Avidity - zvinorevei? Avidity IgG antibodies kuna Cytomegalovirus: zvinhu uye decrypting

Zvino kupfuura kare, zvakakosha mangwanani kuonekwa uye kudzivirira zvirwere. Izvi zvinoda yepamusoro uye nokukurumidza chirwere nzira. Pachivanhu kiriniki anoshandisa serological nzira nokuda kuziva kwokuomerwa kwacho uye chokwadi vaitama nemavhairasi, kwemabhakitiriya uye fungal zvirwere. Asi miedzo izvi hazvisi hanya zvokuti asiyanise chikuru noutachiona, reinfection uye wava kusvutazve. Naizvozvo, masayendisiti ano zvinganaka nzira nokuda kuziva avidity pamusoro IgG-antibodies.

Avidity: zvinorevei?

Kusiyanisa pfungwa pane sungano uye avidity. Sungano - a thermodynamic unhu quantitatively kutsanangura simba kukurukurirana pamusoro antibody uye antigen iyeyo. Uyewo avidity inosarudza chisungo simba pakati antigen uye antibody. Dzidziso idzi chokuita zvakananga nomumwe. The zvakawanda antigen zvimedu kugara, akasimba papi. Kusiyanisa pasi uye yakakwirira avidity.

Izvo zvinoreva mukuru avidity? Rega kuongorora. Kana maantigen kupinda muviri kokutanga, ivo inotokonya B masero kuti inongomutsa immunoglobulins. Kutanga IgM, asi zvino vava ne IgG. Mushure kuonana pamusoro sungano, uye saka avidity, pasi, sezvo chete muviri kuzvidzivirira zvigadziriswe kuchinja kuti utachiona hwakakura itsva. Pashure pevhiki nomwe, IgG «yakura», muri zvikuru zvakananga, uye naizvozvo, muprista avidity. Zvino, ari nyaya apiwa chirwere, masoja emuviri achava vakagadzirira kupindura nokukurumidza kutyisidzira.

avidity indekisi

Level avidity inversely novimba antigen dose uye hunhu uye pamwero kunotouraya mumasero dzevanhu. The maduku kwokutanga dose, dzakanga dziri sungano, uye vakutarisire.

Zvadaro pathophysiology uye immunology vari nomubvunzo Chiitiko kuti kuderera mune kutapata nezera. Taifunga uye vaziva vamwe reshiyo, inonzi avidity indekisi. Zvinorevei avidity indekisi? Nhamba iyi inoratidza hama basa immunoglobulin kusunga antigen. The indekisi siyana pakati 15 uye 50 muzana ichiratidza chikuru chirwere, kana mutengo kwazvo 50 muzana, zvino murwere akatotanga aitambura kubva chirwere.

rubella

The rubella utachiwana ane chaizvo inokanganisa azvarwa, saka zvakakosha kuti aone kana amai vanepamuviri akarwara pamwe chirwere, kana asati pamuviri iye anofanira nhomba. For chirwere kushandiswa serological nemiedzo kuti sungano antibodies kune maantigen. Kana immunoglobulins zvinenge zvachose nokuda nemavhairasi nezvimedu, saka yakakwirira avidity antibodies. Izvi zvingaratidza kana dzakamboitika utachiona, uye kutapata zvakanaka pashure kubaya.

Dzimwe nguva, nokuda kweiyi lymphocyte miitiro inoburitsa zvinhu zvakanyatsofanana pamusoro rubella utachiona iri dzakaonekwa zvenhema zvakanaka maitiro kuti immunoglobulin M. Mukuwedzera, kwakadaro zvinogona kuonekwa varwere avo umo akakwidziridza ropa RA chinhu. Chete pane pamberi antibodies kuti vakaderera avidity. Zvinorevei? Izvi zvinogona kunzi sechiratidzo chikuru chirwere pamwe rubella utachiwana. In Obstetrics vanoshandiswa chiratidzo kuti pamuviri.

toxoplasmosis

Kazhinji, chirwere ichi rwakavanzwa, uye nokuratidzwa kunotoda kurapwa zviratidzo pamwe vawana zvokurwara (semuenzaniso, akadai zvimba node nodes) ane pasi chirwere kukosha, kana uchida kuziva kuti refu munhu anorwara. Kutsunga IgG avidity antibodies iri zvikuru chaizvo uye anenge nzira nokuda nechirwere kuti rikwanise chepuraimari toxoplasmosis, riri kunyanya kukosha kana kuongorora vakadzi vane pamuviri kubvisa dzingangoitika mukana vachiberekwa toxoplasmosis muvana.

