Estradiol uye progesterone: dzemunharaunda uye kuongorora zvarakasiya

Makemikari kujairika mu pakugadzira vanoshingaira zvinhu, izvo kuita kwete utano asiwo chakavanzika nyika munhu. Nature zvaitwa kuitira kuti muviri womukadzi pakarepo pashure pamuviri dzinovhurika nokuda dzakananga mahormone pamuviri - estradiol uye progesterone, izvo kwete chete kubatsira zvibereko zvakazara kubuda, asi kumutsa mukadzi kunzwa ramai.

Sei uchifanira kuongorora ufanane mahormone

Padariro vakamirira mwana mufundisi kuchinja kuitika mumuviri mumwe mukadzi (zvikurukuru, ichi rinoreva hormone kumashure). Kuchinja vari yose kwemakemikari anobudiswa hurongwa. Amai vanepamuviri, zvachose reconstructed, anosika ezvinhu kutakura, uyewo kukura mwana zvakasikwa kubvira kutanga kwekupwanyiwa pamuviri anotanga kugadzirira yokusununguka.

Zvachose vose muviri hormone zviratidzi vevanaamai ramangwana basa rinokosha - ndivo vanonyanya zvikonzero kuti zvakakodzera paumbwe azvarwa. Uye panyaya iyi, progesterone uye estradiol hazvo zvinodzorwa nerimwe gayinakorojisiti Zvimwe miedzo kuti mukadzi runodiwa zvakaitika kanenge kaviri munguva pamuviri: 1st trimester (10-12 masvondo) uye 2nd trimester (16-18 mavhiki).

The mahormone akazvitakura

Hormone kuongororwa compulsorily dzine miedzo nokuda kwevari estradiol uye progesterone. Zvidzidzo zvakadai yaifanira kazhinji zvichibvira, uye regai tobvisa kushanyira chiremba wako, ndiani zvinotitungamirira Kuregwa Analyses izvi. Just ndivo anokosha kukura mwana, kuti pave pamuviri utano. Uye ndicho chikonzero chikuru mahormone anonzi gestation.

estradiol

Zviri hormone dzokubereka nadzo, iyo ine rakananga kushanda kuti paumbwe munhukadzi yechipiri bonde unhu. Estradiol uye progesterone "kuongorora" basa rose dzokubereka nadzo. In zvinetso munhukadzi muviri kubudisa estradiol zvizere vana kwakaoma zvisingaiti. Uyezve, kemikari ichi anoita basa guru rebhuku zvakasikwa paumbwe pabonde zvikamu mwana panguva yokuyaruka rwakazara.

Estradiol anogadzirwa kazhinji nokuda ovaries uye adrenal mumasero ari maduku rwakapetwa rukoko. Panguva pamuviri, iro saturation kuti kemikari ichi yekudyidzana kwakawedzera mukati vasiri mwero. Zvinogamuchirwa kuwanda estradiol ari follicular chokutambudzika shanduko kubva 97,5 kusvika 592 mol / L, ari luteal - kubva 120 kusvika 738 mol / L, panguva kubereka vazodzikisa kuna 14.9 mol / L. In gono estradiol uye progesterone wakawana, asi mune diki zvakawanda.

Zvakakura estradiol dzakaonekwa mune zvakadai chirwere rinoti se:

• follicular ovarian cysts;
• estrogensekretiruyuschie uye granulosa anomera;
• namamota kuti secrete ari pamuviri kemikari (human chorionic gonadotropin) ;
• cirrhosis;
• kufutisa;
• Gynecomastia (varume).

Akazoita saturation kuti estradiol pamwe hypogonadism (mu vanhurume) chero Genesisi. Uyewo progesterone, mune bvunzo ropa kuziva kemikari ichi yaifanira ari zvachose ushandiswe nachiremba zuva.

progesterone

Zvinonzi vakatenda steroid kemikari neve ovaries vakadzi, kuti zvikuru chiduku kumwero adrenal rukoko uye danho pamuviri - placenta. Chokwadi, munhu dzinongoitika kuchinja uye mabasa munhukadzi muviri havachafaniri pasina progesterone. Chinangwa chikuru kemikari kugadzirisa kuenda kumwedzi uye pakuvimbisa abudirire gestation. Rizowedzerwa ropa progesterone uye estradiol Anofanira kuva pachena pazuva yainorongwa gayinakorojisiti.

