IHC kudzidza - chii ichi?

Nekenza ndivo kupfuura anotyisa chokwadi kuti ruzhinji rwevanhu. Asi kuti nenguva kuona dambudziko chakakomba uye kutanga kuchiparadza zvinobudirira, inokosha anoona yaifanira. исследование. Mumwe wavo - IGH- kudzidza.

Majini, receptors uye kukura zvinhu

Chaiwo Zvikonzero kuti kuti masero kuti zvinoshingaira kugovera, zvichiumba growths itsva, kazhinji oncology nezvechii, sainzi achiri kuzivikanwa. Asi pano ari kuti kukura masero, chava kuzivikanwa. Zvinyama masero vane zvakaoma kunzwisisa. -рецепторы. On muchitokisi pamusoro pane inonzi HE R-2 receptors. Ivo ave mhando kanyanga, teererai muviri murayiro. берет начало от английского словосочетания human epidermal growth factor receptor 2 , что в дословном переводе значит "рецептор человеческого эпидермального фактора роста". Sezvineiwo, mashoko chidimbu IYE R-2 anobva kubva Chirungu okuti munhu epidermal kukura chinhu Kanotokonya 2, rinoreva "Kanotokonya ndiye munhu epidermal kukura chinhu." Zviri receptors izvi uye kuti sero achikamuka kukura uye kuzvigadzirisa.

Active basa Kanotokonya uye bundu

Zvinosuruvarisa, muviri womunhu hakuwanzoshandi sezvo kuva, Zvakanakisa, pasina kukundikana uye chirwere. -рецепторы начинают активно получать команды "делиться и размножаться". Chero bedzi sayenzi haazivi chaizvo sei, asi zvinoitika kuti HE R-2 receptors vari kutanga kugamuchira mirayiro "kamura muwande." Uye sezvo izvi cellular zvinhu Executive chaizvo, vanoita masero vari kushingaira kuparadzanise, pova bundu. bvunzo mishonga chete, kusanganisira IHC -Studies kubvumira tinosarudza mamiriro namamota, uyewo for mishonga uye murwere upenyu.

Majini mamiriro bundu

dzidzo kenza pakurapa kwemazuva ano vari pakutsvaga mamiriro nezvaizoitwa kemikari yokutsiva mishonga. chinzvimbo ichi kungava kunaka (kunaka) kana zvakanaka (zvakanaka). Zvakanyatsonanga yezvakaita anomera anobatsira IGH- kudzidza. Izvi zvinoratidza immunohistochemistry? Kudzidza uku kunobatsira kusimbisa hormone nemataundi neoplasms - gertsept chinzvimbo uye, naizvozvo, kusarudza zvakarurama kurapwa nzira kuti vanobudirira zvabuda.

Negative uye zvakanaka

Chii gertsept hormone mamiriro bundu anonzi "zvakanaka" kana "kunaka", yakawanda wehurukuro chiremba anokwanisa. Asi pano voga, tsanangudzo iyi regai chokuita manyawi, sei nyore murume munzira vanofunga, akatanga kunzwa CGS-kudzidza. Zvakaziviswa yakanaka gertsept mamiriro kunoratidza kuti ichi mhando kenza zvikuru zvesimba zvakasikwa, zviri kukura nokukurumidza, kupararira kuburikidza muviri metastasis. Asi panguva imwe chete, akadaro akaipa nebundu dzakakwirira mukana achapindura mamwe zvinodhaka. Negative mapundu gertsept chinzvimbo vachakuudza kuti bundu hwapedyo zvishoma nezvishoma, asi zvakakwana kurapwa wake haana.

Immunohistochemistry - chii?

Mumwe inonyanya kenza pakati pavakadzi - zamu kenza. IHC kudzidza kunobatsira kuona mhando neoplasm ndinonongera kurapwa maererano mamiriro ezvinhu. Immunohistochemistry - a murabhoritari yokudzidza biopsy (biomaterial, wakatorwa panguva biopsy) kushandisa rinokosha coloring mumiririri. -рецепторы, и чем больше рецепторов, влияющих на появление и развитие "ненормальной" клетки, тем ярче будет окраска исследуемого биоматериала. Izvi fuma echitema HE R-2 receptors, uye zvakawanda receptors chokuita nechitarisiko uye kukura masero "mwero", iro chaipenya sedare bvunzo biomaterial.

Sei chinzvimbo pakati anomera?

Painted biomaterial panguva Murabhoritari kunovhenekwa kuona gertsept chinzvimbo vari nemaziso yokuongororwa. Mabhii pamwero ichi chinokosha, iro rine gradient ruvara kubva 0 kusvika 3+. Nzira Izvi zvinoita kusiyanisa mana makuru chikumbaridzozve, zvichienderana iyo iri kutarisirwa kutungamirira murwere mberi. Zvinoita sokuti - zviri nyore? Aizonyatsovachenesa kuti zvinyama chaiwo fuma, akaisa pasi maikorosikopu, nyatsofunga tichienzanisa zvaakaona kudzora ruvara ivhu, uye kuisa gertsept mamiriro bundu. Asi pano mukuru basa reDare vanhu chinhu, kunyanya chiedza uye zvichingodaro.

