Fibrates - chii? The sezvamunoita, kushandiswa, contraindications

Zvinozivikanwa kuti zvemwoyo vari pakati rakajairika pathologies munyika. Zvinenge zvose vakwegura munhu anotambura neBP uye angina. Vakawanda vane nhoroondo zvikuru anoregereiko zvirwere, zvakadai myocardial infarction uye cerebrovascular tsaona. Iye parizvino ari nesayenzi nekusimba chokwadi kuti zvemwoyo chirwere wakabatana dyslipidemia zvakananga. chinzvimbo ichi zvinoreva kuchinja zviri remafuta akawandisa uye mafuta acids muropa. Kuti normalize ari lipid nepakati, varwere vaishandisa statins uye fibrates. boka iri zvinodhaka chinoda varwere vose vakanga kuwedzera remafuta akawandisa muropa, zvisinei chechikadzi uye zera.

Fibrates - chii uye zvavari kushandiswa

Zvinozivikanwa kuti kurapa atherosclerosis hazvibviri pasina kushandisa statins. Vari ushandiswe varwere vose vane katsika kufutisa, nechirwere chemwoyo, thrombosis. Kuwedzera statins, pane rimwe boka gadziriro - fibrates. mashandiro avo chiito siyanei. Saka, mishonga iyi ushandiswe hazvisi zvose. Vane fibric asidhi nomukaka. The chikuru mashandiro chiito - rakasungwa kuti lipid muviri mumuviri. Fibrates - chii uye chii vari pamusoro? Kuburikidza kushandiswa kugadzirira izvi akaratidza chinokosha zvinoderedza ropa triglycerides. The chikuru mashandiro chiito kuti fibrates vari chokwadi kuti Activate zviri enzayemu - lipoprotein lipase, nokudaro kukurumidzisa akasimudza muviri kwemafuta. Kureva zvinokanganisa nokukanganisika pezvakaitwa kuitika mumuviri. Kuwedzera rakasungwa dyslipidemia, fibrates nevamwe migumisiro. Pakati pavo - pakurwisa vakasununguka radicals, Anti-anogumbura uye tonic maturo. vari zvakare anticoagulants.

zvairatidza fibrates

Nokuti kuti zvinodhaka izvi vakawanda Migumisiro, vane guru zvakawanda mafomu. Mukuru chiratidzo nokuda kwavo chinangwa ndiyo metabolic syndrome. Ichi chirwere haisi yakazvimirira chirwere, asi sechinhu chikuru predisposing chinoita kuti pave zvemwoyo pathologies. Nzira dzekuziva kuti metabolic urwere:

1. Abdominal kufutisa (muchiuno saizi kuwedzera pedyo masendimita 90 uye yakakwirira).
2. High remafuta akawandisa mu kuongororwa ropa.
3. Kuderedza uwandu kumusoro arambe achirema lipoproteins.
4. Dzakakwirira triglycerides uye LDL.

Kazhinji, ari metabolic chirwere unobatanidzwa pamwe mhando 2 cheshuga, kunoitika vakwegura. Zvinhu izvi predispose kukudziri- atherosclerosis, kureva kuunganidza lipids ari vascular pamadziro. Fibrates - chii uye kuti chii chinangwa vari kutarisirwa? Kuwedzera metabolic urwere, zviratidzo dzokushandisa vari: nhaka siyana dyslipidemia, uye hypertriglyceridemia. Vanewo akaratidza varwere nhoroondo zveshuga uye gout.

Under chii ezvinhu fibrates zviri contraindicated

Pasinei chokwadi kuti fibrates vane nhamba zvakanakira ichienzaniswa nezvimwe zvinodhaka kuderedza remafuta akawandisa (statins), vanogona kushandiswa kwete varwere vose. Yeuka kuti zvinodhaka izvi kukanganisa muviri, saka shandisa navo zvachose hakubvumidzwi mune dzimwe inoti. Fibrates vane contraindications pakushandisa zvinotevera:

1. Pamuviri uye uchiyamwisa.
2. chiropa chirwere. contraindication ichi nokuti kuti boka iri zvinodhaka zvinokanganisa muviri womunhu mafuta acids. In chiropa cirrhosis uye zvinwiwa gepatoze basa muviri kuti yekudyidzana maturo. Nokuda kwechikonzero ichi, fibrates kungaita varwere akadaro kwazvo nemigumisiro, kusvikira chiropa kutadza.
3. Calculous cholecystitis. Mumwe anokonzerwa fibrates ndiko kusimbisa lithogenicity, kureva, paumbwe matombo omunduru.
4. Chirwere renal kukundikana. Fibrates kuwedzera padanho creatinine muropa. Naizvozvo, vanogona sembura chirwere renal kukundikana.
5. Zvokungwarira zvinofanira ushandiswe fibrates vanorwara nevakwegura. Kushandiswa wavo chisingadiwi vanhu vachitambura nekuora chidhakwa.

