"Gabapentin" uye doro: wongororo. "Gabapentin": mirayiridzo kushandiswa, murefu uchapupu uye vanachiremba

Kubva nguva nenguva, tsandanyama chinyamunhari chinorwadza kutambudzirei vanhu vazhinji. Zvisinei, vanhu vashoma kuti nei zvakadaro inoti kazhinji simuka.

Maererano unyanzvi, pfari inogona dzakasiyana: generalized (tonic, clonic, tonic-clonic uye myoclonic) uye haasaruri (nyore uye kunzwisisa). munhu anoshandiswa kurapa pfari pakupedzisira se "Gabapentin" chinodhaka. Mirayiridzo kushandiswa, wongororo uye contraindications zvinodhaka zvichakurukurwa gare gare.

Zvinofanira pakarepo kucherechedzwa kuti, nokuti kukwana pfari dzinoratidzwa kusavapo kurasikirwa chavanoziva. Kwakadaro isingawanzowanikwi ezvinhu. Vanoonekwa clonic pfari hunhu inosanganisira mhasuru maoko, tsoka uye chiso.

Zvinoumba, description, kavha chigadzirwa chacho sezvamunoita

vakatengesa medicament "Gabapentin" In ipi? Testimonials dzinoshuma kuti mushonga uyu inogona kutengwa mishonga iri muchimiro zvakaoma gelatin capsules chena. kugutsikana kwavo chena kana yellowish upfu zvinodhaka.

The vanoshingaira wemafuta mumiririri uyu gabapentin. Uyewo, rinosanganisira zvimwe ive fuma muchimiro yavaibvisa carboxymethyl starch, karusiyamu stearate uye microcrystalline cellulose. Kana capsules, dzine gelatin uye titanium dioxide.

In pasuru vaitengesa zvinodhaka "Gabapentin"? Consumer ongororo vanoti pamusoro echiShinto pakati Pharmacies mushonga anogona kuwanikwa makadhibhokisi packs it, izvo vanoiswa kana polymeric capsules magaba kana gandiwa muchitokisi.

Pfungwa chiito ane mushonga

Sei mushonga "Gabapentin"? Instructions (wongororo yacho mishonga dzinoturwa panoperera nyaya) rinoshuma kuti mushonga racho Dendere iri rakafanana neurotransmitter wegamma-aminobutyric asidhi (neGhebha kuti pfupi). Zvisinei, zvinofanira kucherechedzwa kuti nheyo dzaro chiito Evhangeri yemvura noMweya ndiyo zvimwe zvinodhaka kuti anosangana neGhebha-receptors (semuenzaniso, valproate, barbiturates, benzodiazepines, neGebha transaminase FIs, neGebha reuptake FIs, neGebha agonists uye prodrugs pamusoro neGhebha).

Viewed mushonga haana neGhebha-dzichiitirana zvivako uye asingauyi kukanganisa kubatwa uye muviri pamusoro neGhebha. Research nyanzvi zvakaratidza kuti yezviri wemafuta pomutumwa nokusunga kuti α2-δ-subunit kuti voltage-zvaanoda karusiyamu migero, achidzikisa zvikuru kubuda calcium ions, izvo kutamba inokosha basa kutanga neuropathic marwadzo.

Features anticonvulsant mushonga

Ndezvipi zvimwe zvivako zviri vakagarwa ne zvinodhaka "Gabapentin"? Reviews vanachiremba vanoti zviri chaizvo kuti neuropathic kurwadziwa. mushonga uyu kunoderedza glutamate-zvaanoda neuronal rufu, kuwedzera neGhebha usage, uyewo nedanho kudzvinyirira ose neurotransmitter yokusunungurwa uye monoamine mapoka.

Hatigoni kutaura kuti pane akaora akakodzera kuwanda zvinodhaka "Gabapentin" asingadi kusunga kune receptors vemamwe zvinodhaka (kana neurotransmitters), kusanganisira muGibhiya receptors uye GABAB, uye glutamate, benzodiazepine receptors, glycine, uye N-methyl-D- aspartate.

