"Levodopa / benserazide-din email": mirayiridzo kushandiswa, analogs uye wongororo

Chii chinogona kutsiva zvinodhaka ichi se "L-Dopa / benserazide"? Analogues Mushonga uyu ichakurukurwa gare gare munyaya. Ticharamba kuuyawo pharmacological unhu chokushandisa ichi, ayo chimiro yaakazosunungurwa, zviratidzo uye nzira kushandiswa.

Form, akafanana, kavha

The medicament "levodopa / benserazide-din email", mirayiridzo iri akanyudzwa mukati makadhibhokisi bhokisi riri pauri muchimiro mapiritsi, mumapepa muhombodo 30, 20, 60 kana 50 zvidimbu. The chikuru zvacho zvinodhaka levodopa uye benserazide protrude. Panyaya mamwe zvinoriumba, zvinosanganisira: mannitol, karusiyamu rehydrogen phosphate (anhydrous), MCC, crospovidone, pregelatinized chibage starch, colloidal nesilicon dioxide, povidone K25, magnesium stearate, uye colorant tsvuku ferric oxide.

pharmacological unhu

Kugadzirira "levodopa / benserazide" rinomirira kukabatanidzwa antiparkinsonian mumiririri zvinosanganisira wayo sezvamunoita ari decarboxylase inhibitor (peripheral) inonhuwirira L-amino asidhi uye dopamine aizotangira.

In parkinsonism, dopamine asunungurwa kubva basal ganglia iri kukwana akawanda. yokutsiva Its rinoitwa kuburikidza levodopa, inova metabolic aizotangira kuti dopamine.

Kudeuka chikamu ichocho iri peripheral nyama iri dzikwanise dopamine, izvo haabatanidzwi muna antiparkinsonian chaizvoizvo, sezvo haina kupinda neropa-pfungwa mhinganidzo, uye ari zvakare mhosva vazhinji nenjodzi.

The kinetics zvinodhaka

Senyanzvi munguva mushonga mu mubvunzo, kana pane, ayo kinetic-muitiro? Levodopa pamwe benserazide Wakanyura runonyanya ari ura duku. Kana kugamuchira mushonga kupinda nhamba wevasungwa zvasvika pashure anenge 65 maminitsi.

Zvinofanira kunyanya kuzivikanwa kuti Absorção de Água kuti zvinhu izvi zvinoenderana intragastric ph zviratidzo, uyewo mwero excretion ose gastric mukati.

Kana kugamuchira levodopa pakarepo pashure kudya soro wevasungwa raro yeplasma anenge 30% shoma, uye mwero Absorção de Água - 15% ezasi.

Akawanda, mushonga uyu rinowanikwa duku ura, itsvo, uye chiropa. Zvisinei, chete 1% anopinda uropi.

hafu-upenyu mushonga pasi review, nguva yava maawa matatu.

Kusiyana levodopa, zvakadai zvinoriumba Pfungwa sezvo benserazide, usingasii zvinopfuura BBB. fuma iyi vaunganidza munyika zvemapapu rinenge itsvo, chitaka uye ura diki.

Kana achiita?

Drug "Levodopa / benserazide" rinorambidza Parkinsonistic. Naizvozvo, zvinokurudzirwa kugadza:

• parkinsonian syndrome (chirwere Kunze kunokonzerwa antipsychotic zvinodhaka);
• Parkinson nehosha;
• kunzvaira makumbo urwere, kusanganisira vanhu vane chirwere renal kukundikana vari dialysis.

Kurambidzwa kushandiswa

Kana pane contraindications ari zvinodhaka "Levodopa / benserazide-din email" (mhinduro achiratidza zvechokwadi, tinofanira kufunga pazasi)? mushonga uyu hakubvumidzwi kugadza:

• mupfungwa kurwara;
• hypersensitivity kuti vamiririri zvinhu;
• zvakakomba kuvhiringidzika kwemakemikari anobudiswa mugadziriro, uyewo midziyo uye mwoyo;
• zvirwere itsvo uye chiropa, asi mberi kudzikama makumbo chirwere pamwe kubatanidzwa goho dialysis;
• lactation;
• kuvhara yemaziso;
• zvinofambirana chikumbiro nonselective Mao FIs;
• pamuviri;
• pasi makore 25;
• kuti dzokubereka zera iri naka pabonde, kwete kushandisa hwakavimbika nzira pamuviri.

