Acid phosphatase muropa: kutsunga, decoding uye mwero

Acid phosphatase - imwe enzayemu kuti Inowedzera kuti manyowa kubva mamorekuru pamuviri. Kutsunga kwayo dhigiri ropa kunokosha kuti diagnosing noutano ezvinhu. Kune mhando anoverengeka asidhi phosphatases, izvo navo vakuru kufanana, asi akasiyana zvikuru kubva mumwe pachinhu dzomuviri munyama, chromosomal mavambo, akafanana.

kwadzo

Powered enzayemu muna acidic runyararo, saka zita. Acid phosphatase inowanikwa munyama siyana uye masero vanogona riri lysosomes uye mberi. Nhamba huru akatsunga kweprostate gland, uyewo masero anotevera nhengo:

• chiropa;
• chirwatata;
• mwongo;
• ropa masero (erythrocytes, maplatelet, macrophages).

Mune imwe nhengo utano basa iine acid phosphatase iri nani pasi. The vamiririri hono hafu pamwero kwayo kuchibva prostatic phosphatase, uye izvo rakaparadzwa chiropa uye ropa masero. Makemikari munhukadzi muviri aumba zvinoparadzwa chiropa uye erythrocytes, maplatelet zvachose.

Lysosomal asidhi phosphatase

It iri mumasero dzakawanda. ainge Its chinhu autosomal recessive chirwere, izvo vaiona kuti mugumisiro pathological metabolic kwendangariro. Symptomatology chirwere pachena pacharo sezvinotevera:

• inoratidza svoto uye kurutsa;
• simba, kurasikirwa kunyatsoshanda;
• BP;
• pauduku - opisthotonus (pfari kuti kuitika arching ari kumashure chinhu chakakombama, varwere vanovimba pemvura pamubhedha chete mutsipa uye tsoka);
• ropa.

Kana enzayemu pamwero iri kushomeka chete muropa masero machena, varwere vanowanzotambura exacerbations echirwere zvirwere.

Prostatic asidhi phosphatase

It anonzi chiratidzo nekenza pezvakaitwa yeprostate. Izvi rworudzi enzayemu yakatsunga uye kumbeu zvechinguvana mvura iri nemiedzo (chibharo). Acid phosphatase unomutswa, uye mazuva mashomanana pashure pakuvhiya kweprostate gland kana biopsy background.

Optimum ph paakati kuti zvakakodzera kushanda enzayemu - 4,6. Basa anooneka bedzi pashure munhu vachiyaruka.

Pari Pakusarudza pachiyero prostatic phosphatase sezvo chiratidzo kenza tinokanganwa kupinda pakanyorwa kufarirwa prostate-zvakananga antigen, rinogona kuzosimbisa pamberi chirwere panguva kwokutanga zvokukura kukura. Kunyange zvakadaro, zviratidzo zviri prostatic iine acid phosphatase inokosha iri vachifanotaura ari dzokororo kenza kwacho pashure kuvhiyiwa yakakura yeprostate rokubvisa.

The kuongorora kuona kubudirira Mabatirwo prostatic hyperplasia isiri yekenza uye dzimwe prostatic pathologies.

eritrotsitarnaja phosphatase

Ichi polymorphic enzayemu kuti harisi chete matsvuku masero asiwo dzimwe mumasero omuviri. The optimum ph nokuda huchishanda zvichisiyana 5.2 kusvika 6.2.

Acidic phosphatase ropa zvinogona tsunga kujekesa ubaba. Mamwe mashoko enzayemu chokuita zvinotevera ezvinhu:

• majini kubatwa kune hemolytic kupererwa neropa;
• zvokurwara, iyo inozivikanwa nokuva kukura hemolytic kupererwa neropa necheseri vachidya bhinzi;
• kupererwa neropa kushandisa zvimwe zvinodhaka kana kuva chinhu hweHIV nemavhairasi uye kwemabhakitiriya mavambo.

Kune marudzi erythrocyte iine acid phosphatase chokuita kutyorwa kuti kuitika pauduku zvakananga.

Macrophage mhando asidhi phosphatase

The enzayemu inokosha mune chirwere pamusoro Gaucher chirwere. Iri nhaka chirwere iyo anoratidza kuunganidza ari chiropa, chirwatata, itsvo, uropi, zvemapapu glucocerebroside (Organic zvinhu kubva boka mafuta). The chirwere achabatsirwa kuwedzera kukura kwemiviri ichangobva kutaurwa, rakapinza vasanyanye nhamba masero ose ropa, nezvipusha, spastic nezvipusha, mupfungwa retardation.