Zvichienderana chokutambudzika kumwedzi, progesterone wevasungwa ari munhukadzi muviri angava:

• mu follicular - kubva 0,4 kusvika 5.4 nmol / L;
• ari luteal - kubva 3,3 kusvika 71,3 nmol / L;
• pamberi ovulation - kubva 1.23 kusvika 18.7 nmol / L;
• pakutanga pamuviri (4-12 mavhiki) - kubva 35,6 kusvika 136 nmol / l.

Mukuwedzera yokuwana munhukadzi, "inonakidza" chinzvimbo, mukuru progesterone saturation kungawedzera nezvirwere zvakadai:

• adrenal mota;
• matadza pamuviri;
• horionepitelioma dumbu;
• vachiberekwa adrenal hyperplasia isiri yekenza.

Achideredza kwevari progesterone inowanikwa zvakaitika mukadzi anogona kuva nokupfupfudzika. Kunyange apo endocrinopathy (kuperevedza pakati luteal kutotanga) uye galactorrhea chirwere, amenorrhea. Vose vari vokutanga uye kana yechipiri chichiburutswa zvikuru progesterone, estradiol.

testosterone

Izvi anonyanya mukono kemikari (androgen) anokonzera paumbwe yechipiri pabonde unhu rume wembereko uye kuvaka mabasa. Testosterone anoramba spermatogenesis, kunokanganisa kukura tsandanyama uye mapfupa kukura, zvinosimudzira erythropoiesis. Natural Kuwanda kemikari ichi ari munhurume ari kuwanda kubva 11 kusvika 33.5 nmol / l. In vakadzi testosterone ane bhuku duku zvikuru - kubva 0.2 kusvika 2.7 nmol / L.

mukati hombe kemikari kwakadaro mumuviri kungaenderana zvinotevera pathologies:

• testosteronprodutsiruyuschih testicular neoplasms;
• endogenous kortitsizma;
• yechipiri adrenal dysplasia rukoko.

Inosimudzira testosterone saturation (kana kwete kufunga kemikari progesterone uye estradiol) ari munhukadzi muviri kakawanda akaona virilizing ovarian anomera uye polycystic.

Kwakaderedza Kuwanda kemikari uyu anokwanisa, kana:

• chiropa kutadza;
• cryptorchidism;
• Down kuti urwere;
• kwokutanga vachidzokorora hypogonadism;
• uremia.

Zvakakosha kuziva kuti pakatanga tyisa testosterone mumuviri zvinogona kuchinja zvikuru kushanda ezvinhu hono dzokubereka nadzo.

Zvakaipira hormone kukundikana

Kuderedza uwandu dzokubereka mahormone ari navarandakadzi muviri kunokanganisa kwete chete kushanda nokubereka vana, asi pakuonekwa. Runningaway kunyanya testosterone mumuviri mumwe mukadzi kunoita kuti kunyanya bvudzi kukura munharaunda maloharakternyh pamusoro wake uye paumbwe mburwa.

Kuwedzera kuwanda mukadzi mahormone ari munhurume kunotungamirira kuti paumbwe yechipiri kurara unhu nehadzi somuenzaniso kuzvimba zamu (gynaecomastia). Uyezve, hormone zvikonzero vanachiremba vachiri kuona sezvo mukuru chinhu pamusoro kusagadzikana zvepabonde.

Chii prices inogona kubva kemikari

Nokuti kuipa hadzi muviri sezvingatarisirwa pave prolactin, progesterone, estradiol zvakakwana. Zvino tinotaura ichi kemikari ndiko estradiol, mwero mukadzi anofanira kuva:

• ari follicular chokutambudzika, - kubva pg / Rine mamiririta 57 227;
• mu luteinizing - kubva pg / Rine mamiririta 77 kusvika 226;
• mu pre-ovulatory - kubva 127 kusvika 475 pg / Rine mamiririta.

