"Oseltamivir": mirayiridzo kushandiswa, analogs, rondedzero yacho zvinodhaka

Sei taurira mushonga "Oseltamivir"? Mirayiridzo yokushandisa, analogs, zviratidzo uye contraindications zvinodhaka achapiwa kurondedzerwa zvishoma mberi. Nesuwo kukuudza pamusoro chimiro idzo unogona kutenga akati medicament, chii ehupfumi ine, kana nemishonga uye zvichingodaro. D.

The chimiro, mamiriro, rondedzero zvinodhaka

In yavakatengesa zvinodhaka anouya muchimiro capsules tsvuku-chena. "Oseltamivir" - iri prodrug. Kana anwa zvinonzi hydrolyzed uye kutendeukira yezviri chirungiso - oseltamivir carboxylate.

Kuwedzera capsules uye medicament iri asunungurwa muchimiro chiedza upfu kuti nomumukanwa kuturika.

Features mishonga

zvinodhaka "Oseltamivir" sei kushanda? Mirayiridzo application rinoti kuti mishonga mugumisiro mishonga iyi inobva kudzvinyirira pakati webasa makemikari, izvo riri pamusoro pemvura virion yokuSpain utachiwana.

Pamusoro okutambirwa ari medicament kupinda muviri wayo chikuru chinoumba iri kushandurwa kuti zvinoshingaira metabolite. Saka, oseltamivir carboxylate zvokusarudza kuchititadzisa neuraminidase. Somugumisiro dzokuteerera kwakadaro rinopera nemavhairasi sero chokuwanziridza rikurumidze.

Maererano unyanzvi, mushonga uyu anofanira kuzviita mukati maawa 35 pashure zviratidzo yokuSpain rokutanga. Chete nenzira iyi ya chirwere kunogona kuderedzwa 30%, uye mukana yematambudziko nekuomarara zviratidzo - 40%.

Pharmacokinetics zvinodhaka

Kana mishonga wefodya "Oseltamivir"? Mirayiridzo dzokushandisa kunoratidza kuti vanenge 90% kubva oseltamivir phosphate kunakidzwa gastro-intestinal turakiti. The rinoita fuma iri kuchinjwa kuti carboxylate pamusoro oseltamivir, uye ipapo anopinda systemic riparadzirwe.

About 3% yezviri chirungiso chichaparadza mapuroteni eplasma. bioavailability wayo anenge 76-85% uye kubviswa hafu-upenyu - maminitsi 120.

Kubva evanhu oseltamivir carboxylate Rinobva ne itsvo (vanenge 80%) uye dumbu (20%). Hafu-upenyu zvinodhaka ndiko maawa 6-10.

zvairatidza

Sei taurira mushonga "Oseltamivir" (purazi boka -. Antiviral vamiririri)? Maererano mirayiridzo, kuti medicament inoshandiswa kurapa yokuSpain A uye B. Uyewo rinowanzoshandiswa kudzivirira nemavhairasi zvirwere.

Contraindications

Ko contra "Oseltamivir" (rondedzero kugadzirira kwave vakaisawo pamusoro)? Maererano mirayiridzo, zvinodhaka wokukundwa hakubvumidzwi pa:

• Hypersensitivity kune basa chirungiso;
• renal kukundikana (kuchengeteka uye efficacy zvinodhaka pavarwere izvi haina kuzivikanwa);
• Vana vaduku pane 1 gore (pane chokwadi kuti paumbwe BBB muvana);
• pamuviri uye achiyamwa (haisi kuzivikanwa kuti mushonga wacho yabudiswa muna mukaka pavakadzi, uye kana zvinokanganisawo mudumbu).

Zvinofanira kucherechedzwa kuti mishonga iyi haina varumbidzwa vana pasi pemakore 13, sezvo nyanzvi hadzina vasarudzirwa kuchengeteka uye efficacy emvere Oseltamivir 'nokuti kudzivirirwa uye dambudziko yokuSpain.

Drug "Oseltamivir": mirayiridzo kushandiswa

Vidal (Medicines Handbook) rine nzwisisika ruzivo pamusoro munofanira kutora sei uye chii chipimo chemushonga chezvinodhaka mu mubvunzo. Zvisinei, zvinofanira kucherechedzwa kuti varayire mashoko mushonga vanofanira chiremba chete. Pashure pezvose, chete ane ruzivo nyanzvi achakwanisa kusarudza zvakanaka kurapwa zvaiitwa, izvo nokukurumidza uye zvinobudirira kuparadza zvose zvinoitika zviratidzo zvechirwere nemavhairasi chirwere.

Saka chii chipimo chemushonga iri ushandiswe "Oseltamivir"? Mirayiridzo dzokushandisa inoratidza kuti zvinodhaka izvi zvinofanira kushandiswa mukati 2 Mazuva pashure kutanga nezviratidzo chikosoro wokutanga.

Vana vakura kupfuura makore 13 uye vakuru vane zvinodhaka raitongwa mune mari kaviri 75 MG zuva 5 mazuva. Zvinofanira kuva pakarepo akataura kuti kuwedzera uwandu husingakuvadzi zvinodhaka (semuenzaniso, kusvikira 150 MG pazuva) haana kutungamirira vawedzere kuchirapa kushanda.