Macrophage iine acid phosphatase zvakare vaiona imwe zvechinguvana kuti mvere muchitokisi neleukemia. chirwere ichi pamwe pagadzirwe zvinokosha mari yacho enzayemu, zvakatemwa muropa.

phosphatase osteoclasts

Akadana osteoclasts pfupa masero anokonzera kuparadzwa kwayo. Danho iri rinokosha kufunga pfupa kukura uye yagadziriswa chikwata. High nokukurumidza mapfupa kurasikirwa kuitwawo zvinotevera zvirwere:

• Paget nehosha (pathological kwetunhu kwomuzvarirwo pfupa inotungamirwa nezvinhu zvaro);
• hypercalcemia pamusoro malignancy;
• wokusagadzikana of thyroid uye parathyroid mumasero ;
• postmenopause akabatana osteoporosis.

Result - kakawanda mitswe uye mberi rive dete repfupa zvivako. Kutsunga iine acid phosphatase osteoclasts zvinoratidza yakakwirira kwevari makemikari ari pakanyorwa pamusoro pathologies.

Kugadzirira uye kuitisa Diagnostics

Quantitative zviratidzi takatsunga muna murabhoritari ezvinhu. The kuongorora yaifanira pashure 2 Mazuva kubvira panguva dzimwe chirwere dzokuvhiya. Kana uchida kuongorora pachiyero prostatic iine acid phosphatase, ichi chinofanira kuitwa asina yapfuura pane maawa 48 mushure biopsy, palpation kweprostate, dundira catheterization. In nevakomana nyaya, migumisiro kungava positives venhema.

Fence zvinhu yokutsvakurudza kuitwa usina chawadya. Unogona kunwa mvura chete, kunwa tii, kofi, facial uye zvimwe zvinwiwa hakubvumidzwi. Masikati, unofanira kusiya doro, mafuta, aisvuta ndiro, 1 awa risati ongororo - kubva kusvuta. Yokupedzisira hafu yeawa pamberi yaunodya kwemashoko inofanira kuitwa zvizere pfungwa norunyararo.

Nokuti nechirwere rimwe venous ropa rinoshandiswa, kureva serum kwayo tichidzivisa hemolysis. The Ongororo Migumisiro vanozivikanwa rakatevera pakudzidza.

The nzira inoshandiswa

Kujekesa pamwero zvachose iine acid phosphatase akashandisa immunochemical dzokubvisa pamwe chemiluminescent vasabatwa. Shandisa anokosha substrates kuti anosangana zvimwe makemikari. Pari hurongwa anoshandisa luminol nomukaka peroxidase akabatana rehydrogen peroxide mhinduro. Izvi zviri akawedzera initiator (semuenzaniso, N-yodofenol) anokwanisa kuwedzera luminescence kuti mhinduro zviuru kanoverengeka.

Pane dzimwe hurongwa kuti dzinoshandisa alkaline phosphatase uye AMPPD substrate, kuita chirwere nzira kunyange unetseke. Zvakanakira nzira vanofanira kudzidza kugadzikana reagents akashandiswa, hapana radiological ngozi. Nokuremara kwakavakirwa kunzwisisa kwakaita chirwere muitiro.

wokuyera

Total iine acid phosphatase assays yakaratidza U / L. zvinobvumidzwa parameters Its zvinosiyana zvichienderana nezera uye kuti munhui.

Normal prostatic iine acid phosphatase zviratidzi - asingasviki 2.1 kumar / Rine mamiririta. All inofananidza kumusoro kuratidza mafungiro mugumisiro nechirwere.

Kana ufanane enzayemu yakawedzera?

Mamiriro ezvinhu zvakakura iyo quantitative matanho pamusoro dzose:

• thrombocytopenia - a kwakaderedza nhamba masero eropa anokonzera rayo pakugwamba;
• thromboembolism - blockage of lumen huru tsinga thrombus, vakanyarara kubva mudziyo parusvingo, kana embolus, vari muropa;
• Hemolytic chirwere - chirwere aine kuparadzwa muhombe masero matsvuku eropa kusunungura zvinokosha yakawanda bilirubin iri muropa;
• budiriro Paget nehosha - mapfupa zvokurwara midziyo panguva iyo ive kusaenzana pakati pfupa inotungamirwa uye kuparadzwa zvinoumba vachida yokupedzisira;
• myeloma - akaipa bundu muitiro hunhu, ndiko wakapindwa B-lymphocytes, basa kwetunhu masero anodzivirira;
• Niemann-Pick chirwere - nhaka zvokurwara dzinoratidzwa havachanyatsogoni mafuta muviri uye kuunganidza lipids ari makuru zvomukati (chitaka, chirwatata, bapu, mwoyo, itsvo);
• mazuva mashomanana pashure pakuvhiya kweprostate gland wayo tishu biopsy.

Acidic, alkaline phosphatase - boka makemikari anokonzera pezvakaitwa kukosha mumuviri. Ndizvo achibatsirwa wavo kuchibva zvinokosha akatevedzana siyana. Pakusarudza pachiyero makemikari anobvumira nguva kuongorora Kuwanikwa zvokurwara uye rigomutungamiriravo kutsigira rakasungwa kwohumwe yepamusoro upenyu.