Kusiyana "Carbamazepine" uye "phenytoin", vaiona medicament asingadi kushamwaridzana yavaibvisa makwara. Kugadzirira "gabapentin" aoma attenuates migumisiro glutamate Kanotokonya agonist akadai N-methyl-D-aspartate. Uyezve, yekudyidzana izvozvo zvinoderedza kusunungurwa monoamine neurotransmitters.

The kinetic ehupfumi zvinodhaka

Ndezvipi yokusafa kinetic parameters capsules "Gabapentin"? Testimonials havazokwanisi kupindura mubvunzo uyu. Kuti tiwane izvozvo, unofanira kuenda ruzivo nyanzvi kana akanyudzwa mirayiridzo.

Maererano yokupedzisira, iro bioavailability pamusoro vakati zvinodhaka havasi Proportional kuti chipimo chemushonga wokurera. Kana chitsama zvinodhaka ipfupi.

Pamusoro pokugamuchira medicament yake kunonyanyisa yeplasma wevasungwa aona pashure 3 h. The Mhedziso bioavailability zvinodhaka mune capsules iri vanenge 60%. Food, kusanganisira mafuta kwazvo, asina zvainoita kinetics zvinodhaka.

Kushaya hanya "Gabapentin" ropa murwere rinoitwa ne Linear muenzaniso. nguva hafu-upenyu yakazvimirira dose uye maawa anenge 5-7.

The kinetic ehupfumi zvinodhaka haachinji kunyange kana rikashandiswa kakawanda. Wevasungwa zvinodhaka muropa inogona afanotaura kwakavakirwa migumisiro chete dose kwayo.

The medicament "Gabapentin" substantially asingadi kusungira kuti mapuroteni eplasma (asingasviki 3%). It kunoratidzwa muna kuchinja chimiro pedyo neitsvo.

Metabolize mishonga haisi pachena. Uyezve, hazvingaiti kunyengedza hepatic oxidative makemikari, izvo zvinobatanidzwa mune muviri nedzimwe zvinodhaka.

The Clearance pakati pomutumwa kubva ropa zvinoderedza vari vanhu vakura uye varwere vasingadzoreki itsvo chaitika.

Kugadzirira "gabapentin" rinobviswa muviri hemodialysis.

Zvairatidza kuti kurapwa

In chii nezvirwere tiri kufunga zviri abudirire zvinodhaka? Chii vanhu vanoti inofambiswa ichi?

"Gabapentin" anoratidza zvakanaka pacharo mu:

• neuropathic marwadzo pavarwere akura (makore 18 uye vakuru);
• monotherapy kana somunhu nopindirana zvinodhaka nokuda pakurapa zvishomanana nezvipusha, achiperekedzwa zvavo yechipiri muna vakuru uye kuyaruka kubva makore 12.

Contraindications kugamuchira mushonga

Ndezvipi contraindications zvinodhaka ane "Gabapentin"? Reviews chikumbiro kushuma kuti ine kunambwa mumuviri, kana mishonga yave kugamuchirwa pa:

• hypersensitivity mumwe nefuma;
• rushoma pfari pasi makore 12.

Special hanya inzira nachiremba itsvo kukundikana.

Ndingatarira kutora mishonga "Gabapentin"?

Reviews (neuralgia chingamubatsira ichi chinobatsira zvakanaka chaizvo) mamiriro kuti mushonga anofanira kuzviita chete nachiremba ane ruzivo, pashure zvakarurama zvawanikwa.

Gelatin capsules akatorwa nomuromo kupfurikidza pakuparadza rose, avo chimiro. The mushonga apere pasinei kudya, kushambidzwa pasi pamwe zhinji zvokunwa. Kana uchida kuti kuderedza uwandu husingakuvadzi kuti mishonga kudzima kana kutsiviwa analogue yaro, zvino ichi zvinofanira kuitwa zvishoma nezvishoma pamusoro pavhiki.

