"Sodium dichloroacetate": sezvamunoita, pfungwa uye mirayiridzo kushandiswa

Nemhaka masayendisiti kubva University of Alberta nzvimbo yakanga yagadzirwa muna Canada, akundwe kenza. Inogona chete akakurirwa activation pamusoro mitochondrial chirwere kunge woutsinye. Yakaitwa zvinodhaka "yavaibvisa dichloroacetate," maererano masayendisiti, kutsungirira dambudziko iri uye kurwisana nezvirwere zvakawanda kenza.

Kunyanya inoshanda zvinodhaka chiratidzo pakurwisa nekenza mumapapu, uropi uye chipfuva. Kare 30s remakore rechimakumi maviri, masayendisiti vakagumisa kuti dzichipfekeka abnormalities pakati mitochondria masero kukonzera kenza. Mitochondria dzinokosha organelles ane muchitokisi mupenyu, uye kusvikira munguva ichangopfuura, masayendisiti vaitenda kuti kuparadzwa kwavo - haisi chinokonzera kenza, uye mugumisiro. Naizvozvo, kubva 2005 Michelakis uyo akapokana pfungwa iyi, muedzo vakatanga basa mamorekuru ose yavaibvisa dichloroacetate.

Laboratory zvidzidzo zvinodhaka

Laboratory miedzo uye miedzo mhuka zvakaratidza kuti zvinodhaka "yavaibvisa dichloroacetate" ane activator pamusoro mitochondrial makemikari kuti woutsinye pamusana zvirwere pasinei norudzi kenza. Rutapudzo kuti masero kenza zvinoitwa normalizing mashandiro anoita organelles. The mushonga zviri zvakasiyana kubva mishonga isina chepfu uye haaiti achidzvinyirira pamusoro masero utano zvomurwere.

Professor Michelakis anoti kuti pakawanda zviri pafuma huri chigadzirwa, zvinoita kuti tikwanise kukurira vakawanda marudzi kenza, kunze sarcomas. Mishonga ane zvainoita kenza dzidzo, risingagoni kukanganiswa nevamwe mishonga. Pafuma zvinodhaka haisi chero aivapo makambani anogadzira, saka mushonga hakusi bvumidzwa. Izvi zvakakanganisa chaizvo affordability ake.

Laboratory kuedza akaratidza kuti chinodhaka, achiita kudzora anoita masero kenza pasina kukanganisa utano panguva imwe chete riri nhengo dzomuviri.

Kana kutanga kutora zvinodhaka?

Zvakakosha chaizvo pakurapa kenza rinoreva "Sodium dichloroacetate" tora kana muviri ezvinhu richiri inogutsa. Usamirira kwemutemo anoverengeka yamabwe mishonga, iyo ine nokuparadza chinokosha. Uyezve, masero kenza vanowanzopedzisira vava kutapata kuti makemikari. It vagara vanachiremba vakaona. Okutanga mapoka mashomanana mishonga vakaita vane kunobatsirawo weboka chirwere, rakatevera, nekusiyana, hadzibatsiri. Saka, mushonga vanofanira kutanga kutora nekukurumidza, kunyange pachiimbwa yamabwe kemisitiri. Zvisinei, kuti chipimo chemushonga haafaniri kupfuudza 15 MG pa 1 kg uremu.

Kugadzirira "yavaibvisa dichloroacetate": mamiriro

The Kuronga zvinodhaka - the yavaibvisa munyu dichloroacetic acid. Sol ari Pfungwa iri chimiro monohydrate, kuti ndiye anenge 12% - .. Water akapfupikisa.

Masayendisiti dziri kuongorora nzira yokuderedza toxicity yacho vaiona zvinodhaka uye kubudirira kwayo pakurwisa kenza.

mushonga

Zvakakosha kuziva, kana ukasarudza kutenga zvinodhaka "yavaibvisa dichloroacetate." Sei kutora mushonga kuti kubatsira nhengo achirwara, masayendisiti kutoziva. Kubva pana 1 kg kurema - 25-50 MG yose zuva. Kushandisa zvinodhaka kwemakore maviri pa 50 MG kunogona kukonzera peripheral neuropathy, saka dose chipimo chemushonga wacho wakaderedzwa kusvika 25 MG, iyo akasimudzira kumbomira hachifadzi mananara.

Kana mushonga ari chipimo chemushonga 25 MG pa 1 kg kurema kunokonzera fufune, kuda kurutsa, chiveve muruoko minwe, kufema zvinetso (rinogonawo kukonzera kuora mwoyo, tremor, dzungu, hope, kuita weti kakawanda, kufunganya), kuti dose anofanira airarama 10 MG pa 1 kg muviri uremu . Dzimwe nguva yekupinda vakawanda kurega kuushandisa kwamazuva mashoma. Zvadaro zvakare zvakakodzera kudzokera chete dose - 25 MG pa 1 kg kurema muviri pazuva. Kuzivikanwa zviitiko cucumber acid, izvo zvakapa mananara kudukupiswa peripheral neuropathy pashure pakugamuchira "yavaibvisa dichloroacetate" gadziriro. Mirayiridzo kushandisa kudiwa sanganisa kuti vaiona medicament nemvura (100-150 Rine mamiririta). Izvi zviri nyore kuita, sezvo mushonga ari upfu chimiro. Unofanira kuita ganda kuonana chigadzirwa - zvinogona kukonzera bundu.

