Agranulocytosis - chii ichi? Agranulocytosis muvana uye vakuru: Zviratidzo, zvinokonzera uye kurapwa

Laboratory kuongorora ropa vanoita dzinenge ose chirwere. Izvi chokuita mashoko zviri munhu akaidza. On rokuchinja nomumwe parameters ropa zvinogona kuonekwa pamusoro etiology kwezvirwere, kwokuomerwa ari pathological muitiro. Information kuwedzera kana kudzikisa zvimwe chaiyo yeplasma masero achibvumira chaiwo vaifungidzirwa kutyorwa. Somuenzaniso, neleukemia,-siyana kupererwa neropa. Mumwe rabhoritari zviratidzo vaiona agranulocytosis. chirwere ichi, izvo zvinogona kuitika chete kana akabatana nevamwe kuchinja muropa. chiratidzo ichi zvinoratidza kuvapo zvikuru noutachiona.

Agranulocytosis - chii ichi?

Zvirwere ropa vaiita zvesayenzi hematology. Kukanganisa, izvo zvinoratidza zvikuru pathological zvichiitika agranulocytosis. chirwere Izvi dzinoratidzwa raidudzwa kudzikisa huwandu chena ropa masero - leukocytes. Ivo zvinodiwa kudzora zvinotapuriranwa yomuchipatara kupinda muviri panguva pazvirwere.

Normal chena eropa count akaenzana 4-9 x 10 ⁹ / l. Kuwedzera kwenhamba masero aya anoratidza kukura anogumbura pfungwa. Kushaya ropa masero machena zvingaitika kana kukundikana zvirwere, chinovhiringidza pamusoro hematopoiesis, kudhaka. Agranulocytosis - murabhoritari chirwere hwokuratidza kuderera mune padanho ropa masero machena 1 x 10 ⁹ / L zvichidzika (neutrophil - 0.75 * 10 ^9). Nokuda raidudzwa kushayiwa masero masoja varipo siyana pezvakaitwa rwarisa kwemabhakitiriya kana nemavhairasi etiology. Kuziva chirwere, chiremba bvunzo ropa kunokosha.

The kakawanda panowanikwa agranulocytosis

Izvi hematologic chirwere kunoitika pakati navarandakadzi kwevanhu. Vachiberekwa agranulocytosis kashoma zvakanyorwa, kana tichienzanisa vawana chirwere. Saizvozvowo, kuchinja cellular Zvinoumba Ropa tichikurumidza vakadzi repakati (kubva pamakore 40). The kakawanda ichi yezvirwere kuchiitwa yakasiyana munyika dzakasiyana. Paavhareji, agranulocytosis dzakaonekwa muna 1 kubva 1200 vanhu. A chinokosha zvinoderedza uwandu ropa masero machena tichikurumidza kuvaRungu.

Zvikonzero kukura agranulocytosis

Sei kuva agranulocytosis? Zvikonzero ichi pathological ezvinhu kunoenderana-siyana chirwere. Vachiberekwa agranulocytosis anokonzerwa nhaka zvinhu. The chirwere zvinoreva kuvabereki kutsunga pathologies. Njodzi kuti mwana akaberekwa amai kana baba anorwara, kuchaitika chirwere ichi chaizvo. Zvikonzero zvichikonzera vawana agranulocytosis dzinosanganisira:

1. Autoimmune zvirwere. pathologies akadaro chinonzi systemic lupus erythematosus, scleroderma, dzinonzi rheumatoid arthritis. In zvirwere izvi, masoja kudzivirira haasi chete zvainanga dzimwe nezvimedu, asiwo pachake masero omuviri.
2. Kuonana ionizing nemwaranzi. chakaita Izvi zvinotungamirira nokumanikidza hakusi chete chena, asiwo tsvuku hematopoietic utachiona.
3. Kugamuchira zvinodhaka cytostatic. medicaments izvi zvinoratidzwa nekuda rheumatic zvirwere uye kenza. Zvakaipira kurapwa pamwe cytostatics ndechokuti zvinodhaka kuparadza masero.
4. kushandiswa Long-rokuti inorwisa mabhakitiriya (semuenzaniso, tiibhii), NSAIDs uye antiparasitic nevamiririri.
5. Chakakomba noutachiona. The unopinza Kuderera kwenhamba neutrophils inogona kuonekwa nemavhairasi chiropa, gwirikwiti, rubella, chibhokisi, yokuSpain, uye zvichingodaro. D.

Zvinokosha kucherechedza kuti agranulocytosis haisi yakazvimirira chirwere. chirwere ichi haagoni kuva pasina chikonzero chaicho. Ari nguva dzose chokuita nevamwe pathological migumisiro.

