti kuziva kuti vaiona zvinodhaka chinhu anokwanisa kuwedzera secretion pamusoro bile, uye vakandizvidza kuparadzana yaro ura.

Kuonawo kuti zvinodhaka "Ademethionine" analogs zviri pasi apa, inozadza yokushomeka SAM, asiwo kunomutsa paumbwe iri chiropa. Uyezve, iyi zvinoreva zvakanaka kunowedzera plasma wevasungwa pamusoro cysteine, taurine, glutamine tigutsikane ari chiropa, nokudaro normalizing ari metabolic pezvakaitwa ari chiropa uye kuderedza padanho methionine mu serum.

Under chii ezvinhu rinoreva "Ademethionine" zvinobudirira zvikuru? Mirayiridzo dzokushandisa inoratidza kuti zvinodhaka uyu anoita zvakanaka ductal uye tubular hepatic cholestasis. It anoita conjugation LCD uye sulfation ari chiropa mumasero, uye ipapo lowers toxicity yavo.

Maererano nemishumo nyanzvi, choleretic uye hepatoprotective zvinokonzerwa pashure discontinuation yokurapa "Geptralom" zvakachengetwa kusvikira 3 months.

Kana hurukuro iyi zvinoreva vanhu vane opioid muropa, zvichiteverwa chiropa chirwere, izvozvo anovandudza ichi nhengo basa monooxygenase oxidation pezvakaitwa, asi kunoitawo kuti regression kunotoda kurapwa zviratidzo zvinodhaka kurega.

Antidepressant mugumisiro pashure kushandiswa kwezvinodhaka ichi nezvechinhu zvishoma nezvishoma. Zvisinei, achava dzikamisa mumakore mavhiki maviri.

zvinoreva mano kinetic

mushonga "Ademethionine" kunyura? Mirayiridzo yokushandisa nezvembiri kuti nomuromo waro bioavailability 5%, uye kana uchishandisa jekiseni - 100%.

Yepamusoro wevasungwa zvinodhaka muropa panguva chete dose mumwe hwendefa iri kuchengetwa kwemaawa 2-6.

The yeplasma-akasungwa ezvinhu mumiririri uyu chete diki zvakawanda. Zvinofanira kucherechedzwa kuti mushonga chinopinda zvakanaka kupinda BBB, uye pamatunhu kuwanda hunogona kungoparara kuona kunyange cerebrospinal mvura.

Biotransformation zvinodhaka riri pachena chiropa. Its kubviswa hafu-nguva kwemaawa 1.5. Rinobva mushonga mu neitsvo.

Zvairatidza kuti pakunzi nzira

Nei tichifanira kuva mushonga "Ademethionine" (mutengo zvinodhaka inotaurwa pazasi)? mushonga uyu rinowanzoshandiswa nachiremba:

• zviratidzo zvokuora mwoyo;
• intrahepatic cholestasis uye panguva cirrhotic pretsirroticheskih inoti, kusanganisira hepatic steatosis;
• chisingaperi cholecystitis pasina mabwe;
• chisingaperi chiropa;
• cholangitis;
• chepfu hepatic maronda akasiyana mavambo, kusanganisira nemavhairasi, doro uye zvinodhaka (tricyclic antidepressants, nemishonga, antivirals, antitumor uye Anti TB madhiragi, nemumuromo nhumbu);
• cirrhosis;
• intrahepatic cholestasis vakadzi vane pamuviri;
• encephalopathy, kusanganisira chokuita hepatic insufficiency (doro).

Kurambidzwa kushandiswa

Under chii ezvinhu havafaniri kupiwa mushonga "Ademethionine" kana "Geptral"? Izvi zvinoreva rirege kushandiswa nemagene zvinetso kukanganisa methionine kutenderera, uyewo kukonzera hyperhomocysteinemia kana homocystinuria. Uyewo zviri contraindicated kugamuchira pauduku uye kuyaruka uye yakakwirira aikanganiswa ademetionina.

