Avastin muOfthemology: kuongorora, mirayiridzo yekushandiswa nekugadzirwa

Muchirapa, pane zviitiko apo mari yakagadzirwa kuitira kurapwa kweimwe zvirwere inoratidza migumisiro yakanaka murapi yevamwe. Izvi zvinoitika semugumisiro wezviongorori zvakawanda musati mishonga ichisvika kune mutengi. Izvi zvakaitika nemishonga yakagadzirirwa kurapwa kwemakumbo emukenza, anonzi Avastin. Muhuputi, maongorudzo nemigumisiro yerapi yakaita kuti vafunge nezvechinangwa uye chirwere icho chiri nani kushandisa mushonga.

"Avastin"

Kurasikirwa kwechiono ndechimwe chevamwe vakasuruvara zvikuru shamwari dzekwegura. Kusvikira munguva pfupi yapfuura, dzakawanda zvehutano mukati meziso zvaive zvakaoma kuzvidzora, asi mumakore achangopfuura, ophthalmology yakaita zviwanikwa zvakadzivirira kukura kwezvirwere zvinotyisa muhupofu.

Nokuda kwechikonzero ichi, kugadzirira kwemapoka akasiyana-siyana anoshandiswa, somuenzaniso, mutevedzeri wekurapwa kweAvastin oncology mune ophthalmology inoshandiswa nekubudirira kukuru. Mhinduro yomurwere inopupurirwa nekuti chirwere chacho chinonyanya kukwanisa. Asi kuti unzwisise kuti inobudirira sei, zvakakosha kufunga nezvekugadzirwa kwezvirwere zveziso.

Mechanism of development disease

Kurasikirwa kwezviratidzo kunoitika semugumisiro wehutachiona hwekuwedzerwa kwemajasipira eropa. Imiti midziyo itsva inomera inomera kuburikidza nemumakumbo, ichivhiringidza maitiro eziso. Uyezve, kuwanda kwemidziyo yeropa kunokonzera kazhinji kushaya ropa, izvo zvinogona kunzwiwa nemunhu uye zvinokanganisa unhu hwekuona. Makukutu akaparara ari kupera, uye huwandu hwakawanda hwehutachiona hunovhiringidza nzira yekudyisa retina yeziso.

Iyi nguva inogona kuonekwa sekutanga kwekuona kutadza. Zvakakosha kucherechedza kuti maonero ane hutano hwakadaro hunosimbiswa zvachose, sezvo chimiro chinowanzosara. Asi zvisinei, hutano hwehupenyu hwevanhu hunowira zvakanyanya.

Pasinei nekuti chifananidzo chechirwere chinotarisa kunetseka zvikuru, uye panguva yakatarisa kuongororwa, chirwere chinogona kumira kana kuchengeta chiratidzo. Nokuda kwechikonzero ichi, Avastin inoshandiswa muhupfumi. Kuongororwa nevarwere uye vanachiremba vanosimbisa hutachiwana hwakanaka

Mishonga inoshanda sei

"Avastin" inonzi drug antitumor, yakashandiswa muoncology kwemakore akawanda uye inoratidza migumisiro yakaisvonaka. Nheyo yebasa rayo iri kudzivisa kushandiswa kwematomu ekuwedzera, kuparadzaniswa kwemasero. Nokudaro, nekudzikisa kukura kwemidziyo mitsva, inogumisa chikonzero chaicho chechirwere.

Kwenguva refu pane kusava nechokwadi kwekuti kana kugadziriswa kwe "onastological" "Avastin" inogona kuita zvakakodzera kurapwa kwakakosha muhupfumi. Kuongororwa kwemasayendisiti uye vanachiremba vakataura kuti molecular weight of its active is high: it's about three times the molecule of other drugs with the same effect. Saka, muchirevo, mishonga haigone kukunda kuvhara kwemuviri we retina, uye naizvozvo, ine nzira yekurapa.

Asi, maererano nezvitsvakurudzo, "Avastin" inopinda zvakakwana mumatanho ose e retina, kuderedza kuwanda kwekuwedzera kweropa remapilisiri. Nekuongorora kwenguva yakakodzera uye kurapwa kwakatanga, unogona kuchengetedza zvakakwana maonero ako.