Kutozosvikira munguva ichangopfuura, chete iripo serologic munhu akaidza kuona kwokuomerwa kwacho kwaiva kuziva immunoglobulin kirasi M uye kuwedzera titer pakati IgG. Kana mukati pavhiki uwandu immunoglobulin G yakawedzera nguva mana kana kupfuura, zviri kunanga uchapupu chirwere kunoita.

Kunyange serological miedzo chiremba Zvakaoma kuziva kana munhu noutachiona, sezvo immunoglobulin M uye G kungapfuurira kwenguva refu muropa. Naizvozvo, chete rakavimbika nzira yokuziva avidity. Zvinorevei? Rezasi sungano uye nokudaro avidity Toxoplasma ari kare rakapinda kupinda mumuviri. Uyezve, munguva ichangopfuura akazarura nzira kupatsanura pasi sungano uye yakakwirira sungano antibodies kuti nyore kuverengwa uye kuziva mhando chirwere.

Herpes simplex utachiwana

Vanhu vakawanda vari munyika vari yasvibiswa herpes simplex utachiwana. chirwere munhu kunoitika nenzira Isimba rakadini rinogona kubudiswa chimiro, asi zviratidzo akawanda vari kuchengetwa, kunyange kana vari vaduku. Uyezve, pane dzimwe aiomerwa kuziva kuti avidity kuti herpes. Zvazvinoreva uchidzidzira? utachiwana ichi kunoratidzwa atypical antibody, kungava mumuviri kuti upenyu, kupa dzenhema-akanaka uye venhema-nemigumisiro yakaipa. negatives zvenhema takatsunga kana immunoglobulins havasi kuumbwa kana vari serum iri chero mari. Chenhema-nemigumisiro yakanaka kuitika nokuda mazhinji achiparadzira antibodies zvisinei ane chirwere.

Uyezve, ine muchinjikwa reactive maantigen kuti kutevedzera sei histocompatibility maantigen pamusoro dzose nyama dzomuviri, uye dzimwe mhando herpes utachiona. Chimwe yakanaka zvenhema siyana takatsunga ne chirwere yechipiri pamwe immunodeficiency kwevanhu utachiwana.

cytomegalovirus chirwere

utachiwana ichi ndicho muparanzvongo kuti pamuviri mukutanga pamuviri. Mukana wokutapukirwa kunoenderana pachiyero antibodies vari mai panguva pamuviri. Kana kutanga chirwere kwakaitika pakutanga trimester, mukana chirwere ndiyo 50 muzana.

Zvinorevei avidity kuti CMV? Sezvo dzimwe nguva dzose, vakatsunga nokushamwaridzana pakati IgG pamwe IgM zvakanaka sei zvakarurama kusimbisa kana kuramba kuvapo chikuru CMV hutachiona. Uyezve, zvinoita here kuti kudzivisa kurwadza uye zvinodhura nzira nokuda amai vanepamuviri.

Hepatitis C utachiwana

Chirwere kubva nehepatitis kwakavakirwa Pakusarudza chaizvo zvezvinangwa zvichiratidza kukura chirwere kwacho. Muchiitiko chino, IgM anogona kuitika zvikuru paya pane kuti IgG, kana panguva imwe chete navo. Zvakaoma kuziva pakatanga chirwere uye nguva chinonyanya noutachiona.

The chete yakavimbika serological ongororo iri serokoversiya uye IgG avidity pamusoro. Zvinorevei? Kana avidity indekisi yakaderera, iri rakananga kusimbisa zvikuru utachiwana. Kana kuziva refu avidity IgG kirasi antibodies vanogona kutaura nechivimbo chisingaperi chiropa kana vaitama.