Dosing "Ademethionine" Mahwendefa

Guest vanamazvikokota vanoti inotaura nzira kutorwa ari pakati zvokudya mangwanani, kwete kukuvadza kana dög. Panyaya iyi, hwendefa anofanira kubviswa kavha rwetende rinodyiwa.

The daily chipimo chemushonga mishonga iyi mahwendefa 2-4, uye nguva yokurapa kunobva huripo.

Mirayiridzo kushandiswa kugadzirisa

Ndingatarira kushandisa injectable mhinduro "Ademethionine" analogues chinogona kuwanikwa chero chezvinodhaka? gadziriro iyi inotengeswa ampoules, intramuscularly kana nomutsinga. Saka intravenous jekiseni rinoitwa zvishoma nezvishoma.

The mushonga Kugadzirisa rinogadzirirwa chete pamberi jekiseni achishandisa lyophilized upfu kuti dilution solvent uri makadhibhokisi pasuru.

Pashure jekiseni vakasara zvinodhaka anofanira kuraswa.

Zvinofanira kucherechedzwa kuti injectable chimiro "ademethionine" zvaisaenderana alkaline mhinduro uye Formulations ine Ca ions.

The chipimo chemushonga zuva nezuva mumiririri kuti TOLC 1-2 ampoules. Treatment pamwe medicament ichi rinovapo kwevhiki mbiri.

Kana mwoyo kuti vaiona zvinodhaka inoshandiswa yakafanana dose. Kana jekiseni iri kuitwa kwemazuva 15-18.

Kana murwere kunoda anotsigira kurapa, ipapo hwakatamisirwa pahwendefa chimiro "Heptral".

nemishonga

Maitiro api asina kunaka anogona kukonzera mishonga "Ademethionine" (400 MG) Kazhinji panguva kurapwa pamwe zvinodhaka izvi varwere vane manyoka, abdominal marwadzo uye svoto.

Mune zvisingawanzoitiki zviitiko kushandiswa "Geptral" mhinduro, uyewo yaro piritsi chimiro anogona kukonzera kukura:

• Dhimoni Duku (i.e. Urinary turakiti zvirwere);
• laryngeal edema, hypersensitivity siyana;
• paresthesia, kufunganya, nomusoro, kushaya hope, dzungu, kuvhiringidzika;
• kuvaviwa, ganda kuratidzwa Kurwara, rashes, angioedema, vangadikitira;
• kuzvimba kwemasvingo zvachero mutsinga, zvirwere zvomwoyo uye ropa midziyo, kupiswa;
• bloating, muromo yakaoma, kurutsa, esophagitis, kuda kurutsa, abdominal marwadzo, manyoka, dyspepsia, chadzo zvirwere zviri zvomudumbu turakiti, bloating, biliary colic, chiropa cirrhosis, ropa siyana GI turakiti;
• kurwadza kwemajoini, tsandanyama spasm;
• zvakawanda zvive, yokuSpain-kufanana urwere, fivha, chills, peripheral edema, asthenia.

Mari zvinodhaka, analogs uye wongororo

How zvikuru mishonga iyi se "Ademethionine"? Mutengo chigadzirwa ichi anenge 1,500 rubles por hwendefa chimiro uye vanenge 1900 rubles por jekiseni.

kushuma medicament anogona kutsiviwa kana kutsvakwa pachishandiswa dzakadai "Glutamic asidhi" "Karnith" "Histidine" "carnitine", "Epilapton", "Elkar".

Chii vanhu vakati pamusoro zvinodhaka vanozvishandisa? Maererano nemishumo varwere atambura zvinodhaka chiropa chirwere "Ademethionine" ndiyo chete chaiyo nokushanda gepatoprotektor. Varwere chirwere kuti "cirrhosis" nharo kuti kurapwa zvabuda zvinogona kuwanika chete kana yezviri chinodhaka atora 2 pagore-mwedzi 3 mapoka.

Kana vanachiremba, mushumo kuti zvinodhaka "Ademethionine" hakuiti kupa raidudzwa uye nokukurumidza kushanda muna anogumbura zvirwere chiropa, kunoteverwa kurega kunotanga kubva bile munyama muviri.