Kana mushonga uchida kuti ndipe vana vane makore makore 1-12, kuti chipimo chemushonga iri kugadziridzwa zvichienderana dzomwana muviri uremu.

Kuti adzivise yokuSpain vanhu vakuru nevana makore 13 ushandiswe 75 MG 1 kamwe 6 kwemavhiki pazuva (semuenzaniso, panguva idenda).

Varwere Cl creatinine Rine mamiririta asingasviki 30 paminiti zvaida kururamiswa chipimo chemushonga (75 MG kamwe kwemazuva 5 pazuva).

Side Migumisiro zvinodhaka pashure ingestion

Chero nenjodzi dzinoitika pashure kwokubatsira 'Oseltamivir' gadziriro? Mirayiridzo application inoti anowanzodanwa kwakaratidzwa nenjodzi ndiwo svoto uye kurutsa. Kazhinji, migumisiro ava munyoro kana mwero akaratidza uye kazhinji kuitika mumazuva kurapwa okutanga.

Zvinofanira kucherechedzwa kuti mune vamwe varwere, Varwere pakugamuchira mushonga pasi review, kuva bronchitis, vertigo, kushaya hope, kusagadzikana angina, pseudomembranous colitis, kupererwa neropa, mabayo, musoro humerus, peritonsillar pute uye fivha.

Very kusingawanikwi muvanhu kutora zvinodhaka "Oseltamivir", pane abdominal kurwadziwa, kugumbuka kunzwa, nosebleeds uye conjunctivitis. Kazhinji, nouku kuitika kamwe chete uye inonyangarika pachavo, pasinei nokuramba kurapa. Kwakadaro mananara regai zvinoda discontinuation kurapwa.

Zvichitevera kugadzwa antiviral zvinodhaka muvana uye kuyaruka kunoonekwawo nemigumisiro. Izvi zvinosanganisira zvinhu zvakadai mapundu, chepfu epidermal necrolysis, kuzvimba rurimi kana chiso, arrhythmia, kuvhiringidzika, pfari uye kuwedzera pamusoro chirwere cheshuga kuyerera.

zvinodhaka kwavatori

Information yakawanikwa iri kosi yacho pharmacokinetic uye pharmacological zvidzidzo vanotaura kuti kukura akaora inokosha zvinodhaka mukukurukurirana vane mushonga uyu ungangova.

The Mirayiridzo yaisanganisira pamwe mushonga, zvinonzi akati mawa pokushandisa medicament pamwe probenecid kunotungamirira kuwedzera AUC yezviri metabolite 2 nguva. Zvisinei, dose kugadziridzwa haisi kuzvireva.

zviitiko ovhadhozi

Ndezvipi zviratidzo kuonekwa varwere "Oseltamivir" yepamusoro mishonga yacho zvinodhaka? Reviews nemirayiridzo vanotaura kuti kune zuva hapana nyaya dzakadaro akasimuka. Zvisinei, dosages kuroorwa antiviral mishonga inogona kukonzera kurutsa kana svoto.

Kugadzirisa zviratidzo izvi, symptomatic kurapa.

Dzinenge kurumbidza pakugamuchira mushonga

Zvaunofanira kuziva murwere, asati kutora "Oseltamivir"? Mirayiridzo kushandiswa (vana uye vakuru vanogona kuona zvakasiyana nemishonga) zvinoratidza kuti mushonga haasi kushanda kuti wepagore kubaya. Haana kudzivirira kukura yematambudziko kuti munogona nemavhairasi zvirwere, uyewo zvirwere zvinokonzerwa noutachiona.

Analogs medicament

"Oseltamivir" - mushonga kuti vaida kuti kurapwa uye kudzivirira yokuSpain. It is antiviral mumiririri iyo inesungano FIs pamusoro neuraminidase. mushonga uyu unonyanyozivikanwa pasi zvizivikanwe zita "Tamiflu". Structural analogs nayo haako. The dzepedyo, asi zvishoma vaduku kuita, zvinotevera zvinodhaka ndivo Sevamiririri, "Relenza", "Arbidol", "Flustol", "Kagocel" uye vamwe.

Reviews uye dzinoongorora kubudirira mushonga

Maererano pakuongororwa dzakanga akanzwirwa muUnited States uye Mexico, kuti nemavhairasi itsva ndivo nehanya neuraminidase FIs ( "Zanamivir" uye "Oseltamivir"), asi ivo husingakwanisi rimwe boka - adamantanes ( "rimantadine", "Amantadine") .

Zvinofanira kucherechedzwa kuti nyanzvi haina efficacy zvinodhaka ichi pakurapa yokuSpain kwave kuiswa mune vanhu vane chirwere mwoyo uye zvirwere zvokufema.

Maererano vanachiremba, mushonga kunoderedza ya zviratidzo 1 zuva, asi ichi ndicho chete zvazviri kana kurapwa chakatangwa muna mumaawa mashomanana okutanga pashure kuonana murwere.

To musi, hapana mashoko akavimbika pamusoro kana kubata yaunodya zvinodhaka riri kuitika yematambudziko ose nemavhairasi kana zvirwere zvinotapuriranwa.