Medicine 'Methotrexate'. kurayira

Medicine "Methotrexate" mirayiridzo anoshanda kune Anti-metabolites chikamu, pyrimidine analogs. Anoreva zvakafanana: "Zeksat", "Treksan", "Triksilem" uye vamwe.

Rinoreva "Methotrexate" (Mahwendefa) anobvumirwa kushanda se rimwe mumiririri kana sechikamu kunzwisisa mishonga.

By zvinoratidza zvinosanganisira neleukemia myeloblastic uye lymphoblastic, myelogenous neleukemia chisingaperi chokubuda ari akazotevera danho, lymphosarcoma. Sesangano Integrated himiolecheniya mushonga "Methotrexate" muperekedzi anokurudzira ovarian kenza, yemapapu, zamu.

At dzakakwirira mishonga (apo kugamuchira filinata karusiyamu) zvinodhaka nachiremba osteogenic sarcoma, bundu Ewing vake, choriocarcinoma uterine sarcoma kuti nyoro tishu.

Pfungwa (jekiseni) rinoshandiswa kusimbisa zviratidzo zvechirwere psoriatic ganda maronda.

Rinoreva "MTX" iri makemikari mamiriro (User rine mashoko akadaro) pedyo folic asidhi panguva ino ine vanetsane. Zvaaiva antimetabolite antagonist uye kupa antifolievym Chaizvoizvo, mushonga DZEMUNHU DZINODZORA muchitokisi weboka, kukura tichishingairira kuwedzera munyama, mwongo pamwe. The medicament "MTX" chinowedzera tava kuderera kukura nyanyisa neoplasms.

The mushonga waakaudzwa mukati.

Mugore kunzwisisa pakurapa zvinodhaka "Methotrexate" Chinyorwa anokurudzira munhu mukuru kuna 0,03 magiramu kaviri pavhiki. Nokuti vana dose pazuva - 0.02 magiramu por mativi sendimita muviri huri nzvimbo.

Duration kurapwa - kusvikira vhiki mbiri.

Kosi kunosanganisira kugadzwa akura dose 0,02-0,025 magiramu daily. Duration kurapwa - kusvikira mazuva mashanu.

Nokufamba kunwa mushonga "Methotrexate" Chinyorwa anokurudzira kutora yokumbozorora imwe kana mbiri mavhiki.

Mishonga contraindicated muna immunodeficient inoti, chiropa chirwere, thrombocytopenia, leukopenia, kupererwa neropa (kusanganisira aplastic uye apoplastic) hypersensitivity.

Kwete mashoko zvakakwana kuita kuchirapa yamabwe mishonga "Methotrexate" pamuviri uye lactating. Maererano mishonga iyi muna antenatal nguva uye panguva lactation haina basa.

Pane vane zvinodhaka "Methotrexate" nemishonga. The mushonga anogona kukonzera gagging, kuda kurutsa, manyoka, kuzvimba ari nemumuromo mucosa (stomatitis). Refu Kushandisa zvinodhaka "MTX" anozivikanwa lesion pamwe ropa ari nemumuromo mucosa kuti maronda hunhu, akaderedza platelet Counts, kurasikirwa bvudzi, ungaderedza Chizenga tigutsikane muropa. Mune zvimwe zviitiko, chirwere yechipiri inogona kuchengetwa, zvichida kuti hunokachidza chiropa (yemanyorero kana kushandisa yepamusoro mishonga), renal maronda.

Kuti tidzivise chitange varwadziwe ari kuchirapa kosi voitakura kunze pasi kuzviomesera pokudzora chiremba.

Kana zvikashandiswa zvakapfurikidza ari usatsungirira chaizvo kuratidzwa. Diagnosing mamiriro ezvinhu kuitwa zviri zvinodhaka "Methotrexate" plasma.

Zvokungwarira

The turusi haisi kushandiswa pleural effusion, ascites, maronda, maronda colitis, itsvo chirwere kana gout.

Regai kutora mishonga varicella (kusanganisira vachangobva Kutamiswa kana pashure kuonana nomunhu ane chirwere), herpes zoster nezvimwe chakasimba zvirwere zvinotapuriranwa mavambo.

Pakutanga uye mukufamba kurapwa zvinokosha kudzora peripheral mufananidzo ropa, chiropa uye itsvo basa.

In nokushandisa mushonga mu psoriasis kana dzinonzi rheumatoid arthritis, izere neropa count akaita kanenge kamwe pamwedzi.

Panguva tsvakurudzo akanga akawanikwa mutagenic uye carcinogenic migumisiro mishonga "Methotrexate".