The mashandiro kuti kukura agranulocytosis

Neutrophils ndiwo anodzivirira masero eropa. Ivo achiumbwa mumwongo uye akasunungurwa akawanda akaramba. Masero aya pamusana anenge 70% zvachose leukocytes. With kushaya kukura ropa zvinhu izvi zviri kuitika neutropenia. Agranulocytosis vaiona mazhinji siyana mamiriro. Vachiberekwa kushayiwa of neutrophil uye zvachose chena sero count kunoitika nokuda pamberi mwero Gene.

Somugumisiro exogenic zvikonzero, kukura ropa masero machena ipfupi kana rinopera zvachose. Chimwe mashandiro ari chirwere anonzi Kugadzirwa antibodies kuna neutrophils. Saka, pane agranulocytosis. miedzo ropa panguva zvichachinja zvinenge pakarepo. Pashure pezvose, panguva upenyu neutrophils hupfupi. Zviri kubva 2 3 mazuva.

Kupatsanura pakati pathological ezvinhu

Zvichienderana chikonzero uye pathogenetic mashandiro secrete wandei classifications agranulocytosis. Maererano neizvi, voga vachiberekwa uye akawana kushayiwa neutrophils. Muchiitiko chokutanga, kuti hematological chirwere kunoitika apo zvinotevera nemagene pathologies:

1. Granulomatous chirwere.
2. Rwapedyo neutropenia.
3. Shvahmana-Dayemonda syndrome.
4. Kostmann chirwere.
5. Syndrome Shediac-Shtaynbrinka-Higashi.
6. Vachiberekwa aleukia.

Akawana kushayiwa ropa masero machena rakakamurwa autoimmune, uye hapten myelotoxic agranulocytosis. Mumwe nemumwe siyana idzi ine yayo mashandiro okukura. Nechezasi pathological muitiro ari oga chakasimba uye chirwere inoti agranulocytosis. Uyewo ari kupatsanura anobva kwokuomerwa yacho syndrome.

Description masoja agranulocytosis

Immune agranulocytosis chokuita pathological anokonzerwa antibodies pamusoro masero matsvuku eropa. It zvinogona kukonzerwa zvose endogenous uye exogenous mashandiro. Muchiitiko chokutanga, chirwere kunoitika nokuda autoimmune kurwisa. mamiriro kwakadaro kunotungamirira systemic connective tishu zvirwere. Rokuzvidzivirira masero asina kushandurwa muna sezvamunoita, asi ivo vari sezvo vakanga "reprogrammed." Somugumisiro, vanotanga vanoshora nhengo pachake munyama. Granulocytes nokukurumidza akura uye kuzvidzora vaparadzwa. Exogenous zvinhu munyika iyi zviri hazvishandi. zvirwere agranulocytosis chirwere kunoitika muna pathologies zvakadai chinonzi systemic lupus erythematosus uye dzinonzi rheumatoid arthritis. Panguva iyoyowo dhefisiti pamusoro neutrophils pamwe kushaya zvimwe masero eropa.

Chimwe musiyano wezvinyorwa pamusoro chirwere, kunoitika pazuva pakanyorwa masoja urongwa, munhu hapten agranulocytosis. In chimiro ichi pathological muitiro vaberekawo imwe antibody kune neutrophils. Musiyano ndechokuti zvavakanga anobudiswa havasi voga, uye pashure uchirapwa nemimwe mishonga - hapten. Akadzokorora yaunodya izvi zvinhu kunokonzera zvirwere mhinduro, anotaurwa granulocytes kuparadza. The haptens vanogona kuita zvimwe nemishonga, antiinflammatory uye hypoglycemic nevasori, barbiturates.

Description myelotoxic agranulocytosis

Myelotoxic agranulocytosis kukura somugumisiro exogenous zvinofurira. Aigara pamwe erythromycin uye thrombocytopenia. Kazhinji, myelotoxic musiyano wezvinyorwa chirwere inobatanidzwa yokuwana chemotherapeutic yomuchipatara uye ionizing nemwaranzi. Zvinhu izvi kutungamirira chinovhiringidza kuti hematopoiesis panzvimbo dzapasi kwevari kwayo kukura. Kuna cytostatic mishonga anokonzera zvakafanana sei zvinoreva cyclophosphamide, fluorouracil, mercaptopurine, etc. D. chinovhiringidza pamusoro hematopoietic wokutsauka masero kunotungamirira zvinoderedza nhamba granulocytes mu mumwongo. Izvi nokuda kuibvisa ropa zvirwere utachiona.

Kuwedzera exogenous zvinofurira, kushaya masero hematopoietic ikabuda dzimwe mhando kupererwa neropa uye neleukemia. zvikonzero izvi kazhinji kunokonzerwa agranulocytosis vana. Kazhinji, hematologic kuchinja nhaka. Mienzaniso vaiona hemolytic uye aplastic kupererwa, Fanconi kuti syndrome. Chenjera uye chisingaperi myelogenous neleukemia ikabuda pauduku uye yevanhu vakuru.

