The mushonga "sofosbuvir": mirayiridzo kushandiswa, mashandiro basa, analogs

To musi, vanhu venyika anenge matatu namakumi miriyoni vari utachiwana nehepatitis C. Zvisinei, achiri asina akakudziridza mushonga kuzorwa chirwere ichi ngozi.

Zvakakurukurwa chirwere

Vanotyisa Utachiona hwacho masero anokosha mutumbi upenyu hwevanhu - chiropa. Pashure hepatitis C anosika kopi zvinopfuura njodzi masero kuparadzira zvirwere.

Today akaratidza nzira dzinoverengeka nemavhairasi nehepatitis chirwere:

• nokuda ropa;
• nyora, jekiseni, uye dzimwe nzira dzinoshandiswa kana non-chena tsono;
• kushandisa chete tsono muropa vanhu;
• zvepabonde;
• kubva mai mwana panguva pamuviri.

Features kurapwa

vanachiremba vakawanda enzanisa hepatitis C pamwe HIV. Pakurwara uku chinouraya haisi Pari zvinobvira. Kunyange zvakadaro, pane zvimwe mishonga yakagadzirirwa kudzivirira kupararira kweutachiwana.

In kurapa kwakadaro Kazhinji aishanda zvinodhaka mbiri: "interferon Arfa" uye "Ribavirin". Wokutanga kunodzivisa kupararira hutachiwana masero utano, uye wechipiri nechinangwa kudzivisa kwayo kubereka. Zvisinei, izvozvo kurapa zvaiitwa ari kuwanda nemishonga uye vakaderera efficacy.

Saka, vatsvakurudzi vanoramba kuva mishonga mitsva kuti anobatsira kurwisa nehepatitis C. Rimwe achangobuda nebudiriro mushonga chinhu itsva zvinodhaka "sofosbuvir". Mirayiridzo kushandiswa zvine zvose zvakafanira mashoko ari pamusoro payo.

Description rekugadzirira

The mushonga inowanika piritsi muchimiro dzeraundi chimiro, ane nomumativi ari zvemapuranga chete soluble mune gastric muto. ruzivo urwu rine vasiyana mushonga "sofosbuvir" mirayiridzo. The sezvamunoita unotora rakasiyana zvinodhaka fuma chine zita dzakafanana zvinodhaka uye Excipients.

The inodiwa chipimo chemushonga zvinodhaka riri 400 MG uye ari chete piritsi. The pasuru rine mapiritsi 28, iri zvakakwana nokuda yawapiwa kwemwedzi.

Zvinoitika pamuviri

Rinotsanangura sei muviri riwanikwe mushonga "sofosbuvir" mirayiridzo Chinyorwa. The mashandiro chiito, zviri nyore, ndiko kuti zvinokosha fuma iri medicament inhibitor pamusoro enzayemu ano nehepatitis C. It ane kunzwisisa zvainoita zvakakanganisa muviri ane utachiwana. miedzo Clinical kwakaratidza kuti kunyange pane zvikuru simba chirwere muviri pasi nemadhiragi kwave vachiwana akanaka muitiro. Izvi ichokwadi kuti HCV genotypes 1-4.

Zvisinei, apo chirwere pamwe hepatitis C uye utachiona hweHIV, vanachiremba vakawanda havarangariri zvakakodzera kushandisa zvinodhaka ichi. Chokwadi ndechokuti iyi, kushanda kwaro harina zvakaratidza. Zvakakosha kunzwisisa kuti pasinei hwakadzama nhungamiro kuti rine mushonga kuti "sofosbuvir" mirayiridzo kushandiswa, ari mugadziri rinonyevera kuita kuzvidzora. Ndichibvunza kurapa pamusoro chirwere chakafanana hepatitis C anogona kupiwa bedzi chiremba ane ruzivo. Yawapiwa rinoitwa pasi pokudzora nyanzvi.

zvinodhaka Usage

vanachiremba vakawanda vanodavira kuti zvinodhaka "sofosbuvir" zvinofanira kutorwa chete akabatana nevamwe mishonga. Nokuti ichi dzinozivikanwa akashandisa anotevera zvirongwa, izvo kuvimba genotype chirwere:

• Kana genotypes 3-6 mhando mushonga "sofosbuvir" ushandiswe zvinodhaka, "Ribavirin" uye "interferon Alpha". mushonga uyu nyaya akapfuudza 3 months.
• Kana nehepatitis 1 uyewo hazvibviri kushandiswa yakadaro medicament se "Interferon Alpha" (pamberi munhu asingashiviriri kana contraindication). Panyaya iyi, kosi yacho yave chokuwedzera kaviri.
• Kana kushandisa mubatanidzwa kugadzirira 2 genotypes zano "sofosbuvir" mushonga "ribavirin" nokuda 3 months.
• Kana murwere akamirira kuti chiropa inokurudzirwa kushandisa zvose mishonga, "Ribavirin" uye "sofosbuvir". Mirayiridzo yokushandisa rinorumbidza kuwedzerwa kurapwa kusvikira transplantation.

Kana kana paine marwadzo chokuita kutora imwe mishonga wemishonga mishonga inofanira vakarega kurapa. Data pamusoro efficacy kurapa pavarwere vasina asvika zera ruzhinji, munyika kwete.