Migumisiro Yechiri

Kana tikafunga Avastin, mirayiridzo yekushandiswa, uchapupu uye zvakafanana nemitemo yekushandisa inotaura chete pamusoro pekugamuchira kwemukati, iyo inowanzoitika mukurapa kenza. Nokudaro, migumisiro yemigumisiro yemishonga ndeyotevera:

• Internal bleeding;
• Hypertension;
• Kushungurudzika mubasa regumbo rekudya;
• Proteinuria;
• Dermatitis;
• Neuropathy;
• Asthenia.

Nyaya yemagumisiro paunenge uchishandisa mushonga panguva yekurapwa yakakura zvikuru, sekune chero mishonga yekurapa ye oncology.

Kushanda muhupfumi

Asi munyaya iyi, mushonga hauna kujowa mukati, asi zvakananga mu vitreous. Uye rwechipiri, muyero wacho wakasiyana zvakanyanya kubva kune wakashandiswa kweiyo oncology. Somuenzaniso, inenge 500 mg yemishonga inorohwa mukati, mukati maziso iri i-1.25 mg chete.

Kunyange zvakadaro, imwe yechirwere chekubata Avastin iripo: kuora kwemvura panzvimbo yejairo, kunzwa kunopisa uye kupfurikidza nemisodzi. Hapana mimwe migumisiro yakakomba yakawanikwa mune zvidzidzo kana mukuita.

Method of application

Nhamba ye 1.25 mg inopindwa mumuviri we vitreous kamwe pamwedzi, kana katatu, kana mana. Mushure maizvozvi, unogona kuongorora kushanda kwaAvastin mune ophthalmology. Mhinduro dzevarwere dzinoratidza kuti nguva pfupi mushure mechikoro, kuwedzera kwemaonero anoonekwa kunoonekwa mune zvidzidzo 4 kubva pane gumi. Muvanhu vatatu kubva pane gumi, nzira yekurapa inotungamirira kugadziriswa kwechiono, ndiko kuti, kuderedzwa kwehuwandu hwekufambira mberi kwemapurisa uye kudarika.

Mhedzisiro ndeyekuti retina yeziso inowedzera, kureva, kukwana kwayo uye chikafu chemaziso maziso anowedzera. Kazhinji, murwere anonzwa kuwedzera kwemaonero anooneka mushure mekuvhara kwekutanga, uye majekiseni anotevera anogadzirisa. Nenguva yakawanda zvakakosha kudzokorora majekesiti, zvichienderana nezvinoitika mumunhu. Maererano nehuwandu, inotevera injection course inoitwa mumwedzi 2-3.

Contraindications

Chiremba hachina kukurudzirwa vana, vakadzi vane pamuviri uye vanaamai vanoyamwisa. Uyewo, nekuchenjerera kukuru kunofanira kushandiswa "Avastin" apo pane zvikanganiso zvechiropa netsvo, kunyanya kukanganisa kushanda kwezvikamu izvi.

Asi iwe unofanirwa kufungisisa chokwadi chokuti izvi zvinopesana zvinongoshanda chete nehutachiona hwekutonga, uye kana kupinza muziso hakungave nekukosha. Chero zvazvingava, chisarudzo chekugadzwa kwaAvastin mune ophthalmology, iyo inogona kuwanikwa kubva kune imwe kliniki yakakodzera, inofanira kuitwa nechiremba anoenda.

Zvisinei, zvinofanira kurangarirwa kuti nekushandiswa kwechirongwa chechirwere, vanachiremba vakanyatsorayirwa kuti vadzivirire pachavo kuitira kuti varege kudzivirirwa kusingadiwi. Kushandisa chirwere semushandi wekutarisa kwemaziso, zvinokosha zvakare kutora ruzivo urwu paunenge uchironga mabasa emhuri.

Analogues

Munyika yose, iyi nzira yekuchengetedza zviratidzo yakashandiswa kwenguva yakareba, asi mamwe mishonga, yakadai saMacugen naLucentis, anoshandiswa nokuda kwechinangwa ichi. Asi mumakore achangobva kupfuura zvidzidzo zvakawanda uye zvakawedzerwa, izvo zvinoratidza kuti Avastin inoshanda zvikuru mune ophthalmology. Asi kusvikira pane ruzivo pamusoro pemigumisiro yakasununguka yekushandisa mishonga yekurapa kwemaziso, icharamba iri mishonga yekurapa kwekenza.