Mabatirwo neuropathic marwadzo nedzevakuru

Sezvo ari mamiriro mabasa vaiona mishonga iyi? Chii vanhu vanoti zvokurapa wongororo? "Gabapentin" zvinobudirira kwazvo hworatidza pacharo kuti neuropathic kurwadziwa. Mukurapa akadaro ezvinhu kutanga zuva nezuva dose inofanira kuva 900 MG. Akati chitsama inokamukana migove mitatu. Kana waida kuti dose iri kuwedzera zvishoma nezvishoma kuti vaifanira (i.e., kusvikira 3600 MG pazuva).

kukwana pfari

Ndinofanira kutora mishonga "gabapentin" iri chirwere ichi? Reviews akashuma kuti mudziyo anogona kupiwa kwete chete kune vakuru, asi makore kuyaruka kubvira 12.

Chinobudirira dose kuti haasaruri pfari vaiona 900-2400 MG pazuva. Kurapa chirwere ichi chinogona kutanga 300 MG zvinodhaka katatu pazuva. Naizvozvo dose daily vanofanira ngazviwedzerwe 900 MG, uye zvakawanda uye kusvika 2400 MG pazuva (akakamurwa zvitatu dzakaenzana mishonga).

The nguva penguva pakati mishonga zvinodhaka panguva yayo kugamuchirwa nekatatu havafaniri kuva maawa kupfuura 12 (kudzivisa resumption kuti pfari).

nemishonga

Chii nenjodzi zvingaitika Varwere kugamuchira anticonvulsant? Chii vanhu vanoti ichi Mutengi wongororo? "Gabapentin" pakurapa neuropathic marwadzo anogona kukonzera:

• asthenia, netsaona, marwadzo akasiyana localization, musana marwadzo, utachiona, dzihwa chirwere, nomusoro, kufuta, peripheral edema;
• gait chinovanetsa, ataxia, kukanganwa, hypoesthesia, kuvhiringidzika, dzungu, havachanyatsogoni mafungiro, hope, tremor;
• kupatira, flatulence, manyoka, kurutsa, muromo yakaoma, dyspepsia, kuda kurutsa, abdominal kurwadziwa;
• ganda upundu;
• kupfupika mweya, zvikuru huro;
• amblyopia.

In pakurapa rushoma nezvipusha, mushonga kunoita kuti chitarisiko:

• musana marwadzo, kurukutika, fivha, nomusoro, chaikonzerwa noutachiona, peripheral edema, kufuta, kurukutika, zvakawanda zvive, chiso edema;
• kupatira, mazino chirwere, manyoka, fufune, wakawedzera kudya, yakaoma muromo kana huro, kuda kurutsa kana kurutsa, abdominal marwadzo, bloating, kudya gingivitis;
• chiratidzo vasodilation kana neBP;
• leukopenia, purpura;
• mitswe, myalgia uye arthralgia;
• kukanganwa, ataxia, kuvhiringidzika, incoordination, kuora mwoyo, dysarthria, mupfungwa lability, kushaya hope, kutya, nystagmus, hope, zvemamiriro mafungiro, tremor, tsandanyama twitching, dzungu, hyperkinesia; pfuma, simba kana kusavapo hunenge, kufunganya, paresthesia, utsinye;
• abrasions, mburwa, ganda kuvaviwa, ganda mapundu;
• chikosoro, pharyngitis, rhinitis, mabayo;
• amblyopia, diplopia, madzerere;
• Urinary turakiti utachiona, kusabetsera.

zviitiko ovhadhozi

Chii zviratidzo ovhadhozi kungaita akati medicament? Zvakadini ichi kutaura wongororo? "Gabapentin" ovhadhozi kunokonzera kaviri chiratidzo, dzungu, hope, havachanyatsogoni matauriro, lethargy uye manyoka.