Shandisa zvinodhaka ari lysis anomera

The mushonga anogona kukonzera lysis kuti nyanyisa anomera munzvimbo chakasimba nhengo dzinobudisa neleukemia, asiri Hodgkin kuti rwekenza yelymphoma, rikwanise mielotsiticheskoy neleukemia, kenza yemazamu, sero carcinoma, chisingaperi nhengo dzinobudisa neleukemia, testicular kenza, sero carcinoma, medulloblastoma.

Lysis ose akaipa bundu yainzi nokukurumidza chaizvo apoptosis masero kenza (chiite muchitokisi rufu), achiperekedzwa unopinza Kuipa mamiriro utano (mu aakatipa nguva, zvinogona kukonzera rufu). Muzviitiko zvakadaro, unofanira pakarepo misa zvinodhaka uye chiremba. Pashure pemazuva mashoma, zvichida, kubvumirwa kutangazve kushandiswa kwezvinodhaka, apo nokuderedza dose.

Information pamusoro zvinodhaka kusapindirana rinoreva "Sodium dichloroacetate" nevamwe zvinodhaka hakusi nokuda utsva kwayo (Kunze - mishonga "Lasix").

Shandisa panguva imwe chete kofeinizirovannymi teas, yakakwirira mishonga vhitamini B1, wemishonga cucumber acid, coenzyme Q, Alpha-lipoic asidhi yakawedzerwa efficacy.

Kubudirira mushonga

Efficacy medicament "yavaibvisa dichloroacetate" kunoenderana zvinoverengeka pamusoro. Sezvineiwo kunoderedza kwayo kuchirapa ehupfumi varombo ezvinhu omurwere. Somuenzaniso, kana nokuda chirwere kukanganiswa zvinokosha zvomukati, kana kuparadzwa kwakaitika pasi pokudzora mishonga. Uyewo, regai kutokurudzira kushandisa mari, kana murwere rukasafashukira, nguva dzose pakurwadziwa, anotora zvinodhaka.

It akazoita kunyatsoshanda rekugadzirira uye simba kukundwa chiropa chirwere. Harigoni kukurira vakafa bundu masero uye manyowa zvinogadzirwa kuti kuwira ropa, zvinhu hunowedzera kuoma.

Yakaderera dose kubudirira zvinodhaka yakaderera, kana guru dose mugumisiro anova kuchioneka. Asi pane zvimwe zvinokonzera njodzi. Panguva dzakakwirira mishonga, izvozvo zvingaitika kuti kuora zvibereko bundu chiropa haagoni kurarama. Izvi achaita kudhaka, kuda kurutsa uye kurutsa. Naizvozvo, kuti chipimo chemushonga inofanira vakasarudzwa nemazvo.

Where kutenga?

Zvakadini kana mumwe munhu anofanira kutenga zvinodhaka "yavaibvisa dichloroacetate"? Where kutenga? Available vaitirei mushonga muCanada, saka unogona kuigadzira kushandisa Internet pfuma vaburitsi. Panewo mukana kutenga zvinodhaka vanotengesa kuRussia, kutenga nawo Canada. Mutengo mushonga haisi yakakwirira, saka kuzvitenga mari varwere enzvimbo akasiyana mumagariro strata.

Reviews kugadzirira

Mugumisiro wacho zvinodhaka "yavaibvisa dichloroacetate" izvo akaongororazve ngaadarowo, kunogona kurondwa Varwere kenza zhinji. The mushonga rinoshandiswa panguva imwechete uye weboka mishonga, uye nezvimwe mishonga kuti haana kubudirira kwayo. Vamwe vanachiremba havatendi yavaipora varwere vavo. Vakashamiswa apo varwere vakanga vari gadzira. Vazhinji nguva kuti kushaya divi anokonzerwa apo achitora zvinodhaka.

Negative Wongororo vashoma chaizvo. Vose anotaura ineffectiveness zvinodhaka "yavaibvisa dichloroacetate." Chii? Zvinozivikanwa kuti mune vamwe varwere mushonga havana kubatsira kubvisa chirwere. Vamwe vanhu Wakacherechedza kwaita chirwere dzokororo.

Sei kuziva nepakatanga zvinodhaka

Nderechokwadi "Sodium dichloroacetate" chinodhaka kunoratidza zvinoverengeka: inoitwa crystals chena, zvinovava kuravira. Kana ruvara iri yellowish crystals, kuti medicament ane kbps, uye haina inokurudzirwa. Kana Kuparadzwa mushonga mumvura, haufaniri chisanyanya shungu kuravira. Kana rakasanganiswa kuti slurry madota nguva nenguva kureva paganda honokono kana yomukati pose pamafudzi pana zvikamu 1 miniti panguva maminitsi 10, uyezve shure kwechinguva chiduku chete reuna aumbwa unobtrusive gwapa. Uye pashure pemaawa 5-10 kubva panzvimbo ino ichava zvikuru zvitsvuku uye yakajeka. Mushure memazuva mashoma panzvimbo ino ganda angatanga peel they and and. nzira iyi ongororo inokurudzirwa kushandisa kwazvo nyaya: achiwedzera guruva rinopfumburwa sulfuric asidhi inoshandiswa bhatiri motokari, zvavave kunoitika ne-shanduka nokupisa kunhuhwirira dichloroacetic acid. mishonga Self ane anenge asina kwakanaka. The yakakwirira kunaka zvinodhaka, shoma kwakanaka. Kana paunoravira upfu, zvichaita kukonzera kusanzwa, coolness uye astringent kushanda.