Sei IHC kudzidza

Nokuti vanofungidzirwa nekenza yemazamu kuitwa pakudzidza. Achiongorora zvaive immunohistochemical kudzidza ine zvose nezvikumbaridzo mana. Asi dambudziko riri kuti avhareji kukosha vaviri, uye zvichava 1+ uye 2+ pamwero anoratidza munhu kujeka mugumisiro, rinoda mberi kuongorora neimwe nzira. Izvozvo IGH- kudzidza - kupfuura gakava nzira Detective anomera gertsept hweHIV. Kuwedzera migumisiro pakutsvakurudza simba rinoshanda, Sezvambotaurwa, vanhu chinhu uye kwokunze ezvinhu. Chinhu bedzi zvikuru zvakarurama vakatsunga vaviri magumo mugumisiro - kunaka 0 (bundu ane kunaka gertsept mamiriro) uye 3+ (yakanaka hormone mamiriro bundu).

Female hormone mota

Sezvo mushonga ano, ruzhinji namamota vanhukadzi dzokubereka nadzo dziri novimba muviri hormone siyana. budiriro yavo vanoshingaira kukanganisa hadzi hormone - progesterone uye inonzi estrogen. Receptors nokuti mahormone izvi kuziva paumbwe uye kugadzira kenza. Akagadzawo kemikari nedoro kuona zvakajeka yakakwana kurapa zvaiitwa achiteverwa inokosha fungidziro. Uyezve, receptors izvi nezvaanoita kwete chete oncology zamu, asiwo nezvinetso zvakakomba zvakadai mukadzi kushaya mbereko, endometriosis uye kenza zvirwere zvounzenza bhora - muchibereko chemusikana, ovaries, cervix. Gertsept nhengo bundu, inosidzikwa pachidzidzo IGH- endometrium Somuenzaniso, akarayira kurapwa anobvumira chaiyo avo mishonga inogona kubatsira kuita mukana wakakwana mugumisiro pasina zvisina kufanira kwacho pamwe kusarudzwa zvinodhaka mune chimwe nechimwe chiitiko.

kana mbereko

Kushaya mbereko - dambudziko rakakura mhuri dzakawanda ano. Kuitisa nesayenzi yezvokurapa masangano netsvakurudzo kuti mune zvakakwana yokuwanda kacho kushaya mbereko iri nokuda kwokushayiwa hormone endometrium - the epithelial rukoko lining ari uterine mhango. It gertsept chinzvimbo uye rinozivisa IGH- kudzidza nokugamuchira of endometrium. Female kurara mahormone - zvinoshingaira nzvimbo pakati paumbwe zai rayo fertilization, mudumbu muchibereko ari dumbu, uyewo haizopereri kutakura nepamuviri uye pakusununguka. CGS-kudzidza endometrium, sezvatakagamuchira akati, anozivisa gertsept mamiriro endometrial masero kuti inonzi estrogen uye progesterone, uye maererano nemigumisiro kuti mukadzi asarudze zvakarurama kurapwa.

kuongorora chirwere rwekenza yelymphoma

Kenza - dambudziko vanhu. Kunyange ano pharmacology uye michina zviitiko zvinoita wokugadzirisa zvirwere izvi. Asi Diagnostics zvinokosha zvikuru, kunyanya mukutanga nzendo chirwere. Oncology node - nevakawanda dambudziko. IHC kudzidza rwekenza yelymphoma - imwe nzira kuti kuongororwa zvakarurama, ipapo kugadza yakakwana kurapa. Kudzidza uku kwainge kwave pamusoro biopsy pakati node Urume kana zvinyama hematopoietic hurongwa. Kuendeswa kufundwa iri pasi chaiwo coloring zvinhu kuti kukubatsira kuona bundu zvezvinangwa. Zvinosuruvarisa kutsvakurudza uku hakusi vakakwana uye kakawanda vaisanganisa nezvimwe chirwere nzira. Mukuwedzera, kazhinji haana nhengo dzinobudisa hurongwa kunokonzera matambudziko. Izvi ndizvo zvinoratidza IHC kudzidza node.

IHC ongororo - vachinyatsoziva ruzivo

Zvinetso zvoutano anofanira yakakodzera dzakaonekwa uye vanozivikanwa. Kwaizvozvi, kudiwa uye siyana kuongorora nzira, ongororo. исследование - один из наиболее распространенных методов диагностики новообразований или других проблем с тканями различных органов. IGH- kudzidza - chimwe chezvinhu zvakafanana nzira nechirwere anomera kana zvimwe zvinetso munyama-siyana dzomuviri. Imwe ongororo pamusoro IHC akatorwa kuziva zvinhu nyaya - vanonzi biopsy. The acho ari dzakapendwa anokosha zvinhu mumwe chinangwa chaicho uye kutarisana kuenzanisa inoitwa histologists chiremba isingachinji bundu zvezvinangwa, kuratidza imwe dambudziko. Kusakwana immunohistochemical kudzidza ndechokuti zvinhu kungasava zvakakwana kuridza basa dzevanhu zvinhu kana zvimwewo zvinhu haazobvumiri kuti vatange mufananidzo yakarurama dambudziko. исследование. Chero zvazvingava zvakakwana kuti chirwere chirwere, kunyanya Cancer zvakafanira kuitisa ongororo yakaoma, sezvamakaropafadzwa mumwe matanho zvichaita IGH- kudzidza. какого-ибо органа, ткани? Chii nekenza vamwe muviri tishu? Biopsy anoongororwa kuti bundu zvezvinangwa kuongorora kuvapo kwavo mharidzo. Sechinhu chinoyamura nechirwere pamusoro IHC kudzidza hunokosha, sezvazvakanyorwa vachishingaira kushandiswa pave zvinokonzera mukadzi kushaya mbereko.

Medicine, uye chirwere kusanganisira nguva dzose Virtual. Zvichida munguva pfupi immunohistochemical kudzidza vachaitwa kuti vakwane uye achabvumira vanhu vazhinji kuisa yakakwana chirwere pamwe mudukusa zvekushandisa nguva uye kushanda nesimba.