Mukuru mukadzi, shoma estradiol usapera pakuongororwa. Kana riri kubereka, kemikari mwero vakadzi iri vanenge 19,6-83 pg / Rine mamiririta.

Vakadzi nevarume vapiswa estradiol anogona kuonekwa kana varipo vakadaro mananara:

1. Kuzvimba nhengo dzokubereka nadzo.
2. Kudya miriwo.
3. Kusvuta.
4. Kwemakemikari anobudiswa zvirwere.
5. Kuvhiringidzika pituitary shwanu unongotaura.
6. Inosimudzira prolactin mumatunhu.
7. Active muviri.
8. Mishonga (siyana nhumbu) pasina mushonga.

zvakawedzera estradiol

Vakadzi kazhinji kuita chinokonzera zviratidzo zvakadai:

• alopecia (bvudzi kurasikirwa);
• kugumbuka;
• mburwa;
• kufutisa;
• akaderedza tembiricha Mbabvu;
• kunyanyisa nekuneta;
• bundu;
• kushaya hope;
• hadzina kufambiswa zvakanaka mune zvomudumbu turakiti;
• mwedzi chinji;
• marwadzo zamu.

Yakakwirira progesterone uye estradiol vakadzi panguva kuongororwa angava anoratidza generating nzvimbo yakawedzerwa thyroid mahormone, nyanyisa namamota uye mangwanani padanho inotungamirwa ovarian endometriosis.

yakaderera estradiol

Chirwere pane vakadzi pakuparwa ropa hakuitiki mukati 6 mwedzi, chipfuva uye dumbu vari kuderedzwa uye ganda riri dryish. Conception hazvigoni kuitika izvi. Estradiol uye progesterone zvinogonawo vadonhedzera kure mune tanga pamuviri.

progesterone dzemunharaunda

hormone kwakadaro anokonzera akanakira pamuviri kunofanira anowanzoita kuva ari follicular chokutambudzika 0,2-3,07 Ng / Rine mamiririta ari luteal - 0,32-20,6 Ng / Rine mamiririta. Panguva "inonakidza" chinzvimbo padanho progesterone ari mukadzi kutsunga trimester. Kazhinji, rokutanga trimester kemikari anoda kubva 19-53 kumar / ML rechipiri - 24-81,2 Ng / Rine mamiririta, uye wechitatu - 62-3135 kumar / Rine mamiririta. Fungidzira zvinoita zvibereko progesterone angava ovarian neoplasm, chirwere cheshuga mellitus, uye corpus luteum mbeu chikofu. A vanodira aigona kuita pacharo unoziva kushaya mbereko.

Low progesterone (uye estradiol uyewo) inonzi luteal insufficiency uye haikwani kuti pamuviri, uye kunyanya zvibereko. Chimwe chinoratidza kuti luteal wenhando anoonekwa pfupi kumwedzi. Yakaderera saturation muropa progesterone kuonekwa zvisingafadzi nezvekufadza ari mazamu nekusazvidzora makono mahormone. Chikonzero chechipiri anogona kutsamwisa nechitarisiko mburwa, nokufamba BP, uyewo chitarisiko ruvara rweganda.

chitsamba

zviito zvose kuti atore nzvimbo womunhu nomuviri titsigire, uye saka kuvakazve pamwero mumwe kana vaviri mahormone kunokanganisa zvimwe zviratidzo zvakare. Uye kuti gayinakorojisiti akakwanisa kuongorora zvinonakisa hadzi mahormone, zvinonzi vaite marudzi ose bvunzo mahormone. Zvingava nani kana nzendo dzakadaro nyanzvi achava enderana richiona nezvezvabuda mukuru uye hormone ezvinhu utano murwere.

Zvechokwadi, chinhu chinokosha kuti chero akanaka zvepabonde zvaigara yavo. Estradiol, progesterone - ndivo mahormone kuti vane basa yakarurama kushanda yose dzokubereka nadzo inokosha.