Uropi wenyu kukwegura nokukurumidza sei? Masayendisiti akaratidza majini anokosha

Uropi Your anogona kutanga zera zvikuru nokukurumidza kana iwe kutendeukira makore 65 okuberekwa. Kana varege kutanga. Zvakaratidza, zvinoenderana chii shanduro imwe Gene kuwanikwa genome yenyu. Ndizvo masayendisiti akawana zvichangobva kudzidzwa. The nevatsvakurudzi zviratidzo kuti anodzora nokukurumidza panguva iyo pfungwa yako kuchembera, uye panguva imwe chete vanoti kuti imwe shanduro Gene ichi ingashandiswa kudzivirira vakawanda vezera-chokuita chetsinga zvirwere zvakadai penga nokuda kokuchembera dementia.

Gene kuti anogona kukudzivirira dementia?

Gene ichi, anonzi TMEM106B, anotanga kuita vakapoteredza nguva munhu akatendeuka makore 65 okuberekwa. Nguva pfupi pashure pacho, muna vanhu vane kuvapo ari shanduro Gene zvakaipa, uropi vachatarira vakura kupfuura pfungwa vanhu vaya vane kuvapo muna akanaka, anobudirira shanduro Gene makore 10-12. Izvi zvakawanikwa zvingabatsira vanachiremba ndevapi vanhu vari panjodzi huru panowanikwa chetsinga chirwere mamiriro nokuti vane shanduro zvakaipa majini. It vangabatsirawo pakasikwa mishonga, matambudziko izvo zvichashandiswa nangananga kuti Gene kupa vanhu vane kuchembera pfungwa zvikuru utano.

Chinonyanya kukosha pakati dzose majini

Mumakore achangopfuura, masayendisiti vakawana vakawanda majini chokuita cheAlzheimer uye Parkinson uye zvimwe zvirwere chetsinga. Zvisinei, majini izvi vanokwanisa kutsanangura chete chiduku chikamu zvirwere izvi. Sezvo tichiziva nhasi, mukuru ngozi nokuda neurodegenerative chirwere ari kuchembera. Chinhu Kuchinja muuropi kana wakura, uye izvi zvinotungamirira chokwadi kuti vava kubatwa nezvirwere wouropi. Mirayiridzo majini kuti anopa TMEM106B Gene kungava kuti "chinhu." Uye zvikwata izvi zvinogona kana kudzivirira matambudziko anokonzerwa kukwegura kana sembura navo. Kana ukatarira panguva boka revanhu vakwegura, vamwe vavo vachava kutarira vakuru vamwe, uye vamwe -molozhe. Chaizvo kusiyana chete akwegure zvinogona kuonekwa mune frontal cortex, uropi nharaunda anokonzera kunzwisisa pfungwa pezvakaitwa.

New tsvakurudzo pamusoro pakanyorwa yapfuura

Zvidzidzo Previous akabatanidza Gene ino isingawanzowanikwi muchimiro dementia inonzi frontotemporal degeneration. Asi kudzidza itsva inoratidza kuti Gene ichi vari zvikuru nevakawanda chokuita pfungwa kuchembera uye anosarudza sei zvakanaka vanhu vakwegura varambe zvishande ushande. Kuti uone kuti kudzora pfungwa kukwegura, vatsvakurudzi maviri vakaongorora majini mashoko kubva kupfuura 1200 uropi ivhu vaiva avo vanhu vasina nechirwere chero neurodegenerative chirwere kana vachiri vapenyu. Vainyanya kusimbirira mashoma zana majini kuti kana kuwedzera efficacy kwokutanga kana yakaderera panguva kwevanhu zvokukwegura. Masayendisiti akaita chati pamusoro mashoko aya, zvavakanga inonzi "differential kukwegura". girafu Izvi zvinoratidza kusiyana chipo (kana anotevedzana) uropi zera rake zera chaiyo.

Chii peculiarity kuti Gene ichi?

Mumwe Gene, zvakafanana TMEM106B, vakamira kunze kubva zororo, achiratidza pacharwo sezvo differential kukwegura yacho injini. Zvakaratidza kuti Gene ichi anodzora kuzvimba uye kurasikirwa Tutsinga tunofambisa mashoko utwu muuropi. Asi naGene ichi chine mhando mbiri, kana pane, alleles maviri: wokutanga Rinobatanidzwa mikana yakawanda nokukurumidza kukwegura uropi, apo mumwe munhu wokudzivirira uye kudzivirira wakakurumidza zvokukwegura. Mumwe munhu ane shanduro mbiri Gene iri genome, uye vanenge makumi matatu muzana yevagari izvi shanduro mbiri - zvakaipa. Makumi mashanu muzana, mumwe allele ndiye unodzivirira, uye dzinoodza ekushandiswa pamusoro uropi, zvakanaka, uye akasara makumi maviri muzana alleles mbiri unodzivirira.

A-siyana anofambidzana, uye chii ichi nzira

Kana toreva inogona vatongwe panguva ino, inokanganisa pakati alleles vaviri tinofanira kugara. Izvi zvinoreva kuti uropi hwomunhu, ine mbiri dzisina alleles, anotarira vakura kupfuura pfungwa vanhu vane imwe chete kunaka allele makore mashanu. Uye pfungwa dzavo, akavapindurawo, anotarira vakura kudarika pfungwa dzevanhu vaya vasina kunaka alleles makore mashanu. Saka mumwe mukuru hypotheses pamusoro jini munhu maererano iyo TMEM106B anodzora enderana mhinduro iri uropi hwomunhu pazera zvinoshungurudza. Sezvo chikamu chete kudzidza, vatsvakurudzi akatarira uropi nevaya muupenyu hwake nechirwere cheAlzheimer kana Huntington uye akawana anawo mugumisiro majini pamusoro yakwegura wouropi. Zvinokosha kuyeuka kuti Gene ichi kunova chinobudirira kana zvasvika makore 65, pamberi pavanhu vose vari chete chechetere.