Kubvisa vakadaro inoti symptomatic kurapa, uyewo munhu kusuka dumbu uye kumupa neactivated charcoal.

Varwere zvakakomba renal insufficiency, hemodialysis kunoratidzwa.

Drug "Gabapentin" uye doro

Reviews nyanzvi dzinotaura kuti kunyatsoshanda kuti vaiona mishonga chaizvo. Asi chete chiitiko kuti nguva kushandisirwa murwere Maramwirwa chose kushandisa doro.

Kana mushonga unobatanidzwa pamwe doro, murwere anogona yekudyidzana achiipa nenjodzi kubva nechepakati tsinga (ndivete ataxia, etc.).

zvinodhaka kwavatori

Drug "gabapentin" iri neuroscience, wongororo zvacho kupfuura zvakanaka, dzinogona kubatanidzwa kwete mishonga yose.

Maererano mirayiridzo, antacids kuderedza bioavailability zvinodhaka.

Myelotoxicity zvinodhaka zvinowedzera haematotoxicity capsules "Gabapentin".

Kana pamwe morphine pharmacokinetics ayo hakuna kushanduka. Zvisinei, kana zvakadaro mubatanidzwa chinofanira nokungwarira kuongororwa fungidzira kukunakira pakati tsinga.

Viewed medicament zvingarerutswa panguva imwe chete antiepileptic zvinodhaka (semuenzaniso, "pentobarbital", "Carbamazepine", "Phenytoin" uye valproic acid) uye kunanzvana pamuviri. Muchiitiko chino, hazvina kuchinja kinetics.

chaizvo kurumbidza

Pasinei nokuti kushaya chirwere pamwe panowanikwa pfari pakurapa "gabapentin" haana kwakaratidzwa ane chimbichimbi kumbomira kurapwa pamwe antiepileptic zvinodhaka vanhu vane haasaruri pfari vanogona kumutsa nokugwinha simba.

mishonga Viewed haisi zvinobudirira nzira kurwisa pamwe kusavapo netsviyo.

Vanhu vanoda kunzwisisa kurapa pamwe morphine, angada yakawedzerwa dose kuti "gabapentin". Muchiitiko chino, nechokwadi kuramba zvichiongororwa murwere nekuda kukura hope. Nechepakati kuziva mishonga dose inofanira zvakakwana ipfupi.

Kana zvabatanidzwa "gabapentin" nevamwe zvinodhaka anticonvulsant dzave kushumwa zvenhema zvakanaka kunoguma kutsunga mapuroteni mu weti uchishandisa bvunzo rinoparadza Ames N-Multistix SG. Panyaya iyi, nokuti zvidzidzo zvakadaro urumbidze kushandisa imwe kunayisa nzira nokuda sulfosalicylic acid.

Reviews nyanzvi uye vatengi

Wongororo Most kuvarapi uye varwere pamusoro "Gabapentin" gadziriro akanaka. Mishumo izvi zvinoratidza kuti mushonga zvinobudirira kukurira basa. Zvisinei, kana yava pamwe doro kazhinji kuva zvakakomba nenjodzi dziri tsinga.

Hazvibviri kuona chokwadi chokuti chimbichimbi kurega zvinodhaka kungaita varwere zvokomara kuziva, lethargy uye kwindi.

Vanhu vazhinji vakaona kuti kudya izvi zvinoreva vane mwoyo uye kuda kuzviuraya. Uyewo, kurapwa kunowanzokonzera kukura rikwanise pfungwa nomuviri zvemwana asati.

Nyanzvi vanokurudzira kuti zvinodhaka kurapwa "Gabapentin" chete pasi pokudzora chiremba uyo achakwanisa nokukurumidza kuchinja kuchirapa zvaiitwa sezvinodiwa.