Alpha-fetoprotein chaiye uye pathological ezvinhu

Alpha-fetoprotein ari zvinhu mapuroteni mavambo iyo anogadzirwa riye embryo pashure pokuberekwa - ari zvomudumbu turakiti uye chiropa mumasero. Kazhinji, muRugwaro zvirimo muviri 15 Ng / Rine mamiririta.

Alpha-fetoprotein atsunga panguva yepamuviri rokuongorora kuremara ari mudumbu. Unosvikowana Chikumbiro tsanangudzo chinoratidza uye oncology. Alpha-fetoprotein ari oncomarker testicular kenza uye chiropa. Munenge 70% yevanhu vane testicular mapundu rakakwirira, kunyanya mu nedanho metastasis.

Pakutanga, ndiko puroteni fuma synthesized ari ovaries, iyo corpus luteum mbeu. Nezuva rechishanu vhiki, fetus anotanga kubudisa vayo. Alpha-fetoprotein anodzivirira fetus kubva zvirwere kwaamai, nokuti izvo ndiye yokumwe mumiririri.

wevasungwa Its rwuchiwanzwa zvakaenzanirana sezvo embryo ropa uye rwaamai ropa. The Zvakanyanya Kunaka Panguva Yepamuviri Kukosha parameter iri nechirwere - panguva mavhiki 12-16. Pamasvondo 32-34 pamuviri kunosvika kufadza pamwero yeAlpha-fetoprotein. utano wokuyera kwevanhu kunokwanisika mugore upenyu rokutanga.

Research nzira yekudyidzana kukanganisa tsanangudzo chinoratidza. Kazhinji akabvuma rokuti abnormalities yeAlpha-fetoprotein raiva multiplicity ari evaMedhia (Amai). MuMedhia akapiwa ndiyo pakati nhamba mune akarayira tsika mapuroteni wevasungwa chaiye pamuviri mukati ichi izwi. Saka, munhu anogona enzanisa Arifa-fetoprotein pamuviri panguva dzakasiyana-siyana, uye inoongorora akaita mumarabhoritari siyana. Kwevari indekisi ichi kubva 0.5 kusvika 2,5 Amai vari muupenyu.

Kuwedzera AFP anogona kuva chiratidzo:

• Mapundu ose principales.
• Chiropa metastases.
• Kenza mudumbu, rwatata, bapu, chiropa, muura, zamu.
• Embryo testicular uye ovarian anomera.

Kwenguva uye yakambotongwa kwakawedzera Alpha-fetoprotein zvinotevera pathologies:

• Chiropa cirrhosis,
• Chirwere chiropa kutadza,
• Alcoholism kuvapo chiropa kukuvara,
• Chirwere kana chenjera nemavhairasi chiropa.

Nhamba iyi yakawedzera panguva pamuviri rinowanikwa zvinotevera nyaya:

• Multiple pamuviri.
• Renal chirwere ari mudumbu.
• Achiine rukuvhute heniya ari mudumbu.
• Fetus chiropa necrosis.
• Malformations of Neural chubhu (rahishizis, anencephaly).
• Mumukaha rusvingo pamberi mudumbu ari mudumbu.
• Other malformations.

Zvisinei, akaderedza Alpha-fetoprotein mune nhumbu zvingaratidza zvinotevera:

• pamuviri Nhema.
• Kunonoka kukura.
• Fetal rufu.
• Matadza pamuviri.
• Vaingoerekana pamuviri.
• Trisomy kuti chromosome 18 kana 21.

The kwakaderedza wevasungwa yeAlpha-fetoprotein zvingaratidza ane kururama Kutsunga ya pamuviri, ndiro pamuviri zvakaitika gare gare.

In Gynecology panguva ino Danho iri chikuru vanoshingaira chinoratidza zvechinguvana fetus chromosomal zvirwere uye pathologies akazvitakura. Zvarakasiya kubva chakaipa fetus kushandura chakaipa wevasungwa mapuroteni zvinhu zviri muropa ramai. Chokwadi, panofanira kuva kwete chete tsanangudzo chinoratidza ichi, sezvazvakaita anodzidzisa. Hako vanofanira kuitisa Ultrasound zvidzidzo, zvichiita kuti pave dudziro zvakakodzera rokuti, pamuviri pevana vakawanda uye zvichingodaro. Uyewo, zvinokosha kuziva uye placental mahormone (chorionic gonadotropin uye estriol vakasununguka), achibvumira kuongorora yakarurama fetoplacental hurongwa. Kubatana kwavo Arifa-fetoprotein chinorondedzerwa pabvunzo nekatatu runovabvumira kuona ngozi zvakasiyana siyana malformations ari mudumbu.