The mushonga "sofosbuvir" kutora 1 nguva rimwe zuva ari dose chairayirwa chiremba. Pane mitemo inofanira kutevedzerwa munyaya iyi:

• Haufaniri kutsenga kana vagovane mapiritsi, sezvo vane kwazvo kuravira. Mishonga chinotarisirwa munguva kudya.
• Kana emesis mumaawa maviri mushure medicament vanofanira kunwa mamwe dose.
• Uchisiya mishonga, kana kunonoka ari maawa asingasviki 18, achitora kurashikirwa piritsi. Kana nguva yakapfuura zvakawanda - kutora inotevera dose nenguva yakarongwa.

Zvokungwarira

Zvemarudzi ose mamwe mashoko kuti zvinokosha kuziva kana kutora mushonga rine, vasiyana mushonga "sofosbuvir" mirayiridzo. Zvairatidza kuti kushandiswa kwezvinodhaka iri kunzwisisa kurapa zvikuru kuona nemishonga.

In kurapika, unofanira kuziva zvinotevera:

• akaderedza wevasungwa uye maitiro nokukurumidza, saka unofanira kurega kutyaira uye mamwe mabasa;
• pamuviri hakungodiwi, saka unofanira nechokwadi chokuti rakavimbika nzira pamuviri.

nemishonga

Nhasi kwakaratidza haana zvose kurutivi migumisiro gadziriro "sofosbuvir". Mirayiridzo dzokushandisa rine mashoko kuti kuvimba ibatanidzo mushonga nedzimwe mishonga.

Kana kubatanidza zvinodhaka pamwe zvinodhaka, "Ribavirin" yakati:

• anopfuura 10% nyaya - kuderera Chizenga pamwero uye zvibereko bilirubin muropa, kuda kurutsa, kurukutika, hope nenyonganiso, nomusoro, kutya;
• 1% nyaya - kuzvimba lining mhino uye pahuro, kuderedza mwero resimbi muropa, kuora mwoyo, chikosoro, akatsamwa vonyanya, nezvinetso kushanda zvomudumbu turakiti, kurasikirwa bvudzi, kuvaviwa, cramping, fivhiri.

With mamwe yaitonga zvinodhaka riri zano "Interferon Alpha" pane ngozi yokuti kuchava:

• kupererwa, kushaya hope, dzungu, ungaderedza uwandu neutrophils, maplatelet uye lymphocytes nokuwedzerwa bilirubin muropa, mapundu, kuvaviwa, fivha, manyoka, kurutsa, fivhiri;
• uremu, kuora mwoyo uye kutya chirwere, migraine, kupatira, kupfupika mweya, marwadzo uye zvimwe zvinokonzerwa.

Muudzame ose nemishonga anorondedzerwa vasiyana mushonga "sofosbuvir" mirayiridzo Chinyorwa.

analogs

Kune akawanda analogues zvinodhaka "sofosbuvir". Vanogona kukamurwa kuva 2 mapoka. Analogs yezviri fuma vari: "Viropak", "Grateziano", "Hepsinat", "Hopetavir". A pamazita mishonga kuti vane "sofosbuvir" yakafanana kuchirapa nezvinozoitika yakakura zvikuru. To zita chete vamwe vavo: "Algeron", "Ledipasvir", "Neovir", "TSikloferon" uye vamwe vakawanda.

Zvisinei, unogona kusimbisa zvinoverengeka zvakanakira "sofosbuvir" pamberi vezera ake:

• Disinfection dzakasiyana genotypes ose hepatitis C;
• mukuru kunyatsoshanda;
• nzira pfupi yokurapa zvichienzaniswa nedzimwe zvinodhaka zhinji;
• tsime Akashivirira;
• Hazvina chokuita unhu murwere woupenyu.

mari

Modern mushonga haazivi zvinodhaka runziro dzakawanda zvokuti zvinobudirira kubatsira kurwisa hepatitis C, vakapfuura kupinda chirwere pachikuva. mushonga German "sofosbuvir" akakodzera varwere vakuru. Mirayiridzo kushandiswa kunoita kuti iwe enzanisa pamwe nemamwe mishonga yakafanana.

Nokuda kuti chinodhaka ichi zvinoratidza hwakanyatsorwisa yakakwirira kunyatsoshanda, ane yakajeka zvakwakanakira tichienzanisa analogues, rinodhura zvakakwirira zvikuru. Imwe nzira achaita mari murwere zviuru zvishomanana zvemadhora. Ndokusaka kuwana mushonga "sofosbuvir" iri Pharmacies kwakaoma zvisingaiti.

Nhasi, kupfuura akakwana uye njodzi mushonga rinoshandiswa kuti kurapa hepatitis C, ndiko nzira. ruzivo urwu zvinosimbisa wanamatira medicament "sofosbuvir" mirayiridzo. Analogs, maererano vanachiremba, usarega kuita zvinokosha nemigumisiro akadaro.

Chaizvo nokuti zvinodhaka ichi kunozivikanwa yakakura nhamba kuvarapi munyika yose. Vanodavira kuti nhasi mumwe hubudirire mishonga kuti yekudyidzana anogona kuderedza upenyu wevarwere kurwara, anongoti haako.