"Azithromycin" vana: kurairira manual, wongororo

Kana kuoma zvirwere asingagoni kubata kuti penicillin yakavakirwa nemishonga, vanachiremba akarayira "azithromycin". Nokuti vana (mirayiridzo kushandiswa zvinoreva nayo) mushonga une simba chaizvo, dzimwe nguva, zvinogona kuvhiringa asati aumbwa zvakazara muviri, saka tora zvakakodzera pasipasi mishonga.

Release chimiro uye sezvamunoita

Pfungwa ine basa fuma uye ebetsero Excipients azithromycin iyo kupa zvetsika fomu pamahwendefa. Uyewo nemhaka zvinhu izvi zviri kunyura zvinodhaka nani.

Nokuda chakarondedzera mushonga kushandisa dzakasiyana-siyana kusunungurwa zvinodhaka zvaishandiswa pharmacology ano:

• Hard gelatine capsules ane muvharo muviri uye zvitema, yebhuruu mukati riri chena kana akacheneruka yero upfu (kana iripo guru). Kana iwe achizviendesa yokuzorora. The capsules huri kuwedzera kushingaira chirungiso, microcrystalline cellulose, yavaibvisa lauryl sulfate uye magnesium stearate.
• "Azithromycin" (125) mirayiridzo kushandiswa vana rinotsanangura sezvo mahwendefa firimu zvemapuranga yebhuruu, imwe dzeraundi makavharidzira chimiro, biconcave. Kune rumwe rutivi vane achiita zvokutemera "PLIVA", pane dzimwe - "125". Kana iwe kuputsa, unogona kuona kuti pane kwezana mapiritsi chena. Inoitwa zvinotevera adjuvants: anhydrous karusiyamu rehydrogen phosphate, hypromellose, chibage starch, microcrystalline cellulose, pregelatinized starch, yavaibvisa lauryl sulfate uye magnesium stearate.
• Drug "Azithromycin" vana mirayiridzo application anokurudzira chimiro kuturika, saka Pharmacies anogona kutenga upfu chakakosha gadziriro waro cherry kana mabhanana kunhuwidza.

Mari mushonga kuwedzera zvichienderana zviri basa fuma.

pharmacological unhu

"Azithromycin" rinoreva mishonga inorwisa mabhakitiriya. Apo mukuru kuwanda chinangwa kuzvimba anowanikwa rufu tusingaoneki.

Most inonyatsoziva zvinodhaka giremu-akanaka cocci: Streptococcus pneumoniae, Streptococcus mapoka CF uye G, anonzi Staphylococcus aureus, St. Pyogenes, St. Viridans, St. agalactiae; Giremu negative bacteria: Moraxella catarrhalis, H. Ducrei, Haemophilus influenzae, Legionella pneumophila, Bordetella pertussis, Neisseria gonorrhoeae, B. Parapertussis, Gardnerella vaginalis uye Campylobacter jejuni; anaerobic zvinenge: Chlamydia trachomatis, Bacteroides bivius, Ureaplasma urealyticum, Peptostreptococcus spp, Clostridium perfringens, Borrelia burgdoferi, Treponema pallidum, uye Mycoplasma pneumoniae. Giremu-akanaka utachiona husingakwanisi erythromycin, mushonga unorwisa ari kuchinjwa kuti akaneta muchimiro.

Pharmacokinetics

"Azithromycin" vana (mirayiridzo kushandiswa anoreva izvozvo) yava kunyura kubva nemudumbu nokuda kuramba acidic nomutoo uye lipophilicity. Nokukurumidza richiparadzirwa munyika muviri. Nyore panoparadzana mwoyo kwete chete munzvimbo kufema turakiti, nyoro zvinyama uye ganda, asiwo kune mapazi ari urogenital turakiti. Somugumisiro, mumwe pasi nokusungwa azithromycin uye serum mapuroteni, kupinda kugona muzvitokisi eukaryotic uye mumisasa mu unosvikirwa pamwe yakaderera ph, kwezvakatipoteredza lysosomes yakawedzera nguva hafu-upenyu uye yevasungwa mune munyama.

izvi zvose anosarudza chikuru Vhoriyamu nokuparadzirwa (31.1 litres pa kg) uye yakakwirira yeplasma Clearance. Nokuti kuparadzwa intracellular utachiona ose zvikuru kukosha kukwanisa "Azithromycin" uchingounganidza zvakananga lysosomes.

Nokuda phagocytes mushonga zvikanzwika nzvimbo chirwere, kwaakanga rakabudiswa nedanho phagocytosis. Mushure memaawa 12-72 yokupinza ainyanya kuzvimba kunokwanisika nemupristi wevasungwa zvinodhaka, izvo zviri kupfuura shoma inhibitory wevasungwa nokuda hweHIV utachiona.