"Levodopa / benserazide": wezvokutengeserana zita, nzira chikumbiro

Purchase nehanya medicament anogona kuva chero chemishonga. zita zvinodhaka Trade unorira "Levodopa / benserazide-din email".

In chii chipimo chemushonga raitongwa varwere vaiona mishonga? Treatment nzira idzi kutanga pasi dose, iyo kuwedzera zvishoma nezvishoma (nokuti mumwe murwere nomumwe).

Maererano nenyanzvi, unofanira kudzivisa dzakakwirira mishonga zvinodhaka ichi. Zvinotevera dosing zvaiitwa inofanira kukurukurwa sezvinoitwa zvayo kurumbidzwaka.

"Levodopa / benserazide", akatorwa nomuromo kweinenge hafu yeawa asati kana pashure 65 maminitsi pashure zvokudya.

Vanhu kare kutora izvi zvinoreva, pakutanga yokurapa kutokurudzira kushandiswa 12,5 / 50 MG levodopa uye benserazide nguva zvina pazuva. With tolerability of chipimo chemushonga zvakanaka yakawedzera zvakaenzana ose mazuva matatu. Tevera titration rinoitwa ane kakawanda 1 ose mazuva 30.

Kazhinji, asi mishonga mugumisiro pashure kwokubatsira mushonga vakachengeta kare kana kugamuchira 100 MG benserazide uye 400 MG pamusoro levodopa pazuva.

The chepamusorosoro chipimo chemushonga zvinodhaka pazuva iri 800/200 MG pakati levodopa uye benserazide azvaitwa. Akati yakawanda medicament inofanira kugoverwa 4 kana kupfuura mishonga. Saka vanofanira yakagoverwa kuitira kupa murwere pamwe Zvakanyanya Kunaka Panguva Yepamuviri kuchirapa mugumisiro.

With kukura nenjodzi vanofanira kuwedzera dose kana kumira, kana kuderedza nayo.

The chipimo chemushonga zvaiitwa zvinodhaka iri rinokosha zvekuchipatara ezvinhu

Ndingatarira kutora mishonga "Levodopa / benserazide"? Nyanzvi Guest dzinoshuma kuti varwere kutarisana injini nokufamba, nezuva dose mishonga iyi inofanira kugoverwa zvinopfuura 4 rubvumo.

Pakukwegura, mukanyanyisa chipimo chemushonga vanofanira kutora nzvimbo zvishoma nezvishoma.

Zvakaitika zvinodhaka muvana uye kuyaruka ane paanogumira.

In hepatic uye renal kukundikana medicament dose kuchinja kunodiwa.

With pave kwatangwa kufamba, kunyanya munguva dzinouya nzendo kurapwa, Zvinokurudzirwa kuti kuderedza uwandu husingakuvadzi. Izvi zvinoshandawo varwadziwe ari CCC.

Zviratidzo ovhadhozi

Kugamuchirwa "Levodopa / benserazide" dzakakwirira mishonga yacho chinodhaka, anoreva zvakafanana, izvo zvichakurukurwa pazasi, anogona kukonzera zviratidzo zvakadai kuda kurutsa, kwemashifiti, involuntary fambisa munhu pathological hunhu, kushaya hope, kurutsa, kuvhiringidzika. Zvinofanira kucherechedzwa kuti pokumuka zviratidzo zvakadai anogona kunonoka nokuda kuderedza Absorção de Água zvinodhaka kubva ura.

Nokuti pakurapa ezvinhu akarondedzera symptomatic kurapa (ushandiswe mishonga antiarrhythmic, kufema ANALEPTIC uye neuroleptics), uye nguva dzose kuongorora anokosha muviri.

kudyidzana

Drug "Levodopa / benserazide" interacts nedzimwe zvinodhaka sezvinotevera:

