Mishonga fluoroquinolones - basa varwi utano hwako

Muna 1962, apo mishonga dzeboka iri yokutanga simba, hapana rakafanotaura kubudirire zvakadaro. Vakanga yakagadzirwa senzira kubata Urinary turakiti zvirwere, asi gare gare vakava kupfuura akakurumbira inorwisa mabhakitiriya. In kurapwa tsika, boka iri chipimo chemushonga vakatsva vachishingaira aishanda chete muna 80-ies pamusoro XX remakore. Nhasi, mishonga, fluoroquinolones inongova irreplaceable pakurapa zvirwere zvokufema. On muganhu Russia kwakakurumbira munyika kupatsanura inorwisa mabhakitiriya izvi zvizvarwa zvaizotevera. Asi zvinosuwisa, nokupesana ichi haabvumiri yomuchipatara kuziva kwavo makemikari anoumba uye chakarondedzera kwebasa. Naizvozvo, kazhinji anenge fluoroquinolones (nemishonga), muti, allocating 2 mapoka - old uye itsva.

kupatsanura zvinodhaka

Kuti Medicines ekare boka vari "Ofloxacin" zvinodhaka "enoxacin" "Ciprofloxacin" uye vamwe. mishonga New - mushonga "sparfloxacin", "Klinafloksatsin", "Moxifloxacin". Zvisinei, vamwe dzakabudirira mishonga havachisiri iripo, sezvo nyanzvi dzakakomba nemishonga chokuita zvavo kushandisa dzawanikwa.

Kushandiswa kwemishonga inorwisa mabhakitiriya

Ichi boka zvinodhaka rakagara richidudzirwa kushandiswa zvirwere Urinary turakiti, zvirwere intestinal uye zvirwere, pabonde. Nokuti pakurapa zvirwere zvokufema fluoroquinolone nemishonga inoshandiswa, zvinosuwisa, vashoma kwazvo, kunyange vava kukwanisa vanoshingaira kushanda mamwe utachiona.

The zvinodhaka

Mishonga Fluoroquinolones zvakanaka yokuita zvinoitwa nemudumbu, uye maximize mura Kuisa pfungwa pachinhu mune nyama pashure maawa 3 pashure kushanda kwavo. Kana panguva imwecheteyo kudya zvokudya, asi Absorção de Água yezviri ikakuruma kunonoka, asi chiito achava kutoshanda. The mashandiro chiito zvinodhaka ndiko chinovhiringidza DNA gyrase uye topoisomerase IV utachiona, saka hapana muchinjikwa-kuramba mamwe inorwisa utachiona nevamiririri. Ava zvinowanzoshandiswa mishonga kuti Gynecology (munhukadzi dzokubereka nadzo zvirwere), kunyanya inflammations ari pelvic zvomukati, izvo inomuka nokuda simba basa Micro-zvipenyu kupinda muimba pasikarudzi turakiti. Tora quinolones vanorumbidzwa usina chawadya, kunyange bvumidzwa uye kushandisa pashure kudya.

nemishonga

Mishonga, fluoroquinolones vari zvakanaka akashivirira pamusoro ingestion uye intravenous majekiseni. Nenjodzi hadziwanzowaniki, asi kana vachiita, ivo yemanyorero kukanganisa basa zvomudumbu turakiti uye tsinga chaitika. Unogona kuona kuda kurutsa, manyoka, nomusoro, dzungu, chinyamunhari chinorwadza, kutya. Kazhinji, izvi boka inorwisa mabhakitiriya kunoratidzwa pevane pharmacokinetic parameters.

Basic matanho fluoroquinolones danho

1. The kupinda napakati Kamudzira kupinda muchitokisi.
2. Chinovhiringidza of enzayemu DNA gyrase.
3. DNA biosynthesis.
4. Kuparadzwa algorithm Sero nokupesana.
5. Changes muchitokisi mamiriro.
6. Sero rufu.

Ichi boka inorwisa mabhakitiriya zvinonzi nevakawanda inoshandiswa mukurapa, uye kana akashandisa anokwanisa kupa rutsigiro kunobudirira utano hwevanhu.