Sezvambotaurwa, hafu-upenyu refu muitiro, saka Somuenzaniso, zvinoda maawa 60 kusvika 76 kubvisa micheka. Bactericidal wevasungwa zvinodhaka inochengeterwa dzimwe nzvimbo kuti kuzvimba mazuva 5-7 mushure rokupedzisira dose, saka zvinokwanisika kushandisa chete mushonga masikati, yawapiwa haasi kupfuura pavhiki.

Matafura "Azithromycin" runonyanya muna bile, uye chete chikamu chiduku - kana vanhurume.

Zvairatidza kuti rubvumo

"Azithromycin" mirayiridzo kushandisa vana vanokurudzirwa sarudza mune yezvirwere uye anogumbura nezvirwere, izvo kunokonzerwa utachiona kubatwa azithromycin. zvirwere zvakadai dzinosanganisira: nemabayo, bronchitis, sinusitis, pharyngitis, nyoro zvinyama uye ganda zvirwere, tonsillitis, otitis nhau, chirwere cheLyme uye urethritis. Nokuti vanofungidzirwa nemabayo pediatricians vanowanzotevedzera pakarepo taurira nemishonga, kunyange pasina migumisiro X-ray kuzviongorora. Kurapa chirwere ichi vanofanira kutanga munguva yakanaka, zvikasadaro ungasangana kupfuura yezvinongoerekana zvaitika. The mushonga panyaya dzakadaro anosarudzwa kufungisisa zvose zviratidzo, asi zvinonzi utachiona hwakakura uye kurapwa mufananidzo yose. Pakusarudza muviri kukonzera chirwere, makore mwana kufungwa nezvazvo. Kana nemabayo iri vanofungidzirwa mune mwana ane makore 1 kusvika 6 mwedzi, ipapo. Ungangove, pomutumwa - anonzi Staphylococcus aureus, kubva gore rimwe makore matanhatu - Streptococcus pneumoniae. With vose Mhando utachiona zvinobudirira achirwira "Azithromycin".

Dosing

Marapirwo zvaiitwa achaenderana chirwere, asi yose dose anofanira kuchengetedzwa. Chiremba anogona mishonga mushonga "Azithromycin" vana. Mirayiridzo dzokushandisa achibvumira mahwendefa kutora chete vakuru kubva dzine 250 kusvika 500 MG pamusoro vanoshingaira fuma, uye mari iyi rinowanikwa iri guru asi guru. Chokwadi kuti mahwendefa zvinofanira kumedzwa rose, havasi varumbidzwa kupwanya kana nokugedagedesa naizvozvo saka havagoni kuramba zvavakabvumirana chipimo chemushonga mumwe chete-nguva kushandiswa (10 MG / kg). Chikonzero ichi kuti vayaruki sezvo antibacterial yomuchipatara raitongwa "Azithromycin" (125). Mirayiridzo dzokushandisa vana hwendefa unorambidza kushandisa makore 12, vanogona ichatsiviwa manyuchi kana kumisa.

Nokuti pakurapa chakasimba anogumbura yemweya zvirwere, otitis, mabayo akagadza kuroora dose zvinodhaka (10 MG / kg). Drug "Azithromycin" (125) mirayiridzo kushandiswa vana pamahwandefa rinokurudzira kuti chete pashure kusvika makore 14. Kurapa Children akaita chete kushandisa slurry.

Zvinofanira kutaurwa kuti muna 5 magiramu kuti manyuchi "Sumamed" (yetea) uye dzimwe analogs Pfungwa uyewo aine 125 MG kuti basa fuma. Saizvozvowo, mureza dose vana vakura iri 1-2 spoon, zvichienderana uremu. Mumazuva anotevera zvina kurapwa mberi, asi panguva imwe chete chipimo chemushonga ipfupi kusvika 5 MG / makirogiramu. Kana chakakomba chirwere dose anogona kaviri, asi mumamiriro ezvinhu akadaro, kushandiswa mushonga bvumidzwa chete pasi pokudzora nyanzvi. Kugadzirira "Azithromycin" (125) mirayiridzo kushandiswa vana angashandiswa chete kana kuti kugamuchira kamwe kana kaviri ari chipimo chemushonga 30 MG / makirogiramu muviri uremu.

Contraindications

Drug "Azithromycin" vana kurairira Chinyorwa unorambidza anoyera makirogiramu asingasviki shanu. Uyezve, zvinonzi contraindicated mu varwere hypersensitivity kuti hurongwa zviri murwiyo kune mamwe macrolide inorwisa mabhakitiriya. mushonga uyu uri kuzvidzosera harifaniri kushandiswa zvikuru chiropa uye itsvo kukundikana.