• Kugamuchira trihexyphenidyl kunoderedza mwero asi kwete rwakadini Absorção de Água kuti levodopa.
• Antihypertensive zvinodhaka, opioids, neuroleptics uye zvinogadzirwa ine reserpine, tunodzivisa zviito zvinorondedzerwa medicament.
• Nokushanda antacids akazoita rwakadini Absorção de Água zvinoreva pasi kuongorora 32%.
• Metoclopramide kunowedzera Absorção de Água mwero levodopa.
• Rubvumo pyridoxine kunoderedza mugumisiro mishonga antiparkinsonian.
• Levodopa uye benserazide rirege kushandiswa pachiimbwa non-anyatsosarudza Mao FIs.
• Viewed chinodhaka potentiates kuitwa sympathomimetic.
• Levodopa uye benserazide nemamwe zvinodhaka antiparkinsonian runogonesa yakanaka uye zvisingadiwi nemigumisiro.

chaicho mashoko

Usati watanga kutora "Levodopa / benserazide" vanofanira achindireverera kuchipatara kuongorora zvizere. Izvi imhaka yokuti pane nhamba zvirwere umo kushandisa chokushandisa ichi nokungwarira zvakanyanyisa:

• In pamberi rakavhurika angled yemaziso kurapa musatanga kusvikira kuporesa murwere zvakakwana.
• Hazvitenderwi zvinodhaka payakakurudzirwa kukanzura "halothane", sezvo kungawedzera kukura kwezvinhu neuroleptic akaipa chirwere weruzhinji yokutindivadza.

Zvinofanira kucherechedzwa kuti pakutanga wandichavatorera mishonga yake vasiri parameters hazvingashandurwi kubudikidza murwere. Panyaya iyi, mukufamba kurapwa kunodiwa kuti aedzwe nguva kuongorora pakurarama zvose zvomukati.

Vanhu vane chirwere cheshuga vanofanira kuva kakawanda pazuva kuti aone ropa shuga.

Mari zvinodhaka uye ayo analogues / anoreva zvakafanana

chinodhaka ichi se "L-Dopa / benserazide-din email" anoita sei? Mutengo zvinodhaka izvi kunoenderana nenhamba mahwendefa por rongedza. It kazhinji yemakomo 600-1250 rubles.

Chii chinogona kunzi kutsiva antiparkinsonian zvinodhaka? Its chikuru analogues anoreva zvakafanana zvinosanganisira zvinotevera zvinoreva: "Zimoks", "Duellin", "Isik," "Lac" "Dopar 275", "Carbidopa / Levodopa," "Sinemet", "Sindopa", "Tidomet", " Tremonorm ". Zvinofanira pakarepo kucherechedzwa kuti pharmacological unhu uye nzira kushandisa zvinodhaka izvi zvingasiyana zvikuru kubva apa. Naizvozvo, kuti kutsiva kwavari, "levodopa / benserazide-din email" tinofanira chete yachiremba audzwa.

Inofambiswa kubudirira mushonga

Hazvina chakavanzika kuti chirwere chinonzi Parkinson chirwere chakakomba zvikuru. Uyezve, zviri chakakomba kwakaoma varwere uye vadiwa vavo.

Maererano vanachiremba uye vatengi panguva kurapika ichi chinobata kuvarwere zvose zvakasiyana. Dzimwe nguva kunyange pasi kuzviomesera pokudzora chiremba ane refu negashiro mahwendefa vari kuchengetwa dzevanhu varwere kushatirwa uye kudhakwa yaiparadza. Uyewo, divi kuitike sezvo zvisipo uye dzungu.

Akaroromesawo chipimo chemushonga mune vamwe varwere zviratidzo chirwere chepfungwa vari kunyangarika, apo gwenya basa haina kuremara. Zvisinei, mune dzimwe varwere, kunyange pashure wakakwana discontinuation zvinodhaka zvose chirwere chepfungwa zvikaramba zviripo. Uyezve, avo gwenya basa kuipa yekudyidzana.

Nezvokumutswa ose apa, tinogona zvakachengeteka kugumisa kuti negashiro mari inodiwa kugadzirira kukura zvikuru nemishonga, sezvataurwa pamusoro apa.

Maererano nemishumo nyanzvi, chirongwa Mabatirwo Anti-Parkinsonistic kugadzirira zvinofanira kuitika chete pasi kuzviomesera pokudzora chiremba. Izvi zvichaita kuti kunyange chamber miniti kuchinja murwere ezvinhu kuti kumwoyo uye psyche, uye kana zvakakodzera - kuti sei nenzira yakakodzera nenzira.