"Valsartan": mirayiridzo kushandiswa. Medicine "Valsartan" - analogues wongororo

The mushonga unonzi "Valsartan" mirayiridzo Chinyorwa anotsanangurwa aibatanidza nzira, akabatanidza pharmacological mapoka peripheral vasodilators mhando. Kushandiswa kwezvinodhaka ichi ane raidudzwa vane chirwere cheBP zvainoita murwere. Uyewo, mushonga uyu ane zvokusarudza anopikisana zvainoita AT ₁ receptors zviri mhosva Implementation pakati nedanho angiotensin II. Uyewo, unhu diuretic Migumisiro dzinaro Muviri chinhu yaisanganisa mudziyo, se "Valsartan". Analogs kugadzirira ichi - Kamudzira "Diovan" "Exforge" "Tantordio" uye "Valsakor" - vane ehupfumi zvakafanana.

Mamiriro Akaita pharmacological chiito

Kana zviri pharmacological zviito antihypertensive vamiririri, ndiko, yavlyas antagonist chaiyo inonzi angiotensin II Kanotokonya, zvinobudirira rakavhara AT ₁ receptors uye anowedzera plasma wevasungwa pakati angiotensin II. Nenguva mushonga chete "Valsartan" (mirayiridzo kushandiswa anotsanangura sezvamunoita kwayo) hakurevi tunodzivisa angiotensin-rokutendeutsa enzayemu. Uyewo, hapana kana agonist basa panyaya AT ₁ -receptors. Pakati pezvimwe zvinhu, wepakuvamba "Valsartan" hakuiti adzikatidza Ion hova uye receptors nezvimwe mahormone kuti zvinokosha kunowanzoitika mutemo kumwoyo. Mukuwedzera, mushonga une maturo nenhanho tireoglobulinpa, uric acid, zvachose remafuta akawandisa uye plasma shuga.

Pharmacokinetics

Kana isu kutaura pamusoro pharmacokinetics ari Anti-vane chirwere cheBP vamiririri, sezvo mushonga "Valsartan" Saka, somunhu mutemo, zviri nokukurumidza woga kubva nemudumbu pashure nemumuromo kutarisira kunyange ukuru Absorção de Água kunoenderana munhu kusiyana.

In ichi antihypertensive zvazviri kazhinji anotanga kuitika pashure zana - zana namakumi maviri maminitsi pashure chete dosing zvinodhaka, uye kunonyanyisa kuchirapa kushanda kunokwanisika Paavhareji mana - kwemaawa matanhatu. The Mhedziso bioavailability uyu mushonga inongova pamusoro 22%. Uyewo, ndichisunga kuti ropa mapuroteni (kunyanya sealbumin) ndiyo 94-98%. Plasma Clearance zvinodhaka "Valsartan", iro mamiriro rine zvakananga simba pamusoro payo, ndiye anenge 2 L / h. It rwunoratidzwa antihypertensive mumiririri kunyanya faeces (anenge 70%) uye, kuti zvikuru chiduku zvakadini ne weti. The mugadziri Kunosimbisawo kuti panyaya mhingaidzo zviri bile ducts kana biliary cirrhosis, ichi mushonga AUC kunowedzera avhareji hafu. Mukutsinhana kushandiswa kwezvinodhaka chero kuchinja pharmacokinetic zvivako uye parameters kuchengetwa.

Description of zvinodhaka

Yakabudiswa antihypertensive mushonga "Valsartan" (mirayiridzo kushandisa iyo kunodiwa zvirimo mumwe rongedza) muchimiro mapiritsi, film-zvemapuranga, uye muchimiro upfu chena. fuma Izvi kushanda insoluble mune zvavo mumvura uye nyore soluble mune methanol uye panyaya iyi. The samolecular kurema Pfungwa iri pamusoro 430-435. Kana Zvinoumba ichi unosvikirwa-vasodilating, ipapo sezvo huru anodawo zvinhu izvozvo ine angiotensin II Kanotokonya mhando uye thiazide diuretic.

MUNDA mishonga kushandiswa

Tora piritsi "Valsartan" mirayiridzo kushandiswa Anonyanyowanika ndaizoitwa chikamu vanonzi mubatanidzwa kurapa vanhu vanotambura nekuora mwoyo nokukundikana kana BP.