Agranulocytosis: Zviratidzo

Kushomeka granulocytes achiperekedzwa zvikuru zvekuchipatara kuratidzwa. Vangave zvakasiyana, zvichienderana runotikurudzira chirwere, izvo zvakaita kuti panowanikwa neutrophil kukanganisika. Sei agranulocytosis? Zviratidzo zvirwere:

1. Zvakakomba simba.
2. High fivha.
3. Lymphadenopathy.
4. Hepatosplenomegaly.
5. Necrotic maronda ari mucous membranes.
6. Hemorrhagic syndrome.

Hapten agranulocytosis, kusafanana nedzimwe siyana, iri ichazivikanwa noku rikwanise kosi. Varwere awedzere nokukurumidza anovandudza fivha, pane maronda pamuromo. Damage matadza, tonsils, uvula, nyoro mukanwa mberi, zvichitungamirira tishu necrosis. Zvinonzi achiperekedzwa marwadzo, kutadza kwakaita kumedza, kunyanya salivation.

Kana myelotoxic agranulocytosis musiyano wezvinyorwa kazhinji kuva ropa. Vari zvakabatanidzwa kwete chete ulceration pamusoro mucous membranes, asiwo platelet kukanganisika. Nemuumbi nasal, gingival, uterine, gastrointestinal kubuda ropa. On ganda ngapaonekwe hematoma. Nokuda urikanwi-necrotic pezvakaitwa ari ura vakachengeta manyoka, abdominal marwadzo. Somugumisiro chido ropa hwapedyo Hemorrhagic nemabayo.

Zvakachinja assays imwe agranulocytosis

Kazhinji agranulocytosis budiriro kunoitika pavarwere vane kenza, systemic uye zvakakomba zvinotapukira. chirwere ichi chinogona vaifungidzirwa maitiro akadai nefivha, kurukutika uye chitarisiko nemaronda pamuromo. Zvakanyanya kuoma rokuongorora vachiberekwa agranulocytosis. A bvunzo ropa zvaanofanira kuita zvikuru pallor ganda mwana, Hemorrhagic anokuzviratidza. In kuferefeta pane kuderera pamusoro leukocytes (asingasviki 1 × 10 ⁹ / l). chinowanzoonekwa chokuita kupererwa neropa uye thrombocytopenia.

Kuti uzive, nokuti chero chikonzero, akakurukura hematological chirwere, kuita immunogram ponji uye mwongo. Rokuongorora kuti matambudziko anokonzerwa kushayikwa granulocytes kuitwa paku tsvakurudzo. Pakati pavo - chipfuva X-ray, colonoscopy. Zvinodawo nyanzvi zano - otolaryngologist, oncologist, chiremba wemazino, rheumatologist uye gastroenterologist.

Zvokurwara Nzira kurapwa

Anodei murwere muchipatara, kana akawanikwa agranulocytosis. Treatment ine mukurapa ulcerous uye necrotic hukawanika akambozvishandisa kuuraya utachiona vamiririri, namafuta gadziriro. Murwere haasi pasi mumwe chirwere yechipiri, izvozvo anoiswa mukamuri racho isolator. Kana kukuvaradzwa intestinal mucosa iri dzinofambiswa nenzira parenteral nzira.

Mishonga nokuti nokurapa agranulocytosis

Kudzivirira kukura chirwere (nemabayo, sepsis), Mishonga inorwisa uye antifungal mishonga. Nomutsinga raitongwa zvinogadzirwa neropa, kunyanya leukocyte guru. Kana masoja agranulocytosis dzakaratidza mishonga hormone. Izvi zvinosanganisira "Hydrocortisone" zvinodhaka "Prednisolone". Kana urwere kunokonzerwa chinovhiringidza pamusoro hematopoiesis, stimulatory mumiririri chinotarisirwa. Pakati pavo vane mhinduro "Granocyte", "leucogen", "Virudan". Treatment rinoitwa ari hematology dhipatimendi.

Kudzivirira agranulocytosis muvana uye vakuru

Kudzivirira vachiberekwa agranulocytosis zvinosanganisira mangwanani vasabatwa zvirwere. Kuti izvi zvidaro, vana kuita CBC pagore. By wokudzivisa zviyero anosanganisira kuongorora wevarwere kugamuchira zvinodhaka cytotoxic, Anti-chirwere cheshuga mishonga. Kana murwere kare Zvakacherechedzwa hematological Kupindura kwokubatsira zvimwe zvinodhaka, zvinodhaka izvi hazvigoni kuzosarudzwazve kuti ave mubati.

For muupenyu agranulocytosis

The fungidziro kunoenderana mhaka syndrome. Inonyanya ngozi chimiro hapten agranulocytosis, nokuti kukurumidza kukura tishu necrosis. Autoimmune uye myelotoxic kukuvara rinorapika nemhaka kuzvitsinhanisa mishonga. Poor fungidziro aona kukura yematambudziko chaicho zvokurwara. Pakati pavo - hombe ropa, perforation pamusoro bowel rusvingo, Hemorrhagic mabayo, sepsis.