Side anokonzerwa fibrates

Fibrates - chii uye chii vane divi migumisiro? Zvinofanira kucherechedzwa kuti, kusafanana nedzimwe zvinodhaka, boka iri zvinodhaka ari chaizvo kazhinji kunokonzera ane sema kuita. Naizvozvo anogona kushandiswa mune varwere nhoroondo mikoko, nouswa, uye zvichingodaro. D. Zvisinei, fibrates vane zvimwe nemishonga. Zvinonyanyozivikanwa kuda kurutsa uye kurutsa, flatulence, abdominal distension. Vanogonawo kukanganisa tsinga. Mune zvimwe zviitiko, kukonzera nomusoro, kushaya hope uye kuora mwoyo. Marwadzo vanoonekwa uye kuchinja nokukanganisika kuongorora ropa: yakawedzera creatinine, alt, AST. Pasina chisingaperi renal chirwere uye chiropa hakusi nengozi kuti utano murwere.

Ndezvipi mishonga ndivo fibrates boka?

To musi, pane vanenge 10 mhando boka iri zvinodhaka. To fibrate zvinodhaka zvinosanganisira: "Clofibrate", "bezafibrate", "Gemfibrozil" uye "Fenofibrate". Mumwe nomumwe gadziriro izvi zvakasiyana maererano nokuwanda nemishonga uye uwandu husingakuvadzi. Mahwendefa "Clofibrate" dzave kuzivikanwa kwemakore akawanda uye harichambonyanyi kushandiswa. Pasinei refu kunyatsoshanda, kazhinji kukonzera marwadzo akadai zvinetso zviri zvomudumbu turakiti, marwadzo mu tsandanyama (myositis), nhaka yakakwirira lithogenic. Zviri zvishoma hunokachidza zvinodhaka "bezafibrate". Akanga asina kubudirira sezvinobvira uye nokukurumidza yabudiswa kubva mumuviri. Mahwendefa "Gemfibrozil" kwete varumbidzwa kushandiswa nokuda dzakawanda nemishonga (asi muduku kupfuura kushanda medicament "Clofibrate"). Uyewo, nokuda kudiwa kushandiswa kwenguva refu uye rakakwirira mishonga. Most mumiririri ano boka iyi chinodhaka "Fenofibrate". It ane mukuru Kushanda uye akapotsa hapana marwadzo. Uyezve, zviri ushandiswe varwere vane gout, sezvo zvinoderedza pachiyero uric acid.

Fibrates: mirayiridzo Kushandisa zvinodhaka izvi

kazhinji sei uye chii dosages kushandisa mishonga iyi zvinoenderana worudzii rokugadzirira anogadzwa kuti kupinda chiremba. Kazhinji kacho vanofanira kudya kwerinenge mwedzi (kana kupfuura) 2-3 mapiritsi rimwe zuva. The chikuru chiratidzo - iri metabolic syndrome. varwere kuti vakadaro kazhinji ushandiswe fibrates. Kugadzirira vanofanira kubatanidzwa kudya zvinovaka muviri uye kushandisa kudzorwa lipid. Mahwendefa "Gemfibrozil" rinoshandiswa 1-2 kanomwe pazuva maminitsi 30 vasati zvokudya kwemwedzi mishoma. analogues dzavo mishonga "Gevilon" uye "Normolit". Kugadzirira "bezafibrate" rinowanikwa pamahwandefa 200 MG uye rakundwa 2 kanomwe pazuva kwemwedzi mumwe. Also zvaisanganisira ane analogue - medicament "kutadzisa" ine 400 MG kuti basa fuma. Drug "Fenofibrate" rine 2 kusunungurwa siyana: mahwendefa uye nanoparticles. Anopa hubudirire Absorção de Água uye bioavailability rinoshandisirwa 1 nguva zuva (200 MG) sezvo mishomanana. analogs Its - mushonga "Traykor" uye "Lipantil".

Fibrates: zvinodhaka mukukurukurirana

Usati watanga kushandisa zvinodhaka pane boka iri, unofanira bvunza chiremba wako uye nezvei chii mimwe mishonga inoshandiswa. Fibrates hazvigoni nezvaaiitawo nephrotoxic uye hepatotoxic nevamiririri. Zvikurukuru, "Cyclosporin" chinodhaka. Kushandiswa fibrates hakungodiwi varwere vachitora anticoagulant "Warfarin". Uyewo, boka iri mishonga havafaniri kubatanidzwa nemamwe dipolipidemicheskimi yomuchipatara (statins). Sezvo anowedzera mukana wokuti dzichiri myositis.

Reviews vanachiremba uye varwere pamusoro fibrate

Varwere vakawanda kushandisa fibrates asi sezvataurwa vasanyanye LDL remafuta akawandisa, triglycerides uye remafuta akawandisa. Doctors vanokurudzira zvinodhaka izvi varwere vose vane metabolic chirwere nokuti dzavo dzakakwirira kunyatsoshanda uye yakafara-chakarondedzera. The chete drawback ndiyo contraindication pakushandisa fibrates, izvo kazhinji kuwanikwa varwere vakwegura.