Kusvika iye zvino, kuiswa-murayiridzo hakurevi chinhu pamusoro pekurapa kwameso. Nokudaro, iyo chete inopa ruzivo pamusoro pekushandiswa kweAvastin mune ophthalmology ndiyo mhinduro. Mutengo wemushonga unovimbika zvikuru, izvo zvinoita kuti zvigone kudhura kupfuura zvakafanana.

Izwi rokuti "analogue" rinowanzoreva mishonga inenge yakagadzirwa zvakafanana, iyo yakafanana inoshandiswa. Hapana mishonga yakadaro pamusika wemishonga yekuRussia yemishonga, iyo inogona kutsanangurwa nokuenzanisa maitiro, sezvo yave ichinyora zvinyorwa izvo mirayiridzo yekushandisa inoshandiswa kuAgastin yekugadzirira inoshanda. Nhaurirano, mutengo waro unosvika pamutengo unodhura kusvika unodhura, une mhando yakafanana yezviratidzo. Asi imwe nzira yakakosha inokonzerwa nezvimwe zvikamu.

Kuzvigadzirira zvakadaro zvinogona kuwanikwa mune imwe nzvimbo yemishonga, kunetseka:

• "Arzerra".
• "Acellbia".
• "Vectibix".
• "Herceptin lyophilizate."
• Herceptin.
• "Campas".
• "MabThera."
• "Perieta".
• Removab.
• "Rituximab."
• Erbitux.

Nzira yepamutemo yekushandiswa

Mishonga yepamutemo nhasi haina kukurudzira kushandiswa kweAvastin mune ophthalmology. Mhinduro dzevarwere dzinowanzova dzakanaka, asi panewo dambudziko rakakura raunoda kuziva pamusoro.

Pane mhirizhonga yakabatana nemushonga weAvastin: mirayiridzo yekushandiswa mune ophthalmology (mhinduro kubva kuvasayendisiti nezvimwe zvinhu, zvakare) haibvumi kushandiswa kwemari mukurapa kweziso. Muiti wezvinodhaka anozivisa pachena kuti hapana chepakutanga kana shanduro yemhando yezvinodhaka "Bevacizumab", yakabudiswa muRussia, haifaniri kushandiswa mune ophthalmology. Chivimbiso chemashoko aya chinogona kuwanikwa pawebsite yeRoszdravnadzor.

Asi pane mamwe masimba, somuenzaniso, pane zvikamu zvakatsaurirwa kune ophthalmology, unogona kuwana ruzivo rwekuti mushonga unoshanda zvikuru kune zvirwere zvemaziso. Izvi zvinokonzerwa nekuti kushandiswa kwesayenzi pamusoro pekushandiswa kwechirwere ichi kwave kuri uye kuchiri kuenderera mberi, kuchiratidzira migumisiro yakanaka. Zvisinei, vasati vadzivirirwa zvizere zvechirwere zvinopupurirwa pamusoro pemamiriro ehutano hwavo hwepamusoro, murayiridzo haungasanganisi ruzivo rwakakodzera mune chikamu "Zviratidzo zveKushandisa".

Shandisa maitiro

Panyaya iyi, "Avastin" inoshandiswa chete mumamiriro ezvinhu ekunyanya kudiwa, apo imwe nzira ndiyo kurasikirwa kwakakwana kwemaonero. Pakuedzwa kwakaitwa mune rimwe remakiriniki eRussia zvakaratidzwa kuti kuvharwa kwaAvastin hakuna kutungamirira kumigumisiro yakakomba, hazvina kukuvadza chiratidzo uye hazvina kukonzera kupofu. Asi varwere vakanyunyuta pamusoro pokuputika uye kupisa munzvimbo yemaziso.

Nokudaro, Avastin imishonga inobatsira zvikuru yekurapa maitiro emagetsi. Muitiro uyu, maererano naAvastin yakatanga kutora ophthalmology, anoongorora varwere zvikuru zvikuru. Asi nemukana wekusarudza, zvakakosha kushandiswa kushandisa izvo chete zvinodhaka izvo zvakagadzirirwa zvakakwana kugadzirisa dambudziko rakanyanya, kunyanya mumutengesi wemishonga, pane zvekare zvinodhaka zvinodhaka zvinogona kuderedza kufambira mberi kwechirwere chetachiona chetinopathy, mvura yakaoma ye macular degeneration.

Nokudaro, "Avastin" inogona kushandiswa chete mumamiriro ezvinhu akaipisisa pasi pekutariswa kwepedyo kwechiremba.