Uyezve, iyi mifananidzo antihypertensive mumiririri kushandiswa kuwedzera kupona vanhu kusachengeteka kukuru myocardial infarction (kusanganisira yakaoma ventricular systolic dysfunction kana kuruboshwe ventricular kukundikana). Varwere mwoyo chirwere vanoita zvetsika zvinodhaka, diuretics tiri kazhinji raitongwa mishonga "Valsartan". Analogues kuti chokushandisa ichi kunogona kushandiswa mune zvose pamusoro apa.

chipimo chemushonga

Tora antihypertensive chinodhaka, vanachiremba kazhinji akakurudzira mumwe kana kaviri pazuva masere kana makumi mana milligrams, ukuwo. In pasina kutsvakwa kuchirapa zvazviri, nezuva chipimo chemushonga anogona ngazviwedzerwe. Zvisinei, izvi zvinofanira kuitwa zvishoma nezvishoma uye chete ushandiswe nachiremba. The kunonyanyisa dose zvakafanana kwezvinodhaka mazana matatu namakumi maviri milligrams.

The mazita contraindications pakushandisa

Shandisai chishandiso-vasodilator nyanzvi zvakasimba dzinokurudzira kuti kana paine munhu nomunhu hypersensitivity kune imwe yenhengo dzayo. Kana waisa neutachiona analogously haafaniri kutora mapiritsi "Valsartan". The mushonga yepakutanga haafaniri kutorwa nevarwere vasina kuwana makore gumi nemasere. Zvapedzisira imhaka yokuti kuchengeteka kushandiswa antihypertensive zvinodhaka Muzviitiko zvakadaro hakuna aizvinzwisisa.

Shandisa panguva pamuviri

Ushandiswe mushonga "Valsartan" vakadzi anotakura mwana, zvachose contraindicated. vakaronga zvidzidzo yezvokurapa izvi anoratidza kumbonyanya yakakwirira pangozi nemigumisiro ine antihypertensive vamiririri pamusoro azvarwa. Zvisinei, kana chakakomba chirwere zvinouraya umo hazvibviri kushandisa vamwe, mishonga njodzi, kana vari zvishoma inobudirira, pokushandisa zvinodhaka-vasodilator. Yoga inofanira akati pamusoro inadmissibility ari kushandiswa chishandiso apo zvokudya achangozvarwa pamwe mukaka.

Possible divi Maitiro

Kugadzwa akadaro antihypertensive zvinodhaka ane, se "Valsartan" anogona kukonzera nezve nani kwazvo nomusoro, dzungu, chikosoro uye utera. Uyezve, panowanzova kuda kurutsa, manyoka, hyperkalemia, syncope, uye kushaya hope. Abdominal marwadzo, vertigo, neutropenia, thrombocytopenia, arthralgia, musana marwadzo, myalgia, kurukutika, uye kuzvimba kunogona kuitika somugumisiro zvinodhaka kutarisira zvakafanana "Valsartan". Reviews wevarwere ndambodzidza akarishandisa, anoratidzawo ngozi pharyngitis, rhinitis, sinusitis, akasiyana-siyana kutapukirwa noutachiona uye zvirwere kukanganisa okumusoro madhipatimendi kufema. Uyezve, vanhu vakawanda vakachengeta hyperbilirubinemia, ungaderedza hematocrit, hypercreatininemia, kuwedzera ropa urea senitrogen tigutsikane uye vasanyanye hemoglobin. Uyezve, nguva dzose unofanira kurangarira kuti mawa negashiro rinoreva-vasodilator "Valsartan" uye mishonga kubva boka potassium-kukudzivirirai diuretics zvinogona kukonzera hyperkalemia kukura. Kana zvinodhaka ovhadhozi zvingaitika ezvinhu akadai bradycardia, hypotension kana tachycardia.

Basic zvokungwarira

In mhedziso, zvinofanira kutaurwa kuti zvinokosha nokungwarira akanyanyisa uye chete pasi zvachose zvokurapa pokudzora kugadzawo negashiro antihypertensive mumiririri vari varwere yavaibvisa kushaikwa, yakanyanya kutyora itsvo, bilateral stenosis paiya inonzi renal tsinga kana anyatsoona zvinoderedza achiparadzira rwakapetwa ropa. Izvi imhaka zvikurukuru ine ngozi varwere arterial hypotension. Uyezve, unofanira kubhadhara ngwariro chaiyo vanhu vanotambura biliary cirrhosis kana zvakakomba kusagadzikana chiropa. Varwere pamwe renal tsinga stenosis kunoda kuramba zvichiongororwa pamusoro kuwanda urea senitrogen uye serum creatinine. Uyewo, ngwariro chaiyo roga zvinoda varwere mhingaidzo pamusoro biliary turakiti, kugamuchira potassium-kuuraya diuretics, inokosha kalisodergaszczye potassium zvokuwedzera kana zvinodhaka. Pakupedzisira, kungwarira akanyanyisa inofanira kushandiswa antihypertensive zvinodhaka "Valsartan" vanhu vane basa chokuita nokufambisa upi motokari, uye avo vane basa iri interfaced zvakananga rurefu yevasungwa kunzwa.