"Spironolactone": analogues, kurayiridza, kushandiswa, zvinodhaka tsananguro

"Spironolactone" - ndiko potassium uye magniysberegayuschy diuretic. The mushonga ndiwo simba diuretic, izvo kunotadzisa leaching muviri munyu zvinokosha. Rinotaurawo lowers ari acidity kuti weti. Zvakakosha kuti kuteerera, kuedza kutsiva mishonga "spironolactone". Analogs zvinodhaka hakusi nhaka ehupfumi akadaro.

Mamiriro uye Kuronga

mushonga uyu inowanika piritsi fomu. Active zvinoriumba ndiyo spironolactone. Mune imwe piritsi rine 25 kana 100 MG yacho fuma. Uyewo rinoumbwa ebetsero zvinoriumba: mbatatisi starch, monohydrate, lactose, povidone, karusiyamu stearate. Mahwendefa vakagumisa dzaizara ari makadhibhokisi bhokisi zvidimbu 20.

Pharmacological migumisiro

Drug "spironolactone" ane aldosterone antagonist. It chinhu adrenocortical kemikari. Aldosterone tichibatanidza pamwe mapuroteni receptors distal nephron masero akazoita excretion kuti yavaibvisa uye mvura uye anowedzera potassium leaching. "Spironolactone" kukwikwidzana kemikari ichi uye mabasa zvakanyatsosiyana. Kugadzirira anokurudzira excretion nemvura yavaibvisa kubva mumuviri, rarinoshevedzwa potassium ions. Electrolyte mwero haina kuvhiringidzwa.

Pari zvakakwana kudzidza pharmacodynamics zvinodhaka. Pamusoro kubvuma kuti nemudumbu payo wefodya nokukurumidza nokusunga kuti mapuroteni eplasma. Bioavailability mahwendefa iri dzinenge 99%. Mumwe akapfura Mishonga Inowedzera Absorção de Água yezviri zvinodhaka kushingaira fuma.

The kuchirapa zvazviri, maererano nemirayiridzo kunoitika mukati 5 mazuva. Zvinoda kwayo kuwanda zvishoma nezvishoma mumuviri kusvikira imwe pfungwa kuti Activate chezvinodhaka. Zvikasadaro, mune tsika mushonga nayo inonzi tinofanira kugara kushanda. Active fuma chinopinda nokukurumidza kupinda mukaka, uye zvinobva muviri pamwe mutsvina yadzo weti uye. Ndezvipi zvirwere vanachiremba varayire "spironolactone"?

zvairatidza

The mirayiridzo "spironolactone" rakashuma kuti mushonga wacho akaronga kunorapwa zvinotevera zvirwere uye pathologies:

• Edematous chirwere kuti kunoitika pamusoro yaitwa mwoyo kukundikana.
• Hyperaldosteronism.
• Essential neBP.
• Secondary hyperaldosteronism anokonzerwa cirrhosis.

Kurapwa chirwere vanofanira kutanga pashure zano chiremba.

Contraindications

Mune zvimwe zviitiko, hazvina yakarumbidza kutora zvinodhaka "spironolactone"? Zvairatidza kuti kushandiswa akauya pamusoro haasi chikonzero nokuzviremekedza kurapwa. mushonga uyu ane zvakawanda nemishonga uye contraindications.

Mirayiridzo kuna Drug Administration akati kuti kushandiswa kwayo nokuda kuchirapa zvinangwa haana pachii vanhu vane Addison nechirwere, hypercalcemia, chirwere cheshuga. Nokungwarira yokunyanyisa inofanira kushandiswa mushonga vakadzi vane kumwedzi hadzina kufambiswa zvakanaka, zamu nedumbu.

Mirayiridzo yokushandisa

medicament ichi zvakakodzera nomumukanwa yaitonga. The dose vagara vandifungira chiremba nomunhu, kwakavakirwa kwokuomerwa kutyorwa mvura-electrolyte mwero uye hormone kwevari murwere.

Kana edema kwakakonzera neurotic urwere, kurapa akatanga pamwe 100-200 MG zvinodhaka pazuva. The chipimo chemushonga anofanira huviri kana zvitatu mishonga. Ya kurapa iri mavhiki matatu. Kana hyperaldosteronism uye vakaderera potassium ropa medicament "spironolactone-Darnitsya" riri basa 300 MG pazuva.