Ovhadhozi uye divi migumisiro

Nokuti avo moms vari kushandisa zvinodhaka "Azithromycin" vana, mirayiridzo kushandiswa (murefu uchapupu pamusoro nokushandiswa kwemishonga inorwisa mabhakitiriya chiri ichi acho) inopa mazita nemishonga. Pamusoro chikamu nhengo dzinobudisa emuviri uye ropa inotungamirwa zvingamuka trombotsipenii.

Varwere pachena sehasha, wokusagadzikana, kutya uye kuzvidya mwoyo. Kubva tsinga dzungu, kugwinha, nomusoro, somnolence, uye kana kutofenda. Mune zvisingawanzoitiki zviitiko, mushonga hunokonzera atadze kurara, kurukutika, paresthesias, uyewo zvakashatirisa omumwe kunhuwirira uye kuravira.

Kazhinji macrolides (boka zvinodhaka, hwaro kwemakemikari mamiriro iyo protrude macrocyclic 14- kana 16-membered lactone mhete pamwe vakakoshesa carbohydrate residues), uye raiva "azithromycin" kutungamirira kunzwa kurasikirwa. Kashoma, asi zvakadaro pane divi Migumisiro dyspeptic hunhu uye pachena neutachiona.

"Azithromycin" mirayiridzo iri kushanda kunoita vana kushandisa, asi vana zvinodhaka inogona kutorwa chete muchimiro kuturika. Nokuti vana vakura kukodzera uye Kamudzira chimiro mushonga. Asati kushandisa mishonga, unofanira kuwana yachiremba mvumo uye verenga nokungwarira pasuru muwedzero mirayiridzo.

About ovhadhozi zvingaratidza manyoka, kwenguva kusanzwa, kuda kurutsa uye kurutsa. Kana kwazvo zvavakabvumirana mishonga vanofanira pakarepo kumboshamba mudumbu, vobva vaita symptomatic kurapa.

Zvokungwarira

Kushandiswa "Azithromycin" panguva pamuviri iri chisingadiwi zvikuru, asi kunogamuchirika kana kutotadzisa kurishandisa kubatsira mukadzi (zvinodhaka kwakabatsira fetus pa 100% kwave asina kudzidza). The lactation nguva apo yaishandiswa panguva asingaurayiwi kurapwa dzivaidza achiyamwa.

Children pasi pemakore 12 nani kusarudza imwe analoginen "Azithromycin".

Kunwa doro hazvirevi kukanganisa Zvakaitwa zvinodhaka, zvisinei kushandiswa chawo chakawedzerwa neipi chirwere. Naizvozvo, uwandu doro inokurudzirwa kuderedza kuti vaifanira, uye kunyange nani mapfumo pasi kurapwa zvakakwana.

zvinodhaka kwavatori

Pamusoro pokugamuchira "Azithromycin" pamwe antacids kuti ane calcium, magnesium uye aruminiyamu, izvozvo DZEMUNHU DZINODZORA ari Absorção de Água ari mushonga, naizvozvo, zvakakodzera kuchengeta 2-awa penguva pakati mishonga zvinodhaka izvi.

Musiyano mukuru pakati zvinodhaka izvi kune dzimwe macrolide nemishonga - hapana kutaurirana pamwechete cytochrome hurongwa. Naizvozvo, kana kutorwa ne "theophylline", "carbamazepine", "Digoxin", "terfenadine" uye "triazolam" hakuna kumbova kudyidzana.

Kana mushonga rinoshandiswa "warfarin", zvinokosha kuongorora prothrombin nguva.

Lincosamides kuderedza kubudirira mushonga uye chloramphenicol uye tetracycline zvawanzwa.

Conditions uye mazwi

The mushonga dzinofanira kuchengetwa ari kuitwa vana ari tembiricha kusvika 25 inegumi. Pasherefu upenyu uchapupu riwanikwe mushonga "Azithromycin" (vana), kudzidziswa Chinyorwa. The kuturika akagadzirira inogona inochengeterwa hapana anopfuura 5 mazuva, madota pacharo - 2 years, uye mahwendefa uye capsules - anosvika 3 years.

Analogs uye zvinofungwa varwere

Vaya vaishandisa "Azithromycin" vana (mirayiridzo kushandiswa iri capsules havasi varumbidzwa kutora kuvana), akasiya wongororo kunyanya akanaka. Mushure dose of mushonga kure nouchapupu kuvandudzika wokutanga, kufambira mberi mberi.

By analogues zvinodhaka zvinosanganisira "Azitsin", "Zomax," "Sumamed", "Azitral", "Azaks", "Zitroks" uye vamwe.