At munhu hydropic urwere, chokuita chirwere hunhu cardiac insufficiency, kurapwa 5 mazuva. Mahwendefa vari kutarisirwa nenzira chipimo chemushonga pamusoro 100-200 MG. Uyezve, varwere kazhinji ushandiswe thiazide uye loop diuretics. Kana zvakanaka rinomutsa vana kupora chipimo chemushonga iri zvishoma nezvishoma yakaderera kusvika 25 MG pazuva.

nemishonga

Ndezvipi marwadzo anenge "spironolactone"? Analogs zvinodhaka uyu murombo portability. "Spironolactone", kusiyana, dzinoratidzwa nokukurumidza Absorção de Água uye zvakanaka kuchirapa kushanda. Apo neapo chirwere nemishonga, izvo zviri rakawedzerwa muchimiro anorondedzerwa pazasi.

1. Muviri: Kuchinja asidhi-nechigadziko nomwero, hyperuricemia.
2. CNS: wakawedzera hope, kutemwa nomusoro, lethargy.
3. Kweropa hurongwa: megaloblastoz, thrombocytopenia.
4. GI: abdominal marwadzo, maronda, intestinal chinyamunhari chinorwadza, manyoka.
5. Kwemakemikari anobudiswa maitiro: erectile dysfunction, zamu carcinoma, brutalization vhoti.
6. Neutachiona: kuvaviwa, mapundu, mikoko.

Kana mukawana nezviratidzo vanofanira kuona chiremba zvatsanangurwa pamusoro. Sezvo kutonga, nyanzvi anosarudza kutsiva "spironolactone". Analogs zvinodhaka ichi vane mamwewo matambudziko, asi vari vakaratidza kuti muduku pamwero.

Zvokungwarira

Panguva kurapwa "spironolactone":

• Zvinokurudzirwa kudzivisa kudya zvokudya potassium yakawanda.
• Zvaisambobvumirwa vose doro.
• It haafaniri kubva mawa kushanda medicaments mu murwiyo izvo potassium aripo.

Kana marapirwo zvatowedzera basa NSAIDs, zvinokosha kuongorora kushanda itsvo uye zviratidzo zviri electrolytes muropa.

In Paunotanga kurapa Zvinokurudzirwa kurega kutyaira motokari uye kushanda pamwe zvenhengo huru kuti zvinoda refu mwero psychomotor siyana uye kutarisirwa. Ya mitemo yakadaro iri nomumwe, kwakavakirwa tolerability, "Spironolactone".

Mutengo zvinodhaka uye kuchengetera zvinhu

Mari zvinodhaka zvichisiyana ayo chipimo chemushonga. Nokuti mumwe kavha mahwendefa achafanira kuripira kubva 30 kusvika 50 rubles. Vose mutengo inobvawo pane kumahombekombe, inosidzikwa zhinji ngetani chemishonga.

Maererano mirayiridzo, kugadzirira kuchengetwa panguva tembiricha kwete kupfuura 20 madhigirii, pasingasvikirwi vana maoko nzvimbo. Pasherufu upenyu 3 years.

zvinodhaka analogues

Ndezvipi zvinodhaka zvinogona kutsiviwa ne "spironolactone"? Analogs of medicament kakawanda vane sezvamunoita zvakafanana uye mumisasa huru zvinoriumba. Izvi zvinosanganisira zvinotevera zvinodhaka: "Veroshpilakton", "aldactone", "Veroshpiron". The yokupedzisira kakawanda kushandiswa panzvimbo nhau munyaya ino chezvinodhaka.

Pakati mishonga inonyatsozivikanwa Generic zvinosanganisira zvinotevera: "Dekriz", "Inspra", "Espirit", "Epletor". Mashandiro chiito ivo zvakafanana "spironolactone". Zvairatidza uye bioavailability iyeyo. diuretics ava zvikuru vanobudirira kuti normalization ropa nevezera, kushaya yebongozozo zvinwiwa kubva mumuviri. Zvisinei, zvisinei, Generic kushanda kwete kuchengetedza pamusoro leaching kuti potassium uye magnesium, vanachiremba vakawanda vanoda kushandisa pakutanga zvinodhaka.

To muchidimbu

Zvino kuti unoziva pasi chii pathologies uye zvinetso kugadza "spironolactone". Mutengo zvinodhaka uye ayo Kuwanikwa zvakapararira - huru mbiri nzira iyo varwere vakawanda vanosarudza nayo medicament ichi. Vakawanda Wongororo kuratidza zvikuru kunobudirira "spironolactone".